IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CIZ1 Ensembl ENSG00000148337 Chromosome 9 Start 129968165 End 130006483
Description Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1)(Nuclear protein NP94)(Zinc finger protein 356) [Source:UniProtKB/Swiss-Prot;Acc:Q9ULV3]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 16744
     Entrez Gene : 25792
     UCSC : uc004btt.2
     GeneCards : 16744
     RefSeq : NM_001131015
     CCDS : CCDS6894.1
     Uniprot : Q9ULV3
     Interpro : Q9ULV3
     OMIM : 611420
     GeneTests : CIZ1
     CGAP : CIZ1
     PMID : 10529385

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  33826_at  -0.01  9.26e-1  9.47e-1  0.01  9.15e-1  9.43e-1
 HG_U133A  205516_x_at  0.06  3.30e-1  3.84e-1  -0.40  9.27e-6  1.08e-5
 HG_U133A  211358_s_at  0.22  1.16e-4  2.39e-4  -0.62  7.23e-10  9.04e-10
 HG_U133A  213976_at  0.23  2.73e-3  4.67e-3  2.33  1.51e-75  5.52e-75
 HG_U133A  213977_s_at  0.03  6.82e-1  7.24e-1  -2.50  7.17e-43  1.45e-42
 HG_U133_Plus2  205516_x_at  -0.09  3.77e-1  4.67e-1  0.42  5.19e-5  1.21e-4
 HG_U133_Plus2  211358_s_at  -0.38  1.23e-3  3.14e-3  0.02  8.68e-1  8.92e-1
 HG_U133_Plus2  213976_at  0.07  5.72e-1  6.53e-1  0.44  6.06e-5  1.39e-4
 HG_U133_Plus2  213977_s_at  -0.06  6.49e-1  7.21e-1  0.78  1.53e-10  7.17e-10
 Stanford  21495  0.42  1.90e-1  3.78e-1  0.37  1.58e-1  3.66e-1
 Agilent_HS_21.6K  6256  -0.05  6.77e-2  1.80e-1  -0.01  7.16e-1  8.16e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205516_x_at  0.06  8.61e-1  9.89e-1  0.02  8.91e-1  1.00e+0
 HG_U133A  211358_s_at  0.13  5.35e-1  9.35e-1  0.02  9.02e-1  1.00e+0
 HG_U133A  213976_at  -0.19  5.16e-1  9.34e-1  0.02  9.43e-1  1.00e+0
 HG_U133A  213977_s_at  0.57  1.65e-1  8.15e-1  0.02  9.32e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 33826_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205516_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211358_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 213976_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 213977_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205516_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211358_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 213976_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 213977_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 21495    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 6256    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ciz1 breast cancer We also showed that down-regulation of DLC1 and Ciz1 reduced both Cdk2 activity and cell cycle progression of breast cancer ZR-75 and MCF-7 and endometrial Ishikawa cancer cells. 16740735 Human
ciz1 cancer We also showed that down-regulation of DLC1 and Ciz1 reduced both Cdk2 activity and cell cycle progression of breast cancer ZR-75 and MCF-7 and endometrial Ishikawa cancer cells. 16740735 Human
ciz1 cancer These findings suggest that interactions among DLC1, Cdk2, and Ciz1 play a regulatory role in cell cycle progression of cancer cells presumably by influencing the levels of nuclear p21(WAF1). 16740735 Human
ciz1 tumorigenesis The potential activities of Ciz1, including those involved in brain tumorigenesis, are discussed. 12824700 Human
ciz1 breast cancer We recently showed that Cip-interacting zinc finger protein 1 (Ciz1) participates in the regulation of the cell cycle in estrogen-stimulated breast cancer cells. 17108141 Human
ciz1 breast cancer Despite the emerging significance of Ciz1 in the biology of breast cancer cells, regulation of endogenous Ciz1 in hormone-responsive cancer cells remains unknown. 17108141 Human
ciz1 cancer Despite the emerging significance of Ciz1 in the biology of breast cancer cells, regulation of endogenous Ciz1 in hormone-responsive cancer cells remains unknown. 17108141 Human
ciz1 tumorigenesis To shed light on the role of Ciz1 in breast tumorigenesis, we defined the regulation of Ciz1 by the ER pathway and found that Ciz1 is an estrogen-responsive gene. 17108141 Human
ciz1 breast cancer In addition, we found that Ciz1 overexpression confers estrogen hypersensitivity to breast cancer cells and promotes the growth rate, anchorage independency, and tumorigenic properties of breast cancer cells. 17108141 Human
ciz1 tumorigenesis These findings revealed the inherent role of Ciz1, a novel DNA binding and ER coactivator, in amplifying estrogenic responses and promoting breast cancer tumorigenesis. 17108141 Human
ciz1 breast cancer These findings revealed the inherent role of Ciz1, a novel DNA binding and ER coactivator, in amplifying estrogenic responses and promoting breast cancer tumorigenesis. 17108141 Human

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