IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SET Ensembl ENSG00000119335 Chromosome 9 Start 130485996 End 130498488
Description Protein SET (Phosphatase 2A inhibitor I2PP2A)(I-2PP2A)(Template-activating factor I)(TAF-I)(HLA-DR-associated protein II)(PHAPII)(Inhibitor of granzyme A-activated DNase)(IGAAD) [Source:UniProtKB/Swiss-Prot;Acc:Q01105]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 10760
     Entrez Gene : 6418
     UCSC : uc004bvu.3
     GeneCards : 10760
     RefSeq : NM_001122821
     CCDS : CCDS6907.1
     Uniprot : Q01105
     Interpro : Q01105
     OMIM : 600960
     GeneTests : SET
     CGAP : SET
     PMID : 1630450

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40189_at  -0.17  9.09e-2  1.52e-1  0.22  6.55e-2  1.15e-1
 HG_U133A  200630_x_at  -0.07  2.20e-1  2.67e-1  0.59  7.69e-21  1.13e-20
 HG_U133A  200631_s_at  0.05  3.39e-1  3.93e-1  0.10  1.38e-1  1.44e-1
 HG_U133A  210231_x_at  0.19  1.85e-3  3.25e-3  -1.13  9.99e-35  1.79e-34
 HG_U133A  213047_x_at  0.19  4.07e-3  6.77e-3  -1.74  4.69e-80  1.90e-79
 HG_U133A  40189_at  -0.06  3.39e-1  3.93e-1  -4.46  2.98e-143  7.77e-142
 HG_U133_Plus2  200630_x_at  0.31  4.97e-5  1.67e-4  0.64  1.35e-12  8.09e-12
 HG_U133_Plus2  200631_s_at  -0.32  2.99e-5  1.05e-4  -0.36  3.69e-5  8.76e-5
 HG_U133_Plus2  210231_x_at  0.34  4.36e-5  1.48e-4  0.79  1.43e-17  1.51e-16
 HG_U133_Plus2  213047_x_at  -0.17  6.67e-2  1.08e-1  0.19  1.95e-2  3.02e-2
 HG_U133_Plus2  40189_at  -0.24  3.32e-4  9.53e-4  -0.01  8.74e-1  8.97e-1
 Stanford  14569  -0.11  6.65e-1  8.03e-1  0.53  6.64e-2  2.07e-1
 Stanford  21971  0.14  5.01e-1  6.83e-1  0.88  3.21e-3  3.12e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  200630_x_at  -0.07  6.84e-1  9.67e-1  0.23  9.40e-2  1.00e+0
 HG_U133A  200631_s_at  0.14  5.15e-1  9.34e-1  0.04  8.10e-1  1.00e+0
 HG_U133A  210231_x_at  -0.03  8.63e-1  9.89e-1  0.15  3.04e-1  1.00e+0
 HG_U133A  213047_x_at  0.33  1.27e-1  7.93e-1  -0.08  6.92e-1  1.00e+0
 HG_U133A  40189_at  0.31  1.99e-1  8.29e-1  0.02  9.20e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40189_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 200630_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 200631_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210231_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 213047_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 40189_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 200630_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 200631_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210231_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 213047_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 40189_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 14569    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 21971    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
set gene centroblastic lymphoma In the centroblastic lymphoma, one transcript revealed a fusion of the 3'-untranslated region of the set gene and the C-terminal region of the IgL gene. 11420749 Human
set gene acute undifferentiated leukemia TAF-I beta corresponds to the protein encoded by the set gene, which was found in an acute undifferentiated leukemia as a fusion version with the can gene via chromosomal translocation. 9597000 Human
i2pp2a myeloid leukemia N-terminal and internal amino acid sequencing indicated that I2PP2A was a truncated form of SET, a largely nuclear protein that is fused to nucleoporin Nup214 in acute non-lymphocytic myeloid leukemia. 8626647 Human
set gene acute undifferentiated leukemia The protein was identified from its partial sequences as a set gene product, whose gene translocation previously was found in a case of acute undifferentiated leukemia. 8699391 Human
taf-ibeta breast cancer Coimmunoprecipitation experiments demonstrate that TAF-Ibeta is associated with the unoccupied, but not the estrogen-occupied, ERalpha in MCF-7 breast cancer cells. 12511607 Human
set gene acute undifferentiated leukemia Nucleotide sequence analysis revealed that the 39-kDa polypeptide corresponds to the protein encoded by the set gene, which is the part of the putative oncogene associated with acute undifferentiated leukemia when translocated to the can gene. 7753797 Human
igaad tumor metastasis We show that GAAD is NM23-H1, a nucleoside diphosphate kinase implicated in suppression of tumor metastasis, and its specific inhibitor (IGAAD) is SET. 12628186 Human
set gene acute undifferentiated leukemia (aul) The same part of the CAN gene appeared to be involved in a case of acute undifferentiated leukemia (AUL) as well, where it was fused to the SET gene. 1384675 Human
taf-ibeta prostate cancer Furthermore, knockdown of endogenous TAF-Ibeta expression by siRNA also attenuated viability of prostate cancer cells as well. 15930275 Human
taf-ibeta prostate cancer These findings suggest that PCOTH is involved in growth and survival of prostate cancer cells thorough, in parts, the TAF-Ibeta pathway, and that this molecule should be a promising target for development of new therapeutic strategies for prostate cancers 15930275 Human
taf-ibeta prostate cancers These findings suggest that PCOTH is involved in growth and survival of prostate cancer cells thorough, in parts, the TAF-Ibeta pathway, and that this molecule should be a promising target for development of new therapeutic strategies for prostate cancers 15930275 Human
the set gene acute undifferentiated leukemia (aul) The same part of the CAN gene appeared to be involved in a case of acute undifferentiated leukemia (AUL) as well, where it was fused to the SET gene. 1384675 Human
the set gene acute undifferentiated leukemia Nucleotide sequence analysis revealed that the 39-kDa polypeptide corresponds to the protein encoded by the set gene, which is the part of the putative oncogene associated with acute undifferentiated leukemia when translocated to the can gene. 7753797 Human
the set gene acute undifferentiated leukemia TAF-I beta corresponds to the protein encoded by the set gene, which was found in an acute undifferentiated leukemia as a fusion version with the can gene via chromosomal translocation. 9597000 Human
the set gene centroblastic lymphoma In the centroblastic lymphoma, one transcript revealed a fusion of the 3'-untranslated region of the set gene and the C-terminal region of the IgL gene. 11420749 Human

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