IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene LPAR1 Ensembl ENSG00000198121 Chromosome 9 Start 112675365 End 112840186
Description Lysophosphatidic acid receptor 1 (LPA receptor 1)(LPA-1)(Lysophosphatidic acid receptor Edg-2) [Source:UniProtKB/Swiss-Prot;Acc:Q92633]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 3166
     Entrez Gene : 1902
     UCSC : uc004bfc.2
     GeneCards : 3166
     RefSeq : NM_001401
     CCDS : CCDS6777.1
     Uniprot : Q92633
     Interpro : Q92633
     OMIM : 602282
     GeneTests : LPAR1
     CGAP : LPAR1
     PMID : 8922387

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40387_at  -0.59  5.78e-2  1.04e-1  -0.32  4.51e-1  5.55e-1
 HG_U133A  204036_at  -0.51  6.58e-5  1.40e-4  -2.58  4.39e-36  8.02e-36
 HG_U133A  204037_at  -0.28  2.06e-3  3.58e-3  0.29  8.25e-5  9.43e-5
 HG_U133A  204038_s_at  -0.38  3.79e-9  1.25e-8  -0.97  9.65e-32  1.66e-31
 HG_U133_Plus2  204036_at  -0.86  2.20e-10  1.68e-9  -0.73  9.51e-7  2.79e-6
 HG_U133_Plus2  204037_at  -0.81  3.31e-13  3.61e-12  -0.67  9.00e-7  2.65e-6
 HG_U133_Plus2  204038_s_at  0.29  2.59e-3  6.13e-3  0.57  2.10e-9  8.60e-9
 HG_U133_Plus2  232716_at  -0.83  3.33e-6  1.38e-5  -1.17  1.27e-9  5.36e-9

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204036_at  -0.15  6.72e-1  9.65e-1  -0.06  8.25e-1  1.00e+0
 HG_U133A  204037_at  -0.08  7.76e-1  9.78e-1  -0.31  2.11e-1  1.00e+0
 HG_U133A  204038_s_at  0.12  5.48e-1  9.38e-1  -0.12  4.25e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40387_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204036_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204037_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204038_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204036_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204037_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204038_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 232716_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
lpa1 ovarian cancer Edg-4 (LPA2) R transduces proliferative responses, recruitment of autocrine protein growth factors, and migration of ovarian cancer cells, whereas Edg-2 (LPA1) R transduces inhibition of Edg-4 (LPA2) R-mediated responses and concurrently elicits apoptosis 12069824 Human
edg-2 ovarian cancer Edg-4 (LPA2) R transduces proliferative responses, recruitment of autocrine protein growth factors, and migration of ovarian cancer cells, whereas Edg-2 (LPA1) R transduces inhibition of Edg-4 (LPA2) R-mediated responses and concurrently elicits apoptosis 12069824 Human
lpa1 malignant ascites Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1. 14660630 Human
lpa1 human pancreatic cancer Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1. 14660630 Human
lpa1 pancreatic cancer A significant level of LPA1 receptor mRNA is expressed in pancreatic cancer cells with high migration activity to ascites but not in cells with low migration activity. 14660630 Human
lpa1 pancreatic cancer These results suggest that LPA is a critical component of ascites for the motility of pancreatic cancer cells and LPA1 receptors may mediate this activity. 14660630 Human
edg2 follicular thyroid cancers We further assessed mRNA expression of high-affinity receptors EDG2 and EDG4 in 14 normal thyroids, 29 papillary thyroid cancers, 7 follicular thyroid cancers and 13 goiters by quantitative RT-PCR. 11291053 Human
edg2 papillary thyroid cancers We further assessed mRNA expression of high-affinity receptors EDG2 and EDG4 in 14 normal thyroids, 29 papillary thyroid cancers, 7 follicular thyroid cancers and 13 goiters by quantitative RT-PCR. 11291053 Human
edg2 follicular thyroid cancer Normal thyroid, goiter and papillary or follicular thyroid cancer expressed 2 high-affinity cognate LPA receptors, EDG2 and EDG4. 11291053 Human
edg2 metastasis Overall expression of EDG2 receptor was unchanged in malignancy; however, increased EDG2 expression in individual samples correlated with lymphonodular metastasis (p = 0.01). 11291053 Human
edg2 ovarian cancer Both Edg2 and Edg4 were detected in ovarian cancer cells; however, only Edg2 was present in normal ovarian surface epithelial cells and IOSE-29 cells. 11353786 Human
edg2 ovarian tumor Our data suggest that Edg4, but not Edg2, plays a role in LPA stimulation of ovarian tumor growth. 11353786 Human
edg2 ovarian cancer Ovarian cancer cell lines do not express EDG1 mRNA, have variable EDG2 mRNA and protein levels, and frequently exhibit levels of EDG4 mRNA and protein, suggesting that EDG4 may contribute to the deleterious effects of LPA in ovarian cancer. 10818454 Human
edg2 ovarian cancer In contrast, activation of the EDG2 LPA receptor on ovarian cancer cells may lead to apoptosis and counter the effects of other LPA receptors. 10818454 Human
edg-2 human osteosarcoma In this study, transient overexpression of Edg-2 sensitized MG63 human osteosarcoma cells to both LPA- and S1P-mediated stimulation of fibronectin matrix deposition and actin stress fiber formation. 10961347 Human
edg-2 ovarian cancer Expression of the edg-2 LPA receptor was not consistently different between normal epithelial cell lines and ovarian cancer cell lines. 10589790 Human
edg-2 ovarian cancer Northern blot analysis showed that most ovarian cancer cell lines express Edg-2. 10632375 Human
edg-2 metastasis These observations suggest that Edg-2 may be a negative regulator for ovarian epithelial cell growth and metastasis. 10632375 Human
edg-2 lymphoblastoma Mechanisms of suppression of apoptosis by LPA and S1P were studied in the Tsup-1 cultured line of human T lymphoblastoma cells, which express Edg-2 and Edg-4 GPCRs for LPA and Edg-3 and Edg-5 GPCRs for S1P. 9973477 Human
edg2 ovarian cancer Edg2 may represent a negative regulatory LPA receptor inducing apoptosis in ovarian cancer cells. 11775454 Human
edg-2 human breast cancer Cultured lines of human breast cancer cells (BCCs) express Edg-3 > Edg-4 > Edg-5 > or = Edg-2, without detectable Edg-1, by both assessment of mRNA and Western blots with rabbit and monoclonal mouse anti-Edg R antibodies. 10493533 Human
edg-2 metastases In particular, reduced Edg-2 gene product expression was also confirmed in a group of 50 primary melanomas and unrelated metastases. 12702151 Human
edg-2 melanomas In particular, reduced Edg-2 gene product expression was also confirmed in a group of 50 primary melanomas and unrelated metastases. 12702151 Human
edg2 cancer Northern blots revealed that two edg4 mRNA transcripts of 1.8 and 8 kilobases are distributed very differently from edg2 mRNAs in adult human tissues and several cancer cell lines. 9525886 Human
edg2 hepatoma The Ca2+ mobilization by Edg2 and Edg4 was further characterized in stable transfectants of rat HTC4 hepatoma cells. 9804623 Human
edg2 neuroblastoma Here we report that the prototypic LPA(1) receptor (previously named Edg2), when expressed in B103 neuroblastoma cells, mediates transient activation of RhoA and robust, prolonged activation of Rac leading to cell spreading, lamellipodia formation, and st 12393875 Human
lpa1 human colon carcinoma Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1. 12670925 Human
lpa1 colon cancer Our results suggest that LPA acts as a potent stimulator of colon cancer progression, although the binding to LPA1 and LPA2 induces slightly different responses. 12670925 Human
edg-2 tumor BACKGROUND/AIMS: The EDG-2 (endothelial cell differentiation gene-2) has been characterized as one of the high-affinity receptors of lysophosphatidic acid: an extracellular lipid mediator which can induce tumor progression. 14696401 Human
edg-2 tumor Recent studies have revealed that EDG-2 plays an important role in various pathological events including cell proliferation and tumor development. 14696401 Human
edg-2 adenoma In the current study, we examined the immunohistochemical expression of EDG-2 in colorectal mucosa and adenoma, and clarified its relation with the clinicopathological features. 14696401 Human
edg-2 adenoma RESULTS: EDG-2 was expressed almost exclusively in the cytoplasm in colorectal normal mucosa and adenoma. 14696401 Human
edg-2 adenoma EDG-2 expression in normal mucosa and adenoma was 8% and 76%, respectively. 14696401 Human
edg-2 low-grade adenoma EDG-2 expression was increased in low-grade adenoma compared with that in normal mucosa (P < 0.001). 14696401 Human
edg-2 adenomas EDG-2 expression was significantly greater in adenomas with larger diameters (P < 0.001). 14696401 Human
edg-2 adenoma CONCLUSIONS: We demonstrated that EDG-2 expression was increased in the early stage of adenoma. 14696401 Human
edg-2 adenomas A significant correlation between EDG-2 expression and the size of the adenomas suggests that EDG-2 may play an important role in the growth of these adenomas. 14696401 Human

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