IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene AK1 Ensembl ENSG00000106992 Chromosome 9 Start 129668580 End 129679843
Description Adenylate kinase isoenzyme 1 (AK 1)(EC 2.7.4.3)(ATP-AMP transphosphorylase 1)(Myokinase) [Source:UniProtKB/Swiss-Prot;Acc:P00568]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 361
     Entrez Gene : 203
     UCSC : uc004bsm.3
     GeneCards : 361
     RefSeq : NM_000476
     CCDS : CCDS6881.1
     Uniprot : P00568
     Interpro : P00568
     OMIM : 103000
     GeneTests : AK1
     CGAP : AK1

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  36997_at  -0.81  2.08e-6  1.27e-5  -1.96  2.43e-16  1.00e-14
 HG_U133A  202587_s_at  -1.13  9.37e-26  1.09e-24  -2.66  4.77e-91  2.55e-90
 HG_U133A  202588_at  -0.97  2.29e-18  1.59e-17  1.65  1.39e-43  2.85e-43
 HG_U133_Plus2  202587_s_at  -1.23  5.87e-22  1.68e-20  -2.21  5.01e-39  8.10e-37
 HG_U133_Plus2  202588_at  -0.89  9.41e-10  6.60e-9  -1.85  2.32e-27  7.72e-26
 Stanford  6357  -0.50  3.22e-1  5.24e-1  -1.25  1.00e-1  2.73e-1
 Stanford  10360  0.30  6.66e-1  8.04e-1  0.12  8.67e-1  9.41e-1
 Agilent_HS_21.6K  10909  -0.27  2.85e-2  9.77e-2  -0.61  2.01e-11  1.45e-9

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202587_s_at  0.13  7.12e-1  9.69e-1  -0.25  1.44e-1  1.00e+0
 HG_U133A  202588_at  -0.08  8.43e-1  9.88e-1  -0.07  7.02e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 36997_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202587_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202588_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202587_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202588_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 6357    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 10360    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 10909    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
adenylate kinase 1 tumor The levels of adenylate kinase 1, beta-enolase, creatine kinase M chain, hemoglobin beta chain and prohibitin were statistically increased whereas the level of a creatine kinase fragment, which is undocumented, was decreased in the tumor of vaccinated mic 15717328 Mouse
ak1 mouse neuroblastoma To investigate if AK isoenzymes have a comparable function in the energy-demand management of proliferating cells, AK1 and AK1beta were expressed in mouse neuroblastoma N2a cells and in human colon carcinoma SW480 cells. 15194428 Human
ak1 human colon carcinoma To investigate if AK isoenzymes have a comparable function in the energy-demand management of proliferating cells, AK1 and AK1beta were expressed in mouse neuroblastoma N2a cells and in human colon carcinoma SW480 cells. 15194428 Human
ak1 chronic myeloid leukemia (cml) Hybrid cell lines were derived from fusion of rodent cells with leukocytes from a t(9q+; 22q-)-positive chronic myeloid leukemia (CML) patient carrying a chromosome No. 9-linked adenylate kinase-1 (AK1) polymorphism (AK1 1-2). 6286097 Human
ak1 human tumor A large collection of cultured human tumor cell lines was characterized for the phenotypes of 16 polymorphic enzyme loci: ACP1, ADA, AK1, ESD, FUCA, GLO1, GOT2, G6PD, ME2, PEPA, PEPB, PEPC, PEPD, PGD, PGM1, and PGM3 primarily to detect and monitor against 6935474 Human
ak1 embryonal carcinoma When mouse embryonal carcinoma P19 cells were differentiated by retinoic acid into neural cells, the amount of AK1 protein and enzyme activity increased about fivefold concomitantly with neurofilament (NF). 9648858 Mouse
adenylate kinase-1 chronic myeloid leukemia Clonal origin of the Philadelphia translocation in chronic myeloid leukemia demonstrated in somatic cell hybrids using an adenylate kinase-1 polymorphism. 6286097 Human
adenylate kinase-1 chronic myeloid leukemia (cml) Hybrid cell lines were derived from fusion of rodent cells with leukocytes from a t(9q+; 22q-)-positive chronic myeloid leukemia (CML) patient carrying a chromosome No. 9-linked adenylate kinase-1 (AK1) polymorphism (AK1 1-2). 6286097 Human

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