IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene TLR4 Ensembl ENSG00000136869 Chromosome 9 Start 119506291 End 119519589
Description Toll-like receptor 4 Precursor (hToll)(CD284 antigen) [Source:UniProtKB/Swiss-Prot;Acc:O00206]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11850
     Entrez Gene : 7099
     UCSC : uc004bjz.2
     GeneCards : 11850
     RefSeq : NM_138554
     CCDS : CCDS6818.1
     Uniprot : Q9UK78
     Interpro : Q9UK78
     OMIM : 603030
     GeneTests : TLR4
     CGAP : TLR4
     PMID : 9435236

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  221060_s_at  -0.60  1.69e-12  7.48e-12  -1.59  7.78e-44  1.60e-43
 HG_U133_Plus2  1552798_a_at  -1.15  4.25e-7  2.04e-6  -2.02  9.14e-14  6.21e-13
 HG_U133_Plus2  221060_s_at  -0.67  7.05e-7  3.27e-6  -0.91  6.35e-10  2.78e-9
 HG_U133_Plus2  224341_x_at  -1.60  6.51e-19  1.38e-17  -2.31  1.59e-21  2.61e-20
 HG_U133_Plus2  232068_s_at  -1.52  1.27e-16  2.08e-15  -2.03  1.32e-17  1.39e-16
 Agilent_HS_21.6K  6960  -0.23  2.54e-6  5.51e-5  -0.22  7.03e-6  8.38e-5

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  221060_s_at  0.25  4.97e-1  9.27e-1  -0.28  1.53e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133A - 221060_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1552798_a_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 221060_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 224341_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 232068_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 6960    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
tlr4 mouse mammary tumor A candidate protein for the activation of B cells by either mouse mammary tumor virus (MMTV) or murine leukemia virus is the toll-like receptor 4 (TLR4), a component of the innate immune system. 11854525 Human
toll-like receptor 4 mouse mammary tumor A candidate protein for the activation of B cells by either mouse mammary tumor virus (MMTV) or murine leukemia virus is the toll-like receptor 4 (TLR4), a component of the innate immune system. 11854525 Human
tlr4 murine leukemia A candidate protein for the activation of B cells by either mouse mammary tumor virus (MMTV) or murine leukemia virus is the toll-like receptor 4 (TLR4), a component of the innate immune system. 11854525 Human
toll-like receptor 4 murine leukemia A candidate protein for the activation of B cells by either mouse mammary tumor virus (MMTV) or murine leukemia virus is the toll-like receptor 4 (TLR4), a component of the innate immune system. 11854525 Human
tlr4 murine leukemia Additionally, the MMTV- and Moloney murine leukemia virus envelope proteins coimmunoprecipitated with TLR4 when expressed in 293T cells. 11854525 Human
toll-like receptor 4 mouse mammary tumor A recent publication proposed that the retrovirus mouse mammary tumor virus exploits the pattern-recognition receptor Toll-like receptor 4 to achieve more efficient infection. 12110201 Human
tlr-4 cancer These results suggest that during bacterial infections in cancer patients with markedly diminished numbers of leukocytes, endothelial cells become important producers of IL-8 through TLR-4 signaling and, to a lesser extent, TLR-2 signaling. 12853386 Human
tlr4 inflammatory bowel disease TLR4 is not present in epithelium from children with inflammatory bowel disease. 11396812 Human
tlr4 tumor Because TLR4 is involved in both MyD88-dependent and -independent pathways and the latter affects DC maturation, our findings indicate that both pathways cooperate to induce CTL-based tumor immunity. 14744795 Human
tlr4 granuloma Taken together, these results demonstrate that TLR4 controls early events of C. burnetii infection such as macrophage phagocytosis, granuloma formation, and cytokine production. 15004173 Mouse
tlr4 inflammatory bowel disease Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. 11083826 Human
tlr4 granuloma However, TLR4 mutant mice experienced an arrest of body weight gain and showed signs of increased inflammation, with persistent splenomegaly, increase in granuloma number and augmented neutrophil infiltration. 14554248 Mouse
tlr4 granuloma In summary, TLR4 mutant mice show normal macrophage recruitment and activation, granuloma formation and control of the BCG infection, but this is associated with persistent inflammation. 14554248 Mouse
toll-like receptor 4 cancer Sequence variants of toll-like receptor 4 are associated with prostate cancer risk: results from the CAncer Prostate in Sweden Study. 15087412 Human
toll-like receptor 4 prostate cancer Sequence variants of toll-like receptor 4 are associated with prostate cancer risk: results from the CAncer Prostate in Sweden Study. 15087412 Human
tlr4 prostate cancer We performed a systematic genetic analysis of TLR4 sequence variants by evaluating eight single-nucleotide polymorphisms that span the entire gene among 1383 newly diagnosed prostate cancer patients and 780 age- and residence-matched controls in Sweden. 15087412 Human
tlr4 prostate cancer We found an association between a sequence variant (11381G/C) in the 3'-untranslated region of the TLR4 gene and prostate cancer risk. 15087412 Human
tlr4 head-and-neck cancer METHODS: Peripheral blood mononuclear cells (PBMCs) from 28 patients with head and neck cancer were analyzed for TLR4 and MD-2 mRNA expression by reverse transcription-polymerase chain reaction (RT-PCR) analysis. 12591988 Human
tlr4 oral cancer Our clinical examination in oral cancer patients also suggests the requirement of both TLR4 and MD-2 in the OK-432-induced anti-cancer host response. 12630564 Human
tlr4 ibd The aim of this study was to characterize the expression pattern of TLR2, TLR3, TLR4, and TLR5 in primary intestinal epithelial cells from patients with IBD. 11083826 Human
tlr-4 bladder cancer CONCLUSIONS: The stimulation of BCG not only up-regulated the expression of TLR-2 and TLR-4, but also increased the production of IL-12 in bladder cancer T24 cell line. 15062066 Human
tlr-4 crohn's disease The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis. 15194649 Human
tlr-4 crohn's disease Herein, two mutations of the Toll-like receptor (TLR)-4 gene (Asp299Gly and Thr399Ile) resulting in impaired lipopolysaccharide signaling, the -159C/T promotor polymorphism of the CD14 gene, polymorphisms of the lipopolysaccharide binding protein gene and 15207785 Human
tlr-4 gastric cancer We investigated the immuno-suppressive activity of anticancer agents on human peripheral blood mononuclear cells (PBMC), apoptosis inducing activity on gastric cancer cells and expression of Toll-like receptor (TLR)-4 mRNA on immatureDCs (iDCs) by paclita 15553666 Human
tlr-4 melanoma We hypothesized that melanoma inhibits macrophage activation by suppressing TLR-4 signaling. 16125076 Human
tlr-4 melanoma CONCLUSIONS: Melanoma inhibits macrophage activation by suppressing TLR-4 signaling downstream of the TLR-4 receptor. 16125076 Human
tlr-4 tumor The endo-polysaccharide appeared to have other cellular binding sites with TLR-4 and did not show a direct toxicity against tumor cells. 15970296 Human
tlr4 ibd In active IBD, the expression of TLR3 and TLR4 was differentially modulated in the intestinal epithelium. 11083826 Human
tlr4 ibd A TDT on 318 IBD trios demonstrated preferential transmission of the TLR4 Asp299Gly polymorphism from heterozygous parents to affected children (T/U: 68/34, p = 0.01). 15194649 Human
tlr4 crohn's disease In the present study, we demonstrate that the 3020insC frameshift-mutation in the NOD2 gene associated with Crohn's disease results in defective release of IL-10 from blood mononuclear cells after stimulation with the Toll-like receptor (TLR)2 ligand 15214053 Human
tlr4 head-and-neck cancer In the present study, we first examined the effect of OK-PSA on the maturation of dendritic cells (DCs) in vitro by using the DCs derived from 5 healthy donors and 10 patients with head and neck cancer with or without expression of toll-like receptor 4 (T 15289356 Human
tlr4 crohn's disease NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe? 15190267 Human
tlr4 inflammatory bowel disease In all, 612 patients with well-characterised inflammatory bowel disease (252 Scottish CD, 247 Scottish UC, 113 Irish CD) and 304 controls were genotyped for variants of NOD2/CARD15 (1007fsinsC, G908R, R702W, P268S), TLR4 (A299G) and CD14 (T-159C). 15190267 Human
tlr4 solid tumors These findings suggest that the local DC therapy in combination with TS-1 and OK-432 may be a useful strategy for the treatment of solid tumors, and that TLR4 signaling is involved in the success of this therapy. 15534487 Human
tlr4 solid tumors These findings suggest that local DC therapy in combination with TS-1 and OK-432 may well be a useful strategy for the treatment of solid tumors, and that TLR4 signaling is involved in the success of this therapy. 15553665 Human
tlr4 polyposis Eosinophils and neutrophils, highly recruited in nasal polyposis, were found to exert potent antifungal effector activities toward conidia and hyphae of the fungus and to be positively regulated by TLR2 or TLR4 stimulation. 15557653 Human
tlr4 granulomas We did not find a significant correlation between granulomas and TLR4 or CARD15 variants. 15647186 Human
tlr4 granulomas CONCLUSION: In this study of 161 well documented CD patients, we found no significant association between CARD15 and TLR4 variants and granulomas. 15647186 Human
tlr4 ibd A possible interaction of the NOD2/CARD15 with TLR4 and especially CD14, increased the risk of developing inflammatory bowel disease (IBD). 15655821 Human
tlr4 inflammatory bowel disease A possible interaction of the NOD2/CARD15 with TLR4 and especially CD14, increased the risk of developing inflammatory bowel disease (IBD). 15655821 Human
tlr4 leukemia Though induction of TLR2 or TLR4 by 12-O-tetradecanoyl phorbol 13-acetate (TPA) in leukemia cells has been reported, however, the mechanism by which TPA up-regulates TLR2 or TLR4 remains poorly understood. 15670752 Human
tlr4 crohn's disease The toll-like receptor 4 (TLR4) Asp299Gly polymorphism is associated with colonic localisation of Crohn's disease without a major role for the Saccharomyces cerevisiae mannan-LBP-CD14-TLR4 pathway. 15710998 Human
tlr4 tumor Tumor Cells Deactivate Human Monocytes by Up-Regulating IL-1 Receptor Associated Kinase-M Expression via CD44 and TLR4. 15728517 Human
tlr4 tumor Altogether, our findings indicate that deactivation of human monocytes in the presence of tumor cells involves IRAK-M up-regulation, and this effect appears to be mediated by hyaluronan through the engagement of CD44 and TLR4. 15728517 Human
tlr4 epithelial tumour By reverse transcriptase-polymerase chain reaction, Tlr4 mRNA expression was found in some pituitary epithelial tumour cell lines (AtT20, HP75), whereas others were negative (GH3, alphaT3-1). 15796767 Human
tlr4 pituitary tumours Tlr4 protein was detected by immunohistochemistry in a few epithelial cells in normal human anterior pituitaries and in 26 out of 67 human pituitary tumours analysed. 15796767 Human
tlr4 prostate cancer Our previous finding of an association of TLR4 gene sequence variants and prostate cancer risk provides evidence for a role of TLRs in prostate cancer. 15812078 Human
tlr4 inflammatory bowel disease A Synthetic TLR4 Antagonist Has Anti-Inflammatory Effects in Two Murine Models of Inflammatory Bowel Disease. 15879143 Human
tlr4 multiple myeloma Microarray results also revealed changes in genes previously implicated in multiple myeloma pathogenesis (RAS, RAF, IL-6R, and VEGF), as well as others (TLR4, KLF4, and GADD45A) not previously linked to multiple myeloma. 15897243 Human
tlr4 ibd As such, there is a potentially important role of TLR4 in the pathogenesis of inflammatory bowel disease (IBD). 15905704 Human
tlr4 inflammatory bowel disease As such, there is a potentially important role of TLR4 in the pathogenesis of inflammatory bowel disease (IBD). 15905704 Human
tlr4 ibd We studied the involvement of TLR4 in IBD in a large population of Dutch patients with IBD and in family-based controls. 15905704 Human
tlr4 ibd METHODS: In 781 IBD cases and 315 controls, genotyping was performed forAsp299Gly and Thr399Ile variants and for 4 microsatellite markers flanking TLR4. 15905704 Human
tlr4 crohn's disease In addition, interaction of TLR4 with the caspase recruitment domain containing protein 15 gene (CARD15) was studied in patients with Crohn's disease (CD). 15905704 Human
tlr4 tumor We show here that TLRs, including TLR4, are expressed on tumor cells from a wide variety of tissues, suggesting that TLR activation may be an important event in tumor cell immune evasion. 15958541 Mouse
tlr4 tumor Activation of TLR4 signaling in tumor cells by lipopolysaccharide induces the synthesis of various soluble factors and proteins including interleukin-6, inducible nitric oxide synthase, interleukin-12, B7-H1, and B7-H2, and results in resistance of tumor 15958541 Mouse
tlr4 tumor Blockade of the TLR4 pathway by either TLR4 short interfering RNA or a cell-permeable TLR4 inhibitory peptide reverses tumor-mediated suppression of T cell proliferation and natural killer cell activity in vitro, and in vivo, delays tumor growth and thus 15958541 Mouse
tlr4 germinal center hyperplasia TLR4 mRNA levels were significantly greater in thymitis (hyperplasia with diffuse B-cell infiltration) and involuted thymus than in germinal center hyperplasia and thymoma. 15972959 Human
tlr4 hyperplasia TLR4 mRNA levels were significantly greater in thymitis (hyperplasia with diffuse B-cell infiltration) and involuted thymus than in germinal center hyperplasia and thymoma. 15972959 Human
tlr4 (malt) lymphoma We genotyped 87 patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma, 594 Helicobacter pylori positive controls and 358 healthy blood donors to investigate an association of TLR4 Asp299Gly in the development of gastric MALT lymphoma. 16019531 Human
tlr4 gastric malt lymphoma We genotyped 87 patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma, 594 Helicobacter pylori positive controls and 358 healthy blood donors to investigate an association of TLR4 Asp299Gly in the development of gastric MALT lymphoma. 16019531 Human
tlr4 gastric lymphoma Because 10% of caucasians are carriers of the rare allele G TLR4 Asp299Gly appears to be only one factor in the genetic susceptibility to gastric lymphoma. 16019531 Human
tlr4 gastric lymphoma Further studies in larger samples are needed to confirm our findings and fully elucidate the role of TLR4 and its genetic variants in the pathophysiology of H. pylori infection and gastric lymphoma. 16019531 Human
tlr4 crohn's disease BACKGROUND: We investigated the influence of 2 common Toll-like receptor 4 (TLR4) polymorphisms on susceptibility and disease characteristics of Crohn's disease (CD). 15973118 Human
tlr4 gastric carcinoma Toll-like receptors TLR4, TLR5 and TLR9 on gastric carcinoma cells: an implication for interaction with Helicobacter pylori. 16044857 Human
tlr4 metaplasia In this study, TLR4, TLR5 and TLR9 expression was investigated on tumor cells of gastric carcinoma and on its precursor lesions, intestinal metaplasia and dysplasia, by immunohistochemistry. 16044857 Human
tlr4 tumor In this study, TLR4, TLR5 and TLR9 expression was investigated on tumor cells of gastric carcinoma and on its precursor lesions, intestinal metaplasia and dysplasia, by immunohistochemistry. 16044857 Human
tlr4 gastric carcinoma In this study, TLR4, TLR5 and TLR9 expression was investigated on tumor cells of gastric carcinoma and on its precursor lesions, intestinal metaplasia and dysplasia, by immunohistochemistry. 16044857 Human
tlr4 metaplasia Gastric epithelium with intestinal metaplasia (n=10) and dysplasia (n=3) expressed TLR4 and TLR5. 16044857 Human
tlr4 tumor TLR4 was strongly expressed by tumor cells of 17 out of 22 and TLR5 by tumor cells of all 22 patients with gastric carcinoma. 16044857 Human
tlr4 gastric carcinoma TLR4 was strongly expressed by tumor cells of 17 out of 22 and TLR5 by tumor cells of all 22 patients with gastric carcinoma. 16044857 Human
tlr4 crohn's disease Consequence of functional Nod2 and Tlr4 mutations on gene transcription in Crohn's disease patients. 16010583 Human
tlr4 inflammatory bowel disease The incidence of three single nucleotide polymorphisms (SNPs) within the Nod2 gene and one functional SNP within both the Tlr4 and Tlr5 gene in a Dutch cohort of 637 patients with inflammatory bowel disease and 127 controls was investigated. 16010583 Human
tlr4 crohn's disease We investigated polymorphisms of CARD15, TLR4, and OCTN, and environmental factors in a monozygotic twin pair with Crohn's disease and their first-degree relatives. 16024933 Human
toll-like receptor 4 inflammatory bowel disease Polymorphisms of the lipopolysaccharide-signaling complex in inflammatory bowel disease: association of a mutation in the Toll-like receptor 4 gene with ulcerative colitis. 15207785 Human
toll-like receptor 4 head-and-neck cancer In the present study, we first examined the effect of OK-PSA on the maturation of dendritic cells (DCs) in vitro by using the DCs derived from 5 healthy donors and 10 patients with head and neck cancer with or without expression of toll-like receptor 4 (T 15289356 Human
toll-like receptor 4 ibd Toll-like receptor 4 gene in IBD: further evidence for genetic heterogeneity in Europe. 15647200 Human
toll-like receptor 4 inflammatory bowel disease Association between polymorphisms in the Toll-like receptor 4, CD14, and CARD15/NOD2 and inflammatory bowel disease in the Greek population. 15655821 Human
toll-like receptor 4 crohn's disease The toll-like receptor 4 (TLR4) Asp299Gly polymorphism is associated with colonic localisation of Crohn's disease without a major role for the Saccharomyces cerevisiae mannan-LBP-CD14-TLR4 pathway. 15710998 Human
toll-like receptor 4 crohn's disease Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn's disease: Phenotype-genotype correlations. 15770725 Human
toll-like receptor 4 pituitary tumour Bacterial Endotoxin (lipopolysaccharide) Stimulates Interleukin-6 Production and Inhibits Growth of Pituitary Tumour Cells Expressing the Toll-Like Receptor 4. 15796767 Human
toll-like receptor 4 inflammatory bowel disease Association between Toll-like receptor 4 and inflammatory bowel disease. 15905704 Human
toll-like receptor 4 gastric mucosa-associated lymphoid tissue lymphoma Association study of a functional Toll-like receptor 4 polymorphism with susceptibility to gastric mucosa-associated lymphoid tissue lymphoma. 16019531 Human
toll-like receptor 4 crohn's disease The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's disease. 15973118 Human
toll-like receptor 4 crohn's disease BACKGROUND: We investigated the influence of 2 common Toll-like receptor 4 (TLR4) polymorphisms on susceptibility and disease characteristics of Crohn's disease (CD). 15973118 Human
toll-like receptor 4 human bladder cancer INTERFERON-gamma UP-REGULATES TOLL-LIKE RECEPTOR 4 AND COOPERATES WITH LIPOPOLYSACCHARIDE TO PRODUCE MACROPHAGE-DERIVED CHEMOKINE AND INTERFERON-gamma INDUCIBLE PROTEIN-10 IN HUMAN BLADDER CANCER CELL LINE RT4. 16094077 Human
toll-like receptor 4 melanoma Melanoma Inhibits Macrophage Activation by Suppressing Toll-like Receptor 4 Signaling. 16125076 Human
toll-like receptor 4 crohn's disease Is Age of Onset of Crohn's Disease Governed by Mutations in NOD2/Caspase Recruitment Domains 15 and Toll-Like Receptor 4? 16148063 Human

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