IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ENDOG Ensembl ENSG00000167136 Chromosome 9 Start 130620600 End 130624776
Description Endonuclease G, mitochondrial Precursor (Endo G)(EC 3.1.30.-) [Source:UniProtKB/Swiss-Prot;Acc:Q14249]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 3346
     Entrez Gene : 2021
     UCSC : uc004bwc.2
     GeneCards : 3346
     RefSeq : NM_004435
     CCDS : CCDS6912.1
     Uniprot : Q14249
     Interpro : Q14249
     OMIM : 600440
     GeneTests : ENDOG
     CGAP : ENDOG
     PMID : 7789991

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  33286_at  0.14  1.91e-1  2.82e-1  0.26  8.04e-2  1.37e-1
 HG_U133A  204824_at  0.46  5.38e-3  8.79e-3  1.17  4.12e-10  5.17e-10
 HG_U133_Plus2  204824_at  -0.35  2.21e-2  4.13e-2  -0.42  3.12e-2  4.64e-2
 Agilent_HS_21.6K  14586  -0.09  4.27e-3  2.40e-2  -0.04  2.37e-1  3.88e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204824_at  -0.03  9.60e-1  9.98e-1  -0.03  9.36e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 33286_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204824_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204824_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 14586    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
endog cancer Our findings suggest that the presence of EndoG in non-invasive breast cancer cells determines their sensitivity to apoptosis, which may be taken into consideration for developing the chemotherapeutic strategy for cancer treatment. 17046751 Human
endonuclease g human breast cancer Endonuclease G promotes cell death of non-invasive human breast cancer cells. 17046751 Human
endog ductal carcinomas in situ Human ductal carcinomas in situ expressed high levels of EndoG, while invasive medullar and ductal carcinomas had significantly decreased expression of EndoG. 17046751 Human
endog ductal carcinomas Human ductal carcinomas in situ expressed high levels of EndoG, while invasive medullar and ductal carcinomas had significantly decreased expression of EndoG. 17046751 Human
endog breast cancer Our findings suggest that the presence of EndoG in non-invasive breast cancer cells determines their sensitivity to apoptosis, which may be taken into consideration for developing the chemotherapeutic strategy for cancer treatment. 17046751 Human
endonuclease g human colon cancer This study was undertaken to dissect the molecular mechanism underlying sulindac-induced apoptosis in human colon cancer cell line HT-29 (mutant p53), focusing on nuclear translocation of AIF, DFF and endonuclease G. 15946692 Human
endonuclease g necrosis PPAR-alpha ligand ameliorates acute renal failure by reducing cisplatin-induced increased expression of renal endonuclease G. Cisplatin injury to the kidney is characterized, in part, by inhibition of substrate oxidation, inflammation, and tubular cell de 15280156 Human
endonuclease g mds The premature death of MDS MK was accompanied by the mitochondrial release of cytochrome c, Smac/DIABLO and endonuclease G, a caspase-independent death effector, as well loss of the mitochondrial membrane potential and plasma membrane phosphatidylserine e 17245643 Human
endonuclease g human osteosarcoma Caspase-independent death of human osteosarcoma cells by flavonoids is driven by p53-mediated mitochondrial stress and nuclear translocation of AIF and endonuclease G. 17356895 Human
endonuclease g colon carcinoma Consistently, conditional knockdown of mammalian endonuclease G selectively kills tetraploid but not diploid clones of the human HCT116 colon carcinoma cell line. 17471024 Human
endonuclease g oncogene Gene induction by glycyrol to apoptosis through endonuclease G in tumor cells and prediction of oncogene function by microarray analysis. 18418217 Human
endonuclease g oncogenes The microarray data also suggested that GC induces gene expression to p53-dependent apoptosis through endonuclease G, instead of CAD/DFF and AIF/PDCD8, as a downstream-apoptosis factor in human kidney epithelial 293T tumor cells, and induces oncogenes wit 18418217 Human
endonuclease g tumor Hypoxia-induced human endonuclease G expression suppresses tumor growth in a xenograft model. 18551145 Human
endonuclease g tumor We have developed a hypoxia-inducible gene therapy approach for the expression of the mature form of human endonuclease G to facilitate cell death in hypoxic regions of the tumor. 18551145 Human
endonuclease g tumors Thus, the hypoxia-modulated endonuclease G expression has the potential to be used as a gene-based-therapy system to kill malignant cells within hypoxic regions of tumors. 18551145 Human
endonuclease g colorectal carcinomas Increased expression of endonuclease G in gastric and colorectal carcinomas. 18705403 Human
endonuclease g hepatocellular carcinomas Decreased expression of endonuclease G (EndoG), a pro-apoptotic protein, in hepatocellular carcinomas. 18754329 Human
endog squamous carcinoma Reactive oxygen species-dependent EndoG release mediates cisplatin-induced caspase-independent apoptosis in human head and neck squamous carcinoma cells. 17955488 Human
endog human prostate cancer Sensitivity of human prostate cancer cells to chemotherapeutic drugs depends on EndoG expression regulated by promoter methylation. 18565644 Human
endog human prostate cancer A comparison of three human prostate cancer cell lines showed that EndoG is highly expressed in 22Rv1 and LNCaP cells. 18565644 Human
endog prostate cancer These data are the first indication that EndoG may be regulated by methylation of its gene promoter, and partially by histone acetylation, and that EndoG is essential for prostate cancer cell death in the used models. 18565644 Human
endog cancers It may be important to identify EndoG protein expression to predict its function in human cancers. 18705403 Human
endog gastric carcinoma The aim of this study was to explore whether alteration of EndoG expression might be a characteristic of colorectal or gastric carcinoma. 18705403 Human
endog gastric carcinoma METHODS: We investigated EndoG protein expression in 103 colorectal and 60 gastric carcinoma tissues by immunohistochemistry using a tissue microarray approach. 18705403 Human
endog colorectal carcinomas RESULTS: Expression of EndoG was detected in 72 (70%) of the colorectal carcinomas and 41 (68%) of the gastric carcinomas in cytoplasm. 18705403 Human
endog gastric carcinomas RESULTS: Expression of EndoG was detected in 72 (70%) of the colorectal carcinomas and 41 (68%) of the gastric carcinomas in cytoplasm. 18705403 Human
endog metastasis There was no significant association of EndoG expression with clinocopathological characteristics, including invasion, metastasis and stage. 18705403 Human
endog gastric cancers CONCLUSION: Our data indicate that EndoG inactivation by loss of expression may not occur in colorectal and gastric cancers. 18705403 Human
endog tumorigenesis Rather, increased expression of EndoG in colorectal and gastric cancer cells compared to their normal mucosal epithelial counterparts suggests that neo-expression of EndoG may play a role in both colorectal and gastric tumorigenesis. 18705403 Human
endog gastric cancer Rather, increased expression of EndoG in colorectal and gastric cancer cells compared to their normal mucosal epithelial counterparts suggests that neo-expression of EndoG may play a role in both colorectal and gastric tumorigenesis. 18705403 Human
endog hepatocellular carcinomas Decreased expression of endonuclease G (EndoG), a pro-apoptotic protein, in hepatocellular carcinomas. 18754329 Human
endonuclease g tumor Gene induction by glycyrol to apoptosis through endonuclease G in tumor cells and prediction of oncogene function by microarray analysis. 18418217 Human
endonuclease g tumor The microarray data also suggested that GC induces gene expression to p53-dependent apoptosis through endonuclease G, instead of CAD/DFF and AIF/PDCD8, as a downstream-apoptosis factor in human kidney epithelial 293T tumor cells, and induces oncogenes wit 18418217 Human

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