IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene LHX2 Ensembl ENSG00000106689 Chromosome 9 Start 125813710 End 125835257
Description LIM/homeobox protein Lhx2 (LIM homeobox protein 2)(Homeobox protein LH-2) [Source:UniProtKB/Swiss-Prot;Acc:P50458]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6594
     Entrez Gene : 9355
     UCSC : uc004boe.1
     GeneCards : 6594
     RefSeq : NM_004789
     CCDS : CCDS6853.1
     Uniprot : P50458
     Interpro : P50458
     OMIM : 603759
     GeneTests : LHX2
     CGAP : LHX2
     PMID : 8649822

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40528_at  0.51  1.49e-2  3.31e-2  0.98  7.08e-5  2.92e-4
 HG_U95  40529_at  -0.10  5.54e-1  6.53e-1  0.14  5.44e-1  6.42e-1
 HG_U133A  206140_at  0.32  5.17e-2  7.17e-2  4.36  4.33e-100  2.94e-99
 HG_U133A  211219_s_at  -0.30  6.21e-2  8.48e-2  1.59  7.70e-27  1.24e-26
 HG_U133_Plus2  206140_at  0.96  1.67e-4  5.10e-4  2.20  1.71e-10  7.99e-10
 HG_U133_Plus2  211219_s_at  0.58  4.35e-3  9.72e-3  1.45  4.60e-8  1.60e-7
 Stanford  17954  1.31  5.95e-3  4.56e-2  2.44  3.57e-6  2.35e-4
 Agilent_HS_21.6K  11179  0.16  3.83e-4  3.54e-3  0.25  1.96e-2  6.07e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206140_at  0.01  9.84e-1  9.99e-1  1.28  6.53e-3  1.00e+0
 HG_U133A  211219_s_at  -0.79  9.63e-2  7.69e-1  0.09  7.97e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40528_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 40529_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206140_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211219_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206140_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211219_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 17954    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 11179    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
lh2 breast carcinomas Estrogen receptor (ER) analysis was performed in 46 primary breast carcinomas using four monoclonal antibodies (MABs) to ER (AER311, ER1D5, LH1, and LH2), each of which recognizes a distinct domain of the receptor protein. 11127919 Human
lh2 chronic myeloid leukaemia Expression of the LH2 gene in chronic myeloid leukaemia cells. 8683990 Human
lh2 chronic myeloid leukemia (cml) In a recent report, it was suggested that high levels of LH2 expression are consistently observed in chronic myeloid leukemia (CML) patients, whereas no transcription is detected in normal individuals. 8683990 Human
lh2 chronic myeloproliferative disorders We have studied the expression of LH2 in leucocytes from patients with CML or with other chronic myeloproliferative disorders (CMD), and from normal individuals, using an optimised reverse-transcription and polymerase chain reaction (PCR) technique. 8683990 Human
lh2 chronic phase cml Furthermore, all 36 EBV-induced lymphoblastoid cell lines established from six chronic phase CML patients showed unequivocal LH2 expression, regardless of the BCR-ABL status of the line (9 BCR-ABL positive, 27 BCR-ABL negative). 8683990 Human
lhx2 chronic myeloproliferative disorder Lhx2 expression in hematopoietic progenitor/stem cells in vivo causes a chronic myeloproliferative disorder and altered globin expression. 14687986 Human
the lh2 gene chronic myeloid leukaemia Expression of the LH2 gene in chronic myeloid leukaemia cells. 8683990 Human
lh2 cml This led to the hypothesis that aberrant expression of LH2 may represent an additional mechanism for malignant cell proliferation in CML. 8683990 Human
lh2 cml We have studied the expression of LH2 in leucocytes from patients with CML or with other chronic myeloproliferative disorders (CMD), and from normal individuals, using an optimised reverse-transcription and polymerase chain reaction (PCR) technique. 8683990 Human
lh2 cml Twenty-seven out of 29 cDNA samples from normal individuals (93%), 49 out of 51 samples from CML patients (96%) and 20 out of 20 from Philadelphia chromosome-negative CMD showed evidence of LH2 expression. 8683990 Human
lh2 cml Similarly, LH2 transcription was also detected in leucocytes from CML patients in complete cytogenetic remission after treatment with interferon-alpha. 8683990 Human
lh2 cml We conclude that LH2 expression is not confined to CML cells, and that the t(9;22)(q34;qll) does not promote 'de novo' transcriptional activation of this gene. 8683990 Human
lhx2 acute leukemia The disorder was transplantable and the Lhx2-expressing cells could also cause acute leukemia. 14687986 Mouse
lhx2 pituitary tumor Transfection assay to the pituitary tumor derived LbetaT2 cells, and the Chinese hamster ovary cells demonstrated that CLIM2 acts as a corepressor of the porcine Lhx2 function. 17005264 others

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