IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CRAT Ensembl ENSG00000095321 Chromosome 9 Start 130896896 End 130912904
Description Carnitine O-acetyltransferase (Carnitine acetylase)(EC 2.3.1.7)(Carnitine acetyltransferase)(CrAT)(CAT) [Source:UniProtKB/Swiss-Prot;Acc:P43155]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 2342
     Entrez Gene : 1384
     UCSC : uc004bxh.2
     GeneCards : 2342
     RefSeq : NM_000755
     CCDS : CCDS6919.1
     Uniprot : P43155
     Interpro : P43155
     OMIM : 600184
     GeneTests : CRAT
     CGAP : CRAT
     PMID : 7829107

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  41648_at  0.21  9.93e-4  3.12e-3  0.05  6.20e-1  7.10e-1
 HG_U133A  205843_x_at  0.46  1.01e-4  2.10e-4  1.36  9.97e-29  1.64e-28
 HG_U133A  209522_s_at  0.07  3.52e-1  4.06e-1  1.40  1.69e-37  3.16e-37
 HG_U133_Plus2  205843_x_at  0.43  1.42e-2  2.78e-2  0.69  1.38e-3  2.59e-3
 HG_U133_Plus2  209522_s_at  0.15  1.13e-1  1.71e-1  0.13  3.21e-1  3.81e-1
 Stanford  14651  0.57  4.78e-2  1.51e-1  0.53  2.39e-1  4.73e-1
 Agilent_HS_21.6K  16441  -0.02  6.05e-1  7.56e-1  -0.01  8.42e-1  9.03e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205843_x_at  0.63  1.02e-1  7.76e-1  -0.47  1.39e-1  1.00e+0
 HG_U133A  209522_s_at  0.12  7.09e-1  9.69e-1  -0.82  1.06e-2  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 41648_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205843_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209522_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205843_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209522_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 14651    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 16441    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
carnitine acetyltransferase myelodysplastic syndrome Considering the risk of acquiring a myelodysplastic syndrome (MDS) with age, the aim of this study was to quantify mRNA synthesis of the carnitine palmitoyltransferases (CPT1 and CPT2), carnitine acetyltransferase (CRAT), human specific microsomal CPT, an 12802501 Human
crat myelodysplastic syndrome Considering the risk of acquiring a myelodysplastic syndrome (MDS) with age, the aim of this study was to quantify mRNA synthesis of the carnitine palmitoyltransferases (CPT1 and CPT2), carnitine acetyltransferase (CRAT), human specific microsomal CPT, an 12802501 Human
carnitine acetyltransferase tumor Liver and tumor tissues were then assayed for the peroxisome-associated enzymes, catalase and carnitine acetyltransferase, and correlated with serum levels of triglyceride and cholesterol. 6431985 Human
carnitine acetyltransferase tumors The presence of the tumors caused a predictable decrease in liver catalase and a slight elevation of liver carnitine acetyltransferase. 6431985 Mouse
carnitine acetyltransferase tumour TPA is a potent tumour promoter and treatment with this compound of the two cell lines induced peroxisomal fatty acid beta-oxidation, carnitine acetyltransferase, palmitoyl-CoA hydrolase, and catalase activities after 240 h of treatment. 2868750 Human
carnitine acetyltransferase mds Considering the risk of acquiring a myelodysplastic syndrome (MDS) with age, the aim of this study was to quantify mRNA synthesis of the carnitine palmitoyltransferases (CPT1 and CPT2), carnitine acetyltransferase (CRAT), human specific microsomal CPT, an 12802501 Human
crat mds Considering the risk of acquiring a myelodysplastic syndrome (MDS) with age, the aim of this study was to quantify mRNA synthesis of the carnitine palmitoyltransferases (CPT1 and CPT2), carnitine acetyltransferase (CRAT), human specific microsomal CPT, an 12802501 Human
crat mds In MDS bone marrow cells there was a negative correlation of CPT1 and CRAT with the relative proportion of apoptotic cells. 12802501 Human

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