IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ALAD Ensembl ENSG00000148218 Chromosome 9 Start 115188416 End 115203434
Description Delta-aminolevulinic acid dehydratase (ALADH)(EC 4.2.1.24)(Porphobilinogen synthase) [Source:UniProtKB/Swiss-Prot;Acc:P13716]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 395
     Entrez Gene : 210
     UCSC : uc011lxf.1
     GeneCards : 395
     RefSeq : NM_000031
     CCDS : CCDS6794.2
     Uniprot : P13716
     Interpro : P13716
     OMIM : 125270
     GeneTests : ALAD
     CGAP : ALAD
     PMID : 6839527

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  34506_at  0.58  1.11e-4  4.46e-4  0.63  1.35e-3  4.03e-3
 HG_U133A  218487_at  -0.14  9.17e-2  1.21e-1  3.06  1.81e-105  1.42e-104
 HG_U133A  218489_s_at  1.72  2.74e-42  8.69e-41  5.24  8.35e-115  8.59e-114
 HG_U133_Plus2  218487_at  -0.48  1.97e-8  1.15e-7  -1.00  4.38e-15  3.47e-14
 HG_U133_Plus2  218489_s_at  0.94  1.81e-17  3.26e-16  1.14  1.60e-18  1.88e-17
 Agilent_HS_21.6K  2669  -0.04  3.90e-1  5.76e-1  -0.06  1.02e-1  2.11e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  218487_at  0.06  8.55e-1  9.88e-1  -0.40  1.64e-1  1.00e+0
 HG_U133A  218489_s_at  -0.47  1.93e-1  8.25e-1  -0.15  6.72e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 34506_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 218487_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 218489_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 218487_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 218489_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 2669    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
alad polycythemia vera It was concluded that he developed the porphyria because an abnormal ALAD allele was clonally expanded by polycythemia vera. 11929054 Human
alad hepatoma Dimethyl sulfoxide (DMSO) treatment of human HepG2 hepatoma cells increases the activity and the concentration of delta-aminolevulinic acid dehydratase (ALAD) to a comparable degree. 3382408 Human
alad laryngeal cancer In this study we investigated the possible relationship of laryngeal cancer and subclinical lead intoxication, using the depression of aminolevulinic acid dehydratase (ALAD) activity in blood as indicator. 9158246 NA
alad laryngeal cancer Blood ALAD activity values in the patients with laryngeal cancer ranged from 27.1 to 75.3 U/l with a mean of 50.79 U/l. 9158246 Human
aminolevulinate dehydratase mammary carcinoma 1. Aminolevulinate dehydratase (ALA-D) was studied in crude extract from mouse mammary carcinoma, normal mouse liver and tumour bearing mouse liver. 2225774 Human
aminolevulinate dehydratase tumour 1. Aminolevulinate dehydratase (ALA-D) was studied in crude extract from mouse mammary carcinoma, normal mouse liver and tumour bearing mouse liver. 2225774 Human
alad meningioma The enzyme delta-aminolevulinic acid dehydratase (ALAD), which catalyzes the second step of heme synthesis, can be inhibited by several chemicals, including lead, a potential risk factor for brain tumors, particularly meningioma. 16140629 Human
alad brain tumors The enzyme delta-aminolevulinic acid dehydratase (ALAD), which catalyzes the second step of heme synthesis, can be inhibited by several chemicals, including lead, a potential risk factor for brain tumors, particularly meningioma. 16140629 Human
alad intracranial tumors In this study we examined whether the ALAD G177C polymorphism in the gene coding for ALAD is associated with risk of intracranial tumors of the brain and nervous system. 16140629 NA
alad meningioma ALAD genotype was determined for 94% of these samples (355 glioma, 151 meningioma, 67 acoustic neuroma, and 505 controls). 16140629 Human
alad glioma ALAD genotype was determined for 94% of these samples (355 glioma, 151 meningioma, 67 acoustic neuroma, and 505 controls). 16140629 Human
alad acoustic neuroma ALAD genotype was determined for 94% of these samples (355 glioma, 151 meningioma, 67 acoustic neuroma, and 505 controls). 16140629 Human
alad tumor The enzyme delta-aminolevulinic acid dehydratase (ALAD), which catalyzes the second step of heme synthesis, can be inhibited by several chemicals, including lead, a potential risk factor for brain tumors, particularly meningioma. 16140629 Human
alad meningioma These findings suggest that the ALAD2 allele may increase genetic susceptibility to meningioma. 16140629 Human
porphobilinogen synthase acute leukemia [Porphobilinogen synthase activity of the erythrocytes in acute leukemia] The activity of PBG-S enzyme in erythrocytes was studied by referential method of Berlin and Schaller in a control group of 40 healthy males and females and 60 patients with acute l 6946639 Human

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