IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene MPDZ Ensembl ENSG00000107186 Chromosome 9 Start 13095703 End 13269563
Description Multiple PDZ domain protein (Multi-PDZ domain protein 1) [Source:UniProtKB/Swiss-Prot;Acc:O75970]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 7208
     Entrez Gene : 8777
     UCSC : uc010mhy.2
     GeneCards : 7208
     RefSeq : NM_003829
     CCDS : CCDS47951.1
     Uniprot : Q5JUC4
     Interpro : Q5JUC4
     OMIM : 603785
     GeneTests : MPDZ
     CGAP : MPDZ

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  32656_at  -0.83  1.06e-3  3.33e-3  -1.04  1.22e-3  3.70e-3
 HG_U133A  205079_s_at  -0.90  5.87e-30  9.07e-29  -5.24  5.59e-93  3.13e-92
 HG_U133A  213306_at  -1.33  8.01e-25  8.84e-24  -0.80  4.16e-17  5.79e-17
 HG_U133_Plus2  205079_s_at  -0.70  2.32e-10  1.76e-9  -0.68  4.19e-12  2.37e-11
 HG_U133_Plus2  213306_at  -1.15  2.81e-13  3.09e-12  -1.52  2.28e-13  1.49e-12
 Stanford  4670  -0.28  5.21e-1  6.99e-1  -0.19  6.14e-1  7.96e-1
 Agilent_HS_21.6K  17908  -0.05  4.25e-1  6.09e-1  -0.12  1.04e-2  3.72e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205079_s_at  0.05  8.46e-1  9.88e-1  0.01  9.37e-1  1.00e+0
 HG_U133A  213306_at  0.04  9.46e-1  9.97e-1  -0.35  2.99e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 32656_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205079_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 213306_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205079_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 213306_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 4670    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 17908    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
mupp-1 primary breast cancer The aim of this study was to investigate the expression of Zonula Occludens (ZO) proteins ZO-1, ZO-2 and ZO-3, and MUPP-1 (multi-PDZ domain protein 1), peripheral/plaque proteins that function in maintaining tight junction integrity and in transducing reg 15571953 Human
mupp-1 metastatic disease Standardised transcript levels of ZO-1 and MUPP-1 were significantly lower in patients with metastatic disease compared with those remaining disease-free (DF) (median follow-up 72.2 months). 15571953 Human
mupp-1 breast cancer We conclude that low levels of tight junction plaque molecules, such as ZO-1 and MUPP-1, in breast cancer are associated with poor patients prognosis. 15571953 Human
mupp1 cervical tumours In HPV-containing cells derived from cervical tumours, we find that the patterns of expression of the E6 targets hDlg (discs large), hScrib (Scribble), and MUPP1 are consistent with their being substrates for E6-induced degradation. 15378012 Human
mupp1 tumour These results suggest that in the context of HPV-induced transformation Dlg, MAGI-1 and MUPP1 can function as tumour suppressors. 15378012 Human

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