IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene RGS3 Ensembl ENSG00000138835 Chromosome 9 Start 115262358 End 115399839
Description Regulator of G-protein signaling 3 (RGS3)(RGP3) [Source:UniProtKB/Swiss-Prot;Acc:P49796]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9999
     Entrez Gene : 5998
     UCSC : uc004bhq.2
     GeneCards : 9999
     RefSeq : NM_017790
     CCDS : CCDS6797.1
     Uniprot : Q8NC47
     Interpro : Q8NC47
     OMIM : 602189
     GeneTests : RGS3
     CGAP : RGS3
     PMID : 8602223

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37637_at  -0.37  9.28e-5  3.83e-4  -1.13  9.46e-15  2.87e-13
 HG_U133A  203823_at  -0.48  6.75e-9  2.17e-8  -3.37  6.50e-85  2.98e-84
 HG_U133A  220300_at  -0.30  8.62e-3  1.36e-2  0.78  7.71e-13  1.01e-12
 HG_U133_Plus2  203823_at  -0.67  3.17e-13  3.47e-12  -1.07  4.62e-17  4.60e-16
 HG_U133_Plus2  220300_at  -0.51  4.68e-3  1.04e-2  -0.74  9.19e-5  2.06e-4
 HG_U133_Plus2  233395_at  0.14  1.13e-1  1.70e-1  0.05  6.47e-1  6.97e-1
 Agilent_HS_21.6K  8281  -0.20  1.12e-7  3.67e-6  -0.26  8.04e-12  6.85e-10

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203823_at  -0.14  5.86e-1  9.50e-1  -0.04  8.36e-1  1.00e+0
 HG_U133A  220300_at  0.15  7.03e-1  9.69e-1  -0.23  3.37e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37637_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203823_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 220300_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203823_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 220300_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 233395_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 8281    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
rgs3 tumors Possible involvement of CCT5, RGS3, and YKT6 genes up-regulated in p53-mutated tumors in resistance to docetaxel in human breast cancers. 16821082 Human
rgs3 human breast cancers Possible involvement of CCT5, RGS3, and YKT6 genes up-regulated in p53-mutated tumors in resistance to docetaxel in human breast cancers. 16821082 Human
rgs3 glioma Regulators of G-protein signaling 3 and 4 (RGS3, RGS4) are associated with glioma cell motility. 15055445 Human
rgs3 glioma U373MG glioma cell clones overexpressing RGS3 or RGS4 showed an increase of both adhesion and migration. 15055445 Human
rgs3 breast tumors CONCLUSIONS: CCT5, RGS3, and YKT6 mRNA expressions, which are up-regulated in p53-mutated breast tumors, might be implicated in resistance to docetaxel and clinically useful in identifying the subset of breast cancer patients who may or may not benefit fr 16821082 Human
rgs3 breast cancer CONCLUSIONS: CCT5, RGS3, and YKT6 mRNA expressions, which are up-regulated in p53-mutated breast tumors, might be implicated in resistance to docetaxel and clinically useful in identifying the subset of breast cancer patients who may or may not benefit fr 16821082 Human
rgs3 tumors Of these 13 genes, mRNA expression of CCT5, RGS3, and YKT6 was significantly up-regulated in p53-mutated tumors and associated with a low response rate to docetaxel. 16821082 Human

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