IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SLC31A1 Ensembl ENSG00000136868 Chromosome 9 Start 115023638 End 115068495
Description High affinity copper uptake protein 1 (Copper transporter 1)(hCTR1)(Solute carrier family 31 member 1) [Source:UniProtKB/Swiss-Prot;Acc:O15431]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11016
     Entrez Gene : 1317
     UCSC : uc004bgu.2
     GeneCards : 11016
     RefSeq : NM_001859
     CCDS : CCDS6789.1
     Uniprot : O15431
     Interpro : O15431
     OMIM : 603085
     GeneTests : SLC31A1
     CGAP : SLC31A1
     PMID : 9207117

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40364_at  0.02  8.72e-1  9.10e-1  -0.21  1.36e-1  2.12e-1
 HG_U133A  203971_at  0.29  6.43e-5  1.37e-4  1.41  5.13e-42  1.02e-41
 HG_U133_Plus2  203971_at  -0.37  5.03e-3  1.11e-2  -0.96  1.96e-8  7.13e-8
 HG_U133_Plus2  235013_at  -1.13  1.84e-16  2.94e-15  -1.23  2.86e-11  1.46e-10
 HG_U133_Plus2  236217_at  -0.67  2.85e-10  2.14e-9  -0.96  7.20e-10  3.13e-9
 Stanford  7893  -0.36  1.42e-1  3.14e-1  -0.27  3.16e-1  5.56e-1
 Agilent_HS_21.6K  11174  0.01  7.45e-1  8.51e-1  0.01  5.14e-1  6.60e-1
 Agilent_HS_21.6K  15699  -0.18  1.97e-6  4.38e-5  -0.21  2.84e-5  2.75e-4

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203971_at  -0.17  5.56e-1  9.42e-1  -0.06  7.38e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40364_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203971_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203971_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 235013_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 236217_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 7893    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 11174    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 15699    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ctr1 tumor Recent studies have demonstrated that the major Cu influx transporter CTR1 regulates tumor cell uptake of cisplatin (DDP), carboplatin (CBDCA) and oxaliplatin (L-OHP), and that the two Cu efflux transporters ATP7A and ATP7B regulate the efflux of these dr 15607932 Human
hctr1 human tumor To further define the role of hCTR1 in human tumor cells, the ovarian carcinoma cell line A2780 was molecularly engineered to increase expression of hCTR1 by a factor of 20-fold. 15229296 Human
hctr1 ovarian carcinoma To further define the role of hCTR1 in human tumor cells, the ovarian carcinoma cell line A2780 was molecularly engineered to increase expression of hCTR1 by a factor of 20-fold. 15229296 Human
hctr1 human ovarian carcinoma Cisplatin rapidly down-regulates its own influx transporter hCTR1 in cultured human ovarian carcinoma cells. 15475465 Human
hctr1 human ovarian carcinoma The goal of this study was to examine the effect of Cu and DDP on the level and subcellular localization of hCTR1 protein in human ovarian carcinoma cells. 15475465 Human
hctr1 human ovarian carcinoma EXPERIMENTAL DESIGN: Cultured human ovarian carcinoma A2780 cells were exposed to DDP and Cu, and the effect on hCTR1 was determined using Western blot analysis and confocal digital deconvolution microscopy. 15475465 Human
hctr1 small cell lung cancers (sclc) Here, we show that, of five cisplatin-resistant cell lines, only one (SR2) exhibited substantial reduction in hCtr1 expression as compared with that in its sensitive line small cell lung cancers (SCLC), whereas copper efflux transporters ATP7A and ATP7B w 15634647 Human
slc31a1 tumor Our data suggest requirement for the cell surface targets IGF2R, L1CAM and SLC31A1 in tumor cell growth in vitro, and suggests that IGF2R is required for xenograft tumor growth in a mouse model. 15361835 Human

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