IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene LCN2 Ensembl ENSG00000148346 Chromosome 9 Start 129951171 End 129955555
Description Neutrophil gelatinase-associated lipocalin Precursor (NGAL)(p25)(25 kDa alpha-2-microglobulin-related subunit of MMP-9)(Lipocalin-2)(Oncogene 24p3) [Source:UniProtKB/Swiss-Prot;Acc:P80188]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6526
     Entrez Gene : 3934
     UCSC : uc004bto.1
     GeneCards : 6526
     RefSeq : NM_005564
     CCDS : CCDS6892.1
     Uniprot : P80188
     Interpro : P80188
     OMIM : 600181
     GeneTests : LCN2
     CGAP : LCN2
     PMID : 7683678

< Top >


Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  32821_at  1.16  2.88e-4  1.05e-3  0.57  1.36e-1  2.12e-1
 HG_U133A  212531_at  1.84  1.37e-15  7.73e-15  1.30  2.32e-21  3.44e-21
 HG_U133_Plus2  212531_at  0.98  4.35e-4  1.22e-3  0.27  3.44e-1  4.05e-1
 Stanford  23438  1.34  1.51e-1  3.26e-1  0.62  3.06e-1  5.46e-1
 Agilent_HS_21.6K  18368  -0.16  4.34e-1  6.17e-1  -0.06  7.95e-1  8.72e-1

< Top >


Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  212531_at  -0.88  3.92e-1  8.96e-1  -0.55  2.93e-1  1.00e+0

< Top >


Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 32821_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 212531_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 212531_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 23438    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 18368    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

< Top >


Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ngal squamous-cell carcinoma However, strong induction of NGAL in the epidermis was seen in a variety of skin disorders characterized by dysregulated epithelial differentiation such as psoriasis, pityriasis rubra and squamous cell carcinoma. 12473066 Human
ngal basal-cell carcinoma In these tissues production of NGAL was confined to spatially distinct subpopulations of keratinocytes underlying areas of parakeratosis, whereas skin samples lacking parakeratotic epithelium such as lichen ruber planus, acute contact eczema and basal cel 12473066 Human
ngal human breast carcinoma Finally, the biochemical consequences of the NGAL and MMP-9 interaction were investigated both in vitro using recombinant human NGAL and MMP-9 and in cell culture by overexpressing NGAL in human breast carcinoma cells. 11486009 Human
ngal chondrosarcoma In adult cartilage NRL/NGAL was expressed in articular cartilage from osteoarthritic patients and in chondrosarcoma. 11058755 Human
lcn2 rat mammary carcinomas The expression of rat 24p3, encoded by the Lcn2 gene, has been associated with rat mammary carcinomas initiated by the neu oncogene (Stoesz and Gould, 1995). 10702692 Human
ngal adenocarcinomas High NGAL levels were found in adenocarcinomas of lung, colon and pancreas. 10475571 Human
ngal renal-cell carcinomas In contrast, renal cell carcinomas of various subtypes and prostate cancers contained low NGAL levels. 10475571 Human
ngal prostate cancers In contrast, renal cell carcinomas of various subtypes and prostate cancers contained low NGAL levels. 10475571 Human
ngal lymphomas Lymphomas and thymic tumours were negative for NGAL immuno-labeling. 10475571 Human
ngal tumours Lymphomas and thymic tumours were negative for NGAL immuno-labeling. 10475571 Human
ngal pancreatic cancer By screening an SST library derived from pancreatic cancer cells, we identified two secretory proteins (neutrophil gelatinase-associated lipocalin (NGAL) and lung surfactant protein D) and three membrane proteins (carcinoembryonic antigen, BiP/GRP78 and H 9464512 Human
ngal pancreatic cancer NGAL mRNA was expressed in eight of the pancreatic cancer cell lines and eight pancreatic cancer tissues. 9464512 Human
ngal hepatic tumors The expression of NGAL mRNA was also observed in colorectal and hepatic tumors. 9464512 Human
ngal primary breast cancers Heterogeneous expression of the lipocalin NGAL in primary breast cancers. 9842963 Human
ngal breast cancers When breast cancers were examined for NGAL mRNA and protein levels, they were found to exhibit heterogeneous expression. 9842963 Human
ngal tumors NGAL levels varied in these tumors from undetectable to exceeding those in normal breast parenchyma. 9842963 Human
ngal breast carcinoma Immuno-histochemical analysis confirmed the presence of NGAL within breast carcinoma cells but detected only low levels of this protein in normal ductal epithelium. 9842963 Human
ngal breast tumors Interestingly, unlike NRL in rat mammary carcinomas, no significant association between NGAL expression and HER-2/neu activation was found in human breast tumors. 9842963 Human
ngal rat mammary carcinomas Interestingly, unlike NRL in rat mammary carcinomas, no significant association between NGAL expression and HER-2/neu activation was found in human breast tumors. 9842963 Human
ngal breast cancer In contrast, a significant correlation between NGAL expression in breast cancer was found with several other markers of poor prognosis, including estrogen and progesterone receptor-negative status and high proliferation (S-phase fraction). 9842963 Human
ngal breast cancers NGAL levels were stratified as high or low in breast cancers from a cohort of node-positive patients with known outcome. 9842963 Human
ngal inflammatory bowel diseases Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases. 8675096 Human
ngal inflammatory bowel disease A very high expression of NGAL was seen in colonic epithelium in areas of inflammation, both in non-malignant epithelium (diverticulitis, inflammatory bowel disease, and appendicitis) as well as in premalignant and malignant neoplastic lesions of the colo 8675096 Human
ngal adenocarcinoma In adenocarcinoma, the NGAL expression was especially abundant in the transitional mucosa and in the superficial ulcerated area. 8675096 Human
ngal adenocarcinomas On the other hand, no NGAL expression could be detected in lymph node metastases from these adenocarcinomas. 8675096 Human
ngal lymph-node metastases On the other hand, no NGAL expression could be detected in lymph node metastases from these adenocarcinomas. 8675096 Human
lcn2 human colorectal cancer Real-time reverse transcription-PCR analysis of human colorectal cancer cell lines and adenocarcinomas revealed that altered expression levels were also observed for six of the genes Igfbp5, Lcn2, Ly6d, N4wbp4 (PMEPA1), S100c, and Sox4. 15665292 Human
lcn2 adenocarcinomas Real-time reverse transcription-PCR analysis of human colorectal cancer cell lines and adenocarcinomas revealed that altered expression levels were also observed for six of the genes Igfbp5, Lcn2, Ly6d, N4wbp4 (PMEPA1), S100c, and Sox4. 15665292 Human
lcn2 hcc We also identified a set of genes that encode secreted (e.g. GPC3, LCN2, and DKK1) or membrane-bound proteins (e.g. GPC3, IGSF1, and PSK-1), which may be attractive candidates for the diagnosis of HCC. 15735714 Human
lipocalin 2 pancreatic carcinomas Some of the up-regulated genes in this study have been previously described in classical pancreatic carcinomas such as lipocalin 2, galectin 3, claudin 4, and cathepsin E. 12000726 Human
lipocalin 2 breast cancer These results demonstrate that normal and cancerous estrogen receptor-positive cells are distinct at the molecular level and suggest that lipocalin 2 is a new therapeutic target for breast cancer prevention and treatment. 12183401 Human
lipocalin 2 liver tumors In conclusion, these results identify distinguishing features between non-genotoxic and genotoxic carcinogen derived liver tumors as well as genes that are upregulated in both types and suggest that RIKEN cDNA, Ly-6D and lipocalin 2 in particular appear t 12771043 Mouse
lipocalin 2 breast cancer We also found a significant difference in the methylation patterns of maspin and two previously identified hypomethylated genes (trefoil factor 2 and lipocalin 2) between pancreatic and breast cancer cell lines, suggesting cancer-type specificity for some 14716296 Human
lipocalin 2 pancreatic adenocarcinoma Numerous genes were identified as being differentially expressed, some of which have been previously implicated in pancreatic adenocarcinoma (S100P, S100A4, prostate stem cell antigen, lipocalin 2, claudins 3 and 4, trefoil factors 1 and 2) as well as sev 15305381 Human
lipocalin 2 pancreatic cancers A total of 170 unique proteins were identified including known pancreatic cancer tumor markers (e.g., CEA, MUC1) and proteins overexpressed in pancreatic cancers (e.g., hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP) and lipoc 15473694 Human
lipocalin 2 pancreatic cancer A total of 170 unique proteins were identified including known pancreatic cancer tumor markers (e.g., CEA, MUC1) and proteins overexpressed in pancreatic cancers (e.g., hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP) and lipoc 15473694 Human
lipocalin 2 metastasis Lipocalin 2 diminishes invasiveness and metastasis of Ras-transformed cells. 15691834 Human
lipocalin 2 tumor We found that lipocalin 2 could also convert 4T1-Ras-transformed mesenchymal tumor cells to an epithelial phenotype, increase E-cadherin expression, and suppress cell invasiveness in vitro and tumor growth and lung metastases in vivo. 15691834 Human
lipocalin 2 mesenchymal tumor We found that lipocalin 2 could also convert 4T1-Ras-transformed mesenchymal tumor cells to an epithelial phenotype, increase E-cadherin expression, and suppress cell invasiveness in vitro and tumor growth and lung metastases in vivo. 15691834 Human
lipocalin 2 lung metastases We found that lipocalin 2 could also convert 4T1-Ras-transformed mesenchymal tumor cells to an epithelial phenotype, increase E-cadherin expression, and suppress cell invasiveness in vitro and tumor growth and lung metastases in vivo. 15691834 Human
lipocalin 2 metastasis These data characterize lipocalin 2 as an epithelial inducer in Ras malignancy and a suppressor of metastasis. 15691834 Human
lipocalin 2 malignancy These data characterize lipocalin 2 as an epithelial inducer in Ras malignancy and a suppressor of metastasis. 15691834 Human
ngal neoplasia Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases. 8675096 Human
ngal malignancy The NRL homologue in mouse is SIP24, an acute phase protein induced in the animal by turpentine injection; the human homologous protein is NGAL expressed in granulocytes and epithelial cells in pathological conditions, such as inflammation and malignancy. 10777108 Human
ngal malignancy The possible mammalian counterpart is the Neu-related lipocalin (NRL), a lipocalin overexpressed in rat mammary cancer; NRL is homologous to the human neutrophil gelatinase associated lipocalin (NGAL) expressed in granulocytes and in epithelial cells in i 11058755 Human
ngal adenocarcinomas of lung High NGAL levels were found in adenocarcinomas of lung, colon and pancreas. 10475571 Human
ngal thymic tumours Lymphomas and thymic tumours were negative for NGAL immuno-labeling. 10475571 Human
ngal esophageal carcinoma [Cloning and identification of 5'-untranslated region (UTR) and 3'-untranslated region of neutrophil gelatinase-associated lipocalin (NGAL) gene from esophageal carcinoma cell line SHEEC] BACKGROUND & OBJECTIVE: Neutrophil gelatinase-associated 12600287 Human
ngal esophageal carcinoma The authors previously found that NGAL was overexpressed in the progress of malignant transformation from human immortalized esophageal epithelial cell line SHEE to esophageal carcinoma cell line SHEEC. 12600287 Human
ngal cancer [Functions of neutrophil gelatinase-associated lipocalin in the esophageal carcinoma cell line SHEEC] Neutrophil gelatinase-associated lipocalin (NGAL) is a novel member of the lipocalin family and may be a new human oncogene product, but function of NGAL 12621549 Human
ngal esophageal carcinoma It was recently found that NGAL was overexpressed in the progression of malignant transformation from human immortalized esophageal epithelial cell line SHEE to esophageal carcinoma cell line SHEEC. 12621549 Human
ngal tumor The effects of blocking transcription of NGAL gene on invasion, division and proliferation of SHEEC cells were studied by antisense blocking RNA technique and tumor formation in nude mice. 12621549 Human
ngal tumor These results indicate that NGAL is possibly involved in invasion of tumor cells by regulating activity of MMP-9 and MMP-2, but is not apparently related with division and proliferation of tumor cells in SHEEC. 12621549 Human
ngal cyst The suppression of Ngal expression using short hairpin RNA results in increased cyst formation by tubular cells. 15637066 Mouse
ngal breast cancer PURPOSE: Having previously shown that the binding of neutrophil gelatinase-associated lipocalin (NGAL) to matrix metalloproteinase-9 (MMP-9) protects this extracellular matrix remodeling enzyme from autodegradation, we hypothesized that the addition of NG 16061852 Human
ngal breast cancer EXPERIMENTAL DESIGN: Clones of MCF-7 human breast cancer cells differentially expressing NGAL were generated by stable transfection with human NGAL expression constructs. 16061852 Human
ngal mcf-7 human breast cancer EXPERIMENTAL DESIGN: Clones of MCF-7 human breast cancer cells differentially expressing NGAL were generated by stable transfection with human NGAL expression constructs. 16061852 Human
ngal cancer Based on our previous reports that MMPs can be detected in the urine of cancer patients, we also asked whether MMP-9/NGAL could be detected in the urine of breast cancer patients and whether it might be predictive of disease status. 16061852 Human
ngal breast cancer In addition, we analyzed the urine of individuals with breast cancer and age-matched, sex-matched controls using gelatin zymography for the presence of MMP-9/NGAL. 16061852 Human
ngal breast cancer CONCLUSIONS: These findings suggest, for the first time, that NGAL may play an important role in breast cancer in vivo by protecting MMP-9 from degradation thereby enhancing its enzymatic activity and facilitating angiogenesis and tumor growth. 16061852 Human
ngal tumor CONCLUSIONS: These findings suggest, for the first time, that NGAL may play an important role in breast cancer in vivo by protecting MMP-9 from degradation thereby enhancing its enzymatic activity and facilitating angiogenesis and tumor growth. 16061852 Human

< Top >


Download all image files.
Save all PNG files.    Save all PDF files.    Save all PS files.