IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PAPPA Ensembl ENSG00000182752 Chromosome 9 Start 117955892 End 118204420
Description Pappalysin-1 Precursor (EC 3.4.24.79)(Pregnancy-associated plasma protein A)(PAPP-A)(Insulin-like growth factor-dependent IGF-binding protein 4 protease)(IGF-dependent IGFBP-4 protease)(IGFBP-4ase) [Source:UniProtKB/Swiss-Prot;Acc:Q13219]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 8602
     Entrez Gene : 5069
     UCSC : uc004bjn.2
     GeneCards : 8602
     RefSeq : NM_002581
     CCDS : CCDS6813.1
     Uniprot : Q13219
     Interpro : Q13219
     OMIM : 176385
     GeneTests : PAPPA
     CGAP : PAPPA
     PMID : 7679961

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  32549_at  0.11  5.78e-1  6.74e-1  -0.13  5.61e-1  6.57e-1
 HG_U133A  201981_at  0.26  3.64e-2  5.19e-2  2.57  1.35e-53  3.24e-53
 HG_U133A  201982_s_at  0.46  1.76e-4  3.54e-4  5.65  7.59e-125  1.06e-123
 HG_U133_Plus2  1558607_at  0.09  6.62e-1  7.33e-1  -0.11  6.30e-1  6.82e-1
 HG_U133_Plus2  1558608_a_at  0.37  2.97e-2  5.34e-2  0.97  3.36e-6  9.19e-6
 HG_U133_Plus2  1559400_s_at  -0.48  1.42e-2  2.79e-2  -0.60  9.22e-3  1.51e-2
 HG_U133_Plus2  1559928_at  0.21  2.66e-1  3.51e-1  0.72  4.25e-4  8.68e-4
 HG_U133_Plus2  201981_at  0.20  2.61e-1  3.46e-1  0.32  1.22e-1  1.61e-1
 HG_U133_Plus2  201982_s_at  0.59  1.03e-3  2.67e-3  1.39  1.91e-10  8.87e-10
 HG_U133_Plus2  224940_s_at  -0.71  1.79e-4  5.42e-4  -0.89  2.39e-6  6.65e-6
 HG_U133_Plus2  224941_at  -1.07  1.39e-6  6.11e-6  -1.92  7.92e-11  3.84e-10
 HG_U133_Plus2  224942_at  -0.24  1.90e-1  2.65e-1  0.05  7.34e-1  7.75e-1
 HG_U133_Plus2  228128_x_at  -0.46  1.55e-2  3.01e-2  -0.56  4.52e-3  7.82e-3
 HG_U133_Plus2  232748_at  -0.18  2.81e-1  3.67e-1  -0.22  2.32e-1  2.86e-1
 HG_U133_Plus2  240450_at  -0.40  2.22e-2  4.14e-2  -0.46  6.34e-3  1.07e-2
 Stanford  10391  0.65  1.79e-1  3.62e-1  0.18  6.90e-1  8.43e-1
 Stanford  12349  1.82  5.90e-4  1.03e-2  1.69  2.90e-3  2.89e-2
 Agilent_HS_21.6K  17228  0.07  9.79e-2  2.32e-1  0.07  5.89e-2  1.40e-1
 Agilent_HS_21.6K  17654  0.10  2.66e-3  1.66e-2  0.08  9.85e-3  3.54e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  201981_at  0.89  1.39e-2  6.83e-1  0.10  7.49e-1  1.00e+0
 HG_U133A  201982_s_at  0.80  3.25e-2  7.01e-1  0.00  9.89e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 32549_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201981_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201982_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1558607_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1558608_a_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1559400_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1559928_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201981_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201982_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 224940_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 224941_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 224942_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 228128_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 232748_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 240450_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 10391    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 12349    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 17228    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 17654    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
pappa leiomyoma Increased expression of the genes for pregnancy-associated plasma protein A (PAPPA), tomoregulin, cellular retinoid acid binding protein 1 (CRABP1), zinc finger protein 185 (ZFP 185) and latent transforming growth factor beta binding protein 2 (LTBP2) was 11870232 Human
papp-a neointimal hyperplasia These results suggest a possible role for PAPP-A in neointimal hyperplasia. 11231911 Human
papp-a metastasis Genetic downregulation of pregnancy-associated plasma protein-A (PAPP-A) by bikunin reduces IGF-I-dependent Akt and ERK1/2 activation and subsequently reduces ovarian cancer cell growth, invasion and metastasis. 14961570 Human
papp-a ovarian cancer Genetic downregulation of pregnancy-associated plasma protein-A (PAPP-A) by bikunin reduces IGF-I-dependent Akt and ERK1/2 activation and subsequently reduces ovarian cancer cell growth, invasion and metastasis. 14961570 Human
papp-a human ovarian cancer To clarify how reduced levels of PAPP-A may confer repressed invasiveness, we transfected human ovarian cancer cell line HRA with antisense (AS)-PAPP-A cDNA and compared the properties of the transfected cells to those of parental HRA cells. 14961570 Human
papp-a metastasis Here, we show that regulation of uPA mRNA and protein by IGF-I depends on the PI3K and MAPK signaling pathways and phosphorylation of Akt and ERK1/2 is required for IGF-I-mediated cell invasion; that IGFBP-4 protease in HRA cells is identified as PAPP-A; 14961570 Human
papp-a complete moles Serum PAPP-A and SP1 were high in complete moles. 10221724 Human
papp-a chromosomal disease Pregnancy-associated plasma protein A (PAPP-A) is a maternal serum marker of fetal chromosomal disease and a risk marker for adverse outcome. 14594321 Human
papp-a ovarian cancer Reduced PAPP-A mRNA expression has been reported in ovarian cancer specimens compared to normal ovarian surface epithelial cells (OSE). 15146551 Human
pappa ovarian cancer Differential display (DD)-PCR analysis comparing normal ovarian epithelial cultures and ovarian cancer cell lines identified pregnancy-associated plasma protein-A (PAPPA) because of its frequent loss of expression (LOE) in ovarian cancer cell lines. 12555072 Human
papp-a breast carcinoma The primary tumors and metastases from 30 patients with stage II breast carcinoma treated with low- or standard-dose combination chemotherapy (cyclophosphamide, methotrexate, 5-fluorouracil) were studied by the immunoperoxidase technique for pregnancy-ass 2579017 Human
papp-a metastases The primary tumors and metastases from 30 patients with stage II breast carcinoma treated with low- or standard-dose combination chemotherapy (cyclophosphamide, methotrexate, 5-fluorouracil) were studied by the immunoperoxidase technique for pregnancy-ass 2579017 Human
papp-a breast carcinoma Immunostaining for PAPP-A is thus a clinically significant predictor of early recurrence in patients with stage II breast carcinoma. 2579017 Human
papp-a breast carcinoma To identify those patients at risk for early recurrence, we reviewed 33 clinical and pathologic features as well as immunoperoxidase-staining characteristics for carcinoembryonic antigen, human chorionic gonadotrophin, pregnancy specific beta-1 glycoprote 2409349 Human
papp-a recurrent tumors When the independent risk factor of PAPP-A positivity and extensive necrosis were combined, 13 of 16 (81%) of the recurrent tumors were either PAPP-A positive or extensively necrotic compared with four of 24 (16%) of the nonrecurrent group. 2409349 Human
papp-a breast carcinoma Thus, positive immunostaining for PAPP-A and the presence of extensive necrosis are clinically significant independent predictors of early recurrence in patients with stage I, estrogen receptor-negative breast carcinoma. 2409349 Human
papp-a cancer Placental proteins such as human chorionic gonadotrophin (hCG), Schwangerschaftsprotein 1 (SP1) and pregnancy-associated plasma protein A (PAPP-A) are found in the blood of pregnant women and in subjects suffering from cancer. 2417920 Human
papp-a cystic glandular hyperplasia Endometria in the proliferative phase (n = 27) or early secretory phase (days 1-3 postovulation; n = 12), cystic glandular hyperplasia (n = 12), and postmenopausal endometria of untreated (n = 7) or estrogen-treated (n = 5) women were all PAPP-A negative. 6198332 Human
papp-a tumour Production of pregnancy-associated plasma protein-A (PAPP-A) by cultured tumour granulosa cells. 2438194 Human
papp-a tumour Pregnancy-associated plasma protein-A (PAPP-A) was detected by radioimmunoassay in culture media of 2 out of 4 (50%) tumour granulosa cell lines (mean = 104 microIU/10(5) cells/24 h) but not in any ovarian (n = 6) or cervical (n = 2) tumour cell lines. 2438194 Human
papp-a tumour Cultured tumour granulosa cells specifically synthesised and secreted a large protein which was immunologically and physicochemically indistinguishable from in vivo (pregnancy and ovarian follicular) derived PAPP-A. 2438194 Human
papp-a hydatidiform moles In hydatidiform moles, beta-hCG levels are very high demonstrating an intense trophoblastic activity, whereas PAPP-A levels remain in the normal range. 2420291 Human
papp-a human testicular cancer This study was conducted to learn whether circulating levels of PAPP-A can be used as a marker for the monitoring of human testicular cancer. 2427047 Human
papp-a nonseminomatous germ-cell tumor PAPP-A was increased only in certain nonseminomatous germ cell tumor [malignant teratoma undifferentiated (MTU) + seminoma, malignant teratoma intermediate (MTI)], but the overlap with the normal values was too big for PAPP-A to have any clinical signific 2427047 Human
papp-a seminoma PAPP-A was increased only in certain nonseminomatous germ cell tumor [malignant teratoma undifferentiated (MTU) + seminoma, malignant teratoma intermediate (MTI)], but the overlap with the normal values was too big for PAPP-A to have any clinical signific 2427047 Human
papp-a malignant teratoma intermediate PAPP-A was increased only in certain nonseminomatous germ cell tumor [malignant teratoma undifferentiated (MTU) + seminoma, malignant teratoma intermediate (MTI)], but the overlap with the normal values was too big for PAPP-A to have any clinical signific 2427047 Human
papp-a nonseminomatous germ-cell tumors In men, PAPP-A can be produced by certain nonseminomatous germ cell tumors, but its origin in disease-free males is probably not the testis or the prostate. 2427047 Human
papp-a human breast cancer Previous work showed that the early recurrence of human breast cancer correlated with immunohistochemical staining with a commercial antiserum ostensibly directed against pregnancy-associated plasma protein A (PAPP-A). 2465547 Human
papp-a tumor This screen identified suppression of several genes such as CDC-like kinase, LIM domain binding, Ets domain transcription factor, Rho GTPase-activating protein, tyrosine phosphorylation-regulated kinase, hyaluronan-binding protein, matriptase, and pregnan 12571229 Human
papp-a tumors Pregnancy-associated plasma protein A (PAPP-A) was measured in 159 patients with various nontrophoblastic tumors. 6178292 Human
papp-a trophoblastic tumors In three patients with trophoblastic tumors, PAPP-A and human chorionic gonadotropin (hCG) were measured before operation and weekly thereafter. 6178292 Human
papp-a tumors Circulating levels of PAPP-A in patients with nontrophoblastic tumors were not significantly different from the levels in the matched control groups. 6178292 Human
papp-a trophoblastic tumors Circulating levels of PAPP-A and hCG were significantly elevated preoperatively in patients with trophoblastic tumors, whereas the postoperative concentrations of both proteins gradually decreased. 6178292 Human
papp-a cancers The conclusion is that, probably, PAPP-A cannot be considered to be a marker for nontrophoblastic disease, and that measurements of PAPP-A in patients with trophoblastic cancers do not provide any advantage over measurements of hCG. 6178292 Human
papp-a tumours Placenta-associated plasma protein-A (PAPP-A, SP4) in trophoblastic tumours. 6164245 Human
papp-a hydatidiform moles The immunoperoxidase technique was used to study the occurrence of placenta-associated plasma protein A (PAPP-A, SP4) in formalin-fixed paraffin-embedded tissue specimens from 15 hydatidiform moles, 6 invasive moles and 7 choriocarcinomas. 6164245 Human
papp-a invasive moles The immunoperoxidase technique was used to study the occurrence of placenta-associated plasma protein A (PAPP-A, SP4) in formalin-fixed paraffin-embedded tissue specimens from 15 hydatidiform moles, 6 invasive moles and 7 choriocarcinomas. 6164245 Human
papp-a hydatidiform moles PAPP-A was found in the syncytiotrophoblast of all hydatidiform moles, in 5 of the 6 invasive moles and in 6 of the 7 choriocarcinomata. 6164245 Human
papp-a invasive moles PAPP-A was found in the syncytiotrophoblast of all hydatidiform moles, in 5 of the 6 invasive moles and in 6 of the 7 choriocarcinomata. 6164245 Human
papp-a primary tumors The primary tumors and metastases from 30 patients with stage II breast carcinoma treated with low- or standard-dose combination chemotherapy (cyclophosphamide, methotrexate, 5-fluorouracil) were studied by the immunoperoxidase technique for pregnancy-ass 2579017 Human
papp-a stage ii breast carcinoma The primary tumors and metastases from 30 patients with stage II breast carcinoma treated with low- or standard-dose combination chemotherapy (cyclophosphamide, methotrexate, 5-fluorouracil) were studied by the immunoperoxidase technique for pregnancy-ass 2579017 Human
papp-a stage ii breast carcinoma Immunostaining for PAPP-A is thus a clinically significant predictor of early recurrence in patients with stage II breast carcinoma. 2579017 Human
papp-a necrosis Pairwise correlations between recurrence and clinicopathologic features, including tumor marker immunostaining, revealed significant correlations between extensive necrosis, nuclear atypia, mitoses, and PAPP-A staining. 2409349 Human
papp-a necrosis In multivariant linear discriminant analysis, only PAPP-A staining and extensive necrosis entered as significant independent predictors. 2409349 Human
papp-a necrosis In the recurrent group, nine of 16 (56%) were PAPP-A positive compared with one of 24 (4%) in the nonrecurrent group (p less than 0.001), whereas nine of 16 (56%) contained extensive necrosis compared with three of 24 (11%) in the nonrecurrent group (p le 2409349 Human
papp-a necrosis When the independent risk factor of PAPP-A positivity and extensive necrosis were combined, 13 of 16 (81%) of the recurrent tumors were either PAPP-A positive or extensively necrotic compared with four of 24 (16%) of the nonrecurrent group. 2409349 Human
papp-a necrosis Thus, positive immunostaining for PAPP-A and the presence of extensive necrosis are clinically significant independent predictors of early recurrence in patients with stage I, estrogen receptor-negative breast carcinoma. 2409349 Human
papp-a molar pregnancy In the present study we sought to compare levels of PAPP-A and hCG produced by different types of pregnancy: normal, ectopic, threatened abortion and molar pregnancy after evacuation. 2478398 Human
papp-a trophoblastic tumours Placenta-associated plasma protein-A (PAPP-A, SP4) in trophoblastic tumours. 6164245 Human
papp-a choriocarcinomas The immunoperoxidase technique was used to study the occurrence of placenta-associated plasma protein A (PAPP-A, SP4) in formalin-fixed paraffin-embedded tissue specimens from 15 hydatidiform moles, 6 invasive moles and 7 choriocarcinomas. 6164245 Human
papp-a molar pregnancy The ultrasound features, cytogenetic and histopathological findings of 10 cases of molar pregnancy diagnosed at 11-13 weeks of gestation were compared retrospectively with the maternal serum concentrations of human chorionic gonadotrophin (HCG), alpha fet 10221724 Human
papp-a human osteosarcoma To evaluate the role of serum PAPP-A, we tested whether PAPP-A in PS modulated the inhibitory activity of IGFBP-4 on IGF-II-induced cell proliferation in human osteosarcoma MG63 cells. 11158056 Human
papp-a tumour The experimental data allows us to suppose that PAPP-A serves to prevent the recognition of the fetus by the maternal immune system and to suppress locally the host's immune response to the tumour. 15079888 Human
papp-a ovarian tumor Short-term ovarian tumor cell cultures expressed variable levels of PAPP-A and high levels of proMBP, and consequently secreted little or no IGFBP-4 protease activity. 15146551 Human
papp-a necrosis METHODS: In 547 patients with angiographically validated ACS and in a heterogeneous emergency room population of 644 patients with acute chest pain, respectively, PAPP-A as well as markers of myocardial necrosis (troponin T [TnT]), ischemia (vascular endo 15653020 Human
pappa ovarian tumors PAPPA is localized to human chromosome 9q32-33.1, a region associated with significant loss of heterozygosity (LOH) in ovarian tumors (>50%) and in close proximity to the FRA9E CFS. 12555072 Human
papp a tumor Among them, human chorionic gonadotropin (hCG), protein SP1 ("Schwangerschaftsprotein" 1) and some pregnancy-associated plasma proteins such as the PAPP A are very useful in the diagnosis of pregnancy, abortion, foetal abnormality or tumor in th 3073451 Human
papp-a osteosarcoma Similar results were obtained when recombinant proMBP and PAPP-A were incubated in the presence of U2 osteosarcoma cells or when recombinant proMBP was added to the U2 cells overexpressing PAPP-A. 15001398 Human
papp-a hydatidiform mole Circulating levels of four specific placental proteins, human chorionic gonadotrophin (hCG), Schwangerschafts protein 1 (SP1), placental protein 5 (PP5) and pregnancy-associated plasma protein A (PAPP-A), were measured in 31 patients with hydatidiform mol 6189512 Human
papp-a cancer The clinical applications of PP12, PP14 and PAPP-A measurements are not only limited to uterine pathologies but also include cancer (tumour markers) and pregnancy (hydatidiform moles and extra-uterine pregnancies). 2444151 Human
papp-a hydatidiform moles The clinical applications of PP12, PP14 and PAPP-A measurements are not only limited to uterine pathologies but also include cancer (tumour markers) and pregnancy (hydatidiform moles and extra-uterine pregnancies). 2444151 Human
papp-a tumour The clinical applications of PP12, PP14 and PAPP-A measurements are not only limited to uterine pathologies but also include cancer (tumour markers) and pregnancy (hydatidiform moles and extra-uterine pregnancies). 2444151 Human
papp-a endometrial cancer The combined stainings, i.e. either for TPA and SP1 or for TPA and PAPP-A, are efficient immunohistochemical screening methods to use in diagnosing endometrial cancer in the biopsied specimens (p less than 0.05). 2445880 Human
papp-a malignant teratoma undifferentiated (mtu) PAPP-A was increased only in certain nonseminomatous germ cell tumor [malignant teratoma undifferentiated (MTU) + seminoma, malignant teratoma intermediate (MTI)], but the overlap with the normal values was too big for PAPP-A to have any clinical signific 2427047 Human
papp-a nonseminomatous germ cell tumor PAPP-A was increased only in certain nonseminomatous germ cell tumor [malignant teratoma undifferentiated (MTU) + seminoma, malignant teratoma intermediate (MTI)], but the overlap with the normal values was too big for PAPP-A to have any clinical signific 2427047 Human
papp-a nonseminomatous germ cell tumors In men, PAPP-A can be produced by certain nonseminomatous germ cell tumors, but its origin in disease-free males is probably not the testis or the prostate. 2427047 Human
papp-a osteosarcoma Similar results were obtained when recombinant proMBP and PAPP-A were incubated in the presence of U2 osteosarcoma cells or when recombinant proMBP was added to the U2 cells overexpressing PAPP-A. 15001398 Human
papp-a hyperplasia Our finding that PAPP-A gene expression in hCASMC is stimulated by TNF-alpha and IL-1beta suggests a mechanism for the regulation of PAPP-A in response to vascular injury that may contribute to the enhanced IGF-I bioactivity in intimal hyperplasia and ath 16338976 Human
papp-a chromosomal disease OBJECTIVE: First trimester screening for fetal chromosomal disease is now possible using the maternal serological markers pregnancy-associated plasma protein-A (PAPP-A) and the free ss-form of human chorionic gonadotrophin (sshCG) in combination with the 16537243 Human
papp-a tumor necrosis Pregnancy-associated plasma protein-A (PAPP-A) immunopositivity and extensive tumor necrosis have been shown to correlate significantly with early (less than 24 months) recurrence in patients with Stage I breast carcinoma negative for estrogen receptor (E 2414998 Human
papp-a stage i breast carcinoma Pregnancy-associated plasma protein-A (PAPP-A) immunopositivity and extensive tumor necrosis have been shown to correlate significantly with early (less than 24 months) recurrence in patients with Stage I breast carcinoma negative for estrogen receptor (E 2414998 Human
papp-a tumor Pearson chi-square tests revealed significant correlations between early recurrence and PAPP-A tumor positivity (P less than 0.002), younger age (P less than 0.009), and premenopausal status (P less than 0.03). 2414998 Human
papp-a tumors Of the 10 PAPP-A-positive tumors, 4 (40%) recurred within 2 years, compared with no early recurrences in the 20 PAPP-A-negative cases. 2414998 Human
papp-a tumors With a comparison of frequency of PAPP-A positivity of ER-positive (30%) tumors and ER-negative tumors (40%), there was no correlation with ER or PR status. 2414998 Human
papp-a tumor PAPP-A tumor positivity is independent of ER status and is a clinically significant independent predictor of early recurrence in both ER-positive and ER-negative Stage I patients. 2414998 Human
papp-a neointimal hyperplasia For in vivo testing, PAPP-A-/- and WT mice underwent unilateral carotid ligation, a model of injury-induced neointimal hyperplasia. 16959843 Human
papp-a neointimal hyperplasia In WT mice, PAPP-A mRNA expression was markedly elevated 7 and 14 d after carotid ligation, associated with a progressive increase in neointimal hyperplasia and, in many cases, with complete occlusion of the vessel at 28 d. 16959843 Mouse
papp-a epithelial ovarian tumors IGF-I, IGF-II, IGFBP-4, and PAPP-A gene expression was determined in a panel of GCT and compared to the levels in normal ovary and in epithelial ovarian tumors. 17177834 Human
papp-a hyperplasia Investigators concluded that PAPP-A may contribute to airway smooth muscle hyperplasia as an insulin-like growth factor-dependent insulin-like growth factor-binding protein-4 protease in patients with asthma. 17565927 Human
papp-a necrosis Blood samples for the analysis of PAPP-A, creatine kinase-MB (CKMB), and troponin T were drawn at admission and every 6 to 8 hours until biomarkers of myocardial necrosis were consistently decreasing. 18471447 Human
papp-a malignant teratoma undifferentiated PAPP-A was increased only in certain nonseminomatous germ cell tumor [malignant teratoma undifferentiated (MTU) + seminoma, malignant teratoma intermediate (MTI)], but the overlap with the normal values was too big for PAPP-A to have any clinical signific 2427047 Human

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