IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene UGCG Ensembl ENSG00000148154 Chromosome 9 Start 113698867 End 113735168
Description Ceramide glucosyltransferase (EC 2.4.1.80)(Glucosylceramide synthase)(GCS)(UDP-glucose:N-acylsphingosine D-glucosyltransferase)(UDP-glucose ceramide glucosyltransferase)(GLCT-1) [Source:UniProtKB/Swiss-Prot;Acc:Q16739]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 12524
     Entrez Gene : 7357
     UCSC : uc004bft.2
     GeneCards : 12524
     RefSeq : NM_003358
     CCDS : CCDS6782.1
     Uniprot : Q16739
     Interpro : Q16739
     OMIM : 602874
     GeneTests : UGCG
     CGAP : UGCG
     PMID : 8643456

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40214_at  -0.56  1.28e-2  2.90e-2  -1.32  1.41e-5  6.87e-5
 HG_U95  40215_at  -0.22  3.22e-2  6.37e-2  -0.30  1.83e-2  3.89e-2
 HG_U133A  204881_s_at  0.38  1.25e-5  2.88e-5  -0.43  6.74e-3  7.36e-3
 HG_U133A  221765_at  0.47  2.17e-4  4.32e-4  -0.62  3.55e-5  4.09e-5
 HG_U133_Plus2  204881_s_at  -0.37  4.95e-4  1.37e-3  -0.67  1.62e-6  4.61e-6
 HG_U133_Plus2  221765_at  -0.06  7.06e-1  7.71e-1  -0.31  6.60e-2  9.21e-2
 HG_U133_Plus2  224967_at  -0.33  1.34e-5  5.02e-5  -0.44  1.18e-5  2.99e-5
 Stanford  19677  0.51  6.98e-2  1.95e-1  0.45  2.10e-1  4.39e-1
 Agilent_HS_21.6K  14458  -0.07  4.80e-1  6.58e-1  -0.11  2.02e-1  3.47e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204881_s_at  -0.42  1.31e-1  7.95e-1  0.04  8.44e-1  1.00e+0
 HG_U133A  221765_at  -0.26  4.51e-1  9.15e-1  -0.14  5.67e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40214_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 40215_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204881_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 221765_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204881_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 221765_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 224967_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 19677    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 14458    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
glucosylceramide synthase melanoma Transfection of glucosylceramide synthase antisense inhibits mouse melanoma formation. 11971858 Human
glucosylceramide synthase tumor We used a molecular approach--antisense transfection targeting the glucosylceramide synthase gene--to regulate glycosphingolipid synthesis by MEB4 cells and examine the influence on tumor formation. 11971858 Human
glucosylceramide synthase tumor These findings demonstrate that stable transfection of glucosylceramide synthase antisense reduces cellular glycosphingolipid levels and reduces tumorigenicity, providing further experimental support for an enhancing role of gangliosides in tumor formatio 11971858 Human
glucosylceramide synthase neuroepithelioma Antisense to glucosylceramide synthase in human neuroepithelioma affects cell growth but not apoptosis. 12032678 Human
glucosylceramide synthase cancer Glucosylceramide synthase overexpression has been shown to enhance resistance to doxorubicin, suggesting that inhibition of ceramide metabolism or catabolism might enhance cancer chemotherapy. 15013522 Human
glucosylceramide synthase breast tumor We investigated the effect of the glucosylceramide synthase inhibitor 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) on the chemosensitivity of two wild-type and multidrug-resistant human breast tumor cell lines. 12467215 Human
gcs cancer Known for many years as a branch point enzyme directing synthesis of cerebrosides and gangliosides, GCS has recently been implicated in the cytotoxic response of cancer cells to chemotherapy. 12531551 Human
gcs human breast cancer Here we show that multidrug resistance can be increased over baseline and then totally reversed in human breast cancer cells by GCS gene targeting. 11259390 Human
gcs cancer This study reveals that GCS is a novel mechanism of multidrug resistance and positions GCS antisense as an innovative force to overcome multidrug resistance in cancer chemotherapy. 11259390 NA
glucosylceramide synthase neuroepithelioma Potentiation of okadaic acid-induced ceramide elevation but not apoptosis by inhibition of glucosylceramide synthase in human neuroepithelioma cells. 11274971 Human
glucosylceramide synthase leukemia We blocked ceramide metabolism in a series of variably vincristine-resistant cell lines derived from CCRF-CEM leukemia cells using an inhibitor of glucosylceramide synthase, DL-threo-phenyl-2-hexadecanoylamino-3-pyrrolidino-1-propanol (PPPP). 11391632 Human
glucosylceramide synthase tumor N-oleoylethanolamine or D-L-threo 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), which inhibits acid ceramidase or glucosylceramide synthase and then increases endogenous ceramide, enhanced DC apoptosis and ceramide levels in the presence of tum 11564794 Human
glucosylceramide synthase hepatoma Differential chemosensitizing effect of two glucosylceramide synthase inhibitors in hepatoma cells. 11594784 Human
ceramide glucosyltransferase melanoma To explore the question of whether glycosphingolipid binding of ricin or glycosphingolipid synthesis is essential for transport of ricin from the plasma membrane to the Golgi apparatus, retrogradely to the endoplasmic reticulum or for translocation of the 12839497 Human
glucosylceramide synthase cancer It has also been shown that decreased levels of endogenous ceramide by over-expression of glucosylceramide synthase, which clears ceramide levels by incorporating it into glucosylceramide, results in the development of a multidrug resistant phenotype in c 12030784 Human
glucosylceramide synthase tumor SK-RC-45 gangliosides appear to mediate this degradative pathway, as blocking ganglioside synthesis in SK-RC-45 cells with the glucosylceramide synthase inhibitor, PPPP, protected T cells from tumor cell-induced RelA degradation and apoptosis. 15004148 Human
gcs breast cancer To down-regulate ceramide glycosylation potential, we transfected adriamycin-resistant breast cancer cells (MCF-7-AdrR) with GCS antisense (asGCS), using a pcDNA 3.1/his A vector and developed a new cell line, MCF-7-AdrR/asGCS. 10702281 Human
glucosylceramide synthase melanoma METHODS: We tested a ganglioside-rich subline of B16 murine melanoma, MEB4, and MEB4 cells that had been depleted of endogenous gangliosides by incubation with 0.5 microM 1-phenyl-2-hexadecanoylamino-3-pyrrolidino-1-propanol, a specific inhibitor of the e 10841826 NA
glucosylceramide synthase human osteosarcoma Treatment of human osteosarcoma cells, expressing CD4 and various chemokine receptors, with the glucosylceramide synthase inhibitor 1-phenyl-2-hexadecanoylamino-3-morpholino-1-propanol (PPMP), blocked target membrane glycosphingolipid (GSL) biosynthesis a 10864648 Human
gcs tumors We analyzed: the localization of tumors based on CT and MRI examinations and intraoperative observation, the status of consciousness by GCS scale, neurological status and histological findings. 11208288 NA
glucosylceramide synthase human breast cancer Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells. 9873062 Human
gcs breast cancer 272, 1682-1687). In this study, we have introduced glucosylceramide synthase (GCS) into wild type MCF-7 breast cancer cells using a retroviral tetracycline-on expression system, and we developed a cell line, MCF-7/GCS. 9873062 NA
glucosylceramide synthase breast cancer 272, 1682-1687). In this study, we have introduced glucosylceramide synthase (GCS) into wild type MCF-7 breast cancer cells using a retroviral tetracycline-on expression system, and we developed a cell line, MCF-7/GCS. 9873062 NA
gcs breast cancer This work demonstrates that overexpression of GCS, which catalyzes ceramide glycosylation, induces resistance to adriamycin and ceramide in MCF-7 breast cancer cells. 9873062 Human
glucosylceramide synthase rat glioma An in vitro model of Gaucher's disease in murine neuroblastoma x rat glioma NG108-15 cells was used to investigate the physiological effects of two specific inhibitors of glucosylceramide synthase, d,l-threo-1-phenyl-2-decanoylamino-3-morpholino-1-pr 10037475 Human
glucosylceramide synthase murine neuroblastoma An in vitro model of Gaucher's disease in murine neuroblastoma x rat glioma NG108-15 cells was used to investigate the physiological effects of two specific inhibitors of glucosylceramide synthase, d,l-threo-1-phenyl-2-decanoylamino-3-morpholino-1-pr 10037475 Human
glucosylceramide synthase cancer However, the role of glucosylceramide synthase has not been studied in drug-sensitive cancer cells. 14766899 Human
gcs cancer Inhibition of GCS activity has been proposed as a possible target of chemotherapeutic agents for a number of diseases, including cancer. 10393098 Human
gcs human breast cancer By introduction of the GCS gene, cytotoxic resistance to TNF-alpha has been conferred in human breast cancer cells. 10527636 Human
gcs neck squamous cancer PURPOSE: To correlate cellular glutathione content and gamma-glutamyl cysteine synthetase (gamma GCS) mRNA expression with cisplatin sensitivity in a panel of seven head and neck squamous cancer cell lines. 9137534 NA
gcs tumor CONCLUSION: At a non-toxic dose, RU486 may enhance the sensitivity of tumor cells to cisplatin in vivo, possibly through the mechanism of inhibiting GcS expression at the mRNA level. 12651241 Human
gcs cancer Therefore, elevation of GSH as achieved by inducing g-glutamylcysteine synthetase (GCS), the limiting enzyme of GSH synthesis, may contribute to chemoprevention against cancer. 12791507 Human
gcs hepatoma In the present experiment, we used the hepatoma cell line HepG2 to investigate the response of GCS and GSH to five plant-derived chemoprotectants contained in regularly consumed foodstuffs and beverages (kahweol/cafestol [K/C] [15.5-62.0 mM], a-angelicala 12791507 Human
gcs gallbladder cancers We studied the MSI (microsatellite instability) status and p53 expression in a series of 71 gallbladder cancers (GCs) of different histologic type. 12766614 NA
glucosylceramide synthase leukemia Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia. 12538495 Human
gcs leukemia In vivo, the level of ceramide was lower in chemoresistant leukemia patients (6.4 +/- 1.8 pmol/nmol phosphate; n = 14) than in chemosensitive patients (9.5 +/- 2.7 pmol/nmol phosphate; n = 9), and the activities of GCS and SMS were more than 2-fold higher 12538495 Human
gcs leukemia Therefore, it is suggested that a decrease of the ceramide level via activation of GCS and SMS is associated with the chemoresistant condition in leukemia, probably in relation to Bcl-2 but not to MDR-1 expression. 12538495 Human
glucosylceramide synthase tumor Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth. 7775872 Human
glucosylceramide synthase metastasis Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action. 2145065 Mouse
glucosylceramide synthase lewis lung carcinoma Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action. 2145065 Mouse
glucosylceramide synthase tumor metastasis In view of the increasing evidence that glucosphingolipids (GSLs) on tumor cell surfaces play an important role in tumor metastasis, an inhibitor of glucosylceramide synthase, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP) was used to e 2145065 Human
glucosylceramide synthase tumor In view of the increasing evidence that glucosphingolipids (GSLs) on tumor cell surfaces play an important role in tumor metastasis, an inhibitor of glucosylceramide synthase, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP) was used to e 2145065 Human
glucosylceramide synthase cancer Rationales for cancer chemotherapy with PDMP, a specific inhibitor of glucosylceramide synthase. 8086032 Human
glucosylceramide synthase tumor Thus, the enzyme glucosylceramide synthase, which converts ceramide into glucosylceramide, has emerged as a potential target to increase apoptosis and decrease drug resistance of tumor cells. 15134220 Human
glucosylceramide synthase melanoma The absence of functional glucosylceramide synthase does not sensitize melanoma cells for anticancer drugs. 12692077 Human
gcs melanoma Herein, we compared GM95 mouse melanoma cells deficient in GCS activity, with cells stably transfected with a vector encoding GCS (GM95/GCS). 12692077 Human
gcs melanoma Furthermore, N-(n-butyl)deoxynojirimycin, a potent and non-toxic GCS inhibitor, had no chemosensitizing effect on wild-type melanoma cells. 12692077 Human
glucosylceramide synthase murine neuroblastoma Effects of an inhibitor of glucosylceramide synthase on glycosphingolipid synthesis and neurite outgrowth in murine neuroblastoma cell lines. 1834639 Mouse
glucosylceramide synthase melanoma tumor Inhibition of melanoma tumor growth by a novel inhibitor of glucosylceramide synthase. 12839955 Human
glucosylceramide synthase neuroepithelioma Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells. 12873973 Human
gcs neuroepithelioma GCS inhibition, by both antisense and the specific inhibitor (D-threo)-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), results in a drastic decrease of apoptosis induced by the p53-independent chemotherapeutic agent N-(4-hydroxyphenyl)retinamide 12873973 Human
gcs glioma [The effect of nordihydroguaiaretic acid on endothelial cell migration induced by glioma cells] OBJECTIVE: To investigate the effect of nordihydroguaiaretic acid (NDGA) on the migration of endothelial cells (ECs) induced by glioma cells (GCs) in vitro. 11866889 NA
gcs malignant glioma METHODS: Cells of human umbilical vein endothelial cell line ECV-304 and human malignant glioma cell line SHG-44 were co-cultured in the Falcon Cell Culture Insert system, and the effect of NDGA on the migration of ECs induced by GCs was investigated. 11866889 NA
gcs nsclc METHODS: Eighty-five samples of NSCLC were studied using immunohistochemistry with polyclonal antibodies to the heavy and light subunits of gamma GCS (gamma GCS-h, gamma GCS-l), and the expressions were correlated with apoptosis and patients survival. 11753966 NA
gcs cancer [Expression of glucosylceramide synthase mRNA in vincristine-resistant KBV200 cell line in association with multidrug resistance] OBJECTIVE: To investigate the relationship between the expression of glucosylceramide synthase (GCS) mRNA in vincristine-resi 15257901 NA
gcs tumor GCS gene might play an important role in MDR during tumor progression. 15257901 Human
gcs breast cancer High glucosylceramide synthase (GCS) activity is one factor contributing to multidrug resistance (MDR) in breast cancer. 14967819 Human
gcs multidrug-resistant cancer To examine whether GCS is a target for cancer therapy, we have designed and tested the effects of antisense oligodeoxyribonucleotides (ODNs) to GCS on gene expression and chemosensitivity in multidrug-resistant cancer cells. 14967819 Human
gcs cancer To examine whether GCS is a target for cancer therapy, we have designed and tested the effects of antisense oligodeoxyribonucleotides (ODNs) to GCS on gene expression and chemosensitivity in multidrug-resistant cancer cells. 14967819 Human
gcs acute myeloid leukemia (aml) We aimed to show that glucosylceramide synthase (GCS) activity is linked to p-gp expression and resistance to ceramide-induced apoptosis in acute myeloid leukemia (AML). 15661399 Human
gcs cancer Overexpression of glucosylceramide synthase (GCS), a pivotal enzyme in glycolipid biosynthesis, contributes to cancer cell resistance to chemotherapy. 15867385 Human
gcs breast carcinoma [Construction of glucosylceramide synthase-specific siRNA expression vector and its efficiency in reversal of drug resistance in breast carcinoma cells] OBJECTIVE: To construct a glucosylceramide synthase (GCS)-specific small interfering RNA (siRNA) expre 15949329 NA
gcs breast carcinoma CONCLUSION: A GCS-specific small interfering RNA expression vector has been constructed successfully that suppresses the GCS expression and reverses the multidrug resistance in breast carcinoma cells by increasing the ratio of apoptosis in drug-resistant 15949329 Human
the gcs gene human breast cancer By introduction of the GCS gene, cytotoxic resistance to TNF-alpha has been conferred in human breast cancer cells. 10527636 Human
glucosylceramide synthase medulloblastoma Synthesis, shedding, and intercellular transfer of human medulloblastoma gangliosides: abrogation by a new inhibitor of glucosylceramide synthase. 9453539 Human
glucosylceramide synthase cancer [Expression of glucosylceramide synthase mRNA in vincristine-resistant KBV200 cell line in association with multidrug resistance] OBJECTIVE: To investigate the relationship between the expression of glucosylceramide synthase (GCS) mRNA in vincristine-resi 15257901 NA
glucosylceramide synthase neuroblastoma RESULTS: In neuroblastoma cells, ROS generation and apoptosis were associated with fenretinide-induced increased levels of ceramide, glucosylceramide synthase activity, GD3 synthase activity, and GD3. 15339967 Human
glucosylceramide synthase cancer Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells. 15263008 Human
glucosylceramide synthase cancer Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells. 14967819 Human
glucosylceramide synthase breast cancer High glucosylceramide synthase (GCS) activity is one factor contributing to multidrug resistance (MDR) in breast cancer. 14967819 Human
glucosylceramide synthase cancer Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy. 15141021 Human
glucosylceramide synthase other cancer Here, we have studied acquired resistance to Adriamycin, Vinca alkaloids, and etoposide in MCF-7 breast cancer cells, KB-3-1 epidermoid carcinoma cells, and other cancer cell lines to determine if there is an association between expression of glucosylcera 15141021 Human
glucosylceramide synthase breast cancer Here, we have studied acquired resistance to Adriamycin, Vinca alkaloids, and etoposide in MCF-7 breast cancer cells, KB-3-1 epidermoid carcinoma cells, and other cancer cell lines to determine if there is an association between expression of glucosylcera 15141021 Human
glucosylceramide synthase epidermoid carcinoma Here, we have studied acquired resistance to Adriamycin, Vinca alkaloids, and etoposide in MCF-7 breast cancer cells, KB-3-1 epidermoid carcinoma cells, and other cancer cell lines to determine if there is an association between expression of glucosylcera 15141021 Human
glucosylceramide synthase breast cancer In breast cancer, detailed analysis of MCF-7 wild-type and MCF-7-AdrR cells (Adriamycin-resistant) demonstrated enhanced glucosylceramide synthase message and protein, P-gp message and protein, and high levels of glucosylceramide in resistant cells. 15141021 Human
glucosylceramide synthase acute myeloid leukemia P-glycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway. 15661399 Human
glucosylceramide synthase acute myeloid leukemia (aml) We aimed to show that glucosylceramide synthase (GCS) activity is linked to p-gp expression and resistance to ceramide-induced apoptosis in acute myeloid leukemia (AML). 15661399 Human
glucosylceramide synthase human breast carcinoma [Investigation on the relationship between multidrug resistance and expression of glucosylceramide synthase in human breast carcinoma cells] 15842808 Human
glucosylceramide synthase breast cancer Glucosylceramide synthase blockade down-regulates p-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs. 15867385 Human
glucosylceramide synthase cancer Overexpression of glucosylceramide synthase (GCS), a pivotal enzyme in glycolipid biosynthesis, contributes to cancer cell resistance to chemotherapy. 15867385 Human
glucosylceramide synthase breast carcinoma [Construction of glucosylceramide synthase-specific siRNA expression vector and its efficiency in reversal of drug resistance in breast carcinoma cells] OBJECTIVE: To construct a glucosylceramide synthase (GCS)-specific small interfering RNA (siRNA) expre 15949329 NA
glucosylceramide synthase leukemia We also show the relation of ceramide level through regulation of ceramide-related enzymes (sphingomyelinase, ceramidase, sphingomyelin synthase and glucosylceramide synthase) with diseases such as cancer, leukemia, bacterial infections, AIDS, Alzheimer&a 16026301 Human
glucosylceramide synthase cancer We also show the relation of ceramide level through regulation of ceramide-related enzymes (sphingomyelinase, ceramidase, sphingomyelin synthase and glucosylceramide synthase) with diseases such as cancer, leukemia, bacterial infections, AIDS, Alzheimer&a 16026301 Human

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