IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene TNC Ensembl ENSG00000041982 Chromosome 9 Start 116822627 End 116920307
Description Tenascin Precursor (TN)(Tenascin-C)(TN-C)(Hexabrachion)(Cytotactin)(Neuronectin)(GMEM)(JI)(Myotendinous antigen)(Glioma-associated-extracellular matrix antigen)(GP 150-225) [Source:UniProtKB/Swiss-Prot;Acc:P24821]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 5318
     Entrez Gene : 3371
     UCSC : uc004bjj.3
     GeneCards : 5318
     RefSeq : NM_002160
     CCDS : CCDS6811.1
     Uniprot : P24821
     Interpro : P24821
     OMIM : 187380
     GeneTests : TNC
     CGAP : TNC
     PMID : 1704365

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  32818_at  0.19  4.73e-1  5.79e-1  0.94  1.86e-3  5.35e-3
 HG_U95  695_at  0.29  2.56e-1  3.57e-1  0.41  2.84e-1  3.87e-1
 HG_U133A  201645_at  0.79  7.79e-6  1.83e-5  2.45  1.54e-83  6.81e-83
 HG_U133A  216005_at  0.09  5.25e-1  5.78e-1  2.01  2.59e-38  4.88e-38
 HG_U133_Plus2  201645_at  0.34  7.27e-2  1.16e-1  0.97  3.11e-6  8.55e-6
 HG_U133_Plus2  216005_at  -0.68  2.33e-4  6.91e-4  -0.29  1.17e-1  1.55e-1
 HG_U133_Plus2  241272_at  -1.18  3.56e-7  1.73e-6  -1.09  3.25e-5  7.76e-5
 HG_U133_Plus2  243540_at  0.58  1.02e-2  2.09e-2  0.42  7.39e-2  1.02e-1
 Agilent_HS_21.6K  15227  0.41  5.32e-3  2.85e-2  0.55  6.14e-4  3.63e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  201645_at  0.09  8.45e-1  9.88e-1  -0.10  8.23e-1  1.00e+0
 HG_U133A  216005_at  -0.26  5.19e-1  9.34e-1  0.17  5.68e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 32818_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 695_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201645_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 216005_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201645_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 216005_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 241272_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 243540_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 15227    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
tnc cancer Tenascin-C (TNC) is an extracellular matrix protein which appears at active sites of tissue remodelling during embryogenesis or cancer invasion. 12115886 Human
tnc chondrosarcoma The purpose of this study was to determine the specific in vitro TNC splicing patterns of articular chondrocytes and a human chondrosarcoma cell line. 12168675 Human
tnc chondrosarcoma In vivo studies are necessary to verify the expression of the large TNC isoform in chondrosarcoma and the production and integration of the smaller isoform in normal chondroid matrix. 12168675 Human
tnc chondrosarcoma In addition, elucidation of the biologic functions of the two major TNC isoforms may lead to the development of novel diagnostic and therapeutic approaches to chondrosarcoma. 12168675 Human
tnc tumor These results indicate that MMP-9 is activated in all TN-deficient mice, but that TNX exerts a greater effect on tumor invasion than does TNC. 12359049 Mouse
tnc chondrosarcoma The purpose of this study was: (1) to determine the in vitro TNC splicing pattern in cultured human chondrocytes and chondrosarcoma cells, (2) to determine the in vivo TNC splicing pattern in clinical chondrosarcoma specimens, and (3) to perform survival 11721178 Human
tnc tumor The purpose of this study was: (1) to determine the in vitro TNC splicing pattern in cultured human chondrocytes and chondrosarcoma cells, (2) to determine the in vivo TNC splicing pattern in clinical chondrosarcoma specimens, and (3) to perform survival 11721178 Human
tnc chondrosarcoma Clinical chondrosarcoma specimens were obtained intra-operatively and underwent RT-PCR to determine the in vivo TNC splicing pattern. 11721178 Human
tnc chondrosarcoma RESULTS: The in vitro mRNA expression pattern of TNC in normal human articular chondrocytes was characterized by a high ratio of the small to the large splice variant (TNC(small):TNC(large)), whereas the in vitro mRNA expression pattern for cultured chond 11721178 Human
tnc chondrosarcoma CONCLUSIONS: The specific TNC splicing pattern may have clinical significance in chondrosarcoma. 11721178 Human
tnc tumor TNC expression may therefore play a future role in objective tumor grading and novel therapeutic approaches to this malignancy. 11721178 Human
tnc cancer One of a family of extracellular matrix proteins, tenascin-C (TNC) is expressed in a spatiotemporally restricted pattern associated with tissue remodeling during embryonic development, wound healing, cancer invasion and tissue regeneration. 12823230 Human
tnc cancer Tenascin-C (TNC) is an extracellular matrix protein which is highly expressed during development, tissue repair and cancer. 10341205 Human
tnc tumor Furthermore, the number and size of tumors, the number and size of metastatic foci in the lungs, the proliferation rate and apoptosis of tumor cells and tumor angiogenesis were not altered in the absence of TNC. 10341205 Mouse
tnc tumor angiogenesis Furthermore, the number and size of tumors, the number and size of metastatic foci in the lungs, the proliferation rate and apoptosis of tumor cells and tumor angiogenesis were not altered in the absence of TNC. 10341205 Mouse
tnc tumors Furthermore, the number and size of tumors, the number and size of metastatic foci in the lungs, the proliferation rate and apoptosis of tumor cells and tumor angiogenesis were not altered in the absence of TNC. 10341205 Mouse
tnc tumor Histological examination revealed that the tumor organisation, however, was modulated by TNC. 10341205 Mouse
tnc large tumor In the presence of TNC both primary as well as metastatic tumors were organised in large tumor cell nests surrounded by thick layers of extracellular matrix proteins. 10341205 Mouse
tnc tumor In the absence of TNC these tumor cell nests were smaller but still separated from each other by extracellular matrix proteins. 10341205 Mouse
tnc tumor In addition, the TNC-null stromal compartment contained significantly more monocytes/macrophages than tumor stroma from TNC wild-type mice. 10341205 Mouse
tnc tumor Using in vitro coculture experiments we show that TNC-null tumor cells were still able to activate the TNC gene in fibroblasts which express low basal levels of TNC. 10341205 Mouse
tnc metastasis Altogether these data indicate that TNC has a very limited role during the spontaneous development and growth of mamary tumors and their metastasis to the lungs. 10341205 Mouse
tnc tumors Altogether these data indicate that TNC has a very limited role during the spontaneous development and growth of mamary tumors and their metastasis to the lungs. 10341205 Mouse
tnc tumor Together with previous studies showing that TNC expression is involved in the invasive and malignant phenotype of several tumor types, our data suggest that the oncogenic effect of EWS-ETS may be mediated in part by upregulating of TNC expression. 12557222 Human
the tn mrna lung cancer The splicing pattern of TN mRNA was also altered in many lung cancer tissues, showing increased or sometimes decreased expression of the TN mRNA with the extra sequence when compared with their surrounding normal tissues. 1716516 Human
hexabrachion human tumors Hexabrachion proteins in embryonic chicken tissues and human tumors. 3654758 Human
hexabrachion glioblastoma We have compared the heparin and DNA binding of hexabrachion secreted by the human glioblastoma cell line U87MG to that of fibronectin. 2473987 Human
hexabrachion glioblastoma In contrast to hexabrachion isolated from brain, the protein secreted by the human glioblastoma cell line U87MG does not bear the HNK-1 epitope which is on a carbohydrate that can mediate interactions between cells. 2473987 Human
hexabrachion tumors Localization and quantitation of hexabrachion (tenascin) in skin, embryonic brain, tumors, and plasma. 1692456 Human
hexabrachion glioblastoma The highest yield of hexabrachion (1-4 mg from 400 ml of conditioned medium) was from human glioblastoma cell cultures, but the same procedure allowed us to purify and characterize the rat hexabrachion. 1695709 Human
hxb carcinomas Only 5 genes were overexpressed in all carcinomas including fibronectin 1 (FN1), tissue metalloproteinase inhibitor 1 (TIMP1), biglycan (BGN), tenascin-C (HXB), and insulin-like growth factor binding protein 5 (IGFBP5), whereas 16 genes were underexpresse 15642389 Human
tenascin c colorectal carcinomas RESULTS: The tenascin C tissue concentration of normal mucosa was 2.6 +/- 3.4 microg/mg (n = 55), 2.9 +/- 2.1 microg/mg in colorectal adenomas (n = 19), 7.5 +/- 4.7 microg/mg in ulcerative colitis (n = 50), and 18 +/- 15 microg/mg in colorectal carcinomas 9510316 Human
tenascin c colorectal adenomas RESULTS: The tenascin C tissue concentration of normal mucosa was 2.6 +/- 3.4 microg/mg (n = 55), 2.9 +/- 2.1 microg/mg in colorectal adenomas (n = 19), 7.5 +/- 4.7 microg/mg in ulcerative colitis (n = 50), and 18 +/- 15 microg/mg in colorectal carcinomas 9510316 Human
tenascin c colorectal carcinomas CONCLUSIONS: Tenascin C tissue concentrations were not altered in adenomas, slightly elevated in ulcerative colitis, and substantially increased in colorectal carcinomas. 9510316 Human
tenascin c adenomas CONCLUSIONS: Tenascin C tissue concentrations were not altered in adenomas, slightly elevated in ulcerative colitis, and substantially increased in colorectal carcinomas. 9510316 Human
tenascin c metastasis Stroma of both tumors contained nidogen and high amounts of tenascin C, but only a few very low levels of fibronectin, laminin-1, and collagen type I. Beta1 integrin, therefore, increases but is not essential for metastasis of ras-myc transformed fibrobla 10445848 Mouse
tenascin c tumors Stroma of both tumors contained nidogen and high amounts of tenascin C, but only a few very low levels of fibronectin, laminin-1, and collagen type I. Beta1 integrin, therefore, increases but is not essential for metastasis of ras-myc transformed fibrobla 10445848 Mouse
tenascin c glial tumor Glial tumor cell adhesion is mediated by binding of the FNIII domain of receptor protein tyrosine phosphatase beta (RPTPbeta) to tenascin C. 11313993 Human
tenascin c glioblastoma One of these, a 240 kDa protein that was purified from U118MG glioblastoma cell, was identified as tenascin C based on the amino acid sequence of several tryptic peptides. 11313993 Human
tenascin c astrocytoma Adhesion and spreading of SF763T astrocytoma cells expressing RPTPbeta on tenascin C was specifically abolished by the addition of a soluble fragment containing the FNIII domain of the receptor. 11313993 Human
tenascin c glial tumor These results demonstrate that the FNIII domain of RPTPbeta binds to tenascin C and suggest that RPTPbeta present on glial tumor cells is a primary adhesion receptor system to the extracellular matrix. 11313993 Human
tenascin c lymph-node metastasis The tissues of OSCCs with lymph node metastasis exhibited increased expression levels of MMP-1, MMP-3, uPA, integrin-alpha3, paxillin, tenascin C and IL-6 transcripts. 12866027 Human
tenascin c tumors Tenascin C and cathepsin d expression in adipocytic tumors: an immunohistochemical investigation of 43 cases. 14765267 Human
tenascin c carcinomas Cathepsin D (CatD) and tenascin C (Tn-C) have been implicated in invasion and metastasis of carcinomas. 14765267 Human
tenascin c metastasis Cathepsin D (CatD) and tenascin C (Tn-C) have been implicated in invasion and metastasis of carcinomas. 14765267 Human
tenascin c pancreatic cancer Tenascin C expression is upregulated in pancreatic cancer and correlates with differentiation. 15509674 Human
tenascin c breast cancer Tissue expression of tenascin C correlates with prognosis in colorectal, cervical, and breast cancer and in carcinoma of the papilla of Vater. 15509674 Human
tenascin c carcinoma Tissue expression of tenascin C correlates with prognosis in colorectal, cervical, and breast cancer and in carcinoma of the papilla of Vater. 15509674 Human
tenascin c pancreatic cancer AIM: To study the expression of tenascin C in pancreatic cancer and to compare the staining results with the patients' clinicopathological data. 15509674 Human
tenascin c pancreatic carcinoma RESULTS: Tenascin C immunoreactivity was seen in most samples of pancreatic carcinoma: staining was weak in 72 (49%), moderate in 52 (36%), strong in 10 (7%), and negative in 12 (8%) samples. 15509674 Human
tenascin c tumour There was no correlation between tenascin C expression and survival, clinical stage, tumour size, nodal status, distant metastasis, tumour location, or sex. 15509674 Human
tenascin c metastasis There was no correlation between tenascin C expression and survival, clinical stage, tumour size, nodal status, distant metastasis, tumour location, or sex. 15509674 Human
tenascin c other cancers CONCLUSION: Tenascin C expression was increased in most pancreatic carcinomas, but contrary to the results in other cancers, it is not a prognostic factor in pancreatic cancer. 15509674 Human
tenascin c pancreatic carcinomas CONCLUSION: Tenascin C expression was increased in most pancreatic carcinomas, but contrary to the results in other cancers, it is not a prognostic factor in pancreatic cancer. 15509674 Human
tenascin c pancreatic cancer CONCLUSION: Tenascin C expression was increased in most pancreatic carcinomas, but contrary to the results in other cancers, it is not a prognostic factor in pancreatic cancer. 15509674 Human
the tnc gene tumor Using in vitro coculture experiments we show that TNC-null tumor cells were still able to activate the TNC gene in fibroblasts which express low basal levels of TNC. 10341205 Human
tnc metastatic tumors Despite the high levels of TNC in the stroma of primary and metastatic tumors, the function of TNC is not known. 10341205 Human
tnc mammary tumors We report that the absence of TNC had no effect on the temporal occurrence of mammary tumors and their metastatic dissemination in lungs. 10341205 Mouse
tnc metastatic tumors In the presence of TNC both primary as well as metastatic tumors were organised in large tumor cell nests surrounded by thick layers of extracellular matrix proteins. 10341205 Mouse
tnc metastasis to the lungs Altogether these data indicate that TNC has a very limited role during the spontaneous development and growth of mamary tumors and their metastasis to the lungs. 10341205 Mouse
tnc malignant tumors OBJECTIVES: Tenascin-C (TNC) is an oligomeric glycoprotein of the extracellular matrix that is prominently expressed in malignant tumors. 11721178 Human
tnc malignancy TNC expression may therefore play a future role in objective tumor grading and novel therapeutic approaches to this malignancy. 11721178 Human
tnc primary tumor The primary tumor size in TNX - / - TNC + / + mice was significantly larger than that in wild-type mice, but those of TNX + / + TNC - / - and double knockout mice were comparable to that in the wild-type mice. 12359049 Mouse
tnc primary tumors High levels of TNC expression were observed in a subset of ES cell lines (3 of 6) and primary tumors (4 of 6). 12557222 Human
tnc cancer Among various ECM molecules, tenascin-C (TNC) is well known as a regulator of multiple cellular functions during embryogenesis, wound healing or cancer progression. 15024713 Human
tnc nasal polyp [Relationship between the expression of tenascin C and TGF-beta1 in human nasal polyp tissues] OBJECTIVE: To explore the mechanism underlying the increased expression of tenascin C (TNC) in human nasal polyp tissues. 16144346 Human
tnc nasal polyp METHODS: The method of immunohistochemistry was used to detect the protein expression of TNC and transforming growth factor-beta1 (TGF-beta1) and their relationship in nasal polyp tissues. 16144346 Human
tnc nasal polyp RESULTS: (1) TNC and TGF-beta1 protein expression were up-regulated in nasal polyp tissues. 16144346 Human
tnc nasal polyp Up-regulated expression of TNC in nasal polyp tissues is related to eosinophil-derived TGF-beta1. 16144346 Human
tnc tumor Tenascin-C (TnC) is an extracellular matrix protein that is highly expressed in tumor stroma. 16157221 Human
tnc tumor RESULTS: We identified two tenascin gene family members that were significantly deregulated in both human NF1-associated tumors and NF1-deficient primary cells: Tenascin C (TNC) was up-regulated whereas tenascin XB (TNXB) was down-regulated during tumor p 17202312 Human
tnc tumors RESULTS: We identified two tenascin gene family members that were significantly deregulated in both human NF1-associated tumors and NF1-deficient primary cells: Tenascin C (TNC) was up-regulated whereas tenascin XB (TNXB) was down-regulated during tumor p 17202312 Human
tnc tumors Immunohistochemical studies showed that TNC transcripts are translated into TNC protein in TNC-overexpressing tumors. 17202312 Human
tnc solid tumours Tenascin C (TNC) is a component of the provisional extracellular matrix (ECM) that characterizes solid tumours. 16450333 Human
tnc pancreatic ductal adenocarcinoma The aim of this study was to analyse whether TNC and annexin II play a role in the development of pancreatic ductal adenocarcinoma (PDAC). 16450333 Human
tnc pancreatic cancer TNC and annexin II mRNA levels were significantly higher in pancreatic cancer tissues than in the normal pancreas. 16450333 Human
tnc pancreatic cancer Large TNC transcripts were found in pancreatic cancer and in chronic pancreatitis, but not in the normal pancreas. 16450333 Human
tnc pancreatic cancer In conclusion, the expression of TNC and cell surface annexin II increases in the progression from low-grade PanIN lesions to pancreatic cancer. 16450333 Human
tnc panin In conclusion, the expression of TNC and cell surface annexin II increases in the progression from low-grade PanIN lesions to pancreatic cancer. 16450333 Human
tnc malignant transformation CONCLUSION: TNXB and TNC may be involved in the malignant transformation of plexiform neurofibromas. 17202312 Human
tnc metastatic disease In the present study we have crossed TNC-null mice with a mouse strain where both female and male mice spontaneously develop mammary tumors followed by metastatic disease in the lungs. 10341205 Mouse
tnc mammary tumors In the present study we have crossed TNC-null mice with a mouse strain where both female and male mice spontaneously develop mammary tumors followed by metastatic disease in the lungs. 10341205 NA
tnc breastcancer There was no association between breast-cancer risk and mean adipose-tissue levels of OCD and TNC. 11051111 Human
tnc breastcancer DISCUSSION: We found no significantly increased risk of breast cancer associated with breast adipose-tissue levels of OCD or TNC; this is consistent with recent epidemiological studies, indicating that environmental exposure to organochlorine compounds do 11051111 Human
tnc tumorigenesis Extracellular matrix glycoprotein tenascin-C (TNC) expression is up-regulated in tissue remodeling processes such as tumorigenesis and wound healing. 12009782 Human
tnc oncogenic Together with previous studies showing that TNC expression is involved in the invasive and malignant phenotype of several tumor types, our data suggest that the oncogenic effect of EWS-ETS may be mediated in part by upregulating of TNC expression. 12557222 Human
tnc tumorigenesis Tenascin-C (TNC), an extracellular matrix glycoprotein, is involved in tissue morphogenesis like embryogenesis, wound healing or tumorigenesis. 14568337 Human
tnc tumorigenesis Tenascin-C (TNC), an extracellular matrix glycoprotein, is involved in tissue morphogenesis like embryogenesis, wound healing or tumorigenesis. 15780469 Human
tnc chondrosarcoma In this report, we examined the roles of TnC-mediated cell adhesion in the modulation of chondrosarcoma cell survival. 16157221 Human
tnc chondrosarcoma Taken together, these studies support that the TnC-mediated adhesion can promote cell survival through Akt in human chondrosarcoma cells. 16157221 Human
tenascin c lymph node metastasis The tissues of OSCCs with lymph node metastasis exhibited increased expression levels of MMP-1, MMP-3, uPA, integrin-alpha3, paxillin, tenascin C and IL-6 transcripts. 12866027 Human
tenascin c tumor The expression of the extracellular matrix-related genes, such as fibronectin, laminin and tenascin C, and apoptosis-related genes, such as bax, bcl2 and survivin, was evaluated by reverse transcription-polymerase chain reaction (RT-PCR) and by immunohist 16142317 Human
tenascin c malignant breast tumors The expression of the extracellular matrix-related genes, such as fibronectin, laminin and tenascin C, and apoptosis-related genes, such as bax, bcl2 and survivin, was evaluated by reverse transcription-polymerase chain reaction (RT-PCR) and by immunohist 16142317 Human
tenascin c nasal polyp [Relationship between the expression of tenascin C and TGF-beta1 in human nasal polyp tissues] OBJECTIVE: To explore the mechanism underlying the increased expression of tenascin C (TNC) in human nasal polyp tissues. 16144346 Human
tenascin c tumor The additivity of ST2146 and ST2485 in tenascin C binding, shown by in vitro tests, was confirmed by biodistribution studies in a xenograft model where tumor localization of the antibodies was near the sum of each antibody alone, with a tumor-to-blood rat 16203813 Human
tenascin c colon cancer Tenascin C and epidermal growth factor receptor as markers of circulating tumoral cells in bladder and colon cancer. 16211285 Human
tenascin c melanoma Tenascin C has been recently suggested as a tumor marker, however, its levels in serum has been evaluated only in patients with head and neck cancer and melanoma. 16211285 Human
tenascin c tumor Tenascin C has been recently suggested as a tumor marker, however, its levels in serum has been evaluated only in patients with head and neck cancer and melanoma. 16211285 Human
tenascin c head and neck cancer Tenascin C has been recently suggested as a tumor marker, however, its levels in serum has been evaluated only in patients with head and neck cancer and melanoma. 16211285 Human
tenascin c tumor In this study, we investigated Tenascin C expression in blood samples from colorectal and bladder cancer patients, compared to that of epidermal growth factor receptor (EGFR), a known circulating tumor marker in these cancer types. 16211285 Human
tenascin c bladder cancer In this study, we investigated Tenascin C expression in blood samples from colorectal and bladder cancer patients, compared to that of epidermal growth factor receptor (EGFR), a known circulating tumor marker in these cancer types. 16211285 Human
tenascin c cancer In this study, we investigated Tenascin C expression in blood samples from colorectal and bladder cancer patients, compared to that of epidermal growth factor receptor (EGFR), a known circulating tumor marker in these cancer types. 16211285 Human
tenascin c bladder cancer RT-PCR specific for Tenascin C and EGFR was performed on RNAs extracted from blood samples of 60 patients affected by colon or bladder cancer. 16211285 Human
tenascin c tumors While Tenascin C expression seems to influence prognosis in patients with low-stage disease, EGFR appears a marker of worse prognosis in patients with high-staged tumors. 16211285 Human
tenascin c mpnst RESULTS: Six genes (keratin 18, survivin, tenascin C, adenosine deaminase, collagen type VIa3, and collagen type VIIa1) were significantly upregulated in MPNST, whereas one gene, insulin-like growth factor binding protein 6, was downregulated in MPNST. 16443732 Human
tenascin c mpnst Tenascin C was also expressed at the invasive front and tumorous stroma in all MPNST cases. 16443732 Human
tenascin c mpnst MPNST cells expressed tenascin C in four of nine cases. 16443732 Human
tenascin c mpnst CONCLUSIONS: Survivin and tenascin C may be associated with the malignant potential of MPNST and could be considered as potential therapeutic targets. 16443732 Human
tenascin c carcinogenesis Tenascin C and annexin II expression in the process of pancreatic carcinogenesis. 16450333 Human
tenascin c solid tumours Tenascin C (TNC) is a component of the provisional extracellular matrix (ECM) that characterizes solid tumours. 16450333 Human
tenascin c nasal polyp The up-regulated expression of tenascin C in human nasal polyp tissues is related to eosinophil-derived transforming growth factor beta1. 17181107 Human
tenascin c tumorigenesis Microarray-based identification of tenascin C and tenascin XB, genes possibly involved in tumorigenesis associated with neurofibromatosis type 1. 17202312 Human
tenascin c neurofibromatosis type 1 Microarray-based identification of tenascin C and tenascin XB, genes possibly involved in tumorigenesis associated with neurofibromatosis type 1. 17202312 Human
tenascin c tumor RESULTS: We identified two tenascin gene family members that were significantly deregulated in both human NF1-associated tumors and NF1-deficient primary cells: Tenascin C (TNC) was up-regulated whereas tenascin XB (TNXB) was down-regulated during tumor p 17202312 Human
tenascin c tumors RESULTS: We identified two tenascin gene family members that were significantly deregulated in both human NF1-associated tumors and NF1-deficient primary cells: Tenascin C (TNC) was up-regulated whereas tenascin XB (TNXB) was down-regulated during tumor p 17202312 Human
tenascin c tumours In the extracellular matrix that is associated with tumours, laminin 5, oncofetal fibronectin and tenascin C appear. 17643963 Human
tenascin c prostate cancer RESULTS: Our recent microarray analysis suggested downregulation of three fibulins, FBLN1, FBLN4, and FBLN5, in prostate cancer, while two further ECM genes, SPOCK1 (testican) and TENC (tenascin C), appeared upregulated or unchanged. 17929269 Human
tenascin c cancer Tenascin C interacts with ecto-5'-nucleotidase (eN) and regulates adenosine generation in cancer cells. 18062933 Human
tenascin c solid tumors Tenascin C is expressed in invasive human solid tumors; however its specific role in cancer biology remains obscure. 18062933 Human
tenascin c cancer Tenascin C is expressed in invasive human solid tumors; however its specific role in cancer biology remains obscure. 18062933 Human
tenascin c breast cancer Breast cancer cells expressing reduced eN attached 56% weaker (p < 0.05) to immobilized tenascin C. 18062933 Human
tenascin c breast cancer Finally, control breast cancer cells migrated slower on tenascin C when compared with clone with reduced eN expression. 18062933 Human
tenascin c metastasis Of these microRNAs, miR-126 restoration reduces overall tumour growth and proliferation, whereas miR-335 inhibits metastatic cell invasion. miR-335 regulates a set of genes whose collective expression in a large cohort of human tumours is associated with 18185580 Human
tenascin c human tumours Of these microRNAs, miR-126 restoration reduces overall tumour growth and proliferation, whereas miR-335 inhibits metastatic cell invasion. miR-335 regulates a set of genes whose collective expression in a large cohort of human tumours is associated with 18185580 Human
tenascin c tumour Of these microRNAs, miR-126 restoration reduces overall tumour growth and proliferation, whereas miR-335 inhibits metastatic cell invasion. miR-335 regulates a set of genes whose collective expression in a large cohort of human tumours is associated with 18185580 Human
tenascin c tumor In tissue microarray immunohistochemical analyses, SPARC (secreted protein, acidic, rich in cysteine), periostin, and tenascin C exhibited increased protein expression in tumor tissue compared with control tissue, and their expression was primarily locali 18490578 Human
tnc human tumor Many human tumor samples also gained expression of a coordinately regulated module associated with advanced malignancy (ABCC1, FOXO3A, LIF, PIK3R1, PRNP, TNC, TIMP3 and VEGF). 17615082 Human
tnc malignancy Many human tumor samples also gained expression of a coordinately regulated module associated with advanced malignancy (ABCC1, FOXO3A, LIF, PIK3R1, PRNP, TNC, TIMP3 and VEGF). 17615082 Human
tnc colorectal cancers In the current study, we investigated the correlation between 14-3-3sigma expression and the ECM, focusing especially on the presence of tenascin-C (TNC) at the invasive area of colorectal cancers. 17982629 Human
tnc colorectal carcinoma Correlations between the immunohistochemical expression of 14-3-3sigma and TNC, as well as other clinicopathological factors, were evaluated in 123 colorectal carcinoma tissues. 17982629 Human
tnc metastasis Mice injected with clonal MDA-MB-435 cells with reduced expression of TNC demonstrated a significant decrease (P<0.05) in (1) primary tumor growth; (2) tumor relapse after surgical removal of the primary tumor and (3) incidence of lung metastasis. 18504437 Mouse
tnc tumor Mice injected with clonal MDA-MB-435 cells with reduced expression of TNC demonstrated a significant decrease (P<0.05) in (1) primary tumor growth; (2) tumor relapse after surgical removal of the primary tumor and (3) incidence of lung metastasis. 18504437 Mouse
tnc primary tumor Mice injected with clonal MDA-MB-435 cells with reduced expression of TNC demonstrated a significant decrease (P<0.05) in (1) primary tumor growth; (2) tumor relapse after surgical removal of the primary tumor and (3) incidence of lung metastasis. 18504437 Mouse
tnc metastases The TNC signaling pathway plays an important role in mammary tumor growth and metastases, suggesting that TNC may be a relevant target for therapy against metastatic breast cancer. 18504437 Human
tnc metastatic breast cancer The TNC signaling pathway plays an important role in mammary tumor growth and metastases, suggesting that TNC may be a relevant target for therapy against metastatic breast cancer. 18504437 Human
tnc mammary tumor The TNC signaling pathway plays an important role in mammary tumor growth and metastases, suggesting that TNC may be a relevant target for therapy against metastatic breast cancer. 18504437 Human
tnc breast cancers CONCLUSION: FN1, LOX, SPARC, and TIMP3 expression levels are associated with the prognosis of patients with breast cancers, whereas TNC is associated with resistance to tamoxifen therapy. 18765548 Human
tnc tumor 14-3-3sigma expression was frequently observed in budding tumor cells in the invasive area and expression was significantly correlated with budding formation (p=0.001), pTNM classification (p=0.001) and stromal TNC expression (p=0.004). 17982629 Human
tnc tumor TNC surrounding the tumor cells increased 14-3-3sigma mRNA expression 1.8- to 2.2-fold in HCT116 cells. 17982629 Human

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