IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene TRAF1 Ensembl ENSG00000056558 Chromosome 9 Start 122704493 End 122730868
Description TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6) [Source:UniProtKB/Swiss-Prot;Acc:Q13077]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 12031
     Entrez Gene : 7185
     UCSC : uc004bku.1
     GeneCards : 12031
     RefSeq : NM_005658
     CCDS : CCDS6825.1
     Uniprot : Q13077
     Interpro : Q13077
     OMIM : 601711
     GeneTests : TRAF1
     CGAP : TRAF1
     PMID : 8069916

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  848_at  0.33  8.17e-3  1.96e-2  -0.15  3.96e-1  5.02e-1
 HG_U95  849_g_at  0.53  1.32e-4  5.25e-4  0.46  4.45e-2  8.33e-2
 HG_U133A  205599_at  -0.13  2.40e-2  3.53e-2  0.51  7.65e-17  1.06e-16
 HG_U133_Plus2  205599_at  0.03  8.28e-1  8.71e-1  0.12  3.05e-1  3.64e-1
 HG_U133_Plus2  235116_at  0.15  2.27e-1  3.07e-1  0.28  3.48e-2  5.13e-2
 Stanford  12124  0.84  4.46e-3  3.80e-2  0.41  1.14e-1  2.98e-1
 Agilent_HS_21.6K  18413  0.02  3.42e-1  5.29e-1  0.00  8.26e-1  8.93e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205599_at  0.10  6.75e-1  9.65e-1  0.28  9.52e-2  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 848_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 849_g_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205599_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205599_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 235116_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 12124    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 18413    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
traf1 human colon cancer Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-kappaB-dependent pathway. 14981539 Human
traf1 human colon cancers The purpose of this study was to delineate the signaling pathways and TRAF1 promoter elements responsible for phorbol ester-mediated TRAF1 induction in human colon cancers. 14981539 Human
traf1 human colon cancer In conclusion, our results demonstrate selective induction of TRAF1 in human colon cancer cells through a Ca(2+)-dependent PKC/Raf-1/ERK/NF-kappaB-dependent pathway. 14981539 Human
traf1 tumours Previous in situ hybridization studies have demonstrated TRAF1 transcripts in the malignant cells of the majority of Hodgkin's disease (HD) tumours, where the expression of TRAF1 was higher in EBV-associated tumours than in their EBV-negative counter 11400143 Human
traf1 tumours TRAF1 protein was detected more frequently in Hodgkin/Reed-Sternberg (HRS) cells from EBV-positive tumours than in their EBV-negative counterparts. 11400143 Human
traf1 tumours Using a sequential labelling approach, co-localization of LMP1 with either TRAF1 or TRAF2 was also demonstrated in HRS cells from EBV-positive tumours. 11400143 Human
traf1 tumors In vitro, TRAF1 is induced by LMP1, and previous studies have suggested that expression of TRAF1 is higher in EBV-associated tumors than in their EBV-negative counterparts. 11567226 Human
traf1 tumors Twenty-four of 30 LMP1-positive tumors, including both Hodgkin disease specimens, expressed TRAF1, compared with only 3 of 12 LMP1-negative tumors. 11567226 Human
traf1 hodgkin disease Twenty-four of 30 LMP1-positive tumors, including both Hodgkin disease specimens, expressed TRAF1, compared with only 3 of 12 LMP1-negative tumors. 11567226 Human
traf1 tumors These results show frequent expression of TRAF1 at the protein level in LMP1-positive PTLD and related disorders and suggest an important role for LMP1-mediated TRAF1 signaling in the pathogenesis of EBV-positive tumors arising in immunosuppressive states 11567226 Human
traf1 pulmonary adenocarcinoma We demonstrate for the first time TNF-alpha dose-dependent induction of TRAF1 protein and messenger RNA (mRNA) in human H441 and A549 pulmonary adenocarcinoma cell lines, as well as in lung cells of C57BL/6J mice after intratracheal administration of TNF- 10657935 Human
traf1 breast cancer Furthermore, expression of the anti-apoptotic tumor necrosis factor receptor associated factor 1 (TRAF1) and defender-against cell death (DAD-1) is regulated by NF-kappaB in certain breast cancer cells. 10962577 Human
traf1 b-cell lymphomas For example, expression of TRAF1 was highly restricted, with B cell lymphomas consistently expressing this TRAF family member. 11046039 Human
traf1 tumor Consistent with results from tumor cell lines, immunohistochemical analysis of 232 non-Hodgkin lymphomas revealed TRAF1 overexpression in 112 (48%) cases. 11046039 Human
traf1 non-hodgkin lymphomas Consistent with results from tumor cell lines, immunohistochemical analysis of 232 non-Hodgkin lymphomas revealed TRAF1 overexpression in 112 (48%) cases. 11046039 Human
traf1 b-cell chronic lymphocytic leukemia TRAF1 protein levels were also elevated in circulating B cell chronic lymphocytic leukemia specimens (n = 49) compared with normal peripheral blood B cells (p = 0.01), as determined by immunoblotting. 11046039 Human
traf1 lymphoid malignancies These findings contribute to an improved understanding of the cell-specific roles of TRAFs in normal tissues and provide evidence of altered TRAF1 expression in lymphoid malignancies. 11046039 Human
traf1 malignant lymphomas To identify the cells in which TRAF1 is active in vivo, we studied TRAF1 transcripts in normal lymphoid tissue, in Epstein-Barr virus (EBV)-induced lymphoproliferations, and in malignant lymphomas with special reference to those that overexpress the cytok 9885224 Human
traf1 non-hodgkin's lymphoma Nearly all non-Hodgkin's lymphoma show low or no TRAF1 expression. 9885224 Human
traf1 diffuse large b-cell lymphoma Only some cases of diffuse large B-cell lymphoma showed a moderate to high TRAF1 signal. 9885224 Human
traf-1 tumor METHODS: The association of LMP1 with TRAF-1 or TRAF-3 in tumor tissue was studied with double-immunofluorescence microscopy and immunoprecipitation assays. 9580648 Human
traf1 nasopharyngeal carcinoma (npc) However, TRAF1 is absent in many established epithelial cell lines and primary nasopharyngeal carcinoma (NPC) biopsy specimens. 12502848 Human
traf-1 nasopharyngeal carcinoma Apoptosis and TRAF-1 cleavage in Epstein-Barr virus-positive nasopharyngeal carcinoma cells treated with doxorubicin combined with a farnesyl-transferase inhibitor. 12527335 Human
traf1 nasopharyngeal carcinoma Epstein-Barr virus encoded latent membrane protein 1 induces TRAF1 expression to promote anti-apoptosis activity via NF-kappaB signaling pathway in nasopharyngeal carcinoma. 12890376 Human
traf1 nasopharyngeal carcinoma (npc) OBJECTIVES: To identify whether Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1) can induce tumor necrosis factor receptor-associated factor 1 (TRAF1) expression and promote its anti-apoptosis activity via the NF-kappaB signaling pathway, 12890376 Human
traf1 anaplastic large-cell lymphoma Differential expression and function of A20 and TRAF1 in Hodgkin lymphoma and anaplastic large cell lymphoma and their induction by CD30 stimulation. 12754742 Human
traf1 lymphoma Differential expression and function of A20 and TRAF1 in Hodgkin lymphoma and anaplastic large cell lymphoma and their induction by CD30 stimulation. 12754742 Human
traf1 lymphoma Epstein-Barr virus encoded latent membrane protein 1 (LMP1) and TNF receptor associated factors (TRAF): colocalisation of LMP1 and TRAF1 in primary EBV infection and in EBV associated Hodgkin lymphoma. 12782762 Human
traf1 burkitt lymphomas (bl) METHODS: TRAF1 expression was investigated in 26 Hodgkin lymphomas (HL; 18 EBV+, eight EBV-), seven EBV+ Burkitt lymphomas (BL), two infectious mononucleosis (IM) tonsils, and lymphoreticular tissue from eight chronic virus carriers. 12782762 Human
traf1 lymphomas METHODS: TRAF1 expression was investigated in 26 Hodgkin lymphomas (HL; 18 EBV+, eight EBV-), seven EBV+ Burkitt lymphomas (BL), two infectious mononucleosis (IM) tonsils, and lymphoreticular tissue from eight chronic virus carriers. 12782762 Human
traf1 follicular lymphomas Eight of 10 follicular lymphomas expressed TRAF1 in centroblast-like cells. 12782762 Human
traf1 anaplastic large-cell lymphomas Four of seven anaplastic large cell lymphomas weakly expressed TRAF1. 12782762 Human
traf1 large b-cell lymphomas Using standard immunohistochemical techniques, we examined 251 large B-cell lymphomas (78 cases of PMLBCL and 173 cases of other types of DLBCL) to determine whether the expression patterns of c-Rel and TRAF1 could reliably distinguish between PMLBCL and 17197926 Human
traf1 diffuse large b-cell lymphoma Expression of TRAF1 and nuclear c-Rel distinguishes primary mediastinal large cell lymphoma from other types of diffuse large B-cell lymphoma. 17197926 Human
traf1 primary mediastinal large cell lymphoma Expression of TRAF1 and nuclear c-Rel distinguishes primary mediastinal large cell lymphoma from other types of diffuse large B-cell lymphoma. 17197926 Human
traf1 dlbcl Using standard immunohistochemical techniques, we examined 251 large B-cell lymphomas (78 cases of PMLBCL and 173 cases of other types of DLBCL) to determine whether the expression patterns of c-Rel and TRAF1 could reliably distinguish between PMLBCL and 17197926 Human
traf1 dlbcl Thus, the combined nuclear localization of c-Rel and the cellular expression of TRAF1 is a highly specific (specificity=98%) means to distinguish PMLBCL from DLBCL that is readily applicable to routine surgical pathology practice. 17197926 Human
traf-1 breast cancer In the present study, we tested the sensitivity of MCF-7 breast cancer cells overexpressing anti-apoptotic genes TRAF-1, c-FLIP, Bcl-xL, clAP-2 or Mn-SOD to paclitaxel and docetaxel. 16080463 Human
traf1 hodgkin's disease We investigated the constitutive expression of TRAF1 and TRAF2 in Hodgkin and Reed-Sternberg (HRS) cells from archived paraffin-embedded tissues obtained from 21 patients diagnosed with classical Hodgkin's disease (HD). 11144929 Human
traf1 hodgkin's disease In contrast, there was a high and consistent TRAF1 overexpression in EBV-induced lymphoproliferations and Hodgkin's disease. 9885224 Human
traf1 hodgkin's disease Previous in situ hybridization studies have demonstrated TRAF1 transcripts in the malignant cells of the majority of Hodgkin's disease (HD) tumours, where the expression of TRAF1 was higher in EBV-associated tumours than in their EBV-negative counter 11400143 Human
traf1 hodgkin lymphoma Differential expression and function of A20 and TRAF1 in Hodgkin lymphoma and anaplastic large cell lymphoma and their induction by CD30 stimulation. 12754742 Human
traf1 hl Our data suggest that A20 and TRAF1 contribute to apoptosis resistance and, therefore, play an important role in the pathogenesis of classical HL. 12754742 Human
traf1 hodgkin lymphoma Epstein-Barr virus encoded latent membrane protein 1 (LMP1) and TNF receptor associated factors (TRAF): colocalisation of LMP1 and TRAF1 in primary EBV infection and in EBV associated Hodgkin lymphoma. 12782762 Human
traf1 hl METHODS: TRAF1 expression was investigated in 26 Hodgkin lymphomas (HL; 18 EBV+, eight EBV-), seven EBV+ Burkitt lymphomas (BL), two infectious mononucleosis (IM) tonsils, and lymphoreticular tissue from eight chronic virus carriers. 12782762 Human
traf1 hodgkin lymphomas METHODS: TRAF1 expression was investigated in 26 Hodgkin lymphomas (HL; 18 EBV+, eight EBV-), seven EBV+ Burkitt lymphomas (BL), two infectious mononucleosis (IM) tonsils, and lymphoreticular tissue from eight chronic virus carriers. 12782762 Human
traf1 hl In HL biopsies, TRAF1 was strongly expressed independently of EBV status, whereas all BL cases were TRAF1-. 12782762 Human
traf1 hl In EBV+ HL cases, TRAF1 colocalised with LMP1. 12782762 Human
traf1 hl In HL, TRAF1 is expressed independently of EBV status, probably because of constitutive NF-kappaB activation. 12782762 Human
traf1 hl The function of TRAF1 in HL remains to be determined. 12782762 Human
traf1 tumor Our results demonstrate that TRAF1 is expressed in NPC tumor cells in vivo and suggest that TRAF1 expression may be upregulated by LMP1 in NPC. 15352039 Human
traf1 leukemia Given that many human chronic lymphocytic leukemias overexpress TRAF1 and Bcl-2, our findings suggest that cooperation between Bcl-2 and TRAF pathways contributes to the development of this type of leukemia. 15545599 Human
traf1 chronic lymphocytic leukemias Given that many human chronic lymphocytic leukemias overexpress TRAF1 and Bcl-2, our findings suggest that cooperation between Bcl-2 and TRAF pathways contributes to the development of this type of leukemia. 15545599 Human
traf1 classical hodgkin lymphoma TRAF1 expression and c-Rel activation are useful adjuncts in distinguishing classical Hodgkin lymphoma from a subset of morphologically or immunophenotypically similar lymphomas. 15644776 Human
traf1 lymphomas TRAF1 expression and c-Rel activation are useful adjuncts in distinguishing classical Hodgkin lymphoma from a subset of morphologically or immunophenotypically similar lymphomas. 15644776 Human
traf1 anaplastic large-cell lymphoma We demonstrate that the expression of TRAF1 and activated c-Rel, two proteins that function in signaling events downstream of activated CD30 in Reed-Sternberg cells, reliably distinguish classical Hodgkin lymphoma from anaplastic large cell lymphoma, nodu 15644776 Human
traf1 classical hodgkin lymphoma We demonstrate that the expression of TRAF1 and activated c-Rel, two proteins that function in signaling events downstream of activated CD30 in Reed-Sternberg cells, reliably distinguish classical Hodgkin lymphoma from anaplastic large cell lymphoma, nodu 15644776 Human
traf1 diffuse large b-cell lymphoma We demonstrate that the expression of TRAF1 and activated c-Rel, two proteins that function in signaling events downstream of activated CD30 in Reed-Sternberg cells, reliably distinguish classical Hodgkin lymphoma from anaplastic large cell lymphoma, nodu 15644776 Human
traf1 nodular lymphocyte predominant hodgkin lymphoma We demonstrate that the expression of TRAF1 and activated c-Rel, two proteins that function in signaling events downstream of activated CD30 in Reed-Sternberg cells, reliably distinguish classical Hodgkin lymphoma from anaplastic large cell lymphoma, nodu 15644776 Human
traf1 classical hodgkin lymphoma By immunohistochemistry, we found strong TRAF1 staining in 21 of 25 cases of classical Hodgkin lymphoma. 15644776 Human
traf1 anaplastic large-cell lymphoma In contrast, strong TRAF1 staining was present in only 1 of 17 cases of anaplastic large cell lymphoma, 0 of 15 cases of lymphocyte predominant Hodgkin lymphoma, and 2 of 36 cases of nonmediastinal diffuse large B-cell lymphoma. 15644776 Human
traf1 diffuse large b-cell lymphoma In contrast, strong TRAF1 staining was present in only 1 of 17 cases of anaplastic large cell lymphoma, 0 of 15 cases of lymphocyte predominant Hodgkin lymphoma, and 2 of 36 cases of nonmediastinal diffuse large B-cell lymphoma. 15644776 Human
traf1 hodgkin lymphoma In contrast, strong TRAF1 staining was present in only 1 of 17 cases of anaplastic large cell lymphoma, 0 of 15 cases of lymphocyte predominant Hodgkin lymphoma, and 2 of 36 cases of nonmediastinal diffuse large B-cell lymphoma. 15644776 Human
traf1 classical hodgkin lymphoma Taken together, the combination of strong cytoplasmic TRAF1 expression and nuclear c-Rel was present in 80% of cases of classical Hodgkin lymphoma (n = 25) but in only 3% of cases of the other malignant lymphomas tested (n = 62). 15644776 Human
traf1 malignant lymphomas Taken together, the combination of strong cytoplasmic TRAF1 expression and nuclear c-Rel was present in 80% of cases of classical Hodgkin lymphoma (n = 25) but in only 3% of cases of the other malignant lymphomas tested (n = 62). 15644776 Human
traf1 b cell chronic lymphocytic leukemia TRAF1 protein levels were also elevated in circulating B cell chronic lymphocytic leukemia specimens (n = 49) compared with normal peripheral blood B cells (p = 0.01), as determined by immunoblotting. 11046039 Human
traf1 nasopharyngeal carcinoma CONCLUSION: The induction of EGFR by LMP1 CTAR1 may be an important component of EBV infection via an TRAF1, 2, 3 mechanism in the epithelial cells and may contribute to the development of epithelial malignancies such as nasopharyngeal carcinoma. 11783104 Human
traf1 anaplastic large cell lymphoma Differential expression and function of A20 and TRAF1 in Hodgkin lymphoma and anaplastic large cell lymphoma and their induction by CD30 stimulation. 12754742 Human
traf1 anaplastic large cell lymphomas Four of seven anaplastic large cell lymphomas weakly expressed TRAF1. 12782762 Human
traf1 breast tumor The regulatory relationship was further supported by the analysis of primary breast tumor tissues in vivo in which NF-kappaB target TRAF1 was inversely correlated with activated beta-catenin. 14991743 Human
traf1 anaplastic large cell lymphoma We demonstrate that the expression of TRAF1 and activated c-Rel, two proteins that function in signaling events downstream of activated CD30 in Reed-Sternberg cells, reliably distinguish classical Hodgkin lymphoma from anaplastic large cell lymphoma, nodu 15644776 Human
traf1 anaplastic large cell lymphoma In contrast, strong TRAF1 staining was present in only 1 of 17 cases of anaplastic large cell lymphoma, 0 of 15 cases of lymphocyte predominant Hodgkin lymphoma, and 2 of 36 cases of nonmediastinal diffuse large B-cell lymphoma. 15644776 Human
traf1 hyperplasia Underexpressed only in hyperplasia: BOK, CIDEA, TRAF1, TRIP. 16888677 Human
traf1 dlbcl Finally, the combined expression of nuclear c-Rel and TRAF1 was seen in 24 of 45 cases (53%) of PMLBCL, but in only 3 of 156 cases (2%) of other types of DLBCL. 17197926 Human
traf1 dlbcl In addition, cytoplasmic TRAF1 expression was seen in 48 of 78 (62%) cases of PMLBCL, but only 20 of 173 (12%) cases of DLBCL. 17197926 Human
traf1 b cell lymphomas For example, expression of TRAF1 was highly restricted, with B cell lymphomas consistently expressing this TRAF family member. 11046039 Human
traf1 hl Preventing constitutive STAT activation by specific JAK kinases inhibitors induced apoptosis of HL cell lines and was associated with a strong decrease in the expression of the anti-apoptotic genes IAP-1, IAP-2, Bcl-xL, Bfl1 and Traf1. 15967637 Human
traf1 gliomas The authors investigated the expression of NF-kappaB, caspase 3, TRAF1, TRAF2, and TRAF-associated NF-kappaB activator/TRAF-interacting protein (TANK/I-TRAF), a regulator of TRAF activity, in human gliomas. 16304992 Human
traf1 astrocytomas Increased levels of TRAF1, TRAF2, and TANK/ I-TRAF were expressed in astrocytomas compared with levels in normal brain tissue (p = 0.02, 0.006, and 0.01, respectively). 16304992 Human
traf1 gliomas A constitutive expression of TRAF1, TRAF2, and TANK/I-TRAF in human gliomas was documented. 16304992 Human
traf1 npc We report here that parallel accumulation of LMP1 and TRAF3, but not TRAF1 or TRADD, was observed in GSL complexes from lymphoblastoid and LMP1-positive NPC cells. 10225457 Human
traf1 lymphoma Thus, expression of this LMP1 domain in TRAF1-positive lymphoma cells promotes significant JNK activation, which is blocked by dominant-negative TRAF2 but not TRAF5. 12502848 Human
traf1 oncogenic These data further dissect the signaling components used by LMP1 and identify a novel role for TRAF1 as a modulator of oncogenic signals. 12502848 Human
traf1 npc RESULTS: LMP1 induced TRAF1 expression in NPC cells and caused a decrease in apoptosis. 12890376 Human
traf1 npc CONCLUSION: LMP1 induces TRAF1 expression and promotes its anti-apoptosis activity via the NF-kappaB signaling pathway, which may be one of the mechanisms that LMP1 uses to suppress apoptosis in NPC cells. 12890376 Human
traf1 npc Using an RNAse protection assay, high-level TRAF1 expression was detected in an LMP1-expressing NPC-derived cell line (C15) and expression was weaker in 2 LMP1- cell lines (C17, C19). 15352039 Human
traf1 npc Our results demonstrate that TRAF1 is expressed in NPC tumor cells in vivo and suggest that TRAF1 expression may be upregulated by LMP1 in NPC. 15352039 Human
traf1 npc An antiapoptotic function has been proposed for TRAF1, and this may be relevant for the pathogenesis of NPC. 15352039 Human

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