IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene DAB2IP Ensembl ENSG00000136848 Chromosome 9 Start 123368983 End 123587630
Description Disabled homolog 2-interacting protein (DAB2-interacting protein)(DAB2 interaction protein)(ASK-interacting protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q5VWQ8]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 17294
     Entrez Gene : 153090
     UCSC : uc004bln.2
     GeneCards : 17294
     RefSeq : NM_032552
     CCDS : CCDS6832.1
     Uniprot : Q5VWQ8
     Interpro : Q5VWQ8
     OMIM : 609205
     GeneTests : DAB2IP
     CGAP : DAB2IP
     PMID : 11944990

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133_Plus2  225020_at  -0.69  4.17e-11  3.48e-10  -0.12  4.10e-1  4.72e-1
 HG_U133_Plus2  228942_s_at  -0.14  4.94e-1  5.81e-1  0.26  3.02e-1  3.61e-1
 HG_U133_Plus2  235966_at  -0.08  5.89e-1  6.69e-1  -0.01  9.30e-1  9.44e-1
 Agilent_HS_21.6K  13126  -0.29  9.32e-7  2.29e-5  -0.20  1.22e-2  4.21e-2

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133_Plus2 - 225020_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 228942_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 235966_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 13126    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
dab2ip human prostate cancer We demonstrated that DAB2IP is often downregulated in human prostate cancer cell lines. 11944990 Human
dab2ip prostate cancer We mapped the promoter of DAB2IP and studied its regulation in normal and malignant prostate cancer cells. 11944990 Human
dab2ip cancer We further demonstrated that normal prostatic epithelial cells have elevated DAB2IP mRNA compared with cancer cells, which correlates with increased DAB2IP promoter activity. 11944990 Human
dab2ip prostate cancer These data indicate that transcriptional regulation of DAB2IP is responsible for the downregulation of DAB2IP expression in prostate cancer cells. 11944990 Human
dab2ip prostate cancer Down-regulation of Human DAB2IP Gene Expression Mediated by Polycomb Ezh2 Complex and Histone Deacetylase in Prostate Cancer. 15817459 Human
dab2ip human prostate cancer Human DAB2IP (hDAB2IP), a novel GTPase-activating protein modulating the Ras-mediated signaling and tumor necrosis factor-mediated apoptosis, is a potent growth inhibitor in human prostate cancer (PCa). 15817459 Human
doc-2/dab2 interactive protein prostate cancer PURPOSE: Human DOC-2/DAB2 interactive protein (hDAB2IP) gene is a novel member of the Ras GTPase-activating family and has been demonstrated to be a tumor suppressor gene inactivated by methylation in prostate cancer. 15041729 Human
doc-2/dab2 interactive protein tumor PURPOSE: Human DOC-2/DAB2 interactive protein (hDAB2IP) gene is a novel member of the Ras GTPase-activating family and has been demonstrated to be a tumor suppressor gene inactivated by methylation in prostate cancer. 15041729 Human
doc-2/dab2 interactive protein tumor The human DOC-2/DAB2 interactive protein gene (hDAB2IP) is a novel member of the Ras GTPase-activating gene family that is known to act as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers. 15386433 Human
doc-2/dab2 interactive protein breast cancers The human DOC-2/DAB2 interactive protein gene (hDAB2IP) is a novel member of the Ras GTPase-activating gene family that is known to act as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers. 15386433 Human
doc-2/dab2 interactive protein cancers The human DOC-2/DAB2 interactive protein (hDAB2IP) gene is a novel member of the Ras GTPase-activating family and has been demonstrated to be a tumour-suppressor gene inactivated by methylation in several cancers. 15770214 Human

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