IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene NR6A1 Ensembl ENSG00000148200 Chromosome 9 Start 126319380 End 126573410
Description Nuclear receptor subfamily 6 group A member 1 (Germ cell nuclear factor)(GCNF)(hGCNF)(Retinoid receptor-related testis-specific receptor)(RTR)(hRTR) [Source:UniProtKB/Swiss-Prot;Acc:Q15406]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 7985
     Entrez Gene : 2649
     UCSC : uc004bor.1
     GeneCards : 7985
     RefSeq : NM_001489
     CCDS : CCDS35137.1
     Uniprot : Q15406
     Interpro : Q15406
     OMIM : 602778
     GeneTests : NR6A1
     CGAP : NR6A1
     PMID : 9134503

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  35873_at  -0.01  9.59e-1  9.70e-1  0.42  1.16e-1  1.86e-1
 HG_U133A  207742_s_at  -0.05  6.01e-1  6.48e-1  3.88  7.85e-130  1.30e-128
 HG_U133A  210391_at  -0.47  1.58e-16  9.59e-16  0.70  4.70e-10  5.90e-10
 HG_U133A  210392_x_at  0.25  6.48e-2  8.81e-2  -2.13  5.54e-37  1.03e-36
 HG_U133A  211402_x_at  0.18  9.13e-2  1.20e-1  3.65  1.19e-97  7.56e-97
 HG_U133_Plus2  207742_s_at  -0.03  8.56e-1  8.92e-1  0.05  7.64e-1  8.01e-1
 HG_U133_Plus2  210391_at  0.27  1.10e-2  2.23e-2  0.42  1.08e-3  2.07e-3
 HG_U133_Plus2  210392_x_at  0.18  3.06e-1  3.94e-1  0.31  9.52e-2  1.28e-1
 HG_U133_Plus2  211402_x_at  0.33  4.53e-2  7.73e-2  0.47  1.26e-2  2.02e-2
 Stanford  19439  0.57  2.12e-2  1.05e-1  0.57  5.11e-2  1.74e-1
 Agilent_HS_21.6K  6176  -0.03  4.80e-2  1.41e-1  -0.03  6.30e-2  1.47e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207742_s_at  -0.08  7.97e-1  9.82e-1  0.12  5.12e-1  1.00e+0
 HG_U133A  210391_at  0.01  9.55e-1  9.98e-1  -0.05  6.40e-1  1.00e+0
 HG_U133A  210392_x_at  -0.31  5.72e-1  9.47e-1  0.02  9.63e-1  1.00e+0
 HG_U133A  211402_x_at  -0.11  6.89e-1  9.67e-1  -0.05  8.26e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 35873_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207742_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210391_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210392_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211402_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207742_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210391_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210392_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211402_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 19439    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 6176    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
rtr placental choriocarcinoma In this study, we examine the expression of RTR in murine placenta and several human placental choriocarcinoma cell lines. 11969338 Human
rtr rat choriocarcinoma RTR mRNA was also expressed in rat choriocarcinoma Rcho-1 cells and in the human placental choriocarcinoma cell lines BeWo, JAR, and JEG-3. 11969338 Rat
rtr placental choriocarcinoma RTR mRNA was also expressed in rat choriocarcinoma Rcho-1 cells and in the human placental choriocarcinoma cell lines BeWo, JAR, and JEG-3. 11969338 Human
germ cell nuclear factor embryonal carcinoma The mouse germ cell nuclear factor (mGCNF) is an orphan nuclear receptor implicated in diverse biological processes, including gametogenesis, embryonic development and embryonal carcinoma cell differentiation. 10524192 Mouse
germ cell nuclear factor embryonal carcinoma Retinoids induce differential expression and DNA binding of the mouse germ cell nuclear factor in P19 embryonal carcinoma cells. 9563832 Mouse
gcnf embryonal carcinoma We propose that GCNF regulation is an important step during determination of embryonal carcinoma cells. 9563832 Mouse
gcnf carcinoma The germ cell nuclear factor (GCNF, NR6A1) is a nuclear orphan receptor that functions as a transcriptional repressor and is transiently expressed in mammalian carcinoma cells during retinoic acid (RA) induced neuronal differentiation. 12676320 Human
nr6a1 carcinoma The germ cell nuclear factor (GCNF, NR6A1) is a nuclear orphan receptor that functions as a transcriptional repressor and is transiently expressed in mammalian carcinoma cells during retinoic acid (RA) induced neuronal differentiation. 12676320 Human
germ cell nuclear factor carcinoma The germ cell nuclear factor (GCNF, NR6A1) is a nuclear orphan receptor that functions as a transcriptional repressor and is transiently expressed in mammalian carcinoma cells during retinoic acid (RA) induced neuronal differentiation. 12676320 Human
germ cell nuclear factor embryonal carcinoma Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated receptor and its differential regulation during embryonal carcinoma cell differentiation. 9134503 Human
gcnf embryonal carcinoma Induction of differentiation of mouse embryonal carcinoma F9 cells and human embryonal carcinoma NTERA-2 clone D1 (NT2/D1) cells by all-trans retinoic acid was accompanied by a down-regulation of GCNF/RTR. 9134503 Human
rtr embryonal carcinoma Induction of differentiation of mouse embryonal carcinoma F9 cells and human embryonal carcinoma NTERA-2 clone D1 (NT2/D1) cells by all-trans retinoic acid was accompanied by a down-regulation of GCNF/RTR. 9134503 Human
gcnf embryonal carcinoma To test the prediction that GCNF is additionally required for neuronal differentiation, we used the mouse embryonal carcinoma cell line PCC7-Mz1, which represents an advantageous model to study neuronal cells from the stage of fate choice until the acquir 15297607 Human

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