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Keyword |
DiseaseData |
Statement |
PubMed |
Organism |
mupp-1 |
primary breast cancer |
The aim of this study was to investigate the expression of Zonula Occludens (ZO) proteins ZO-1, ZO-2 and ZO-3, and MUPP-1 (multi-PDZ domain protein 1), peripheral/plaque proteins that function in maintaining tight junction integrity and in transducing reg |
15571953 |
Human |
mupp-1 |
metastatic disease |
Standardised transcript levels of ZO-1 and MUPP-1 were significantly lower in patients with metastatic disease compared with those remaining disease-free (DF) (median follow-up 72.2 months). |
15571953 |
Human |
mupp-1 |
breast cancer |
We conclude that low levels of tight junction plaque molecules, such as ZO-1 and MUPP-1, in breast cancer are associated with poor patients prognosis. |
15571953 |
Human |
mupp1 |
cervical tumours |
In HPV-containing cells derived from cervical tumours, we find that the patterns of expression of the E6 targets hDlg (discs large), hScrib (Scribble), and MUPP1 are consistent with their being substrates for E6-induced degradation. |
15378012 |
Human |
mupp1 |
tumour |
These results suggest that in the context of HPV-induced transformation Dlg, MAGI-1 and MUPP1 can function as tumour suppressors. |
15378012 |
Human |
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