IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PTGS1 Ensembl ENSG00000095303 Chromosome 9 Start 124173050 End 124197802
Description Prostaglandin G/H synthase 1 Precursor (EC 1.14.99.1)(Cyclooxygenase-1)(COX-1)(Prostaglandin-endoperoxide synthase 1)(Prostaglandin H2 synthase 1)(PGH synthase 1)(PGHS-1)(PHS 1) [Source:UniProtKB/Swiss-Prot;Acc:P23219]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9604
     Entrez Gene : 5742
     UCSC : uc004bmg.1
     GeneCards : 9604
     RefSeq : NM_000962
     CCDS : CCDS6842.1
     Uniprot : P23219
     Interpro : P23219
     OMIM : 176805
     GeneTests : PTGS1
     CGAP : PTGS1
     PMID : 2512924

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37969_at  -0.60  9.80e-5  4.01e-4  -0.79  6.86e-6  3.59e-5
 HG_U133A  205127_at  -0.08  4.61e-1  5.15e-1  2.54  9.35e-70  3.03e-69
 HG_U133A  205128_x_at  -0.23  9.62e-4  1.75e-3  0.92  5.03e-26  7.98e-26
 HG_U133A  215813_s_at  -0.24  2.24e-4  4.45e-4  -2.79  4.82e-100  3.27e-99
 HG_U133_Plus2  205127_at  -1.00  1.26e-7  6.60e-7  -1.07  1.25e-7  4.13e-7
 HG_U133_Plus2  205128_x_at  -0.17  1.30e-1  1.91e-1  -0.34  1.07e-2  1.74e-2
 HG_U133_Plus2  215813_s_at  -0.16  1.09e-1  1.65e-1  -0.30  1.52e-2  2.40e-2
 HG_U133_Plus2  238669_at  -0.98  3.88e-16  5.95e-15  -1.18  3.58e-16  3.22e-15
 Stanford  2739  0.65  9.34e-3  6.19e-2  0.49  3.48e-2  1.32e-1
 Stanford  24039  -0.02  9.44e-1  9.71e-1  -0.36  2.50e-1  4.87e-1
 Agilent_HS_21.6K  19920  -0.28  8.06e-8  2.78e-6  -0.32  1.18e-8  3.50e-7

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205127_at  -0.19  6.09e-1  9.53e-1  0.16  5.48e-1  1.00e+0
 HG_U133A  205128_x_at  -0.11  6.00e-1  9.52e-1  -0.12  5.33e-1  1.00e+0
 HG_U133A  215813_s_at  0.11  6.20e-1  9.54e-1  -0.15  4.32e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37969_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205127_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205128_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 215813_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205127_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205128_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 215813_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 238669_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 2739    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 24039    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 19920    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
cox-1 oral squamous cell carcinoma COX-1 and COX-2 expression in feline oral squamous cell carcinoma. 16952367 Human
cox-1 oral squamous cell carcinoma This study demonstrated immunohistochemically the expression of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) in feline oral squamous cell carcinoma (FOSCC), with primary polyclonal antibodies raised against human epitopes. 16952367 Human
cox1 head and neck squamous cell carcinoma To better understand the roles of these genes in head and neck squamous cell carcinoma (HNSCCA), we examined the differential expression of the COX1, COX2, VEGF, and PPARdelta genes in these tumors. 11587608 Human
pghs-1 basal-cell carcinomas Steady-state concentrations of PGHS-1 and PGHS-2 mRNA were similar in normal skin and in basal-cell carcinomas, but PGHS-1 mRNA was reduced and PGHS-2 mRNA was elevated in actinic keratoses, squamous-cell carcinomas and keratoacanthomas. 10417761 Human
pghs-1 ovarian adenocarcinomas Sixteen human ovarian adenocarcinomas were studied by immunohistochemistry using specific antibodies recognizing PGHS-1 or PGHS-2. 9405496 Human
pghs-1 ovarian adenocarcinomas Therefore, these results show for the first time that PGHS-1 is expressed in human ovarian adenocarcinomas. 9405496 Human
pghs-1 actinic keratoses Steady-state concentrations of PGHS-1 and PGHS-2 mRNA were similar in normal skin and in basal-cell carcinomas, but PGHS-1 mRNA was reduced and PGHS-2 mRNA was elevated in actinic keratoses, squamous-cell carcinomas and keratoacanthomas. 10417761 Human
cox-1 ovarian cancer Clinical evaluations of a new ovarian cancer marker, COX-1. 7589737 Human
cox-1 cervical tumors A monoclonal antibody was generated against an ovarian cancer cell line, OC-3-VGH and was shown to recognize a unique tumor-associated antigen, COX-1 found in ovarian or cervical tumors. 7589737 Human
cox-1 colonic tumors CONCLUSIONS: COX-2 but not COX-1 gene expression is markedly elevated in most colonic tumors examined in azoxymethane-treated rodents. 8613017 Human
cox-1 gastrointestinal cancer We investigated messenger RNA expression of the COX-1 and COX-2 genes in the gastrointestinal cancer cell lines MKN28, MKN45, KATO III CACO-2, DLD-1 and LoVo. 8931116 Human
cox-1 stomach tumours In human stomach tumours and associated macroscopically normal tissues, we determined the fatty acid composition by gas chromatography, amounts of cPLA2, COX-1 and COX-2 by immunoblotting with specific antibodies and cPLA2 enzyme activity using a tritiate 9337697 Human
cox-1 ibd The expression and cellular localization of COX-1 and COX-2 in normal human colon and inflammatory bowel disease (IBD) surgical resections were studied. 9679035 Human
cox-1 crohn's disease RESULTS: COX-1 protein was expressed at equal levels in normal, Crohn's disease, and ulcerative colitis colonic epithelial cells. 9679035 Human
cox-1 crohn's colitis Immunohistochemistry of normal, Crohn's colitis, and ulcerative colitis tissue showed equivalent COX-1 expression in epithelial cells in the lower half of the colonic crypts. 9679035 Human
cox-1 ibd CONCLUSIONS: COX-1 was localized in the crypt epithelium of the normal ileum and colon, and its expression was unchanged in IBD. 9679035 Human
cox-1 hyperplastic polyps CONCLUSIONS: The proportion of COX-2 to COX-1 expression was elevated in most human colorectal cancers and adenomas, but not in hyperplastic polyps. 9739782 Human
cox-1 colon cancer The efficacy of the sulfides in inhibiting COX-2 activity in inflammatory cells, our recent results on the selectivity of 70 in attenuating growth of COX-2-expressing colon cancer cells, and its selectivity for inhibition of COX-2 over COX-1 in vivo indic 9822550 Human
cox-1 tumors Analysis of COX-1 and COX-2 protein levels in HCA-7 tumor lysates revealed a slight decrease in COX-2 expression levels in tumors taken from mice treated with meloxicam and no detectable COX-1 expression. 9886578 Mouse
cox-1 tumor Analysis of COX-1 and COX-2 protein levels in HCA-7 tumor lysates revealed a slight decrease in COX-2 expression levels in tumors taken from mice treated with meloxicam and no detectable COX-1 expression. 9886578 Mouse
cox-1 transitional cell carcinoma of the urinary bladder The purpose of this study was to characterize COX-1 and COX-2 expression in human invasive transitional cell carcinoma of the urinary bladder by immunohistochemistry and Western blot analysis. 10582676 Human
cox-1 squamous cell carcinoma of the esophagus COX-2, but not COX-1, is highly expressed in human colon carcinoma, squamous cell carcinoma of the esophagus, and skin cancer. 10678579 Human
cox-1 skin cancer COX-2, but not COX-1, is highly expressed in human colon carcinoma, squamous cell carcinoma of the esophagus, and skin cancer. 10678579 Human
cox-1 metastasis We have attempted to determine a relationship between tumor invasion and metastasis of uterine cervical cancer and COX and apoptosis by comparing the protein expression of apoptosis, COX-1, and COX-2 in tumor tissues. 10684704 Human
cox-1 uterine cervical cancer We have attempted to determine a relationship between tumor invasion and metastasis of uterine cervical cancer and COX and apoptosis by comparing the protein expression of apoptosis, COX-1, and COX-2 in tumor tissues. 10684704 Human
cox-1 mammary adenocarcinomas Although dietary 4-HPR did significantly diminish levels of COX-1 gene expression (p < 0.01) in rat mammary adenocarcinomas, this synthetic retinoid did not significantly inhibit COX-2 gene expression. 10697514 Rat
cox-1 melanoma Cox inhibitors (Cox-1 and Cox-2) decreased tumor growth by 35-40% in MCG 101-bearing mice but had no such effect on melanoma-bearing mice, despite the expression of the Cox-2 protein in melanoma cells. 10749148 Mouse
cox-1 benign tumors Small benign tumors that arose spontaneously in 13-month-old mice also stained for COX-1 and COX-2, showing that this elevated enzyme content does not depend on chemical induction. 10753183 Mouse
cox-1 papillary adenomas Different patterns of COX-1 and COX-2 expression were observed in tumors of different growth patterns; only occasional small foci stained in solid adenomas, while most cells in papillary adenomas were immunoreactive. 10753183 Human
cox-1 transitional cell carcinoma OBJECTIVE: To evaluate expression of cyclooxygenase (COX)-1 and COX-2 in the urinary bladder epithelium of clinically normal dogs and in transitional cell carcinoma cells of dogs. 10803639 Human
cox-1 urothelial carcinomas Paraffin embedded tissues from 75 patients with urothelial carcinomas were immunostained with specific antibodies raised against COX-1 and COX-2. 10880372 Human
cox-1 prostatic adenocarcinoma The expression of COX-2 protein was detected less often than that of COX-1 protein in most cases of prostatic adenocarcinoma before hormonal therapy. 10953290 Human
cox-1 bph RESULTS: COX-1 expression in noncancerous prostatic tissue was seen predominantly in the basal epithelial cells of BPH (90% positive staining). 11018637 Human
cox-1 oligodendroglioma Cyclooxygenase (COX)-1 expressing macrophages/microglial cells and COX-2 expressing astrocytes accumulate during oligodendroglioma progression. 11121536 Human
cox-1 anaplastic oligodendrogliomas We have used single and double labeling immunohistochemistry to analyse COX-1 and COX-2 expression in twenty-six primary WHO grade II oligodendrogliomas, sixteen primary WHO grade III anaplastic oligodendrogliomas, twenty-seven matched recurrences and ten 11121536 Human
cox-1 anaplastic oligodendroglioma The number of COX-1 expressing macrophages/microglial cells was significantly lower in primary oligodendrogliomas than in primary anaplastic oligodendrogliomas (P<0.0001) and in anaplastic oligodendroglioma relapses (P=0.011). 11121536 Human
cox-1 oligodendrogliomas The number of COX-1 expressing macrophages/microglial cells was significantly lower in primary oligodendrogliomas than in primary anaplastic oligodendrogliomas (P<0.0001) and in anaplastic oligodendroglioma relapses (P=0.011). 11121536 Human
cox-1 differentiated carcinomas CONCLUSIONS: COX-2 expression is upregulated in well and moderately differentiated carcinomas of the lung, colon, and breast whereas COX-1 appears to be constitutively expressed at low levels. 11135226 Human
cox-1 rat mammary tumors In this study we have demonstrated the presence of two immunoreactive isoforms of cyclooxygenase (COX-1 and -2), and the modulating effects of n-3 fatty acids on their expression, in N-nitrosomethylurea (NMU)-induced rat mammary tumors. 10024686 Rat
cox-1 glioblastoma Here, we have analyzed the localization of COX-1 and COX-2 in rat experimental autoimmune encephalomyelitis (EAE), C6 glioblastoma and 9L gliosarcoma by immunohistochemistry. 10229132 Rat
cox-1 9l gliosarcoma Here, we have analyzed the localization of COX-1 and COX-2 in rat experimental autoimmune encephalomyelitis (EAE), C6 glioblastoma and 9L gliosarcoma by immunohistochemistry. 10229132 Rat
cox-1 laryngeal papilloma STUDY DESIGN: Molecular biological analysis of COX-1 and COX-2 in laryngeal papilloma. 10401857 Human
cox-1 er-negative human breast cancer We determined COX-1 and COX-2 expression, and the corresponding PGE2 secretions, in 4 ER-negative human breast cancer cell lines, the MCF10A breast epithelial cell line, and the same non-cancerous line transfected with a mutated ras gene. 10402236 Human
cox-1 glioblastoma multiforme Here, we have analyzed the expression of COX-1 and COX-2 in 50 gliomas and 10 control brains with no neuropathological alterations by immunohistochemistry; 22 glioblastoma multiforme, 9 anaplastic astrocytomas, 5 protoplasmic astrocytomas, 1 gemistocytic 10483780 Human
cox-1 anaplastic astrocytomas Here, we have analyzed the expression of COX-1 and COX-2 in 50 gliomas and 10 control brains with no neuropathological alterations by immunohistochemistry; 22 glioblastoma multiforme, 9 anaplastic astrocytomas, 5 protoplasmic astrocytomas, 1 gemistocytic 10483780 Human
cox-1 gemistocytic astrocytoma Here, we have analyzed the expression of COX-1 and COX-2 in 50 gliomas and 10 control brains with no neuropathological alterations by immunohistochemistry; 22 glioblastoma multiforme, 9 anaplastic astrocytomas, 5 protoplasmic astrocytomas, 1 gemistocytic 10483780 Human
cox-1 astrocytomas Here, we have analyzed the expression of COX-1 and COX-2 in 50 gliomas and 10 control brains with no neuropathological alterations by immunohistochemistry; 22 glioblastoma multiforme, 9 anaplastic astrocytomas, 5 protoplasmic astrocytomas, 1 gemistocytic 10483780 Human
cox-1 pancreatic carcinoma COX-2 protein expression was detected by the Western blot assay in three of five pancreatic carcinoma cell lines (BxPC-3, Capan-1, and MDAPanc-3), whereas COX-1 protein was detected in two of the five cell lines (BxPC-3 and Capan-1). 10485483 Human
cox-1 human osteosarcoma We describe the presence of COX-1 and COX-2 pathways in the human osteosarcoma 1547 cell line, as well as the conflicting effects of NS-398 (10, 50 and 100 microM) on programmed cell death, PGE2 release and COX-2 expression in 1547 cells cultured under ap 11179483 Human
cox-1 prostatic carcinoma The present study compared and contrasted the expression levels and subcellular distribution patterns of COX-1 and COX-2 in normal prostate [prostate epithelial cell (PrEC), prostate smooth muscle (PrSM), and prostate stromal (PrSt)] primary cell cultures 11289153 Human
cox-1 tumor angiogenesis Interestingly, cox-1, the other isozyme that is expressed in tumor vascular endothelia, participates in tumor angiogenesis, because an anti-sense oligonucleotide of cox-1 suppresses in vitro angiogenesis induced by cox-2-overexpressing cells. 11370818 Human
cox-1 squamous cell carcinomas of skin In mice and humans, deregulated expression of COX-2, but not of COX-1, is characteristic of epithelial tumors, including squamous cell carcinomas of skin. 11381142 Mouse
cox-1 polyposis METHODS: In this study, we evaluated COX-1 and COX-2 expression in 30 polyps collected from 10 patients with familial adenomatous polyposis (FAP) and in 18 polyps collected from 18 patients with sporadic adenomatous polyposis (SAP) using COX-1 or COX-2 is 11495083 Human
cox-1 lung adenomas By RT-PCR, COX-1 and COX-2 PCR products were present in mouse lung adenomas, alveoli and bronchioli. 11497255 Mouse
cox-1 tumor COX-1 was similarly expressed in GC and MALT as in intact mucosa, while COX-2 mRNA was detected only in tumor tissue, being attenuated by H.pylori eradication in GC and abolished by this therapy in MALT-lymphoma. 11535962 Human
cox-1 colorectal cancer The advent of specific COX-2 inhibitors, which do not interfere with the cytoprotective constitutive COX-1 enzyme, and the demonstration of increased COX-2 expression in many common malignancies beside colorectal cancer, has opened up new therapeutic poss 11566043 Human
cox-1 intestinal tumors The epidemiologic evidence and rodent studies suggest strongly that nonselective inhibitors of cyclooxygenase (COX) enzymes such as aspirin, inhibiting both COX-1 and COX-2 isoforms, reduce the incidence of and mortality from intestinal tumors. 11745453 Human
cox-1 prostate neoplasms Our findings indicate that relative decreases in COX-1, COX-2 and EGF expressions might serve as indicators of tumor growth inhibition in prostate neoplasms. 11785654 Human
cox-1 squamous-cell carcinomas Real-time quantitative reverse transcription-polymerase chain reaction and Western blot analysis confirmed enhanced expression of COX-1 RNA, and protein in squamous cell carcinomas and adenocarcinoma of the cervix. 11809691 Human
cox-1 adenocarcinoma of the cervix Real-time quantitative reverse transcription-polymerase chain reaction and Western blot analysis confirmed enhanced expression of COX-1 RNA, and protein in squamous cell carcinomas and adenocarcinoma of the cervix. 11809691 Human
cox-1 transitional cell carcinomas of the urinary bladder We studied the expression of both Cox-1 and Cox-2 by immunohistochemistry in 29 transitional cell carcinomas of the urinary bladder. 11827414 Human
cox-1 osteoid osteomas COX-1 and COX-2 expression in osteoid osteomas. 11853083 Human
cox-1 osteoid osteoma Since the cyclooxygenases are thought to be the source of these prostaglandins, and the central target of NSAIDs, we evaluated the expression of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) in osteoid osteoma tissues from patients following surge 11853083 Human
cox-1 cystadenomas Expression of COX-1 was detected by immunohistochemistry in 75% of 75 invasive ovarian carcinomas and in 75% of 16 low malignant potential tumors, whereas 2 samples from normal ovaries and 8 cystadenomas were positive for COX-1. 11891188 Human
cox-1 liver cancer Because prostaglandins (PGs) and nitric oxide (NO) have been proposed to be involved in angiogenesis in vivo, the production of PGs and NO and the behavior of inducible NO synthase (iNOS), cyclooxygenase 1 (COX-1), and inducible cyclooxygenase (COX-2) wer 11915030 Human
cox-1 metastatic disease Selective cyclooxygenase (COX)-1 or COX-2 inhibitors control metastatic disease in a murine model of breast cancer. 11956094 Mouse
cox-1 glioma In addition to NHA cells, this up-regulation of COX-1 after treatment with HDAC inhibitors was observed in 5 different glioma cell lines. 11877441 Human
cox-1 mouse sarcoma Prolonged expression of COX-2 protein was observed in PDT-treated mouse sarcoma and carcinoma cell lines, whereas COX-1 was not inducible by PDT. 12124326 Mouse
cox-1 carcinoma Prolonged expression of COX-2 protein was observed in PDT-treated mouse sarcoma and carcinoma cell lines, whereas COX-1 was not inducible by PDT. 12124326 Mouse
cox-1 epithelial neoplasms COX-1 is constitutively expressed in most tissues and plays various physiological roles, whereas increased COX-2 expression is known to occur in several types of epithelial neoplasms. 12126310 Human
cox-1 tumor Semi-quantitative RT-PCR and ELISA analysis demonstrated that following NMBA treatment, the expression of COX-1 mRNA was strongly present in tumor tissues, while weakly present in non-tissues; the expression of COX-2 mRNA was induced in both tumor and non 12189197 Human
cox-1 human promyelocytic leukemia All isolates were evaluated for their potential to induce human promyelocytic leukemia (HL-60) cell differentiation, and to inhibit cyclooxygenase-1 (COX-1), -2 (COX-2), and 7,12-dimethylbenz[a]anthracene (DMBA)-induced lesions in a mouse mammary organ cu 12221597 Mouse
cox-1 liver tumor COX-1 and COX-2 expression was determined in 4 liver tumor cell lines (Hep 3B, HuH-7, Hep G2, Sk-hep1) by Northern hybridization and Western immunoblot. 12297835 Human
cox-1 liver tumor COX-1 and COX-2 expression was demonstrable in all tested liver tumor cell lines. 12297835 Human
cox-1 bladder cancer COX-1 and COX-2 mRNA and protein were assessed in the human ureter, in normal human bladder muscle and urothelium, and in urine particulates from patients with urinary tract infections, bladder cancer and bladder cancer with BCG treatment. 12352459 Human
cox-1 lung cancer Despite the fact that SCLC cell lines expressed little or no cytosolic phospholipase A(2), COX-1, or COX-2, sulindac sulfide and PPARgamma agonists also inhibited the transformed growth of these lung cancer cells. 12391285 Human
cox-1 metastatic breast cancer We have shown previously in a model of metastatic breast cancer that murine mammary tumor cells express both cyclooxygenase-1 (Cox-1) and Cox-2 isoforms. 12408376 Mouse
cox-1 lung tumors Lung tumors also have elevated levels of cyclooxygenase (COX) -1 and COX-2 contents relative to normal lungs, but iNOS deficiency did not change COX expression in the tumors. 12460898 Human
cox-1 medullary carcinoma of thyroid An immunohistochemical survey of nine cases of medullary carcinoma of thyroid including reactivity for Cox-1 and Cox-2 enzymes. 12665651 Human
cox-1 cholangiocarcinoma OBJECTIVE: To investigate the expression of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) in extra-hepatic cholangiocarcinoma and the relationship between their expression and clinicopathological parameters. 14607721 Human
cox-1 tumor Biochemical analyses of the primary splenic tumor in rofecoxib-treated mice showed no alteration in COX-1 expression, but significant decreases in the expression of the tumor-promoting proteins COX-2, cyclin D1, cytosolic beta-catenin, matrix metalloprote 12566300 Mouse
cox-1 gastric cancer We found that: (i) SC-236 inhibited growth of gastric cancer cells mainly by inducing apoptosis; (ii) SC-236 induced 15-LOX-1 expression and increased endogenous 13-S-HODE product, instead of 15-S-HETE during apoptosis; (iii) SC-236 did not affect express 12584173 Human
cox-1 breast carcinoma The authors investigated the prognostic impact of expression of the cyclooxygenase (COX) isoforms, COX-1 and COX-2, on disease-free survival and progression-free survival in patients with primary breast carcinoma as well as the association between COX exp 12784332 Human
cox-1 tumor Elevated expression of COX-1 in tumor tissue had no statistically significant influence on patient prognosis. 12784332 Human
cox-1 cervical cancer OBJECTIVES: This study examines the relationship between expression of COX-1, COX-2, and vascular endothelial growth factor (VEGF), and their association with clinicopathological features in primary tumor and metastatic lymph node specimens from cervical 12821346 Human
cox-1 lymph-node metastasis CONCLUSION: COX-2 expression is associated with lymph node metastasis and possibly parametrial invasion, but expression of COX-1 and VEGF is not associated with clinicopathological features. 12821346 Human
cox-1 human testicular cancer In this study, we investigated the expression of cyclooxygenase (COX)-1 and -2 in human testicular cancer (TC) and normal testis (NT) tissues, as well as the effects of COX ligands on viability and proliferation. 12957459 Human
cox-1 esophageal scc METHODS: The expression of COX-1 and COX-2 in 80 surgically removed esophagi due to SCC, as well as in 5 human esophageal SCC cell lines was analyzed, using immunohistochemistry and Western blot analyses. 14707443 Human
cox-1 metastatic cancers RESULTS: COX-1 protein was present in 95/137 (69.3%) of the total cancers studied, with 55/83 (66.3%) of the primary cancers and 40/54 (74.1%) of the metastatic cancers positive for protein. 14766256 Human
cox-1 inclusion cysts COX-1 protein expression was observed in the ovarian surface epithelial cells, especially that of the inclusion cysts. 14766256 Human
cox-1 human colorectal carcinoma In this study, human colorectal carcinoma HCT-116 cells were treated with the Cox-1 specific inhibitor SC-560 and the Cox-2 specific inhibitor SC-58125 to evaluate their ability to induce apoptosis, inhibit cell proliferation, inhibit growth on soft agar 14633654 Human
cox-1 tumors The expression of the constitutive synthesis enzyme COX-1 was diminished, and the expression of 15-prostaglandin dehydrogenase, the key enzyme catabolizing PGs, was increased in treated tumors. 14736730 Human
cox-1 esophageal cancer CONCLUSIONS: Our findings suggest that COX-2 and COX-1 inhibition has potential to become an effective treatment for both histological variants of esophageal cancer. 15145696 Human
cox-1 apl We investigated the expression and activity of COX-1 and -2 during granulocyte-oriented maturation induced by all-trans-retinoic acid (ATRA) of NB4 cells, originated from a human acute promyelocytic leukemia (APL), and in blasts from APL patients. 15190260 Human
cox-1 ovarian carcinoma We have recently demonstrated that treatment of ovarian carcinoma cells with endothelin-1 (ET-1) induces expression of both COX-1 and COX-2, which contributes to vascular endothelial growth factor (VEGF) production. 15347673 Human
cox-1 genitourinary cancer BACKGROUND: We hypothesized that combined treatment with cyclooxygenase (Cox)-1 (catechin) and Cox-2 (NS398)-specific inhibitors would reduce cellular proliferation synergistically in genitourinary cancer. 15546559 Human
cox-1 intestinal-type cancers COX-1 expression was higher in intestinal type cancers than diffuse ones. 15372235 Human
cox-1 colorectal adenocarcinoma EXPERIMENTAL DESIGN: Tissue samples of primary and secondary tumors from 288 patients undergoing surgical resections for colorectal adenocarcinoma were immunohistochemically examined for Cox-2 and Cox-1 expressions. 15623626 Human
cox-1 secondary tumors EXPERIMENTAL DESIGN: Tissue samples of primary and secondary tumors from 288 patients undergoing surgical resections for colorectal adenocarcinoma were immunohistochemically examined for Cox-2 and Cox-1 expressions. 15623626 Human
cox-1 hepatic metastases In contrast, Cox-1 was positive in 42.7% of primary tumor, 84.0% of lymph node metastases, 37.5% hepatic metastases, and was associated with only tumor size. 15623626 Human
cox-1 colorectal cancer CONCLUSIONS: Elevated Cox-2 expression, but not that of Cox-1, was significantly associated with reduced survival and recognized as an independent prognostic factor in our cohort of colorectal cancer patients. 15623626 Human
cox-1 barrett's esophagus To further elucidate the role of these factors in the development of EAC, we measured the gene expressions (mRNA levels) of Cox-2 and Cox-1 by real-time quantitative polymerase chain reaction (QRT-PCR) in tissues from normal esophagus with and without ero 15585388 Human
cox-1 esophageal adenocarcinoma These results confirm the important role of Cox-2 amplification in the pathogenesis of esophageal adenocarcinoma, but the unexpected down-regulation of Cox-1 raises questions about its role in carcinogenesis. 15585388 Human
cox-1 granulosa cell tumors The thecal/granulosa cell tumors were Ep-CAM negative (0/5) and weakly COX-1 positive (4/4). 15695234 Human
cox-1 bone cancer To test the analgesic effects of nonsteroidal antiinflammatory drugs on bone cancer pain, the authors examined the effects of oral administration of a cyclooxygenase-1 (COX-1) selective inhibitor (SC560), a COX-2 selective inhibitor (celecoxib), and a non 16032450 Human
cox-1 metaplasia In contrast, the expression of COX-1, mPGES-1 and -2 was similar between intestinal metaplasia and gastric metaplasia. 16143029 Human
cox-1 gastric metaplasia In contrast, the expression of COX-1, mPGES-1 and -2 was similar between intestinal metaplasia and gastric metaplasia. 16143029 Human
cox 1 nonsmall-cell lung carcinoma (nsclc) METHODS: To evaluate its utility as an intermediate biomarker in bronchial chemoprevention trials, the authors examined Cox 1 and Cox 2 expression in normal and premalignant bronchial epithelial cells and nonsmall cell lung carcinoma (NSCLC) samples using 11920472 Human
cox 1 nsclc Nevertheless, considering the patterns of Cox 1 and Cox 2 expression in tumor cells, Cox expression status may be a useful parameter when designing treatment strategies for a subset of NSCLC patients. 11920472 Human
cox 1 tumor Nevertheless, considering the patterns of Cox 1 and Cox 2 expression in tumor cells, Cox expression status may be a useful parameter when designing treatment strategies for a subset of NSCLC patients. 11920472 Human
cox 1 tumors Although smokers tended to have more Cox 2-positive tumors than nonsmokers (29 of 91 tumors in the smokers [32%] vs. 1 of 10 tumors in the nonsmokers [10%]; P = 0.15), there was no statistically significant relation found between Cox 1 or Cox 2 expression 11920472 Human
pghs-1 mec Human MEC do not express PGHS-1 mRNA in vitro. 15156559 Human
cox-1 polyps Polyps from both untreated and rofecoxib- or sulindac-treated Apcdelta716 mice expressed COX-1 and -2, whereas normal epithelium from all mice expressed COX-1 but minimal amounts of COX-2. 11245490 Mouse
cox-1 granuloma In sponge granuloma, mRNA of COX-1 was constitutively expressed, whereas that of COX-2 was increased with neovascularization in parallel with the increased expression of vascular endothelial growth factor (VEGF). bFGF-stimulated angiogenesis was inhibited 11338378 Human
cox-1 squamous cell carcinomas Real-time quantitative reverse transcription-polymerase chain reaction and Western blot analysis confirmed enhanced expression of COX-1 RNA, and protein in squamous cell carcinomas and adenocarcinoma of the cervix. 11809691 Human
cox-1 squamous cell carcinomas The site of COX-1 expression was localized by immunohistochemistry to the neoplastic epithelial cells in all squamous cell carcinomas and adenocarcinomas studied. 11809691 Human
cox-1 bladder transitional cell carcinoma(btcc) METHODS: Reverse transcriptase-polymerase chain reaction(RT-PCR) and immunohistochemistry(Envision method) were applied to detect the mRNA and protein expression of COX-1 and COX-2 in bladder transitional cell carcinoma(BTCC), tissue adjacent to cancer, n 12526218 Human
cox-1 cancer METHODS: Reverse transcriptase-polymerase chain reaction(RT-PCR) and immunohistochemistry(Envision method) were applied to detect the mRNA and protein expression of COX-1 and COX-2 in bladder transitional cell carcinoma(BTCC), tissue adjacent to cancer, n 12526218 Human
cox-1 intestinal cancer Combination of an EGFR inhibitor with a nonselective COX-1/COX-2 inhibitor prevents the development of intestinal cancer in nude mice. 12684433 Mouse
cox-1 bladder transitional cell carcinoma [Expression of cyclooxygenase in bladder transitional cell carcinoma] OBJECTIVE: To evaluate the role of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) in the development of bladder transitional cell carcinoma. 14981815 Human
cox-1 bladder transitional cell carcinoma The expression of COX-1 was seen in some bladder transitional cell carcinoma and normal bladder. 14981815 Human
cox-1 brain tumours Immunostaining demonstrated low levels of COX-1 expression in capillaries and larger vessels of normal brain and moderately elevated levels of this enzyme in small vessels of brain tumours of various grades. 15118886 Human
cox-1 acute promyelocytic leukemia (apl) We investigated the expression and activity of COX-1 and -2 during granulocyte-oriented maturation induced by all-trans-retinoic acid (ATRA) of NB4 cells, originated from a human acute promyelocytic leukemia (APL), and in blasts from APL patients. 15190260 Human
cox-1 colorectal neoplasms METHODS: The colorectal neoplasms were induced with DMH in mice and the different dose of CHL were administered in different phases, then the prevention of colorectal neoplasms by CHL was examined; The IC50 and growth curve of HT29 cells were measured wit 15566646 Mouse
cox-1 necrosis Blockade of COX-1 and -2 resulted in a decrease of tubular necrosis. mRNA COX-2 was up-regulated post IRI and considerable inhibited after indomethacin or rofecoxib treatment. 15589463 Human
cox-1 tumor We now show that treatment of tumor cells with the nonselective COX-1/COX-2 inhibitor indomethacin or the selective COX-2 inhibitor celecoxib leads to decreased expression of the MHC class I molecules Ld and Kd . 15891886 Human
cox-1 barrett's esophagus Unlike COX-1, which is expressed in the normal esophageo-gastro-colonic mucosa, COX-2 was found to be expressed mainly in the pre-cancer changes in the mucosa including Barrett's esophagus, Helicobacter pylori (H. pylori)-induced gastritis and inflam 16247189 Human
cox-1 pancreatic tumor Reverse transcriptase-polymerase chain reaction analysis (RT-PCR) and Western blot were used to demonstrate expression levels of COX-1, COX-2 mRNA, and protein, as well as Caspase-3 protein in pancreatic tumor BxPC-3 cell strain. 16274041 Human
cox-1 follicular adenoma We investigated the expression of COX-1 and COX-2 in normal thyroid tissue, follicular adenoma and well-differentiated thyroid carcinomas and evaluated the difference in COX-1 and COX-2 expression. 16362262 Human
cox-1 well-differentiated thyroid carcinomas We investigated the expression of COX-1 and COX-2 in normal thyroid tissue, follicular adenoma and well-differentiated thyroid carcinomas and evaluated the difference in COX-1 and COX-2 expression. 16362262 Human
cox-1 follicular carcinomas Ten normal thyroid tissues, ten follicular adenomas, ten papillary carcinomas and ten follicular carcinomas were analyzed by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) for expression of COX-1 and COX-2 mRNA. 16362262 Human
cox-1 papillary carcinomas Ten normal thyroid tissues, ten follicular adenomas, ten papillary carcinomas and ten follicular carcinomas were analyzed by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) for expression of COX-1 and COX-2 mRNA. 16362262 Human
cox-1 follicular adenomas Expression of COX-1 mRNA in the normal thyroid tissues, follicular adenomas and both well-differentiated carcinomas was similar and weak. 16362262 Human
cox 1 nonsmall cell lung carcinoma (nsclc) METHODS: To evaluate its utility as an intermediate biomarker in bronchial chemoprevention trials, the authors examined Cox 1 and Cox 2 expression in normal and premalignant bronchial epithelial cells and nonsmall cell lung carcinoma (NSCLC) samples using 11920472 Human
cox-1 lymph node metastasis CONCLUSION: COX-2 expression is associated with lymph node metastasis and possibly parametrial invasion, but expression of COX-1 and VEGF is not associated with clinicopathological features. 12821346 Human
cox-1 intestinal polyp Both COX-1 and COX-2 play critical roles in intestinal polyp formation, whereas COX-2 is also expressed in cancers of a variety of organs. 12941808 Human
cox1 tumors Up-regulated genes in post-CT tumors included substantial number of genes with previously known implication in mechanisms of chemoresistance (TOP2A, ETV4, ABCF2, PRDX2, COX2, COX7B, MUC1, MT3, MT2A), and tumorigenesis (SCGB2A2, S100A9, YWHAE, SFN, ATP6AP1 16773180 NA
cox-1 myeloma Considering possible tumorigenic activity of cyclooxygenase (COX) isozymes in myeloma, we examined expression levels of COX-1 and -2 in seven human myeloma cell lines (ARH-77, IM-9, RPMI-8226, HPC, HS-Sultan, TSPC-1, and U-266). 16385588 Human
cox-1 nasal polyps Upregulation of COX-1 and COX-2 in nasal polyps in cystic fibrosis. 16517580 Human
cox-1 nasal polyps METHODS: The degree of mRNA and protein expression of cyclo-oxygenase (COX) enzymes 1 (COX-1) and 2 (COX-2) was examined using quantitative reverse competitive polymerase chain reaction (RT-PCR) and Western blot analysis in the nasal polyps from 10 patien 16517580 Human
cox-1 bladder tumours Cohort study of COX-1 and COX-2 expression in canine rectal and bladder tumours. 16573762 Human
cox-1 rectal tumours Objectives: To determine the role that cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) play in malignant transformation in canine transitional cell carcinoma and rectal tumours. 16573762 Human
cox-1 rectal adenocarcinomas Methods: Histological sections of 21 canine rectal adenocarcinomas and 18 canine transitional cell carcinomas were stained for COX-1 and COX-2. 16573762 Human
cox-1 tumor In addition, the effects of this CLX treatment on tumor and adjacent mucosa expression of gastrin, its receptors (CCK2), and COX-1 and COX-2, as well as protein expression of the active form of nuclear factor kappa B (NFkappa B) and the apoptotic-related 16615003 Human
cox-1 bladder papilloma The mRNA levels of cPLA2, COX-2 and mPGES-1 in the bladder papilloma and TCC were significantly higher than those in normal bladder (P<0.01), while the mRNA levels of COX-1 and mPGES-2 in TCC were unchanged compared with normal bladder. 16621493 Human
cox-1 laryngeal carcinoma Immunohistochemical expression of COX-1, COX-2, mPGES, LPGDS, and HPGDS was investigated in 24 laryngeal carcinoma samples. 16720448 Human
cox-1 ovarian carcinoma In the present study, pretreatment of HEY and OVCA 433 ovarian carcinoma cell lines with green tea and EGCG inhibited ET-1/ET(A)R expression, ET(A)R-mediated COX-1/2 mRNA expression, and COX-2 promoter activity. 16741061 Human
cox-1 cervical carcinoma Our preliminary data suggest an adverse prognosis with COX-1 expression in early-stage cervical carcinoma and a trend toward COX-1 expression in disease relapse. 16803521 Human
cox-1 invasive cervical carcinoma COX-1 and COX-2 expression in stage I and II invasive cervical carcinoma: relationship to disease relapse and long-term survival. 16803521 Human
cox-1 tumorigenesis These data suggest that Cox-1 overexpression in immortalized ECV endothelial cells results in nuclear localization of the polypeptide and tumorigenesis. 9261162 Human
cox-1 tumor-associated antigen Studies of a tumor-associated antigen, COX-1, recognized by a monoclonal antibody. 1611619 Human
cox-1 human neuroblastoma RESULTS: ATRA induced a significant increase of COX-2 expression in a dose- and time-dependent manner in SH-SY5Y human neuroblastoma cells, while COX-1 expression remained unchanged. 17204142 Human
cox-1 malignant transformation Whereas COX-1 is expressed ubiquitously, COX-2 is an immediate-early gene often associated with malignant transformation, and a role for the COX enzymes in tumor initiation and promotion is discussed. 10744623 Human
cox-1 adenocarcinoma COX-1 and COX-2 expression in adenocarcinoma cell lines was determined using reverse transcription-PCR and Western blotting for mRNA and protein, respectively. 11059772 Human
cox-1 hepatocarcinogenesis The key enzymes of prostaglandin synthesis, cyclooxygenase I (Cox-1) and II (Cox-2), were present in all unaltered and preneoplastic cells and tended to decrease in the later stages of hepatocarcinogenesis. 11470756 Human
cox-1 adenocarcinomas The site of COX-1 expression was localized by immunohistochemistry to the neoplastic epithelial cells in all squamous cell carcinomas and adenocarcinomas studied. 11809691 Human
cox-1 human promyelocytic leukemia (hl60) All isolates were evaluated for their potential to induce human promyelocytic leukemia (HL-60) cell differentiation, and to inhibit cyclooxygenase-1 (COX-1), -2 (COX-2), and 7,12-dimethylbenz[a]anthracene (DMBA)-induced lesions in a mouse mammary organ cu 12221597 Mouse
cox-1 small cell lung cancer EXPERIMENTAL DESIGN: To elucidate the role of arachidonic acid metabolism via the cyclooxygenase pathway in different human lung tumors, expression of cyclooxygenase isoenzymes (Cox-1 and Cox-2) and downstream enzymes of prostanoid metabolism was investig 12738712 Human
cox-1 primary tumor OBJECTIVES: This study examines the relationship between expression of COX-1, COX-2, and vascular endothelial growth factor (VEGF), and their association with clinicopathological features in primary tumor and metastatic lymph node specimens from cervical 12821346 Human
cox-1 familial adenomatous polyposis We found also in human familial adenomatous polyposis polyps that COX-2 and mPGES were induced in the COX-1-expressing fibroblasts. 12941808 Human
cox-1 carcinogenesis These results confirm the important role of Cox-2 amplification in the pathogenesis of esophageal adenocarcinoma, but the unexpected down-regulation of Cox-1 raises questions about its role in carcinogenesis. 15585388 Human
cox-1 lymphoma Celecoxib inhibited COX-2-mediated prostaglandin E2 (PGE2) production in human dermal fibroblasts (IC50 = 91 nmol/l), whereas it was a weak inhibitor of COX-1-mediated PGE2 production in human lymphoma cells (IC50 = 2800 nmol/l). 16080279 Human
cox-1 hcc In this study we investigated the expression of COX-1 in non-tumor and malignant human liver tissues, as well as the effects of the highly selective COX-1 inhibitor SC-560 on cell growth and apoptosis in human HCC cell lines. 16391822 Human
cox-1 hcc In well-differentiated HCC COX-1 expression was significantly higher than in the poorly-differentiated tissues (p<0.05). 16391822 Human
cox-1 tcc The purpose of this study was to determine COX-1 and COX-2 expression and antitumor effects of COX inhibitors in human TCC cell lines (HT1376, RT4, and UMUC3 cells) and xenografts derived from those cell lines. 16505106 Human
cox-1 oncogenic In the present investigation, we used various genetically engineered mouse models of EOC to determine whether Cox-1 overexpression is unique to specific genetic and oncogenic alterations or is widespread. 16510568 Mouse
cox-1 tcc The mRNA levels of cPLA2, COX-2 and mPGES-1 in the bladder papilloma and TCC were significantly higher than those in normal bladder (P<0.01), while the mRNA levels of COX-1 and mPGES-2 in TCC were unchanged compared with normal bladder. 16621493 Human
cox-1 desmoid tumor We describe and compare four methods for evaluating the expression of estrogen receptors alpha/beta and COX-1 and COX-2 in desmoid tumor-derived cells and tissues: immunocytochemistry, immunohistochemistry, RT-PCR, and two-color Western blot detection wit 16729958 Human
cox-1 ovarian tumors OBJECTIVE: Our purpose was to determine the mRNA and protein expression of cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) in ovarian tumors and normal ovaries of the hen, which is an excellent model for human ovarian cancer. 16797680 Human
cox-1 ovarian tumor RESULTS: Our results indicate that COX-1 mRNA expression is significantly higher (P < 0.05) in ovarian tumor samples compared to normal ovaries while there is no significant difference in expression of COX-2 between the samples. 16797680 Human
cox-1 tumor Tumor samples were assembled in a tissue microarray. c-myc gene dosage was correlated with clinicopathologic parameters, including the survival and gene expression of cyclooxygenases (COX-1 and COX-2) and proangiogenic growth factors (VEGF-A and VEGF-C). 16984727 Human
cox-1 uterine cancer Endogenous COX-2 protein levels were decreased, concomitant with a decrease in production of COX metabolites PGE2 and PGF2alpha, in each uterine cancer cell line expressing detectable levels of COX-1 and/or COX-2 in presence of resveratrol. 17044934 Human
cox-1 cheilitis granulomatosa METHODS: PAR-1, PAR-2, MMP-2, MMP-9, COX-1, and COX-2 expression was evaluated by immunohistochemistry in biopsies taken from oral Crohn's disease (five cases), Melkersson-Rosenthal syndrome (MRS) (six cases), cheilitis granulomatosa (five cases) and 17577330 Human
ptgs1 precancerous lesions We studied the associations between single nucleotide polymorphisms (SNPs) in cyclooxygenase 1 and 2 (PTGS1 and PTGS2), inducible nitric oxide synthase (NOS2A), interferon gamma (IFNG) and its receptor (IFNGR1), and risk of gastric precancerous lesions in 18287876 Human
ptgs1 precancerous lesions We found no association of precancerous lesions with SNPs in PTGS1 and in IFNG. 18287876 Human
ptgs1 colorectal adenoma Polymorphisms in PTGS1, PTGS2 and IL-10 do not influence colorectal adenoma recurrence in the context of a randomized aspirin intervention trial. 17640058 Human
cox-1 laryngeal squamous cell carcinoma OBJECTIVE: To examine the expression of COX-1, COX-2, and two downstream enzymes--microsomal PGE synthase (mPGES) and PGD synthase (PGDS)--using immunohistochemistry in human laryngeal squamous cell carcinoma (SCC). 16720448 Human
cox-1 ductal hyperplasia Cox-1 expression was identified in all the samples, and Cox-2 in all the mammary lesions except ductal hyperplasia. 17416236 Human
cox-1 hyperplastic Here, we investigated the expression profiles of PGES and EP receptors in wild type NMRI mouse skin constitutively expressing COX-1 when compared with the hyperplastic/dysplastic skin of homozygous K5 COX-2-transgenic mice and papillomas of both genotypes 17437488 Mouse
cox-1 papillomas Here, we investigated the expression profiles of PGES and EP receptors in wild type NMRI mouse skin constitutively expressing COX-1 when compared with the hyperplastic/dysplastic skin of homozygous K5 COX-2-transgenic mice and papillomas of both genotypes 17437488 Mouse
cox-1 kaposi's sarcoma Evidence of COX-1 and COX-2 expression in Kaposi's sarcoma tissues. 17467980 Human
cox-1 ks Our results establish that (a) COX-1 and COX-2 are overexpressed significantly in classic and epidemic KS compared with control skin tissues (P<0.01 and P>0.03, respectively, for COX-1; P<0.01 and P>0.03, respectively, for COX-2); (b) the extent and inten 17467980 Human
cox-1 crohn's disease METHODS: PAR-1, PAR-2, MMP-2, MMP-9, COX-1, and COX-2 expression was evaluated by immunohistochemistry in biopsies taken from oral Crohn's disease (five cases), Melkersson-Rosenthal syndrome (MRS) (six cases), cheilitis granulomatosa (five cases) and 17577330 Human
cox-1 granulomatous lesions COX-1 was weakly and variably expressed in both edematous/lichenoid and granulomatous lesions. 17577330 Human
cox-1 head and neck cancer COX-2 expression in tumour cells has been associated with carcinogenesis in many human neoplasms, including head and neck cancer, while the COX-1 isoform of the cyclooxygenase enzyme is constitutively expressed in normal tissues. 17624243 Human
cox-1 oral cancer We measured COX-1 and COX-2 m-RNA expression in samples of both oral cancer and matched oral mucosa from 22 patients by RealTime RT-PCR; clinic pathological data (grading, TNM staging, inflammation, follow-up) of all patients were available for statistica 17624243 Human
cox-1 carcinogenesis Our results suggest that COX-1 may play a role in oral carcinogenesis, and could be regarded as a potential therapeutic target by chemo preventive drugs; moreover, COX-2 expression might be addressed as a new prognostic tool in the clinical management of 17624243 Human
cox-1 upper gastrointestinal cancer Furthermore, the COX-1 isoform may have a potential role in the angiogenic process associated with esophageal adenocarcinoma, which suggests that inhibition of COX-1 may be another effective therapeutic target in upper gastrointestinal cancer. 17691999 Human
cox-1 esophageal adenocarcinoma Furthermore, the COX-1 isoform may have a potential role in the angiogenic process associated with esophageal adenocarcinoma, which suggests that inhibition of COX-1 may be another effective therapeutic target in upper gastrointestinal cancer. 17691999 Human
cox1 neoplasia We conducted a literature review to summarize current evidence of gene-drug interactions between NSAID use and polymorphisms in COX1, COX2, ODC, UGT1A6 and CYP2C9 on risk of colorectal neoplasia by searching OVID and PubMed. 18195728 Human
cox1 gastric cancer COX1 and COX2 polymorphisms and gastric cancer risk in a Polish population. 18214026 Human
cox1 gastric cancer BACKGROUND: Although a number of studies on the polymorphisms in COX1 and COX2 genes in association with risks for a number of cancers have been conducted, their relation to gastric cancer has not been well studied. 18214026 Human
cox1 cancers BACKGROUND: Although a number of studies on the polymorphisms in COX1 and COX2 genes in association with risks for a number of cancers have been conducted, their relation to gastric cancer has not been well studied. 18214026 Human
cox1 gastric cancer PATIENTS AND METHODS: Genotypes of several variants in both COX1 (Ex7+31 C>A and Ex10-4 G>A) and COX2 (-765 G>C, Ex10+837 T>C, Ex10-90 C>T, IVS5-275 T>G, and IVS7+111 T>C) were identified by TaqMan assays in 305 gastric cancer cases and 427 age- and gende 18214026 Human
cox1 gastric cancer RESULTS: We found no statistically significant evidence that the polymorphisms tested in COX1 and COX2 are associated with gastric cancer risk. 18214026 Human
cox1 gastric cancer CONCLUSION: These results suggest that the polymorphisms examined in COX1 and COX2 do not affect the risk of gastric cancer. 18214026 Human
cox-1 skin tumors While it has been established that both the constitutive and inducible forms of cyclooxygenase (COX-1 and COX-2, respectively) play important roles in chemical initiation-promotion protocols with phorbol ester tumor promoters, the contribution of these tw 17219415 Human
cox-1 carcinogenesis To better understand the contribution of COX-1 and COX-2 to UV carcinogenesis, we transferred the null allele for each isoform onto the SKH-1 hairless strain of mouse. 17219415 Mouse
cox-1 tumor While the lack of one allele of COX-1 had no effect on tumor outcome, the lack of one allele of COX-2 resulted in a 50-65% reduction in tumor multiplicity and a marked decrease in tumor size. 17219415 Human
cox-1 tumors Immunohistochemistry of BxPC-3 tumors revealed a significant decrease in Ki-67 and CD31 staining by high-dose sulindac, with no significant changes in COX-1/COX-2 levels or activity in any of the treatment groups. 17541034 Human
cox-1 tumor A careful analysis of wild-type and TRAMP tissues was undertaken for the expression of cyclooxygenase-1 (COX-1) and COX-2 using immunoblotting, quantitative real time polymerase chain reaction (qRT-PCR) and immunohistochemistry approaches in TRAMP dorsal 17942462 Mouse
cox-1 carcinogenesis We found that the expression of COX-1 and COX-2 dramatically decreased during TRAMP carcinogenesis. 17942462 Human
cox-1 meningioma METHODS: One hundred and twenty-four meningioma surgical specimens and normal human cortical tissue samples were immunohistochemically and cytochemically stained for COX-2, COX-1, 5-LO, and prostaglandin E receptor 4 (PTGER4). 17961045 Human
cox-1 meningiomas CONCLUSIONS: Eicosanoid derivatives COX-1, COX-2, 5-LO, and PTGER4 enzymes show a high universal expression in meningiomas but are not upregulated in normal human cortex and dura tissue. 17961045 Human
cox-1 cancer Selective and nonselective COX-1/2 inhibitors and EGFR tyrosine kinase inhibitors have shown promising results in cancer therapy and are currently evaluated in chemoprevention trials. 18045067 Human
cox-1 mcf-7 human breast cancer METHODS: MCF-7 human breast cancer cells were treated with inhibitors for PLA2 (quinacrine), lipoxygenases (LOX-5 and LOX-12; baicalein, REV-5091, nordihydroguaiaretic acid), cyclooxygenases (COX-1, COX-2, indomethacin), and AROM (formestane). 18087590 Human
cox-1 endometrial cancer The aim of this study was to determine whether cyclooxygenase-1 or -2 (Cox-1, Cox-2) is tumorigenetic, as well as whether these two cyclooxygenase isoforms correlate with the clinicopathological characteristics or with another two biomarkers, human epider 18204294 Human
cox-1 endometrial cancer At second, the levels of four biomarkers (Cox-1, Cox-2, Her-2, and VEGF) in 70 endometrial cancer samples were determined by means of real-time PCR. 18204294 Human
cox-1 cancer These drugs act via the inhibition of cyclooxygenase (COX) enzyme of which at least two isoforms were described: COX-1 which plays important roles in homeostatic processes such as thrombogenesis and homeostasis of the gastrointestinal tract and kidneys an 18336314 Human
cox-1 apl We have recently demonstrated that ATRA induces cyclooxygenase-1 (COX-1) expression and prostaglandin synthesis in NB4 cells and in blasts from patients with APL. 18354491 Human
cox-1 endometrial adenocarcinomas [Prognostic significance of cyclooxygenase (COX-1 and COX-2) expression in endometrial carcinoma (clinical and immunohistochemical study)] An immunohistochemical study of 100 endometrial adenocarcinomas assessed expression of COX-1 (40%) and COX-2 (72%) c 18416056 Human
cox-1 endometrial carcinoma [Prognostic significance of cyclooxygenase (COX-1 and COX-2) expression in endometrial carcinoma (clinical and immunohistochemical study)] An immunohistochemical study of 100 endometrial adenocarcinomas assessed expression of COX-1 (40%) and COX-2 (72%) c 18416056 Human
cox-1 tumor However, COX-1, not COX-2, mRNA, and protein levels are elevated in tumor tissues. 18488158 Human
cox-1 ovarian cancer These findings may implicate COX-1 as a suitable target for the treatment of ovarian cancer. 18488158 Human
cox-1 hl COX-1 and COX-2 mRNA expression in HL cells during chlamydial infection was quantified with real-time polymerase chain reaction. 18524544 Human
cox-1 gastric adenocarcinoma The COX-1, COX-2, and COX-1ir expression profiles were measured with real-time PCR in primary (AGS) and metastatic (NCI-N87) gastric adenocarcinoma cell lines treated with butyrate, hyperosmolar medium, and, in the case of NCI-N87, cell-free supernatants 18618313 Human
cox-1 uterine tumors Here, we show that HMGA1a mice on sulindac (a COX-1/COX-2 inhibitor) have significantly smaller uterine tumors than controls. 18645019 Mouse
cox-1 colon tumour Suppression of either COX-2 or COX-1 by RNA interference in HCA-7 and HT29 colon tumour cells reduced FasL expression at both the mRNA and protein level. 18648368 Human
cox-1 nsclc COX-1 was expressed in all cell lines, but COX-2 was expressed only in NSCLC cell lines. 18671849 Human
cox 1 nonsmall cell lung carcinoma METHODS: To evaluate its utility as an intermediate biomarker in bronchial chemoprevention trials, the authors examined Cox 1 and Cox 2 expression in normal and premalignant bronchial epithelial cells and nonsmall cell lung carcinoma (NSCLC) samples using 11920472 Human
cox-1 benign prostatic hyperplasia METHODS: Thirty-one specimens of prostate carcinoma (CaP) and 10 specimens of benign prostatic hyperplasia (BPH) were stained with mouse antihuman COX-1 and COX-2 monoclonal antibodies. 11018637 Mouse
cox-1 acute promyelocytic leukemia We investigated the expression and activity of COX-1 and -2 during granulocyte-oriented maturation induced by all-trans-retinoic acid (ATRA) of NB4 cells, originated from a human acute promyelocytic leukemia (APL), and in blasts from APL patients. 15190260 Human

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