IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SPTAN1 Ensembl ENSG00000197694 Chromosome 9 Start 130354687 End 130435762
Description Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)(Alpha-II spectrin)(Fodrin alpha chain) [Source:UniProtKB/Swiss-Prot;Acc:Q13813]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11273
     Entrez Gene : 6709
     UCSC : uc004bvm.3
     GeneCards : 11273
     RefSeq : NM_001130438
     CCDS : CCDS6905.1
     Uniprot : Q9P0V0
     Interpro : Q9P0V0
     OMIM : 182810
     GeneTests : SPTAN1
     CGAP : SPTAN1
     PMID : 3336352

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  33833_at  -0.70  6.98e-20  4.71e-18  -0.89  6.23e-14  1.58e-12
 HG_U133A  208611_s_at  -0.96  5.54e-57  4.05e-55  -6.62  7.62e-146  2.19e-144
 HG_U133A  214925_s_at  -0.68  3.66e-8  1.09e-7  -2.02  2.55e-27  4.13e-27
 HG_U133A  214926_at  -0.05  6.74e-1  7.16e-1  -2.38  5.61e-37  1.04e-36
 HG_U133A  215235_at  -1.25  2.21e-90  6.83e-88  -0.49  1.70e-9  2.11e-9
 HG_U133_Plus2  208611_s_at  -0.79  2.66e-16  4.17e-15  -0.72  6.85e-10  2.99e-9
 HG_U133_Plus2  214925_s_at  -0.69  3.20e-8  1.82e-7  -0.94  2.85e-14  2.06e-13
 HG_U133_Plus2  214926_at  1.06  1.05e-7  5.56e-7  1.35  3.25e-8  1.15e-7
 HG_U133_Plus2  215235_at  -0.57  2.26e-8  1.31e-7  -0.49  5.75e-6  1.52e-5
 HG_U133_Plus2  241150_at  -0.18  3.31e-1  4.20e-1  0.11  6.12e-1  6.65e-1
 Stanford  9426  0.13  7.05e-1  8.30e-1  -0.11  7.85e-1  8.99e-1
 Stanford  15920  0.06  7.68e-1  8.70e-1  -0.63  5.84e-2  1.90e-1
 Agilent_HS_21.6K  12050  -0.14  1.71e-3  1.17e-2  -0.16  4.40e-4  2.74e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  208611_s_at  -0.23  2.31e-1  8.46e-1  -0.07  5.67e-1  1.00e+0
 HG_U133A  214925_s_at  1.07  1.37e-2  6.83e-1  0.22  4.52e-1  1.00e+0
 HG_U133A  214926_at  0.36  2.26e-1  8.45e-1  -0.18  5.11e-1  1.00e+0
 HG_U133A  215235_at  0.05  7.60e-1  9.75e-1  0.01  9.36e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 33833_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208611_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 214925_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 214926_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 215235_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208611_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 214925_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 214926_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 215235_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 241150_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 9426    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 15920    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 12050    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
sptan1 gastric cancer Expression of SPTAN1 in 7 gastric cancer tissues, 7 premalignant lesions, and 7 normal gastric mucosa tissues were identified by RT-PCR. 15025954 Human
sptan1 gastric cancer One cDNA fragment over-expressed in gastric cancer was homologous to SPTAN1 and its over-expression in gastric cancer was confirmed by RT-PCR. 15025954 Human
sptan1 tumors Up-regulated genes in post-CT tumors included substantial number of genes with previously known implication in mechanisms of chemoresistance (TOP2A, ETV4, ABCF2, PRDX2, COX2, COX7B, MUC1, MT3, MT2A), and tumorigenesis (SCGB2A2, S100A9, YWHAE, SFN, ATP6AP1 16773180 Human
sptan1 tumorigenesis Up-regulated genes in post-CT tumors included substantial number of genes with previously known implication in mechanisms of chemoresistance (TOP2A, ETV4, ABCF2, PRDX2, COX2, COX7B, MUC1, MT3, MT2A), and tumorigenesis (SCGB2A2, S100A9, YWHAE, SFN, ATP6AP1 16773180 Human

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