IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene TNFSF15 Ensembl ENSG00000181634 Chromosome 9 Start 116591421 End 116608233
Description Tumor necrosis factor ligand superfamily member 15 (Vascular endothelial cell growth inhibitor)(TNF ligand-related molecule 1) [Contains Tumor necrosis factor ligand superfamily member 15, membrane form;Tumor necrosis factor ligand superfamily member 15, secreted form] [Source:UniProtKB/Swiss-Prot;Acc:O95150]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11931
     Entrez Gene : 9966
     UCSC : uc004bjh.2
     GeneCards : 11931
     RefSeq : NM_005118
     CCDS : CCDS6809.1
     Uniprot : O95150
     Interpro : O95150
     OMIM : 604052
     GeneTests : TNFSF15
     CGAP : TNFSF15
     PMID : 9434163

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  221085_at  0.61  2.40e-8  7.28e-8  0.20  4.11e-2  4.39e-2
 HG_U133_Plus2  221085_at  0.12  4.83e-1  5.71e-1  -0.60  3.46e-4  7.15e-4
 Agilent_HS_21.6K  5988  0.02  5.63e-1  7.24e-1  -0.02  5.29e-1  6.72e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  221085_at  -0.22  4.53e-1  9.15e-1  0.14  5.36e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133A - 221085_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 221085_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 5988    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
vegi cancer Overexpression by cancer cells of a secretable VEGI fusion protein resulted in abrogation of xenograft tumor progression, but overexpression of full-length VEGI was completely without effect. 11923219 Human
vegi tumor Overexpression by cancer cells of a secretable VEGI fusion protein resulted in abrogation of xenograft tumor progression, but overexpression of full-length VEGI was completely without effect. 11923219 Human
tl1a tumor These data demonstrate DcR3 might not only help tumor cells to escape immune surveillance but also induce angiogenesis by blocking TL1A action in endothelial cells. 14871847 Human
vegi tumor Vascular endothelial growth inhibitor (VEGI), a new member of the tumor necrosis factor family, is an endothelial cell-specific gene and a potent inhibitor of endothelial cell proliferation, angiogenesis, and tumor growth. 11739281 Human
vegi breast carcinoma When examined for growth modulatory effects, VEGI inhibited the proliferation of breast carcinoma (MCF-7), epithelial (HeLa), and myeloid (U-937 and ML-1a) tumor cells; and activated caspase-3 leading to PARP cleavage. 10597252 Human
vegi tumor When examined for growth modulatory effects, VEGI inhibited the proliferation of breast carcinoma (MCF-7), epithelial (HeLa), and myeloid (U-937 and ML-1a) tumor cells; and activated caspase-3 leading to PARP cleavage. 10597252 Human
vegi colon carcinomas VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo. 9872942 Human
vegi tumors Histological examination showed marked reduction of vascularization in MC-38 tumors that expressed soluble but not membrane-bound VEGI or were transfected with control vector. 9872942 Human
vegi cancer The results further suggest that VEGI maybe highly valuable toward angiogenesis-based cancer therapy. 9872942 Human
vegi breast cancer Inhibition of angiogenesis and breast cancer xenograft tumor growth by VEGI, a novel cytokine of the TNF superfamily. 10360832 Human
vegi tumor Inhibition of angiogenesis and breast cancer xenograft tumor growth by VEGI, a novel cytokine of the TNF superfamily. 10360832 Human
vegi breast cancer The anticancer potential of VEGI was examined in a breast cancer xenograft tumor model in which the cancer cells were co-injected with Chinese hamster ovary cells overexpressing a secreted form of the protein. 10360832 Human
vegi tumor The anticancer potential of VEGI was examined in a breast cancer xenograft tumor model in which the cancer cells were co-injected with Chinese hamster ovary cells overexpressing a secreted form of the protein. 10360832 Human
vegi cancer The anticancer potential of VEGI was examined in a breast cancer xenograft tumor model in which the cancer cells were co-injected with Chinese hamster ovary cells overexpressing a secreted form of the protein. 10360832 Human
tl1a inflammatory bowel disease Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease. 14568967 Human
tl1a inflammatory bowel disease The aim of this study was to test the hypothesis that TL1A may play an important role in inflammatory bowel disease (IBD) by functioning as a Th1-polarizing cytokine. 14568967 Human
tl1a ibd The aim of this study was to test the hypothesis that TL1A may play an important role in inflammatory bowel disease (IBD) by functioning as a Th1-polarizing cytokine. 14568967 Human
tl1a ibd The expression, cellular localization, and functional activity of TL1A and DR3 were studied in intestinal tissue specimens as well as isolated lamina propria mononuclear cells from IBD patients and controls. 14568967 Human
tl1a ibd TL1A mRNA and protein expression was up-regulated in IBD, particularly in involved areas of Crohn's disease (CD; p < 0.03 vs control). 14568967 Human
tl1a crohn's disease TL1A mRNA and protein expression was up-regulated in IBD, particularly in involved areas of Crohn's disease (CD; p < 0.03 vs control). 14568967 Human
tl1a inflammatory bowel disease The purpose of this study was to assess the role of recombinant TL1A on IFN-gamma production by cultured PBMC and lamina propria LPMC and to determine whether TL1A expression is altered in inflammatory bowel disease. 15207783 Human
tl1a crohn's disease TL1A transcript was several times more abundant in RNA from mucosal biopsies taken from inflamed Crohn's disease lesions than in those taken from uninvolved areas. 15207783 Human
tl1a cancer Decoy receptor 3 (DcR3), a soluble receptor for FasL, LIGHT and TL1A, is highly expressed in cancer cells. 15661928 Human
tl1a crohn's disease Our data show that the TL1A/DR3 pathway plays a dominant role in the ultimate level of cytokine-induced IFN-gamma production by CCR9+ mucosal and gut-homing PB T cells and could play an important role in Th1-mediated intestinal diseases, such as Crohn&apo 15814728 Human
tnfsf15 tumor VEGI-192, a New Isoform of TNFSF15, Specifically Eliminates Tumor Vascular Endothelial Cells and Suppresses Tumor Growth. 16061878 Human
vegi tumour VEGI (vascular endothelial growth inhibitor), a member of the tumour necrosis factor superfamily, has been reported to inhibit endothelial cell proliferation, angiogenesis and tumour growth. 15702971 Human
vegi tumor angiogenesis CONCLUSIONS: Our findings indicate that VEGI is an endogenous inhibitor of angiogenesis, and that systemic administration of the VEGI-192 isoform resulted in inhibition of tumor angiogenesis and growth. 16061878 Mouse
tl1a crohn's disease Gut T cells and macrophages express TL1A, especially in Crohn's disease (CD), and there is a strong association between CD and tl1a single nucleotide polymorphisms. 17371957 Human
vegi murine colon cancers Local production of a secreted form of VEGI via gene transfer caused complete suppression of the growth of MC-38 murine colon cancers in syngeneic C57BL/6 mice. 9872942 Mouse
vegi tumor VEGI is predominantly an endothelial cell-specific gene, and recombinant VEGI is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. 16517446 Human
tl1a crohn's disease Using two immunogenetically distinct animal models of Crohn's disease, we demonstrate that induction of intestinal inflammation is associated with significant up-regulation of TL1A and tm DR3 in the inflamed mucosa. 16698931 Mouse
tl1a inflammatory bowel disease Our results raise the possibility that interaction(s) between TL1A expressed on antigen-presenting cells and tm DR3 on lymphocytes may be of particular importance for the pathogenesis of chronic inflammatory conditions that depend on IFN-gamma secretion, 16698931 Mouse
tl1a crohn's disease Blockade of the TL1A/DR3 pathway may, therefore, offer therapeutic opportunities in Crohn's disease. 16698931 Mouse
tnfsf15 crohn's disease Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. 16221758 Human
tnfsf15 ibd Our results suggest that the genetic variations in the TNFSF15 gene contribute to the susceptibility to IBD in the Japanese and European populations. 16221758 Human
vegi lewis lung cancer PURPOSE: We determined the antiangiogenic and anticancer activity of VEGI-192, a new isoform of TNFSF15 (VEGI, TL1), with a Lewis lung cancer murine tumor model. 16061878 Human
tnfsf15 lewis lung cancer PURPOSE: We determined the antiangiogenic and anticancer activity of VEGI-192, a new isoform of TNFSF15 (VEGI, TL1), with a Lewis lung cancer murine tumor model. 16061878 Human
tl1 lewis lung cancer PURPOSE: We determined the antiangiogenic and anticancer activity of VEGI-192, a new isoform of TNFSF15 (VEGI, TL1), with a Lewis lung cancer murine tumor model. 16061878 Human
vegi breast cancer Reduced vascular endothelial growth inhibitor (VEGI) expression is associated with poor prognosis in breast cancer patients. 16758268 Human
vegi cancer Very little is known about the significance of VEGI in cancer. 16758268 Human
vegi breast cancer Our study analysed VEGI expression in relation to breast cancer patient clinical parameters. 16758268 Human
vegi breast cancer The VEGI expression profile was assessed qualitatively (RT-PCR), quantitatively (real-time Quantitative-PCR), and immuno-histochemically (IHC), in a panel of 24 human normal and cancer cell lines and in a cohort of 151 mammary tissue samples (n = 33 norma 16758268 Human
vegi cancer The VEGI expression profile was assessed qualitatively (RT-PCR), quantitatively (real-time Quantitative-PCR), and immuno-histochemically (IHC), in a panel of 24 human normal and cancer cell lines and in a cohort of 151 mammary tissue samples (n = 33 norma 16758268 Human
vegi breast cancer Patients who had died of breast cancer or had local recurrence of the disease expressed significantly lower levels of VEGI in comparison to the elevated levels in the disease free patients. 16758268 Human
vegi breast tumours Importantly, patients with breast tumours expressing reduced levels of VEGI had a poorer prognosis than those patients expressing high levels of VEGI. 16758268 Human
vegi tumour However, no significant correlations were observed between VEGI expression and tumour grade, TNM classification, or nodal involvement. 16758268 Human
vegi human breast cancer In conclusion, VEGI is aberrantly expressed in human breast cancer tissues. 16758268 Human
vegi breast cancer VEGI displays prognostic relevance as breast cancer patients with an overall poor prognosis express significantly lower levels of VEGI compared to those with a favourable prognosis. 16758268 Human
tnfsf15 inflammatory bowel disease Association study of TNFSF15 polymorphisms in Japanese patients with inflammatory bowel disease. 16966713 Human
vegi tumor PURPOSE: We determined the antiangiogenic and anticancer activity of VEGI-192, a new isoform of TNFSF15 (VEGI, TL1), with a Lewis lung cancer murine tumor model. 16061878 Mouse
tnfsf15 tumor PURPOSE: We determined the antiangiogenic and anticancer activity of VEGI-192, a new isoform of TNFSF15 (VEGI, TL1), with a Lewis lung cancer murine tumor model. 16061878 NA
tl1 tumor PURPOSE: We determined the antiangiogenic and anticancer activity of VEGI-192, a new isoform of TNFSF15 (VEGI, TL1), with a Lewis lung cancer murine tumor model. 16061878 Mouse
vegi lymphoma The preliminarily in vivo study demonstrated that chimeric protein VEGI-CTT had more potent antitumor activity than VEGI and/or CTT peptide against CA46 human lymphoma xenografts in nude mice. 18769489 Human
vegi tumor Thus, these facts that are derived from the present study suggest that the chimeric protein VEGI-CTT may be used for tumor therapy in the future. 18769489 Human
tl1a crohn's disease Expression of TL1A is increased in the mucosa of Crohn's disease patients and murine models of ileitis. 18598698 Human
tl1a crohn's disease The central role of TL1A represents an attractive, novel therapeutic target for the treatment of Crohn's disease patients. 18598698 Human
tnfsf15 ibd TNFSF15 is an ethnic-specific IBD gene. 17663424 Human
tnfsf15 ibd A recent report suggests that genetic variations in the TNFSF15 gene contribute to the susceptibility of IBD in both Japanese and Caucasian populations. 17663424 Human
tnfsf15 ibd The aim was to confirm the association between TNFSF15 high- and low-risk haplotypes and IBD in a Caucasian population. 17663424 Human
tnfsf15 ibd Of further interest, the haplotype frequency was in the opposite direction in our Jewish case-control panels (both CD and UC), leading us to conclude 1) that TNFSF15 is indeed an IBD susceptibility gene, and 2) the disease susceptibility is ethnic-specifi 17663424 Human
tnfsf15 crohn's disease Contribution of TNFSF15 gene variants to Crohn's disease susceptibility confirmed in UK population. 18338776 Human
tnfsf15 crohn's disease Association of TNFSF15 with Crohn's disease in Koreans. 18422820 Human
tnfsf15 inflammatory bowel disease OBJECTIVES: A recent genomewide association study from a Japanese population identified tumor necrosis factor superfamily member 15 (TNFSF15) as an inflammatory bowel disease gene. 18422820 Human
tnfsf15 crohn's disease Previous studies have shown that expression of TNFSF15 was upregulated in macrophages and lymphocytes of the intestinal lamina propria of Crohn's disease (CD) patients. 18422820 Human

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