IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ENG Ensembl ENSG00000106991 Chromosome 9 Start 129617115 End 129656805
Description Endoglin Precursor (CD105 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P17813]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 3349
     Entrez Gene : 2022
     UCSC : uc004bsj.3
     GeneCards : 3349
     RefSeq : NM_000118
     CCDS : CCDS6880.1
     Uniprot : P17813
     Interpro : P17813
     OMIM : 131195
     GeneTests : ENG
     CGAP : ENG
     PMID : 8404038

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  32562_at  -1.38  4.14e-36  2.75e-33  -1.94  1.24e-24  4.33e-22
 HG_U133A  201808_s_at  -0.10  3.67e-1  4.22e-1  2.48  1.05e-52  2.49e-52
 HG_U133A  201809_s_at  -1.28  2.60e-43  8.79e-42  2.09  2.76e-74  9.81e-74
 HG_U133_Plus2  201808_s_at  0.11  5.97e-1  6.76e-1  0.02  9.30e-1  9.43e-1
 HG_U133_Plus2  201809_s_at  -1.57  4.48e-32  3.95e-30  -1.81  6.98e-29  2.79e-27
 Stanford  16702  -1.22  3.32e-4  7.07e-3  -1.33  1.07e-3  1.48e-2
 Agilent_HS_21.6K  9168  -0.41  5.73e-22  3.87e-19  -0.41  5.47e-15  1.18e-12

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  201808_s_at  0.22  5.56e-1  9.42e-1  -0.48  6.00e-2  1.00e+0
 HG_U133A  201809_s_at  0.38  2.30e-1  8.46e-1  -0.25  2.37e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 32562_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201808_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201809_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201808_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201809_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 16702    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 9168    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
cd105 colorectal adenomas METHODS: We immunohistochemically investigated 54 cases of colorectal adenomas and 20 cases of carcinomas using monoclonal antibodies CD34 and CD105, and microvessel density (MVD) was counted at x200 magnification. 11821796 NA
cd105 carcinomas METHODS: We immunohistochemically investigated 54 cases of colorectal adenomas and 20 cases of carcinomas using monoclonal antibodies CD34 and CD105, and microvessel density (MVD) was counted at x200 magnification. 11821796 NA
cd105 adenomas In contrast, microvessels positive for CD105 were preferentially observed in the surface area of adenomas. 11821796 Human
cd105 carcinomas In carcinomas, CD34 stained only a proportion of blood vessels that were positive for CD105. 11821796 Human
cd105 carcinomas In contrast, an increment of MVD for CD105 from low-grade to high-grade dysplasia (P <.0001) and that from high-grade dysplasia to carcinomas (P <.05) was statistically significant. 11821796 Human
cd105 colorectal cancer CONCLUSIONS: Assessing neovascularization with CD105 in the process of colorectal cancer development may thus be a valuable marker for predicting the risk of colorectal cancer development. 11821796 Human
cd105 prostate adenocarcinoma OBJECTIVES: The present study reports the clinical and histological features of 14 cases of prostate adenocarcinoma coupled with their expression of the TGF isoforms beta2 and beta3, as well as their receptor endogline (CD105). 15112880 Human
cd105 squamous-cell carcinoma Endoglin (CD105) expression in squamous cell carcinoma of the oral cavity. 11891945 Human
endoglin squamous-cell carcinoma Endoglin (CD105) expression in squamous cell carcinoma of the oral cavity. 11891945 Human
cd105 tumor To explain the rating of CD105 expression in 51 squamous cell carcinoma of the oral cavity (SCCOC) we analyzed CD105 expression in tumor tissue and adjacent normal healthy mucosa. 11891945 Human
cd105 squamous-cell carcinoma To explain the rating of CD105 expression in 51 squamous cell carcinoma of the oral cavity (SCCOC) we analyzed CD105 expression in tumor tissue and adjacent normal healthy mucosa. 11891945 Human
endoglin tumor RESULTS: Endoglin expression in tumor tissue was significantly higher than in normal healthy mucosa (p <.001). 11891945 Human
hht1 venous malformation Homozygosity mapping excluded the following loci and/or genes: multiple cutaneous venous malformation (VMCM1; gene, TIE2) on chromosome 9p21; venous malformation with glomus cells (VMGLOM) on chromosome 1p22-p21; hereditary hemorrhagic telangiectasia type 11932989 Human
endoglin venous malformation Homozygosity mapping excluded the following loci and/or genes: multiple cutaneous venous malformation (VMCM1; gene, TIE2) on chromosome 9p21; venous malformation with glomus cells (VMGLOM) on chromosome 1p22-p21; hereditary hemorrhagic telangiectasia type 11932989 Human
cd 105 primary cutaneous malignant melanomas We were interested to see whether there was any correlation between endoglin (CD 105; EDG) expression with tumour thickness in primary cutaneous malignant melanomas (MM), any correlation between EDG expression and clinical outcome in patients with primary 11952710 Human
endoglin primary cutaneous malignant melanomas We were interested to see whether there was any correlation between endoglin (CD 105; EDG) expression with tumour thickness in primary cutaneous malignant melanomas (MM), any correlation between EDG expression and clinical outcome in patients with primary 11952710 Human
cd 105 tumour We were interested to see whether there was any correlation between endoglin (CD 105; EDG) expression with tumour thickness in primary cutaneous malignant melanomas (MM), any correlation between EDG expression and clinical outcome in patients with primary 11952710 Human
endoglin tumour We were interested to see whether there was any correlation between endoglin (CD 105; EDG) expression with tumour thickness in primary cutaneous malignant melanomas (MM), any correlation between EDG expression and clinical outcome in patients with primary 11952710 Human
cd105 tumor Expression of endoglin (CD105) in tumor blood vessels. 11979450 Human
endoglin tumor Expression of endoglin (CD105) in tumor blood vessels. 11979450 Human
cd105 prostate cancer Endoglin (CD105) is expressed on immature blood vessels and is a marker for survival in prostate cancer. 11987155 Human
endoglin prostate cancer Endoglin (CD105) is expressed on immature blood vessels and is a marker for survival in prostate cancer. 11987155 Human
endoglin prostate cancer In this study, endoglin was evaluated as a prognostic factor for prostate cancer progression. 11987155 NA
endoglin prostate cancer METHODS: Immunohistochemical staining of endoglin was examined in 72 cases of prostate cancer and compared with immunohistochemical staining of the pan-endothelial marker von Willebrand factor (vWf), clinicopathological factors, and cancer-specific surviv 11987155 NA
endoglin tumor The median survival times were shorter for patients with tumor vascular count (vc) above median than for patients with vc below median (4 vs. 12 years, P = 0.0007, and 5 vs. 10 years, P = 0.018, for endoglin and vWf, respectively). 11987155 Human
endoglin metastasis Endoglin vc was associated with Gleason score (P = 0.001), local tumor stage (P = 0.0006), metastasis (P = 0.01), tumor cell immunoreactivity for TGF-beta1 (P = 0.0003), and tumor cell proliferation index (r(s) = 0.319, P = 0.02). 11987155 Human
endoglin tumor Endoglin vc was associated with Gleason score (P = 0.001), local tumor stage (P = 0.0006), metastasis (P = 0.01), tumor cell immunoreactivity for TGF-beta1 (P = 0.0003), and tumor cell proliferation index (r(s) = 0.319, P = 0.02). 11987155 Human
endoglin tumors Endoglin, in contrast to vWf, vc was prognostic for survival in the subgroup of patients with Gleason score 5, 6, and 7 tumors. 11987155 Human
endoglin prostate cancer CONCLUSIONS: Endoglin marks principally small, probably newly formed tumor vessels in zthe prostate, and is a promising prognostic marker for prostate cancer patients. 11987155 Human
endoglin tumor CONCLUSIONS: Endoglin marks principally small, probably newly formed tumor vessels in zthe prostate, and is a promising prognostic marker for prostate cancer patients. 11987155 Human
cd105 tumors Administration of 317615 x 2HCI orally twice daily to nude mice bearing subcutaneous MX-1 tumors or SKOV-3 tumors resulted in a decreased number of intratumoral vessels as determined by CD31 and CD105 staining with decreases of 35% and 43% in MX-1 tumors 12201487 Human
endoglin tumors Endoglin is highly expressed in the neovasculature associated with hypoxia such as ischemic tissues and tumors, but the molecular mechanism of this up-regulation is unknown. 12228247 Human
endoglin human prostate cancer Over expression of endoglin in human prostate cancer suppresses cell detachment, migration and invasion. 12447690 Human
endoglin cancer Loss of endoglin expression in cancer, as compared to normal prostate, was seen in human prostate cell lines. 12447690 Human
endoglin prostate cancer Loss of endoglin expression appears to be associated with prostate cancer progression, at least in vitro. 12447690 Human
cd 105 pleomorphic adenoma RESULTS: Analysis of p53, Bcl-2, MIB1, CD 105, p27, and p21 expression did not reveal significant differences between metastasizing pleomorphic adenoma of the salivary gland and the control group of primary parotid pleomorphic adenomas. 14648866 Human
cd 105 parotid pleomorphic adenomas RESULTS: Analysis of p53, Bcl-2, MIB1, CD 105, p27, and p21 expression did not reveal significant differences between metastasizing pleomorphic adenoma of the salivary gland and the control group of primary parotid pleomorphic adenomas. 14648866 Human
cd105 intratumoral microvessel density Expression of Ang-1, Ang-2, or VEGF was examined immunohistochemically; intratumoral microvessel density (IMVD) was examined with immunohistochemical staining against CD34, a marker of pan-endothelial cells (CD34-IMVD), and that against CD105, a marker of 12460935 Human
cd105 metastasis Prediction of metastasis risk (11 year follow-up) using VEGF-R1, VEGF-R2, Tie-2/Tek and CD105 expression in breast cancer (n=905). 15026804 Human
cd105 breast cancer Prediction of metastasis risk (11 year follow-up) using VEGF-R1, VEGF-R2, Tie-2/Tek and CD105 expression in breast cancer (n=905). 15026804 Human
cd105 breast carcinoma Our purpose was to document the prognostic significance of VEGF-R1, VEGF-R2, Tie-2/Tek and CD105 immunoexpression in breast carcinoma frozen samples (n=905, follow-up=11.7 years). 15026804 Human
hht 1 arteriovenous malformations HHT 1 has been correlated with a higher prevalence of pulmonary arteriovenous malformations than HHT 2. 11170071 Human
cd105 breast cancer Angiogenesis in breast cancer: the role of transforming growth factor beta and CD105. 11170303 Human
cd105 breast cancer The administration of an immunotoxin-conjugate, mab to CD105, induces long-term and complete regression of breast cancer growth in SCID mice. 11170303 Mouse
endoglin metastasis Association of serum endoglin with metastasis in patients with colorectal, breast, and other solid tumors, and suppressive effect of chemotherapy on the serum endoglin. 11297243 Human
endoglin other solid tumors Association of serum endoglin with metastasis in patients with colorectal, breast, and other solid tumors, and suppressive effect of chemotherapy on the serum endoglin. 11297243 Human
endoglin metastasis In this report, we present data indicating that the increased serum endoglin (EDG; CD105) quantitated by a double-antibody sandwich assay is associated with metastasis in patients with solid tumors including colorectal and breast carcinomas. 11297243 Human
cd105 metastasis In this report, we present data indicating that the increased serum endoglin (EDG; CD105) quantitated by a double-antibody sandwich assay is associated with metastasis in patients with solid tumors including colorectal and breast carcinomas. 11297243 Human
endoglin breast carcinomas In this report, we present data indicating that the increased serum endoglin (EDG; CD105) quantitated by a double-antibody sandwich assay is associated with metastasis in patients with solid tumors including colorectal and breast carcinomas. 11297243 Human
cd105 breast carcinomas In this report, we present data indicating that the increased serum endoglin (EDG; CD105) quantitated by a double-antibody sandwich assay is associated with metastasis in patients with solid tumors including colorectal and breast carcinomas. 11297243 Human
cd105 tumors T98G tumors were treated with 317615 x 2HCl p.o. twice daily on days 14-30 after tumor cell implantation, the number of intratumoral vessels stained by CD31 was decreased to 37% of control, and the number of intratumoral vessels stained by CD105 was decre 11297259 Human
cd105 tumor T98G tumors were treated with 317615 x 2HCl p.o. twice daily on days 14-30 after tumor cell implantation, the number of intratumoral vessels stained by CD31 was decreased to 37% of control, and the number of intratumoral vessels stained by CD105 was decre 11297259 Human
cd105 tumor The complex of experimental findings accumulated in the last few years strongly indicate that CD105 is a powerful marker of angiogenesis, and that it might play a critical role in the pathogenesis of vascular diseases and in tumor progression. 11382917 Human
cd105 liver cell adenoma Sinusoids were studied by the application of endothelial cell markers (CD31, CD34, CD105, and ATZ 11) in lesions with localized increased perfusion (liver cell adenoma, focal nodular hyperplasia, and macroregenerative nodule), in chronic congestion, in de 11407479 Human
cd105 focal nodular hyperplasia Sinusoids were studied by the application of endothelial cell markers (CD31, CD34, CD105, and ATZ 11) in lesions with localized increased perfusion (liver cell adenoma, focal nodular hyperplasia, and macroregenerative nodule), in chronic congestion, in de 11407479 Human
eng pancreatic carcinoma We therefore studied the expression of UPA, UPAR, IGF2R, ALK5 (TGFBR1), TGFBR2, TGFBR3, ENG, ALK1, TGFB1, TGFB2, and TGFB3 in a series of 14 pancreatic carcinoma cell lines. 11408925 Human
endoglin cancer Endoglin (CD105), a component of the transforming growth factor beta receptor complex, represents a promising target for antivascular cancer therapy. 11407902 Human
cd105 cancer Endoglin (CD105), a component of the transforming growth factor beta receptor complex, represents a promising target for antivascular cancer therapy. 11407902 Human
endoglin tumors Endoglin is expressed predominantly on endothelial cells and is upregulated in angiogenic areas of tumors. 11407902 Human
endoglin arteriovenous malformations This is an autosomal dominant vascular disorder originated by mutations in the endoglin gene and associated with frequent epistaxis, telangiectases, gastrointestinal bleedings, and arteriovenous malformations in brain, lung and liver. 11426329 Human
cd105 melanomas Microvessel density (MVD) was estimated in a series of 202 vertical growth phase (VPG) melanomas and 68 corresponding metastases, using a marker for angiogenic endothelial cells (CD105) and Factor-VIII. 11438469 Human
cd105 metastases Microvessel density (MVD) was estimated in a series of 202 vertical growth phase (VPG) melanomas and 68 corresponding metastases, using a marker for angiogenic endothelial cells (CD105) and Factor-VIII. 11438469 Human
cd105 leukemias Expression rates of CD31, CD62L, CD62E, CD105 and CD144 were significantly higher in AC133(+) leukemia compared to those of AC133(-) leukemia (P=0.045, P<0.001, P<0.001, P<0.001, P=0.003, respectively), but bcl-2, CXCR-1, CXCR4, VLA-4, CD106 expression ra 11489469 Human
cd105 leukemia Expression rates of CD31, CD62L, CD62E, CD105 and CD144 were significantly higher in AC133(+) leukemia compared to those of AC133(-) leukemia (P=0.045, P<0.001, P<0.001, P<0.001, P=0.003, respectively), but bcl-2, CXCR-1, CXCR4, VLA-4, CD106 expression ra 11489469 Human
cd105 tumor Gene expression analysis by cDNA microarray of RNA obtained from short-term tumor cultures revealed high-level expression of a set of genes (including PDGF receptor-alpha and -beta, certain metalloproteinases, and CD105) that were also highly expressed in 11598178 Human
cd105 tumors Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide. 11691802 Human
endoglin tumor Lack of specificity of endoglin expression for tumor blood vessels. 11745447 Human
endoglin tumor Since endoglin has been proposed as a possible target for antiangiogenic therapy in tumor patients and our data demonstrate a sizable amount of endoglin in normal vessels and stroma, its clinical use should be carefully reevaluated. 11745447 Human
eng cancer HHT types 1 and 2 are caused by loss of function mutations in ENG and ACVRL1; polymorphisms in TBRI and TGFB1 are also associated with altered risks for cancer and cardiovascular diseases. 12812985 Human
cd105 tumors Administration of 317615.2HCl orally twice daily to nude mice bearing subcutaneous Calu-6 tumors resulted in a decreased number of intratumoral vessels as determined by CD31 and CD105 staining to 50% of the number in control tumors. 11800028 Human
cd105 tumor angiogenesis CaKi1 tumor angiogenesis was very responsive to treatment with 317615 x 2HCl such that the number of intratumoral vessels stained by CD31 or CD105 was decreased to 20% of the control. 11848470 Human
cd105 colon carcinoma The HT-29 colon carcinoma angiogenesis was also responsive to 317615 x 2HCl, such that the number of intratumoral vessels stained by CD31 or CD105 was decreased to 40% to 50% of the controL 5-fluorouracil, cisplatin or fractionated radiation therapy was c 11848470 Human
hht1 arteriovenous malformations Endoglin is the gene mutated in HHT1, which is associated with a higher prevalence of pulmonary arteriovenous malformations than HHT2, where ALK-1 is the mutated gene. 10625079 Human
endoglin arteriovenous malformations Endoglin is the gene mutated in HHT1, which is associated with a higher prevalence of pulmonary arteriovenous malformations than HHT2, where ALK-1 is the mutated gene. 10625079 Human
hht1 arteriovenous malformations Our data confirm that endoglin levels correlate with the presence or absence of mutation in HHT1 families, allowing the early identification of affected newborns that should be screened clinically to avoid serious complications of this disorder, such as c 10625079 Human
endoglin arteriovenous malformations Our data confirm that endoglin levels correlate with the presence or absence of mutation in HHT1 families, allowing the early identification of affected newborns that should be screened clinically to avoid serious complications of this disorder, such as c 10625079 Human
cd105 renal carcinoma Perfusion of 99Tcm-labeled CD105 Mab into kidneys from patients with renal carcinoma suggests that CD105 is a promising vascular target. 14961584 Human
cd105 renal carcinoma Perfusion was performed through the renal artery of 99Tcm-labeled purified CD105 Mab in freshly excised kidneys from 7 patients with renal carcinoma. 14961584 Human
cd105 breast carcinomas Long-term prognostic significance of neoangiogenesis in breast carcinomas: comparison of Tie-2/Tek, CD105, and CD31 immunocytochemical expression. 14991534 Human
cd105 breast carcinomas The immunocytochemical detection of Tie-2/Tek, CD105, and CD31 was assessed in a large series (n = 905) of breast carcinomas on frozen sections. 14991534 Human
cd105 metastases Marked expression of CD31 (P = 0.024), CD105 (P = 0.001), and Tie-2/Tek (P = 0.01) also correlated with higher risk of metastases in node-negative patients. 14991534 Human
cd105 breast carcinomas It is concluded that CD105 immunoexpression in breast carcinomas is an independent prognostic indicator in node-negative patients, better in terms of overall survival than Tie-2/Tek and CD31. 14991534 Human
hht1 arteriovenous malformations Hereditary hemorrhagic telangiectasia (HHT), associated with brain arteriovenous malformations, is caused by a loss of function mutation in either the endoglin (HHT1) or activin receptor-like kinase 1 gene (ALK-1, HHT2). 14747750 Human
endoglin arteriovenous malformations Hereditary hemorrhagic telangiectasia (HHT), associated with brain arteriovenous malformations, is caused by a loss of function mutation in either the endoglin (HHT1) or activin receptor-like kinase 1 gene (ALK-1, HHT2). 14747750 Human
endoglin ovarian cancer Treatment of ovarian cancer HEY cells with 500 nM 5alpha-dihydrotestosterone (DHT), but not estradiol-17beta or progesterone, for 60 h down-regulated the expression of mRNA for TGF-beta receptors I and II (TbetaR-I and TbetaR-II), betaglycan, and endoglin 10706107 Human
endoglin arteriovenous malformations Endoglin expression is reduced in normal vessels but still detectable in arteriovenous malformations of patients with hereditary hemorrhagic telangiectasia type 1. 10702408 Human
endoglin arteriovenous malformation We report the analysis of endoglin in tissues of a newborn (family 2), who died of a cerebral arteriovenous malformation (CAVM), and in a lung specimen surgically resected from a 78-year-old patient (family 5), with a pulmonary AVM (PAVM). 10702408 Human
endoglin tumour Imaging of tumour neovasculature by targeting the TGF-beta binding receptor endoglin. 10738134 Human
endoglin tumour We hypothesised that endoglin would be an ideal target for imaging since it is strongly upregulated in proliferating endothelial cells of the tumour neovasculature. 10738134 Human
cd105 metastasis Plasma levels of soluble CD105 correlate with metastasis in patients with breast cancer. 10754488 Human
cd105 breast cancer Plasma levels of soluble CD105 correlate with metastasis in patients with breast cancer. 10754488 Human
cd105 early-stage breast cancer In the present study CD105, TGFbeta1 and CD105/TGFbeta1 complexes were quantified in plasma samples from 77 healthy individuals and 92 patients with early stage breast cancer prior to any treatment. 10754488 Human
cd105 cancer When compared with normal controls, both CD105 and CD105/TGFbeta1 complex levels were significantly elevated in breast cancer patients, whereas TGFbeta1 levels were lower in cancer patients. 10754488 Human
cd105 breast cancer When compared with normal controls, both CD105 and CD105/TGFbeta1 complex levels were significantly elevated in breast cancer patients, whereas TGFbeta1 levels were lower in cancer patients. 10754488 Human
cd105 metastasis The most important finding to emerge was that CD105 levels were significantly increased in patients who developed distant metastasis compared with disease-free patients. 10754488 Human
cd105 metastatic disease While there was no significant difference between CD105 levels in controls compared to disease-free patients, it was significantly higher in patients with metastatic disease. 10754488 Human
cd105 metastases Thus patients who had died following local relapse or distant metastases possessed the highest levels of CD105. 10754488 Human
cd105 tumour Neither CD105/TGFbeta1 complex nor TGFbeta1 levels correlated with tumour progression. 10754488 Human
cd105 metastasis Our data indicate that CD105 might be a valuable novel angiogenic marker for identifying breast cancer patients who are at high risk of developing metastasis. 10754488 Human
cd105 breast cancer Our data indicate that CD105 might be a valuable novel angiogenic marker for identifying breast cancer patients who are at high risk of developing metastasis. 10754488 Human
cd105 colorectal carcinoma METHODS: The expressions of TGF-beta1 and CD105 were detected in 55 fresh specimens of gastric carcinoma and VEGF and CD105 in 44 fresh specimens of colorectal carcinoma by immunohistochemical staining (S-ABC). 14669355 NA
cd105 gastric carcinoma METHODS: The expressions of TGF-beta1 and CD105 were detected in 55 fresh specimens of gastric carcinoma and VEGF and CD105 in 44 fresh specimens of colorectal carcinoma by immunohistochemical staining (S-ABC). 14669355 NA
cd105 gastric carcinoma TGF-beta1 and CD105 in 55 gastric carcinoma tissues on the same slide were detected by using double-stain Immunohistochemistry (DS-ABC). 14669355 Human
cd105 lymph-node metastasis The expressions of both VEGF and CD105 (MVD) were related with the depth of invasion (F=5.438, P<0.05; F=4.168, P=0.05), lymph node metastasis (F=10.311, P<0.01; F=20.282, P<0.01) and Dukes stage (F=6.196, P<0.01; F=10.274, P<0.01), but not with histologi 14669355 Human
cd105 tumor angiogenesis CD105, as a receptor of TGF-beta1, can regulate the biological effect of TGF-beta1 in tumor angiogenesis. 14669355 Human
endoglin mammary carcinoma Endoglin is a suitable target for efficient imaging of solid tumors: in vivo evidence in a canine mammary carcinoma model. 10815930 others
endoglin breast cancer Increasing evidence suggests that endoglin (CD105) is a new powerful marker of neovascularization in solid malignancies; thus, using breast cancer as a model, we investigated whether targeting of CD105 by monoclonal antibody (mAb) MAEND3 can be used for i 10815930 Human
cd105 breast cancer Increasing evidence suggests that endoglin (CD105) is a new powerful marker of neovascularization in solid malignancies; thus, using breast cancer as a model, we investigated whether targeting of CD105 by monoclonal antibody (mAb) MAEND3 can be used for i 10815930 Human
cd105 breast cancer Immunohistochemistry and flow cytometry identified differential expression of CD105 on breast cancer and endothelial cells; in fact, neoplastic cells were weakly and rarely stained by mAb MAEND3, which in contrast, strongly and invariably stained blood ve 10815930 others
cd105 breast adenocarcinomas Immunohistochemistry and flow cytometry identified differential expression of CD105 on breast cancer and endothelial cells; in fact, neoplastic cells were weakly and rarely stained by mAb MAEND3, which in contrast, strongly and invariably stained blood ve 10815930 others
endoglin cervical cancer Endoglin expression as a measure of microvessel density in cervical cancer. 10908767 Human
endoglin cervical cancer OBJECTIVE: To evaluate endoglin, a membrane protein and member of the transforming growth factor beta-1 receptor complex, as an endothelial marker of angiogenesis in cervical cancer tissues. 10908767 NA
endoglin lymph-node metastases Endoglin and factor VIII counts correlated significantly with deep stromal invasion (Spearman rho 0.466 and 0.522, respectively, P <.05); however, only endoglin counts correlated significantly with lymph node metastases (rho =.495, P <.01). 10908767 Human
endoglin tumor angiogenesis CONCLUSION: Endoglin is stimulated in tumor angiogenesis and might be relatively more specific than commonly used endothelial markers. 10908767 Human
endoglin lymph-node metastases The endoglin system was more sensitive for staining capillaries in neoplastic cervical tissue, better predicted lymph node metastases, and should be widely applicable for the study of other tumors. 10908767 Human
endoglin arteriovenous malformations Analysis of endoglin expression in normal brain tissue and in cerebral arteriovenous malformations. 11062290 Human
cd105 colon carcinoma Using CD31 and CD105 to identify endothelial cells and endogenous green fluorescent protein labeling of tumor cells, we show that approximately 15% of perfused vessels of a colon carcinoma xenografted at two different sites in mice were mosaic vessels hav 11121063 Mouse
cd105 tumor Using CD31 and CD105 to identify endothelial cells and endogenous green fluorescent protein labeling of tumor cells, we show that approximately 15% of perfused vessels of a colon carcinoma xenografted at two different sites in mice were mosaic vessels hav 11121063 Mouse
cd105 breast carcinoma Breast carcinoma: vascular density determined using CD105 antibody correlates with tumor prognosis. 10029075 Human
cd105 tumor Breast carcinoma: vascular density determined using CD105 antibody correlates with tumor prognosis. 10029075 Human
cd105 breast carcinomas We have assessed the IMD in 106 breast carcinomas using a pan-endothelial marker, CD34, and a recently described mAb to CD105, which preferentially reacts with endothelial cell in angiogenic tissues. 10029075 Human
endoglin tumor Elevated expression of endoglin, a component of the TGF-beta-receptor complex, correlates with proliferation of tumor endothelial cells. 10225446 Human
endoglin tumors In this study, we performed a detailed analysis of endoglin expression in human lung tumors and different tumor and endothelial cell lines, employing reverse-transcriptase-polymerase-chain reaction as well as immunoblotting and immunohistochemistry using 10225446 NA
endoglin tumor In this study, we performed a detailed analysis of endoglin expression in human lung tumors and different tumor and endothelial cell lines, employing reverse-transcriptase-polymerase-chain reaction as well as immunoblotting and immunohistochemistry using 10225446 NA
endoglin tumors In tumors, endoglin expression was strongly elevated in the angiogenic endothelium at the tumor edges. 10225446 Human
endoglin tumor In tumors, endoglin expression was strongly elevated in the angiogenic endothelium at the tumor edges. 10225446 Human
endoglin arteriovenous malformations Most cases are caused by mutations in the endoglin gene on chromosome 9 (HHT type 1) or the activin receptor-like kinase 1 gene on chromosome 12 (HHT type 2), which leads to telangiectases and arteriovenous malformations (AVM) of the skin, mucosa, and vis 11773580 Human
cd105 endometrial carcinoma Endoglin (CD105) expression in endometrial carcinoma. 12819391 Human
endoglin endometrial carcinoma Endoglin (CD105) expression in endometrial carcinoma. 12819391 Human
cd105 endometrial carcinoma (ec) We evaluated endoglin (CD105) as an endothelial marker of angiogenesis in endometrial carcinoma (EC) and its prognostic significance. 12819391 Human
endoglin endometrial carcinoma (ec) We evaluated endoglin (CD105) as an endothelial marker of angiogenesis in endometrial carcinoma (EC) and its prognostic significance. 12819391 Human
endoglin complex endometrial hyperplasia with atypia Fifty-five cases of EC, 10 cases of complex endometrial hyperplasia with atypia (CHA), and 10 cases of simple hyperplasia (SH) were immunohistochemically stained for endoglin, CD31, and vascular endothelial growth factor (VEGF). 12819391 Human
endoglin simple hyperplasia Fifty-five cases of EC, 10 cases of complex endometrial hyperplasia with atypia (CHA), and 10 cases of simple hyperplasia (SH) were immunohistochemically stained for endoglin, CD31, and vascular endothelial growth factor (VEGF). 12819391 Human
endoglin tumor There was a positive correlation of both endoglin and CD31 MV counts with tumor differentiation (p < 0.05) and the depth of invasion (p < 0.01). 12819391 Human
endoglin metastases However, only endoglin counts correlated significantly with the presence of angiolymphatic invasion (p < 0.01), lymph nodes metastases (p < 0.01), and tumor stage (p < 0.001). 12819391 Human
endoglin tumor However, only endoglin counts correlated significantly with the presence of angiolymphatic invasion (p < 0.01), lymph nodes metastases (p < 0.01), and tumor stage (p < 0.001). 12819391 Human
endoglin tumor angiogenesis Our study showed that endoglin, by staining the proliferating MV in EC, is a more specific and sensitive marker for tumor angiogenesis than is the commonly used pan-endothelial marker, CD31. 12819391 Human
endoglin lymph-node metastases Endoglin staining also had prognostic significance, with positive correlation with angiolymphatic invasion, lymph node metastases, and tumor stage. 12819391 Human
endoglin tumor Endoglin staining also had prognostic significance, with positive correlation with angiolymphatic invasion, lymph node metastases, and tumor stage. 12819391 Human
cd 105 endometrial carcinomas Significance of CD 105 expression for tumour angiogenesis and prognosis in endometrial carcinomas. 14629267 Human
cd 105 tumour Significance of CD 105 expression for tumour angiogenesis and prognosis in endometrial carcinomas. 14629267 Human
cd105 endometrial carcinoma In a population-based endometrial carcinoma study with long (median 11.5 years) and complete patient follow-up, mean intratumour microvascular density (MVD) assessed using CD105/endoglin was investigated and compared with previous data for MVD assessed us 14629267 Human
endoglin endometrial carcinoma In a population-based endometrial carcinoma study with long (median 11.5 years) and complete patient follow-up, mean intratumour microvascular density (MVD) assessed using CD105/endoglin was investigated and compared with previous data for MVD assessed us 14629267 Human
cd105 tumor Endoglin (CD105), which is a component of the TGF-beta receptor complex, is highly expressed at the surface of proliferating human endothelial cells such as those of tumor vessels. 10417773 Human
endoglin tumor Endoglin (CD105), which is a component of the TGF-beta receptor complex, is highly expressed at the surface of proliferating human endothelial cells such as those of tumor vessels. 10417773 Human
endoglin cancers Levels of Tie2, angiopoietin (Ang)-1, vascular endothelial growth factor (VEGF), and CD31 mRNAs were higher in cancers than in adjacent noncancerous tissues, in contrast to the fms-like tyrosine kinase (Flt)-1, Flt-4, Tie1, thrombin receptor, endoglin, an 10499626 Human
endoglin arteriovenous malformations Vascular lesions (telangiectasia and arteriovenous malformations) in HHT1 are associated with loss of the capillary network, suggesting the involvement of endoglin in vascular repair processes. 10518029 others
cd105 metastasis METHODS: Paraffin-embedded tissues of 39 NSGCTs (19 organ confined NSGCTs, pathological stage I and 20 NSGCTs with metastasis, pathological stage II) were immunohistochemical stained with antibodies for vascular endothelial growth factor (VEGF) with the l 12932931 NA
cd105 tumors Using CD105 a significantly higher microvessel density was observed in stage II tumors. 12932931 Human
cd105 tumor A difference in microvessel density between tumor stages could only be observed if the specific CD105 antibody was used. 12932931 Human
hht1 venous malformation Two large outbred pedigrees in which the AD diseases familial venous malformation (FVM) and hereditary hemorrhagic telangiectasia (HHT1), linked to 9p and 9q, respectively, were investigated. 9521591 Human
endoglin tumour RESULTS: Endoglin expression in tumour tissue was significantly higher than in normal healthy mucosa (P<0.001). 15113577 Human
endoglin tumours T1 tumours showed a significantly lower staining for endoglin compared with T2, T3 and T4 tumours but there was no increase with each T stage. 15113577 Human
endoglin squamous-cell carcinoma Endoglin may have a significant role in the development of squamous cell carcinoma of the oral cavity and might be relatively more specific than commonly used endothelial markers. 15113577 Human
endoglin choriocarcinoma Endoglin, a component of the TGF-beta receptor system, is a differentiation marker of human choriocarcinoma cells. 9590131 Human
endoglin choriocarcinoma Here, we describe the expression of endoglin by the choriocarcinoma cell line JAR as evidenced by flow cytometry, immunoprecipitation, Western blot and reverse transcriptase polymerase chain reaction analyses. 9590131 Human
endoglin choriocarcinoma Furthermore, staining of human choriocarcinoma tissue sections with a polyclonal antibody to endoglin demonstrated a high expression of endoglin in syncytiotrophoblast-like areas, as opposed to a negative staining of cytotrophoblast-like cells. 9590131 Human
endoglin choriocarcinoma Thus, treatment of the JAR and JEG-3 choriocarcinoma cell lines with methotrexate led to an increase in endoglin expression, as demonstrated by Western and Northern blot analyses. 9590131 Human
endoglin malignant melanoma Immunocytochemical detection of endoglin is indicative of angiogenesis in malignant melanoma. 9703932 Human
cd105 breast cancer Despite the increased interest in the effect of TGFbetas on tumour progression, little is known about the importance of TGFbeta3 and its receptor CD105 in breast cancer. 9761112 Human
cd105 tumour Despite the increased interest in the effect of TGFbetas on tumour progression, little is known about the importance of TGFbeta3 and its receptor CD105 in breast cancer. 9761112 Human
cd105 tumours In COX-2 negative tumours the MVD was 22.1, identified by CD34 immunostaining, and 3.4 for proliferating vessels (CD105), whereas COX-2 positive tumours had a MVD of 18.3 (CD34), and of 5.8, respectively (CD105). 12930427 Human
endoglin myeloma The spleen cells of these infected animals were fused to myeloma cells, allowing efficient generation of several hybridomas which secrete mAbs to human endoglin, as evidenced by their reactivity with purified endoglin as well as with endoglin transfectant 9280294 Human
endoglin tumor Tumor vessels were identified by immunohistochemical staining for the endothelial cell markers CD31, endoglin (CD105), vascular endothelial growth factor receptor-2, and integrin alpha5 (CD49e). 14578181 Human
cd105 tumor Tumor vessels were identified by immunohistochemical staining for the endothelial cell markers CD31, endoglin (CD105), vascular endothelial growth factor receptor-2, and integrin alpha5 (CD49e). 14578181 Human
endoglin arteriovenous malformations A reduction in the level of functional endoglin is thus involved in the generation of HHT1, and associated arteriovenous malformations. 9366572 Human
endoglin acute lymphoblastic leukemia Endoglin was first identified on a cell line derived from pre-B acute lymphoblastic leukemia. 8543807 Human
cd105 bladder carcinoma The regular expression of MAC maturation-associated antigens on infiltrating MO was suppressed within MCS of the undifferentiated bladder carcinoma line J82 with regard to carboxypeptidase M (CPM), MAX.3 antigen and CD105. 8647627 Human
endoglin arteriovenous malformations Clinical heterogeneity in hereditary haemorrhagic telangiectasia: are pulmonary arteriovenous malformations more common in families linked to endoglin? 8728706 Human
endoglin hematopoietic malignancies Angiogenesis contributes to disease progression in solid and hematopoietic malignancies, and endoglin (CD105), a component of the transforming growth factor (TGF)-beta receptor complex, is a powerful marker of neovascularization. 12494455 Human
cd105 hematopoietic malignancies Angiogenesis contributes to disease progression in solid and hematopoietic malignancies, and endoglin (CD105), a component of the transforming growth factor (TGF)-beta receptor complex, is a powerful marker of neovascularization. 12494455 Human
cd105 hematopoietic malignancies Elevated amounts of soluble CD105 (sCD105) have been recently identified in selected solid tumors but no data are available on sCD105 in hematopoietic malignancies. 12494455 Human
endoglin melanoma Expression and structural features of endoglin (CD105), a transforming growth factor beta1 and beta3 binding protein, in human melanoma. 8932339 Human
cd105 melanoma Expression and structural features of endoglin (CD105), a transforming growth factor beta1 and beta3 binding protein, in human melanoma. 8932339 Human
cd105 melanoma Sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis revealed that CD105 expressed by melanoma cells consists of a homodimeric protein with an apparent molecular weight of 180 and 95 kDa under non-reducing and reducing conditions 8932339 Human
cd105 melanoma Cross-linking of 125I-labelled TGF-beta1 to melanoma cells, Mel 97, by disuccinimidyl suberate (DSS) demonstrated that CD105 expressed on pigmented cells binds TGF-beta1; the pattern of binding of TGF-beta1 to melanoma cells was found to be similar to tha 8932339 Human
cd105 melanoma These data, altogether, demonstrate that CD105 is expressed on pigmented cells and might play a functionally relevant role in the biology of human melanoma cells by regulating their sensitivity to TGF-betas. 8932339 Human
endoglin arteriovenous malformations Recently, the tumour growth factor (TGF)-beta binding protein endoglin localized to 9q33-34 was identified as responsible for HHT in several large kindreds with pulmonary arteriovenous malformations (PAVMs). 7633456 Human
endoglin ovarian neoplasms Expression and prognostic significance of TGF-beta isotypes, latent TGF-beta 1 binding protein, TGF-beta type I and type II receptors, and endoglin in normal ovary and ovarian neoplasms. 7637321 Human
endoglin malignant ovarian neoplasms EXPERIMENTAL DESIGN: Tissue samples of normal ovary and benign as well as malignant ovarian neoplasms were examined for expression of transforming growth factor (TGF)-beta 1, -beta 2, and -beta 3, the latent TGF-beta-binding protein (LTBP), TGF-beta type 7637321 Human
endoglin tumor T beta R-I and T beta R-II as well as endoglin were found in tumor tissues and normal ovary without any difference among the groups. 7637321 Human
endoglin tumors Patients with malignant tumors expressing TGF-beta 1, T beta R-I, or endoglin in blood vessels demonstrated longer survival than those having negatively stained tumors. 7637321 Human
endoglin residual tumor In contrast, positive endoglin staining in tumor cells correlated with decreased survival even in advanced disease or in patients having residual tumor bulk after surgery. 7637321 Human
endoglin tumor In contrast, positive endoglin staining in tumor cells correlated with decreased survival even in advanced disease or in patients having residual tumor bulk after surgery. 7637321 Human
cd105 hairy-cell leukaemia (hcl) Microvessel density (MVD), a surrogate marker for angiogenesis, was evaluated by anti-CD34 and CD105 monoclonal antibodies (Abs), and found to be increased in the bone marrow (BM) of hairy cell leukaemia (HCL) patients and in a preclinical model of non-ob 12588359 Human
endoglin arteriovenous malformations Pulmonary arteriovenous malformations were only reported in the endoglin mutation group in our study (p<0.001). 12920067 Human
endoglin tumour Immunohistochemical staining demonstrated CD31 and endoglin protein expression in the EPC tumour cells, which are both angiogenesis related and could confer malignant plasma cells with the ability to grow outside the normal bone marrow environment. 12930383 Human
endoglin papillomas Reduction in endoglin had a dual effect during multistage carcinogenesis, by inhibiting the early appearance of benign papillomas, but increasing malignant progression to highly undifferentiated carcinomas. 12955076 Mouse
endoglin undifferentiated carcinomas Reduction in endoglin had a dual effect during multistage carcinogenesis, by inhibiting the early appearance of benign papillomas, but increasing malignant progression to highly undifferentiated carcinomas. 12955076 Mouse
cd105 cancer Among surface molecules expressed on endothelial cells, endoglin (CD105) is emerging as a prime vascular target for antiangiogenetic cancer therapy. 14528280 Human
endoglin cancer Among surface molecules expressed on endothelial cells, endoglin (CD105) is emerging as a prime vascular target for antiangiogenetic cancer therapy. 14528280 Human
cd105 intratumoral microvessel density Quantification of intratumoral microvessel density by CD105 staining and of circulating soluble CD105 has been suggested to have prognostic significance in selected neoplasias. 14528280 Human
cd105 tumor In addition, the potential usefulness of CD105 in tumor imaging and antiangiogenetic therapy has been well documented utilizing different animal models. 14528280 Human
cd105 non-small cell lung cancer Correlation between apoptotic index and angiogenesis in non-small cell lung cancer: comparison between CD105 and CD34 as a marker of angiogenesis. 12609567 Human
endoglin human tumor We have characterized a murine IgM monoclonal antibody, TEC-11, that recognizes endoglin and may be suitable for targeting cytotoxic agents to human tumor vasculature. 9815965 Human
endoglin tumor Taken together, the increased binding of TEC-11 to tumor vasculature and to dividing as opposed to noncycling HUVECs in vitro suggests that endoglin is an endothelial cell proliferation-associated marker. 9815965 Human
endoglin arteriovenous malformations BACKGROUND AND PURPOSE: Hereditary hemorrhagic telangiectasia type 1 (HHT1) is an autosomal dominant vascular dysplasia caused by mutations in the endoglin gene and characterized by dilated vessels and arteriovenous malformations (AVMs). 12624308 Human
hht1 arteriovenous malformations BACKGROUND AND PURPOSE: Hereditary hemorrhagic telangiectasia type 1 (HHT1) is an autosomal dominant vascular dysplasia caused by mutations in the endoglin gene and characterized by dilated vessels and arteriovenous malformations (AVMs). 12624308 Human
cd105 breast carcinomas CD105 expression is a marker of high metastatic risk and poor outcome in breast carcinomas. 12645339 Human
cd105 tumor CD105 (endoglin) is expressed significantly in activated endothelial cells in culture and in tumor microvessels. 12645339 Human
endoglin tumor CD105 (endoglin) is expressed significantly in activated endothelial cells in culture and in tumor microvessels. 12645339 Human
cd105 metastasis Marked CD105 expression also correlated with a high risk for metastasis among all patients (P = .006) and among node-negative patients (P = .001). 12645339 Human
cd105 tumor The microvessel density (MVD) of tumor tissue was measured after it immunohistochemically stained with CD105 (Endoglin) monoclonal antibody. 12657102 Human
endoglin tumor The microvessel density (MVD) of tumor tissue was measured after it immunohistochemically stained with CD105 (Endoglin) monoclonal antibody. 12657102 Human
eng arteriovenous malformations Hereditary hemorrhagic telangiectasia type 1 (HHT1) is a vascular dysplasia caused by mutations in the endoglin (ENG) gene and associated with epistaxis, telangiectases, and a high incidence of pulmonary arteriovenous malformations. 12673790 Human
endoglin arteriovenous malformations Hereditary hemorrhagic telangiectasia type 1 (HHT1) is a vascular dysplasia caused by mutations in the endoglin (ENG) gene and associated with epistaxis, telangiectases, and a high incidence of pulmonary arteriovenous malformations. 12673790 Human
hht1 arteriovenous malformations Hereditary hemorrhagic telangiectasia type 1 (HHT1) is a vascular dysplasia caused by mutations in the endoglin (ENG) gene and associated with epistaxis, telangiectases, and a high incidence of pulmonary arteriovenous malformations. 12673790 Human
cd105 non-small cell lung cancer Prognostic impact of VEGF, CD31, CD34, and CD105 expression and tumour vessel invasion after radical surgery for IB-IIA non-small cell lung cancer. 15166262 Human
cd105 tumour Prognostic impact of VEGF, CD31, CD34, and CD105 expression and tumour vessel invasion after radical surgery for IB-IIA non-small cell lung cancer. 15166262 Human
cd105 tumour Tumour specimens were stained for VEGF and specific MVD markers: CD31, CD34, and CD105. 15166262 Human
cd105 tumour RESULTS: VEGF expression significantly correlated with high CD105 expression (p < 0.0001) and tumour vessel invasion (p = 0.04). 15166262 Human
cd105 tumour Univariate analysis showed that those patients with VEGF overexpression (p = 0.0029), high MVD by CD34 (p = 0.0081), high MVD by CD105 (p = 0.0261), and tumour vessel invasion (p = 0.0245) have a shorter overall survival. 15166262 Human
cd105 cancer Endoglin (CD105): a target for anti-angiogenetic cancer therapy. 12699349 Human
endoglin cancer Endoglin (CD105): a target for anti-angiogenetic cancer therapy. 12699349 Human
endoglin tumor angiogenesis Among endothelial cell markers, Endoglin, a cell membrane glycoprotein, is emerging as an attractive therapeutic target on angiogenetic blood vessels, and it currently represents a powerful marker to quantify tumor angiogenesis. 12699349 Human
endoglin blast crisis We now report that four mAbs independently produced against human umbilical vein endothelial cells (HUVECs), chronic myelogenous leukemia in blast crisis, or U-937 pro-monocytic cells stimulated with phorbol myristate acetate also react with endoglin. 1371694 Human
endoglin chronic myelogenous leukemia We now report that four mAbs independently produced against human umbilical vein endothelial cells (HUVECs), chronic myelogenous leukemia in blast crisis, or U-937 pro-monocytic cells stimulated with phorbol myristate acetate also react with endoglin. 1371694 Human
endoglin leukaemia The distribution of the RMAC8-recognized molecule was the same as that described for endoglin, i.e. arterial and venous endothelium, myelomonocytic and pre-B leukaemia cells and cell lines; however, unlike 44G4, RMAC8 also reacted weakly with monocytes an 1395096 Human
cd105 tumor Immunohistochemistry studies have revealed that CD105 is strongly expressed in blood vessels of tumor tissues. 12773481 Human
cd105 intratumoral microvessel density Intratumoral microvessel density (MVD) determined using antibodies to CD105 has been found to be an independent prognostic indicator, wherein increased MVD correlates with shorter survival. 12773481 Human
cd105 tumor metastasis CD105 is able to be shed into the circulation, with elevated levels detected in patients with various types of cancer and positively correlated with tumor metastasis. 12773481 Human
cd105 cancer CD105 is able to be shed into the circulation, with elevated levels detected in patients with various types of cancer and positively correlated with tumor metastasis. 12773481 Human
cd105 tumor The potential usefulness of CD105 for tumor imaging has been evaluated in tumor-bearing mice and dogs that have shown the rapid accumulation of radiolabeled anti-CD105 monoclonal antibody in the tumors with a high tumor-to-background ratio. 12773481 Mouse
cd105 tumors The potential usefulness of CD105 for tumor imaging has been evaluated in tumor-bearing mice and dogs that have shown the rapid accumulation of radiolabeled anti-CD105 monoclonal antibody in the tumors with a high tumor-to-background ratio. 12773481 Mouse
cd105 renal-cell carcinomas Immunoscintigraphy in patients with renal cell carcinomas has shown specific localization of 99Tcm-labeled CD105 mab in tumor endothelial cells. 12773481 Human
cd105 tumor Immunoscintigraphy in patients with renal cell carcinomas has shown specific localization of 99Tcm-labeled CD105 mab in tumor endothelial cells. 12773481 Human
cd105 tumor Thus, CD105 is a promising vascular target that can be used for tumor imaging, prognosis, and bears therapeutic potential in patients with solid tumors and other angiogenic diseases. 12773481 Human
cd105 intratumoral microvessel density Both high intratumoral microvessel density determined using CD105 antibody and elevated plasma levels of CD105 in colorectal cancer patients correlate with poor prognosis. 12778073 Human
cd105 colorectal cancer Both high intratumoral microvessel density determined using CD105 antibody and elevated plasma levels of CD105 in colorectal cancer patients correlate with poor prognosis. 12778073 Human
cd105 tumour CD105 and its ligand transforming growth factor beta (TGFbeta) are modulators of angiogenesis, which drives tumour growth and metastasis. 12778073 Human
cd105 metastasis CD105 and its ligand transforming growth factor beta (TGFbeta) are modulators of angiogenesis, which drives tumour growth and metastasis. 12778073 Human
cd105 colorectal cancer In this study, we have examined the prognostic value of MVD identified using Mabs to the pan-endothelial marker CD34 and to CD105 in 111 patients with colorectal cancer. 12778073 NA
cd105 colorectal carcinoma In order to ascertain if this strong expression of CD105 in the tumour vasculature is reflected in patients' plasma, circulating levels of CD105, TGFbeta1 and TGFbeta3 together with the receptor-ligand complexes were quantified in patients with color 12778073 Human
cd105 tumour In order to ascertain if this strong expression of CD105 in the tumour vasculature is reflected in patients' plasma, circulating levels of CD105, TGFbeta1 and TGFbeta3 together with the receptor-ligand complexes were quantified in patients with color 12778073 Human
cd105 cancer Immunostaining revealed that TGFbeta1 was expressed in cancer cells but TGFbeta3 in the stromal cells, whereas CD105 was exclusively expressed in vascular endothelial cells of tumour blood vessels. 12778073 Human
cd105 tumour Immunostaining revealed that TGFbeta1 was expressed in cancer cells but TGFbeta3 in the stromal cells, whereas CD105 was exclusively expressed in vascular endothelial cells of tumour blood vessels. 12778073 Human
cd105 colorectal cancer In conclusion, this study demonstrates that MVD quantified using a Mab to CD105 is an independent prognostic parameter for survival of patients with colorectal cancer, and that plasma levels of CD105, TGFbeta1, TGFbeta3 and CD105/TGFbeta complexes may be 12778073 Human
hht1 arteriovenous malformations A higher frequency of pulmonary arteriovenous malformations (AVMs) has been reported for HHT1 while HHT2 is thought to be associated with a lower penetrance and milder disease manifestations. 12843319 Human
cd105 solid tumors Increasing evidence suggests that endoglin (CD105) is a new powerful marker of neovascularization in solid malignancies; thus, using breast cancer as a model, we investigated whether targeting of CD105 by monoclonal antibody (mAb) MAEND3 can be used for i 10815930 Human
cd105 solid tumors In this report, we present data indicating that the increased serum endoglin (EDG; CD105) quantitated by a double-antibody sandwich assay is associated with metastasis in patients with solid tumors including colorectal and breast carcinomas. 11297243 Human
cd105 squamous cell carcinoma of the oral cavity Endoglin (CD105) expression in squamous cell carcinoma of the oral cavity. 11891945 Human
cd105 squamous cell carcinoma of the oral cavity To explain the rating of CD105 expression in 51 squamous cell carcinoma of the oral cavity (SCCOC) we analyzed CD105 expression in tumor tissue and adjacent normal healthy mucosa. 11891945 Human
cd105 solid tumors Elevated amounts of soluble CD105 (sCD105) have been recently identified in selected solid tumors but no data are available on sCD105 in hematopoietic malignancies. 12494455 Human
cd105 hcl Microvessel density (MVD), a surrogate marker for angiogenesis, was evaluated by anti-CD34 and CD105 monoclonal antibodies (Abs), and found to be increased in the bone marrow (BM) of hairy cell leukaemia (HCL) patients and in a preclinical model of non-ob 12588359 Human
cd105 solid tumors Thus, CD105 is a promising vascular target that can be used for tumor imaging, prognosis, and bears therapeutic potential in patients with solid tumors and other angiogenic diseases. 12773481 Human
cd105 negative tumours In COX-2 negative tumours the MVD was 22.1, identified by CD34 immunostaining, and 3.4 for proliferating vessels (CD105), whereas COX-2 positive tumours had a MVD of 18.3 (CD34), and of 5.8, respectively (CD105). 12930427 Human
cd105 neoplasias Quantification of intratumoral microvessel density by CD105 staining and of circulating soluble CD105 has been suggested to have prognostic significance in selected neoplasias. 14528280 Human
cd105 solid tumors Endoglin (CD105) is a proliferation-associated cell membrane antigen of endothelial cells and strongly expressed in the angiogenic vasculature of solid tumors. 14639611 Human
cd105 malignant tumors Relationship between expression of CD105 and growth factors in malignant tumors of gastrointestinal tract and its significance. 14669355 Human
cd105 malignant tumors At the same time, we also observed the localization of TGF-beta1 and its receptor CD105 in gastric malignant tumors. 14669355 Human
cd105 solid tumors There is strong published and unpublished evidence that our CD105 Mab E9, which is highly reactive with angiogenic endothelial cells, could be a useful reagent to target the vasculature of solid tumors in man. 14961584 Human
cd105 colorectal cancer Endoglin (CD105) and vascular endothelial growth factor as prognostic markers in colorectal cancer. 14657950 Human
cd105 tumor angiogenesis Endoglin (CD105) has been shown to be a more useful marker to identify proliferating endothelium involved in tumor angiogenesis than panendothelial markers such as CD31. 14657950 Human
cd105 breast cancers [The immunohistochemical expression of CD105 is a marker for high metastatic risk and worse prognosis in breast cancers] The quantification of angiogenesis in human solid tumors has been shown to be an indicator of prognosis and tumor microvasculature is 14978873 Human
cd105 tumor CD105 (endoglin) is significantly expressed in activated endothelial cells in culture and in tumor microvessels. 14978873 Human
cd105 metastasis Marked CD105 expression was also correlated with high metastasis risk among all patients (p = 0.006) and among node negative patients as well (p = 0.001). 14978873 Human
cd105 breast carcinomas Prognostic significance of angiogenesis evaluated by CD105 expression compared to CD31 in 905 breast carcinomas: correlation with long-term patient outcome. 15067342 Human
cd105 breast carcinoma Our purpose was to determine the respective prognostic significance of CD105 and CD31 immunoexpression in node negative patients with breast carcinoma, since angiogenesis induces blood borne metastases and death in carcinomas. 15067342 Human
cd105 carcinomas Our purpose was to determine the respective prognostic significance of CD105 and CD31 immunoexpression in node negative patients with breast carcinoma, since angiogenesis induces blood borne metastases and death in carcinomas. 15067342 Human
cd105 metastases Our purpose was to determine the respective prognostic significance of CD105 and CD31 immunoexpression in node negative patients with breast carcinoma, since angiogenesis induces blood borne metastases and death in carcinomas. 15067342 Human
cd105 malignant tumors CD105 (endoglin) has been reported as expressed by activated endothelial cells and consequently should better reflect neoangiogenesis in malignant tumors. 15067342 Human
cd105 breast carcinomas Comparison of CD31 and CD105 immunocytochemical expression was undertaken in a series of 905 breast carcinomas. 15067342 Human
cd105 metastasis Marked CD105 expression also correlated with a high risk for metastasis in all patients (p=0.0002) and in the subset of node negative patients (p=0.001). 15067342 Human
cd105 breast carcinomas Our results suggest that: i) in breast carcinomas, immunoselection of microvessels containing activated CD105 labelled endothelial cells is endowed with a stronger prognostic significance, as compared to CD31 vessels labelling; ii) the CD105 immunoexpress 15067342 Human
cd105 metastasis Our results suggest that: i) in breast carcinomas, immunoselection of microvessels containing activated CD105 labelled endothelial cells is endowed with a stronger prognostic significance, as compared to CD31 vessels labelling; ii) the CD105 immunoexpress 15067342 Human
cd105 urothelial carcinoma We studied expression patterns of Maspin in pTa/pT1 urothelial carcinoma of the bladder and compared them with microvessel density (MVD) for two vascular markers (CD34 and CD105) and correlated the findings with clinical outcome. 15149745 NA
cd105 tumors In tumors with loss of or only weak Maspin expression, the MVD for CD34 was 21.7 vessels per field, and 4.2 vessels per field for proliferating vessels (CD105), whereas Maspin-positive tumors had an MVD of 17.7 vessels per field (CD34), and of 6.0 vessels 15149745 Human
cd105 tumours CD105 (endoglin) is an important component of the transforming growth factor-beta (TGF-beta) receptor complex and is highly expressed in endothelial cells in tissues undergoing angiogenesis such as healing wounds, infarcts and in a wide range of tumours. 15274293 Human
cd105 human breast cancer mRNA expression of the angiogenesis markers VEGF and CD105 (endoglin) in human breast cancer. 15274325 Human
cd105 tumor angiogenesis BACKGROUND: Both VEGF and CD105 (endoglin) have been identified as markers of tumor angiogenesis and prognosis in breast cancer. 15274325 Human
cd105 breast cancer BACKGROUND: Both VEGF and CD105 (endoglin) have been identified as markers of tumor angiogenesis and prognosis in breast cancer. 15274325 Human
cd105 tumors OBJECTIVE: To study, by means of reverse-transcription polymerase chain reaction (RT-PCR), the expression of VEGF and CD105 (endoglin) at the mRNA level in a series of breast cancers and to correlate the results obtained with all available clinical and bi 15274325 NA
cd105 breast cancers OBJECTIVE: To study, by means of reverse-transcription polymerase chain reaction (RT-PCR), the expression of VEGF and CD105 (endoglin) at the mRNA level in a series of breast cancers and to correlate the results obtained with all available clinical and bi 15274325 NA
cd105 breast cancer MATERIALS AND METHODS: Fresh tumor tissue from 103 previously untreated breast cancer patients was studied for VEGF and CD105 (endoglin) expression. 15274325 NA
cd105 fresh tumor MATERIALS AND METHODS: Fresh tumor tissue from 103 previously untreated breast cancer patients was studied for VEGF and CD105 (endoglin) expression. 15274325 NA
cd105 cancers The serial slides of all materials (48 polypoid cancers, 10 non-polypoid cancers, 20 adenomas and 10 normal tissues) were immunohistochemically stained for three endothelial cell markers (CD31, von Willebrand factor and CD105), counted for the number of m 15189502 Human
cd105 adenomas The serial slides of all materials (48 polypoid cancers, 10 non-polypoid cancers, 20 adenomas and 10 normal tissues) were immunohistochemically stained for three endothelial cell markers (CD31, von Willebrand factor and CD105), counted for the number of m 15189502 Human
cd105 breast carcinoma Tumor neoangiogenesis by CD31 and CD105 expression evaluation in breast carcinoma tissue microarrays. 15355911 Human
cd105 tumor Tumor neoangiogenesis by CD31 and CD105 expression evaluation in breast carcinoma tissue microarrays. 15355911 Human
cd105 breast carcinomas PURPOSE: The aim of the study was to evaluate CD31 and CD105 immunohistochemical expressions in tissue microarrays from 360 breast carcinomas. 15355911 NA
cd105 breast carcinomas CONCLUSIONS: It is concluded (a) that CD105 may be suitable in paraffin sections to evaluated neoangiogenesis; and (b) that tissue microarrays are not suitable substrates for neoangiogenesis evaluation as a prognostic indicator in breast carcinomas, in co 15355911 Human
cd105 tumor MATERIAL/METHODS: We analysed, on the one hand, the predictive powers for recurrent disease of the immunohistochemical expressions of p53 and the endothelial markers CD34 and CD105 in 53 NSCLC tumor samples, and, on the other hand, their correlations to s 15328478 NA
cd105 nsclc MATERIAL/METHODS: We analysed, on the one hand, the predictive powers for recurrent disease of the immunohistochemical expressions of p53 and the endothelial markers CD34 and CD105 in 53 NSCLC tumor samples, and, on the other hand, their correlations to s 15328478 NA
cd105 nsclc CONCLUSIONS: The present study demonstrates that p53 expression correlates with CD105 expression, and that p53 overexpression may indicate a lower recurrence risk in patients undergoing surgery for NSCLC stage I-IIIA, although future larger prospective st 15328478 Human
cd105 chronic idiopathic myelofibrosis Chronic idiopathic myelofibrosis: independent prognostic importance of bone marrow microvascular density evaluated by CD105 (endoglin) immunostaining. 15272276 Human
cd105 chronic myeloproliferative disorders Increased serum-soluble CD105 in patients with chronic myeloproliferative disorders, including CIMF, was documented. 15272276 Human
cd105 tumour Angiogenic activity can furthermore be assessed in histological samples by measuring the molecules involved in the establishment of the tumour vasculature, including angiogenic growth factors and their receptors, cell adhesion molecules, proteases and mar 15563306 Human
cd105 myomas Immunohistochemical expression of PDGF, bFGF and VEGF, vascular changes and CD105 expression, as a marker of angiogenesis, were evaluated in myomas obtained after surgery. 15631865 Human
cd105 hepatocellular carcinoma Clinicopathological and prognostic implications of endoglin (CD105) expression in hepatocellular carcinoma and its adjacent non-tumorous liver. 15633211 Human
cd105 hepatocellular carcinoma (hcc) AIM: The expression pattern of endoglin (CD105) in hepatocellular carcinoma (HCC) has not been reported so far. 15633211 Human
cd105 intratumoral microvessel density We hypothesized that CD105 could differentially highlight a subset of microvessels in HCC, and intratumoral microvessel density (IMVD) by CD105 immunostaining (IMVD-CD105) could provide better prognostic information than IMVD by CD34 immunostaining (IMVD- 15633211 Human
cd105 hcc We hypothesized that CD105 could differentially highlight a subset of microvessels in HCC, and intratumoral microvessel density (IMVD) by CD105 immunostaining (IMVD-CD105) could provide better prognostic information than IMVD by CD34 immunostaining (IMVD- 15633211 Human
cd105 hcc RESULTS: In the HCC tissues, CD105 was either negatively or positively stained only in a subset of microvessels. 15633211 Human
cd105 breast cancer [Clinicopathologic significance of CD105 mRNA expression in human breast carcinoma] OBJECTIVE: To study endoglin (CD105) gene expression in breast cancer and its clinicopathologic significance. 15771797 NA
cd105 tumor METHODS: In 40 patients with breast cancers, CD105 mRNA was detected at center and periphery of tumor and at nearby normal tissue by RT-PCR. 15771797 NA
cd105 breast cancers METHODS: In 40 patients with breast cancers, CD105 mRNA was detected at center and periphery of tumor and at nearby normal tissue by RT-PCR. 15771797 NA
cd105 tumor RESULTS: The difference in CD105 mRNA expressions between cancer and normal breast tissue was significant (t = 12.08, P < 0.05), and the expression was significantly higher at the tumor periphery than at the tumor center (t = 7.52, P < 0.05). 15771797 Human
cd105 cancer RESULTS: The difference in CD105 mRNA expressions between cancer and normal breast tissue was significant (t = 12.08, P < 0.05), and the expression was significantly higher at the tumor periphery than at the tumor center (t = 7.52, P < 0.05). 15771797 Human
cd105 lymph-node metastases CD105 over-expression was related to lymph node metastases (t = 2.71, P < 0.05), but not to age, tumor size, pathologic grade or pathologic type (P > 0.05). 15771797 Human
cd105 tumor CD105 over-expression was related to lymph node metastases (t = 2.71, P < 0.05), but not to age, tumor size, pathologic grade or pathologic type (P > 0.05). 15771797 Human
cd105 breast cancer CONCLUSION: CD105 over-expression may play a crucial role in the progression of breast cancer and lymph node metastasis. 15771797 Human
cd105 lymph-node metastasis CONCLUSION: CD105 over-expression may play a crucial role in the progression of breast cancer and lymph node metastasis. 15771797 Human
cd105 human breast carcinoma [Clinicopathologic significance of CD105 mRNA expression in human breast carcinoma] OBJECTIVE: To study endoglin (CD105) gene expression in breast cancer and its clinicopathologic significance. 15771797 Human
cd105 human tumour Differential expression and cytoplasm/membrane distribution of endoglin (CD105) in human tumour cell lines: Implications in the modulation of cell proliferation. 15809709 Human
cd105 human tumour Endoglin (CD105, an accessory component of the TGF-beta receptor complex) expression and distribution on different human tumour cells and its role in cellular proliferation were evaluated. 15809709 Human
cd105 sarcoma The results showed that CD105 was poorly expressed in the majority of human carcinoma cells (10/16), whereas it was highly expressed in most human sarcoma cells (7/8), and differently expressed by miscellaneous tumour cell lines. 15809709 Human
cd105 tumour The results showed that CD105 was poorly expressed in the majority of human carcinoma cells (10/16), whereas it was highly expressed in most human sarcoma cells (7/8), and differently expressed by miscellaneous tumour cell lines. 15809709 Human
cd105 carcinoma The results showed that CD105 was poorly expressed in the majority of human carcinoma cells (10/16), whereas it was highly expressed in most human sarcoma cells (7/8), and differently expressed by miscellaneous tumour cell lines. 15809709 Human
cd105 sarcoma However, CD105 levels in sarcoma cell lines, even though consistently lower than in NHDF, were significantly higher than those observed in carcinoma cells. 15809709 Human
cd105 carcinoma However, CD105 levels in sarcoma cell lines, even though consistently lower than in NHDF, were significantly higher than those observed in carcinoma cells. 15809709 Human
cd105 breast carcinoma Interestingly, CD105 presented a strong expression in the cytoplasm of MDA-MB-453 (breast carcinoma), NPA (papillary thyroid carcinoma), COLO-853 (melanoma) and SaOS-2 (osteosarcoma), but was weakly expressed on their cell membrane. 15809709 Human
cd105 osteosarcoma Interestingly, CD105 presented a strong expression in the cytoplasm of MDA-MB-453 (breast carcinoma), NPA (papillary thyroid carcinoma), COLO-853 (melanoma) and SaOS-2 (osteosarcoma), but was weakly expressed on their cell membrane. 15809709 Human
cd105 melanoma Interestingly, CD105 presented a strong expression in the cytoplasm of MDA-MB-453 (breast carcinoma), NPA (papillary thyroid carcinoma), COLO-853 (melanoma) and SaOS-2 (osteosarcoma), but was weakly expressed on their cell membrane. 15809709 Human
cd105 papillary thyroid carcinoma Interestingly, CD105 presented a strong expression in the cytoplasm of MDA-MB-453 (breast carcinoma), NPA (papillary thyroid carcinoma), COLO-853 (melanoma) and SaOS-2 (osteosarcoma), but was weakly expressed on their cell membrane. 15809709 Human
cd105 tumour Moreover, these data suggest that CD105 is involved in the regulation of TGF-beta effects in human solid malignancies, and therefore it could play an important role in tumour diagnosis and treatment. 15809709 Human
cd105 glioblastoma AIM: To compare endoglin (CD105) and the pan-endothelial marker CD31 in the assessment of angiogenesis in glioblastoma and to evaluate their values in the prognosis of this malignancy. 15861521 Human
cd105 malignancy AIM: To compare endoglin (CD105) and the pan-endothelial marker CD31 in the assessment of angiogenesis in glioblastoma and to evaluate their values in the prognosis of this malignancy. 15861521 Human
cd105 glioblastoma CONCLUSION: CD105 is a more sensitive marker than CD31 in the evaluation of angiogenesis in glioblastoma. 15861521 Human
cd105 glioblastoma Our study is the first report of the better prognostic significance of angiogenesis evaluated with CD105 rather than with CD31 in glioblastoma. 15861521 Human
cd105 lung cancer In lung cancer cell lines, CpG island methylation was frequently detected for TIMP4 (64%), SOX18 (73%), EGF-like domain 7 (56%), CD105 (71%), SEMA2 (55%), RASSF1A (71%), p16 (56%) SLIT2 (100%) and TIMP3 (29%). 15911247 Human
cd105 primary lung tumours In primary lung tumours, methylation of TIMP4 (94%), SOX18 (100%), EGF-like domain 7 (100%), CD105 (69%), SEMA2 (93%), DLC1 (61%), RASSF1A (44%), p16 (47%), SLIT2 (100%) and TIMP3 (13%) was also detected. 15911247 Human
cd105 head and neck basaloid squamous cell carcinoma Endoglin (CD105) expression in head and neck basaloid squamous cell carcinoma. 15966703 Human
cd105 tumour Endoglin (CD105) has been shown to be a useful marker for identifying proliferating endothelium involved in tumour angiogenesis. 15966703 Human
cd105 tumor Approximately 85% of tumor vessels have uniform CD31 and/or CD105 immunoreactivity, but the remainder have focal regions that lack these common endothelial markers. 15994949 Human
cd105 tumors Eleven percent of vessels in orthotopic tumors and 24% of vessels in ectopic tumors had defects in CD31 and CD105 staining measuring on average 10.8 microm (range, 1-41.2 microm). 15994949 Human
cd105 tumor Thus, most regions of tumor vessels that lack CD31 and CD105 immunoreactivity represent attenuated endothelial cells with abnormal expression of endothelial cell markers, but some are gaps between endothelial cells. 15994949 Human
cd105 tumor angiogenesis Endoglin (CD105) is a proliferation-associated protein that is strongly expressed in endothelial tissue and has a role in tumor angiogenesis. 15849752 Human
cd105 esophageal adenocarcinoma Endoglin (CD105) and vascular endothelial growth factor as prognostic markers in esophageal adenocarcinoma. 16153457 Human
cd105 tumor angiogenesis Endoglin (CD105), a member of transforming growth factor beta1 receptor complex, has been shown to be a more useful marker to identify tumor angiogenesis than panendothelial markers such as CD31. 16153457 Human
endoglin malignant tumors Patients with malignant tumors expressing TGF-beta 1, T beta R-I, or endoglin in blood vessels demonstrated longer survival than those having negatively stained tumors. 7637321 Human
endoglin solid tumors In this chapter, we review progress in this "vascular targeting" approach, from the validation of the concept in a mouse model to the characterization of the TEC-11 antibody against endoglin, an endothelial cell proliferation marker that is upre 8534871 Mouse
endoglin ks We investigated the expression of TGF-beta, TGF-beta receptors types I and II, and endoglin, a nonsignaling-type TbetaR-III, by means of immunohistochemistry on skin biopsies from patients with AIDS-related KS. 9815902 Human
endoglin ks Endoglin was weakly expressed on all KS lesions and stained the endothelium of tumor-associated vessels in 92% of the samples. 9815902 Human
endoglin solid tumors Up-regulation of endoglin on vascular endothelial cells in human solid tumors: implications for diagnosis and therapy. 9815965 Human
endoglin solid tumors Endoglin is a suitable target for efficient imaging of solid tumors: in vivo evidence in a canine mammary carcinoma model. 10815930 others
endoglin solid tumors Increasing evidence suggests that endoglin (CD105) is a new powerful marker of neovascularization in solid malignancies; thus, using breast cancer as a model, we investigated whether targeting of CD105 by monoclonal antibody (mAb) MAEND3 can be used for i 10815930 Human
endoglin ca Endoglin was stained on 5-microm slide sections by the DAKO Catalyzed Signal Amplification method (DAKO Corporation, Carpinteria, CA). 10908767 Human
endoglin other tumors The endoglin system was more sensitive for staining capillaries in neoplastic cervical tissue, better predicted lymph node metastases, and should be widely applicable for the study of other tumors. 10908767 Human
endoglin lung tumors In this study, we performed a detailed analysis of endoglin expression in human lung tumors and different tumor and endothelial cell lines, employing reverse-transcriptase-polymerase-chain reaction as well as immunoblotting and immunohistochemistry using 10225446 NA
endoglin solid tumors In this report, we present data indicating that the increased serum endoglin (EDG; CD105) quantitated by a double-antibody sandwich assay is associated with metastasis in patients with solid tumors including colorectal and breast carcinomas. 11297243 Human
endoglin squamous cell carcinoma of the oral cavity Endoglin (CD105) expression in squamous cell carcinoma of the oral cavity. 11891945 Human
endoglin cll These analyses revealed that CLL B cells consistently express mRNA for VEGF receptor 1 (VEGFR1), thrombin receptor, endoglin, and angiopoietin. 11986954 Human
endoglin hcc RESULTS: Significant increases in VEGF, VEGFR3, endoglin and CD31 mRNA expressions were noted in HCC rather than in SL. 12017318 Human
endoglin neoplasias In human neoplasias of different histotype, Endoglin is mainly present on endothelial cells of both peri- and intra-tumoral blood vessels, while it is weakly expressed or absent on neoplastic cells. 12699349 Human
endoglin neoplasias In this review we will summarize the complex of experimental evidences pointing to Endoglin as a vascular target to design innovative bioimmunotherapeutic strategies in human neoplasias. 12699349 Human
endoglin tumors Microarray and subsequent Northern blot and semiquantitative reverse transcription-PCR analyses revealed both a decrease (fibroblast growth factor 1, transforming growth factor beta1, platelet-derived growth factor alpha, erbB2, and c-ets1,) and an increa 14519649 Human
endoglin solid tumors Endoglin (CD105) is a proliferation-associated cell membrane antigen of endothelial cells and strongly expressed in the angiogenic vasculature of solid tumors. 14639611 Human
endoglin colorectal cancer Endoglin (CD105) and vascular endothelial growth factor as prognostic markers in colorectal cancer. 14657950 Human
endoglin tumor angiogenesis Endoglin (CD105) has been shown to be a more useful marker to identify proliferating endothelium involved in tumor angiogenesis than panendothelial markers such as CD31. 14657950 Human
endoglin colorectal cancer We investigated endoglin and vascular endothelial growth factor expression as possible prognostic markers in colorectal cancer. 14657950 Human
endoglin colorectal carcinomas Surgical specimens from 150 patients with resected colorectal carcinomas were immunostained for endoglin, CD31 and vascular endothelial growth factor. 14657950 Human
endoglin lymph-node metastases There was a positive correlation of endoglin, CD31 counts and vascular endothelial growth factor overexpression with the presence of angiolymphatic invasion and lymph node metastases (P<0.05). 14657950 Human
endoglin liver metastases Only endoglin counts correlated significantly with liver metastases and positive vascular pedicle lymph nodes (P<0.05), while vascular endothelial growth factor showed significant correlation with the depth of invasion (P<0.01). 14657950 Human
endoglin tumor angiogenesis Endoglin, by staining higher numbers of the proliferating vessels in colon carcinoma, is a more specific and sensitive marker for tumor angiogenesis than the commonly used panendothelial markers. 14657950 Human
endoglin colon carcinoma Endoglin, by staining higher numbers of the proliferating vessels in colon carcinoma, is a more specific and sensitive marker for tumor angiogenesis than the commonly used panendothelial markers. 14657950 Human
endoglin metastases to lymph nodes Endoglin staining also showed prognostic significance with positive correlation with angiolymphatic invasion and metastases to lymph nodes and liver. 14657950 Human
endoglin tumor CD105 (endoglin) is significantly expressed in activated endothelial cells in culture and in tumor microvessels. 14978873 Human
endoglin malignancy The former, an inherited gastrointestinal malignancy predisposition, is caused by mutations in MADH4 (encoding SMAD4) or BMPR1A, and the latter is a vascular malformation disorder caused by mutations in ENG (endoglin) or ACVRL1 (ALK1). 15031030 Human
endoglin malignant tumors CD105 (endoglin) has been reported as expressed by activated endothelial cells and consequently should better reflect neoangiogenesis in malignant tumors. 15067342 Human
endoglin squamous cell carcinoma of the oral cavity Endoglin may have a significant role in the development of squamous cell carcinoma of the oral cavity and might be relatively more specific than commonly used endothelial markers. 15113577 Human
endoglin prostate cancer Whole-mount prostate sections reveal differential endoglin expression in stromal, epithelial, and endothelial cells with the development of prostate cancer. 15175661 Human
endoglin localized prostate cancer We studied endoglin expression in whole-mount prostate sections from 64 patients with localized prostate cancer, assessing reactivity in the epithelium, the stroma, and blood vessels. 15175661 NA
endoglin prostate cancer Changes in endoglin expression in PIN and malignant cells, the surrounding stroma, and related blood vessels, suggest that endoglin function may be altered in prostate cancer. 15175661 Human
endoglin arteriovenous malformations Mutations in the human endoglin gene result in hereditary hemorrhagic telangiectasia type 1, a vascular disorder characterized by multisystemic vascular dysplasia, arteriovenous malformations, and focal dilatation of postcapillary venules. 15084601 Human
endoglin tumors Active immunotherapy of tumors with a recombinant xenogeneic endoglin as a model antigen. 15214049 Human
endoglin mouse tumor We found that immunotherapy with porcine endoglin was effective at both protective and therapeutic anti-tumor immunity in several mouse tumor models. 15214049 Rat
endoglin tumor The increased apoptotic cells were found within the tumor tissues from the mice treated with porcine endoglin. 15214049 Rat
endoglin tumours CD105 (endoglin) is an important component of the transforming growth factor-beta (TGF-beta) receptor complex and is highly expressed in endothelial cells in tissues undergoing angiogenesis such as healing wounds, infarcts and in a wide range of tumours. 15274293 Human
endoglin human breast cancer mRNA expression of the angiogenesis markers VEGF and CD105 (endoglin) in human breast cancer. 15274325 Human
endoglin tumor angiogenesis BACKGROUND: Both VEGF and CD105 (endoglin) have been identified as markers of tumor angiogenesis and prognosis in breast cancer. 15274325 Human
endoglin breast cancer BACKGROUND: Both VEGF and CD105 (endoglin) have been identified as markers of tumor angiogenesis and prognosis in breast cancer. 15274325 Human
endoglin tumors OBJECTIVE: To study, by means of reverse-transcription polymerase chain reaction (RT-PCR), the expression of VEGF and CD105 (endoglin) at the mRNA level in a series of breast cancers and to correlate the results obtained with all available clinical and bi 15274325 NA
endoglin breast cancers OBJECTIVE: To study, by means of reverse-transcription polymerase chain reaction (RT-PCR), the expression of VEGF and CD105 (endoglin) at the mRNA level in a series of breast cancers and to correlate the results obtained with all available clinical and bi 15274325 NA
endoglin breast cancer MATERIALS AND METHODS: Fresh tumor tissue from 103 previously untreated breast cancer patients was studied for VEGF and CD105 (endoglin) expression. 15274325 NA
endoglin fresh tumor MATERIALS AND METHODS: Fresh tumor tissue from 103 previously untreated breast cancer patients was studied for VEGF and CD105 (endoglin) expression. 15274325 NA
endoglin human tumors In both the rat model and in the human tumors, the proliferation index and vascular count, as determined by Ki-67 staining and endoglin and/or factor VIII-related antigen staining, inversely correlated with pigment epithelium-derived factor mRNA levels. 15313905 Human
endoglin tumor angiogenesis We found that both low-dosage cisplatin and xenogeneic endoglin vaccine individually resulted in effective suppression of tumor growth in 2 tumor models via inhibition of tumor angiogenesis. 15382054 Mouse
endoglin tumor We found that both low-dosage cisplatin and xenogeneic endoglin vaccine individually resulted in effective suppression of tumor growth in 2 tumor models via inhibition of tumor angiogenesis. 15382054 Mouse
endoglin tumor Because endoglin is up-regulated in the vasculature of many solid tumors, this antibody molecule should be capable of lysing tumor endothelial cells and thus destroying the vascular bed of the tumor. 14770081 Human
endoglin solid tumors Because endoglin is up-regulated in the vasculature of many solid tumors, this antibody molecule should be capable of lysing tumor endothelial cells and thus destroying the vascular bed of the tumor. 14770081 Human
endoglin chronic idiopathic myelofibrosis Chronic idiopathic myelofibrosis: independent prognostic importance of bone marrow microvascular density evaluated by CD105 (endoglin) immunostaining. 15272276 Human
endoglin hepatocellular carcinoma Clinicopathological and prognostic implications of endoglin (CD105) expression in hepatocellular carcinoma and its adjacent non-tumorous liver. 15633211 Human
endoglin hepatocellular carcinoma (hcc) AIM: The expression pattern of endoglin (CD105) in hepatocellular carcinoma (HCC) has not been reported so far. 15633211 Human
endoglin oral squamous-cell carcinomas Various immunostaining patterns of CD31, CD34 and endoglin and their relationship with lymph node metastasis in oral squamous cell carcinomas. 15641985 Human
endoglin lymph-node metastasis Various immunostaining patterns of CD31, CD34 and endoglin and their relationship with lymph node metastasis in oral squamous cell carcinomas. 15641985 Human
endoglin squamous-cell carcinomas Methods: Here, we used a panel of three antibodies (CD31, CD34, and endoglin) as blood vessel markers to investigate the distribution and properties of blood vessels in normal oral tissues and squamous cell carcinomas. 15641985 NA
endoglin cancer Ang 2 was significantly correlated to GS, density of endoglin stained blood vessels, metastases, and to cancer specific survival. 15378518 Human
endoglin metastases Ang 2 was significantly correlated to GS, density of endoglin stained blood vessels, metastases, and to cancer specific survival. 15378518 Human
endoglin breast cancer [Clinicopathologic significance of CD105 mRNA expression in human breast carcinoma] OBJECTIVE: To study endoglin (CD105) gene expression in breast cancer and its clinicopathologic significance. 15771797 NA
endoglin arteriovenous malformations Hereditary hemorrhagic telangiectasia type 1 (HHT1) is a vascular disorder associated with ENDOGLIN (ENG) haploinsufficiency and characterized by venous dilatations, focal loss of capillaries, and arteriovenous malformations (AVMs). 15718503 Human
endoglin human tumour Differential expression and cytoplasm/membrane distribution of endoglin (CD105) in human tumour cell lines: Implications in the modulation of cell proliferation. 15809709 Human
endoglin human tumour Endoglin (CD105, an accessory component of the TGF-beta receptor complex) expression and distribution on different human tumour cells and its role in cellular proliferation were evaluated. 15809709 Human
endoglin tumour These data reflect endoglin expression by the normal counterparts of tumour cell lines, i.e. NHDF and 293 cells. 15809709 Human
endoglin sarcoma The results indicated that endoglin is differentially expressed in human carcinoma and sarcoma cells and its overexpression modulates the proliferative rate of human solid tumour cells. 15809709 Human
endoglin carcinoma The results indicated that endoglin is differentially expressed in human carcinoma and sarcoma cells and its overexpression modulates the proliferative rate of human solid tumour cells. 15809709 Human
endoglin solid tumour The results indicated that endoglin is differentially expressed in human carcinoma and sarcoma cells and its overexpression modulates the proliferative rate of human solid tumour cells. 15809709 Human
endoglin glioblastoma Endoglin Is a Better Marker than CD31 in Evaluation of Angiogenesis in Glioblastoma. 15861521 Human
endoglin glioblastoma AIM: To compare endoglin (CD105) and the pan-endothelial marker CD31 in the assessment of angiogenesis in glioblastoma and to evaluate their values in the prognosis of this malignancy. 15861521 Human
endoglin malignancy AIM: To compare endoglin (CD105) and the pan-endothelial marker CD31 in the assessment of angiogenesis in glioblastoma and to evaluate their values in the prognosis of this malignancy. 15861521 Human
endoglin melanomas This review seeks to examine the present knowledge about TGF-beta receptor/SMAD signaling pathway and its related genes (SMADs, SKI, Filamin, endoglin, Follistatin, and other molecules) in melanomas. 15953371 Human
endoglin head and neck basaloid squamous cell carcinoma Endoglin (CD105) expression in head and neck basaloid squamous cell carcinoma. 15966703 Human
endoglin tumour Endoglin (CD105) has been shown to be a useful marker for identifying proliferating endothelium involved in tumour angiogenesis. 15966703 Human
endoglin tumor angiogenesis Endoglin (CD105) is a proliferation-associated protein that is strongly expressed in endothelial tissue and has a role in tumor angiogenesis. 15849752 Human
endoglin arteriovenous malformations Endoglin (ENG) and ALK-1 mutations cause hereditary hemorrhagic telangiecstasia (HHT), an autosomal dominant disorder leading to vascular dysplasia in the form of mucocutaneous telangiectasia and visceral arteriovenous malformations (AVMs). 16059938 Human
endoglin esophageal adenocarcinoma Endoglin (CD105) and vascular endothelial growth factor as prognostic markers in esophageal adenocarcinoma. 16153457 Human
endoglin tumor angiogenesis Endoglin (CD105), a member of transforming growth factor beta1 receptor complex, has been shown to be a more useful marker to identify tumor angiogenesis than panendothelial markers such as CD31. 16153457 Human
endoglin esophageal adenocarcinoma We investigated endoglin and vascular endothelial growth factor (VEGF) expression as possible prognostic markers in esophageal adenocarcinoma. 16153457 Human
endoglin esophageal adenocarcinoma Surgical specimens from 75 patients with esophageal adenocarcinoma treated with esophagectomy were immunostained for endoglin, CD31, and VEGF. 16153457 Human
endoglin metastases Only endoglin MV count was significantly correlated with the presence of angiolymphatic invasion (r = 0.34, P < .05) and lymph node (LN) metastases (r = 0.48, P < .001). 16153457 Human
endoglin barrett's esophagus Endoglin showed a significant increase in MV count in Barrett's esophagus with high-grade dysplasia when compared with Barrett's esophagus low-grade dysplasia (P < .01), whereas CD31 did not show any significant difference. 16153457 Human
endoglin tumor angiogenesis In conclusion, endoglin is a specific and sensitive marker for tumor angiogenesis. 16153457 Human
endoglin tumor Endoglin staining also showed prognostic significance with positive correlation with the presence of angiolymphatic invasion, LN metastases, tumor stage, and survival. 16153457 Human
endoglin metastases Endoglin staining also showed prognostic significance with positive correlation with the presence of angiolymphatic invasion, LN metastases, tumor stage, and survival. 16153457 Human
endoglin tumor The fraction of resected prostate tissue containing cancer, the micro-vessel density (v.d.) when stained for endoglin or von Willebrand factor (vWf), and the percentage of Ki-67 labeled tumor cells were measured using immunohistochemistry. 15990221 Human
endoglin cancer The fraction of resected prostate tissue containing cancer, the micro-vessel density (v.d.) when stained for endoglin or von Willebrand factor (vWf), and the percentage of Ki-67 labeled tumor cells were measured using immunohistochemistry. 15990221 Human
endoglin tumors RESULTS: High levels of vWf v.d., endoglin v.d., and percent cancer of the TURP specimen were significantly associated with short cancer-specific survival in Kaplan-Meier analysis of all patients with GS 6 and 7 tumors. 15990221 Human
endoglin cancer RESULTS: High levels of vWf v.d., endoglin v.d., and percent cancer of the TURP specimen were significantly associated with short cancer-specific survival in Kaplan-Meier analysis of all patients with GS 6 and 7 tumors. 15990221 Human
eng malignancy The former, an inherited gastrointestinal malignancy predisposition, is caused by mutations in MADH4 (encoding SMAD4) or BMPR1A, and the latter is a vascular malformation disorder caused by mutations in ENG (endoglin) or ACVRL1 (ALK1). 15031030 Human
eng arteriovenous malformations Hereditary hemorrhagic telangiectasia type 1 (HHT1) is a vascular disorder associated with ENDOGLIN (ENG) haploinsufficiency and characterized by venous dilatations, focal loss of capillaries, and arteriovenous malformations (AVMs). 15718503 Human
eng arteriovenous malformations Endoglin (ENG) and ALK-1 mutations cause hereditary hemorrhagic telangiecstasia (HHT), an autosomal dominant disorder leading to vascular dysplasia in the form of mucocutaneous telangiectasia and visceral arteriovenous malformations (AVMs). 16059938 Human
hht1 arteriovenous malformations Hereditary hemorrhagic telangiectasia type 1 (HHT1) is a vascular disorder associated with ENDOGLIN (ENG) haploinsufficiency and characterized by venous dilatations, focal loss of capillaries, and arteriovenous malformations (AVMs). 15718503 Human
cd-105 invasive cancer The microvessels within the invasive cancer were highlighted by means of immuno-cytochemical staining to detect CD-31 and CD-105 antigen. 14674140 Human

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