IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene GSN Ensembl ENSG00000148180 Chromosome 9 Start 123009896 End 123134942
Description Gelsolin Precursor (Actin-depolymerizing factor)(ADF)(Brevin)(AGEL) [Source:UniProtKB/Swiss-Prot;Acc:P06396]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 4620
     Entrez Gene : 2934
     UCSC : uc004blf.1
     GeneCards : 4620
     RefSeq : NM_000177
     CCDS : CCDS6828.1
     Uniprot : P06396
     Interpro : P06396
     OMIM : 137350
     GeneTests : GSN
     CGAP : GSN
     PMID : 1652889

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Experimental Evidence        (help)
Expression Sample Number Method Clinical information PubMed Reference
up 49/108(32%) IHCKaplanMeier survival curves(P=0.03) 15364130 Lung Cancer. 2004 Oct;46(1):29-42.

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  32612_at  -1.21  3.25e-17  1.41e-15  -0.88  9.88e-7  6.17e-6
 HG_U133A  200696_s_at  -0.97  9.41e-29  1.34e-27  -1.62  1.32e-65  3.95e-65
 HG_U133A  214040_s_at  0.14  4.22e-1  4.78e-1  -0.06  5.90e-1  6.00e-1
 HG_U133_Plus2  200696_s_at  -0.57  6.05e-6  2.40e-5  -0.12  4.26e-1  4.87e-1
 HG_U133_Plus2  214040_s_at  0.60  2.04e-2  3.84e-2  0.30  3.60e-1  4.21e-1
 HG_U133_Plus2  227957_at  -0.92  3.94e-7  1.90e-6  -1.19  1.89e-7  6.10e-7
 HG_U133_Plus2  227958_s_at  -0.29  1.07e-1  1.63e-1  -0.64  1.11e-3  2.12e-3
 Stanford  3059  -0.60  8.48e-2  2.22e-1  -0.57  1.64e-1  3.76e-1
 Agilent_HS_21.6K  2722  -0.09  2.39e-1  4.21e-1  -0.14  5.76e-2  1.38e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  200696_s_at  0.41  1.48e-1  8.08e-1  0.18  3.99e-1  1.00e+0
 HG_U133A  214040_s_at  0.61  3.84e-1  8.96e-1  0.37  3.31e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 32612_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 200696_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 214040_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 200696_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 214040_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 227957_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 227958_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 3059    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 2722    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
gsn tumors One tumor showed unique LOH at the GSN locus at 9q33, a region frequently deleted in other sporadic tumors while the fourth region of deletion was observed at 9q34 between ASS and ABL-1, in two tumors. 9926930 Human
gsn tumor One tumor showed unique LOH at the GSN locus at 9q33, a region frequently deleted in other sporadic tumors while the fourth region of deletion was observed at 9q34 between ASS and ABL-1, in two tumors. 9926930 Human
gsn bladder tumours In five low grade superficial bladder tumours, the partial deletion was localized to D9S195 located at 9q32-33, with retention of heterozygosity at all other informative loci including D9S103, D9S258, D9S275 and GSN. 9175739 Human
gsn tumors Eight tumors showed distal allelic loss of 9q with a minimal region of common deletion flanked proximally by marker GSN on 9q33. 8895761 Human
gsn tumors The expression of GSN is enhanced in LNCaP cells, LNCaP xenografts, and human prostate tumors after androgen depletion. 12941811 Human
gsn prostate cancer Therefore, blockage of the interaction between AR and GSN could become a potential therapeutic target for the treatment of prostate cancer. 12941811 Human
gsn primary tumours Nineteen paired blood and MB DNA specimens from 16 patients (11 primary tumours, two primary with recurrent tumours, one primary tumour and cell line, two cell lines) were studied by PCR analysis of microsatellites at D9S55 (9p12), D9S15 (9q13-q21.1), D9S 8208343 Human
gsn primary tumour Nineteen paired blood and MB DNA specimens from 16 patients (11 primary tumours, two primary with recurrent tumours, one primary tumour and cell line, two cell lines) were studied by PCR analysis of microsatellites at D9S55 (9p12), D9S15 (9q13-q21.1), D9S 8208343 Human
gsn tumours Nineteen paired blood and MB DNA specimens from 16 patients (11 primary tumours, two primary with recurrent tumours, one primary tumour and cell line, two cell lines) were studied by PCR analysis of microsatellites at D9S55 (9p12), D9S15 (9q13-q21.1), D9S 8208343 Human
gsn leukemia Gelsolin (Gsn) is tightly linked to the gene for complement component C5 (Hc), and dopamine beta-hydroxylase (Dbh) is just proximal to the Abelson leukemia virus oncogene (Abl) and alpha-spectrin 2 (Spna-2). 1315305 Human

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