IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PTGES Ensembl ENSG00000148344 Chromosome 9 Start 131540433 End 131555165
Description Prostaglandin E synthase (EC 5.3.99.3)(Microsomal glutathione S-transferase 1-like 1)(MGST1-L1)(p53-induced gene 12 protein) [Source:UniProtKB/Swiss-Prot;Acc:O14684]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9599
     Entrez Gene : 9536
     UCSC : uc004byi.2
     GeneCards : 9599
     RefSeq : NM_004878
     CCDS : CCDS6927.1
     Uniprot : O14684
     Interpro : O14684
     OMIM : 605172
     GeneTests : PTGES
     CGAP : PTGES
     PMID : 9305847

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Experimental Evidence        (help)
Expression Sample Number Method Clinical information PubMed Reference
up 61/93(66%) RT-PCR- 16952028 Ann Surg Oncol. 2006 Sep;13(9):1224-34.

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  38131_at  1.45  8.54e-8  7.12e-7  1.49  6.41e-6  3.38e-5
 HG_U133A  207388_s_at  0.84  1.95e-25  2.22e-24  2.45  2.15e-90  1.13e-89
 HG_U133A  210367_s_at  1.15  4.88e-28  6.61e-27  -2.98  1.30e-55  3.24e-55
 HG_U133_Plus2  207388_s_at  1.24  1.77e-15  2.53e-14  0.98  1.01e-6  2.96e-6
 HG_U133_Plus2  210367_s_at  1.16  1.30e-11  1.16e-10  1.40  9.67e-16  8.25e-15
 Stanford  14842  2.42  1.33e-3  1.75e-2  1.92  3.72e-5  1.34e-3
 Agilent_HS_21.6K  17435  -0.01  6.40e-1  7.82e-1  -0.01  7.11e-1  8.11e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207388_s_at  -0.17  5.23e-1  9.34e-1  0.04  7.59e-1  1.00e+0
 HG_U133A  210367_s_at  -0.39  1.20e-1  7.88e-1  -0.11  6.10e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 38131_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207388_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210367_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207388_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210367_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 14842    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 17435    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
prostaglandin e synthase epithelial cancer Prostaglandin E synthase: another enzyme in the cyclooxygenase pathway driving epithelial cancer? 11555570 Human
prostaglandin e synthase non-small cell lung cancer Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer. 11555578 Human
prostaglandin e synthase cancer Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer. 11751489 Human
prostaglandin e synthase colorectal adenomas Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer. 11751489 Human
pges tumor Dynamics of natural selection of tumor cells for the [H2O2CA + PGES] marker phenotype during subcutaneous growth and dissemination. 12918352 Human
pges carcinoma We aimed to characterize cPLA(2), cyclooxygenase 2 (COX2) and prostaglandine E synthase (PGES) expression in human transitional carcinoma (TCC) of the urinary bladder and correlate with the Ki-67 proliferating marker. 14499677 Human
prostaglandin e synthase metaplasia Expression of cyclooxygenase 2, microsomal prostaglandin E synthase 1, and EP receptors is increased in rat oesophageal squamous cell dysplasia and Barrett's metaplasia induced by duodenal contents reflux. 14684572 Rat
pges gastric adenocarcinoma Furthermore, mPGES-1 mRNA, protein and microsomal PGES activity were detected in gastric adenocarcinoma cell lines that originated from intestinal type tumors (MKN-7 and MKN-28). 14520691 Human
pges gastric cancer Two gastric cancer cell lines (MKN-45 and MKN-74) did not express mPGES-1 and lacked microsomal PGES activity, but were still able to synthesize PGE(2). 14520691 Human
pges gastric cancer Because all gastric cell lines expressed cPGES as detected by immunoblotting, it is possible that Cox-2 can interact with cPGES or with some other yet unidentified PGES in gastric cancer cells. 14520691 Human
pges cancer Likewise, inducible microsomal PGES (mPGES-1) is expressed in several types of cancer, although its role in benign polyp formation has not been investigated. 12941808 Human
pges benign polyp Likewise, inducible microsomal PGES (mPGES-1) is expressed in several types of cancer, although its role in benign polyp formation has not been investigated. 12941808 Human
microsomal glutathione s-transferase 1-like 1 colorectal cancer Increased production of prostaglandin E(2) (PGE(2)) by the combined activities of cyclooxygenase-2 (COX-2) and microsomal glutathione S-transferase 1-like 1 (MGST1-L1) enhances the progression of colorectal cancer. 12818365 Human
mgst1-l1 colorectal cancer Increased production of prostaglandin E(2) (PGE(2)) by the combined activities of cyclooxygenase-2 (COX-2) and microsomal glutathione S-transferase 1-like 1 (MGST1-L1) enhances the progression of colorectal cancer. 12818365 Human
mgst1-l1 human colon carcinoma Changes in COX-2 and MGST1-L1 expression were not always coincident with a corresponding change in PGE(2) production by human colon carcinoma cells. 12818365 Human
pges human lung cancer Murine carcinogenesis models of human lung cancer reciprocate the relationship between PGIS and PGES expression. 17374734 Human
pges human lung cancer In human lung cancer, prostacyclin synthase (PGIS) and PGI2 are down-regulated, whereas PGE2 synthase (PGES) and PGE2 are up-regulated. 17374734 Human
pges carcinogenesis Murine carcinogenesis models of human lung cancer reciprocate the relationship between PGIS and PGES expression. 17374734 Human
pges transitional carcinoma We aimed to characterize cPLA(2), cyclooxygenase 2 (COX2) and prostaglandine E synthase (PGES) expression in human transitional carcinoma (TCC) of the urinary bladder and correlate with the Ki-67 proliferating marker. 14499677 Human
pges nsclc The immunohistochemical expression levels of COX-2, prostaglandin E synthetase (PGES), ornithine decarboxylase (ODC), the lung-related resistance protein (LRP), and glutathione-S-transferase-alpha (GST-alpha), GST-mu, and GST-pi were quantitatively determ 15386340 Human
pges gastric cancer However, overall situation of COX and microsomal PGES (mPGES) expression in gastric cancer has not been studied in detail. 15372235 Human
prostaglandin e synthase non-small cell lung cancer To investigate the components of the prostaglandin biosynthetic pathway, the characteristics of cyclooxygenase (COX)-1, COX-2, hematopoietic prostaglandin D synthase (hPGDS), microsomal prostaglandin E synthase (mPGES), and thromboxane synthase (TXS) were 15870920 Human
prostaglandin e synthase nsclc To investigate the components of the prostaglandin biosynthetic pathway, the characteristics of cyclooxygenase (COX)-1, COX-2, hematopoietic prostaglandin D synthase (hPGDS), microsomal prostaglandin E synthase (mPGES), and thromboxane synthase (TXS) were 15870920 Human
prostaglandin e synthase small cell lung cancer (sclc) To investigate the components of the prostaglandin biosynthetic pathway, the characteristics of cyclooxygenase (COX)-1, COX-2, hematopoietic prostaglandin D synthase (hPGDS), microsomal prostaglandin E synthase (mPGES), and thromboxane synthase (TXS) were 15870920 Human
prostaglandin e synthase metaplasia The aim of the present paper was to evaluate the expression of cyclooxygenase (COX) and microsomal prostaglandin E synthase (mPGES) in gastric-type and intestinal-type metaplasia in columnar-lined esophagus and compare these with cell proliferation. 16143029 Human
prostaglandin e synthase columnar-lined esophagus The aim of the present paper was to evaluate the expression of cyclooxygenase (COX) and microsomal prostaglandin E synthase (mPGES) in gastric-type and intestinal-type metaplasia in columnar-lined esophagus and compare these with cell proliferation. 16143029 Human
ptges invasive cervical cancers Flow cytometry on primary CVX and NCK and immunohistochemical staining of formalin fixed paraffin-embedded tumor specimens from which primary CVX cultures were derived as well as from a separate set of invasive cervical cancers confirmed differential expr 15629771 Human
ptges paraffin-embedded tumor Flow cytometry on primary CVX and NCK and immunohistochemical staining of formalin fixed paraffin-embedded tumor specimens from which primary CVX cultures were derived as well as from a separate set of invasive cervical cancers confirmed differential expr 15629771 Human
pges cis PGES was expressed in 4/6 CIS, 0/9 pTaG1, 4/9 pTaG3, 2/10 pT1G3 and 5/10 pT2G3. 14499677 Human
prostaglandin e synthase colorectal cancer Clinical significance of prostaglandin e synthase expression in colorectal cancer. 16538022 Human
pges asm Treatment of human ASM cultures with IL-1beta caused a time-dependent induction of both cytosolic PLA2 (cPLA2) and microsomal PGES (mPGES) similar to that observed for COX-2. 16299051 Human
pges non-small cell lung cancer Finally, tissue microarrays identified the same protein expression pattern for PGIS and PGES in 108 different non-small cell lung cancer biopsies, and the detection of PGIS had statistically significant prognostic value in patient survival. 16314486 Human
pges colorectal cancer (crc) Among the known PGES isoforms, microsomal PGES type 1 (mPGES-1) and type 2 (mPGES-2) were found to be overexpressed in colorectal cancer (CRC); however, the role and regulation of these enzymes in this malignancy are not yet fully understood. 16495511 Human
pges malignancy Among the known PGES isoforms, microsomal PGES type 1 (mPGES-1) and type 2 (mPGES-2) were found to be overexpressed in colorectal cancer (CRC); however, the role and regulation of these enzymes in this malignancy are not yet fully understood. 16495511 Human
pges colorectal carcinoma Here, we report that the cyclopentenone prostaglandins (CyPGs) 15-deoxy-Delta(12,14)-PGJ(2) and PGA(2) downregulate mPGES-2 expression in the colorectal carcinoma cell lines Caco-2 and HCT 116 without affecting the expression of any other PGES or COX. 16495511 Human
pges nasal polyps METHODS: The study examined the expression of PGDS and PGES in nasal polyps of 22 CRS patients. 16911359 Human
pges nasal polyps RESULTS: Both PGDS and PGES were detected in nasal polyps by immunohistochemistry. 16911359 Human
pges nasal polyps Significantly greater levels of PGDS mRNA and lesser levels of PGES mRNA were observed in the nasal polyps as compared with uncinate process mucosae, and an inverse correlation between PGDS and PGES expression was observed. 16911359 Human
pges nasal polyps Levels of PGDS mRNA in nasal polyps were positively correlated with degree of infiltration by EG2+ eosinophils, whereas the levels of PGES were inversely correlated. 16911359 Human
pges polyp CONCLUSIONS: These results suggest that PGDS and PGES display an opposite and important role in the pathophysiology of CRS such as polyp formation, and more specifically, a biased expression of these synthases might contribute to the development of CRS by 16911359 Human
prostaglandin e synthase tumor The tumor tissues were quantified for the induction of apoptosis, intratumor levels/expressions of prostaglandin E2 (PGE2), 15 deoxy prostaglandin J2 (15-d PGJ2), microsomal prostaglandin E synthase (mPGES) and cytoplasmic phospholipase A2 (cPLA2). 16052515 Mouse
prostaglandin e synthase colon cancer 15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells. 16495511 Human
prostaglandin e synthase cancer Prostaglandin e synthase: a novel drug target for inflammation and cancer. 16533161 Human
prostaglandin e synthase squamous cell carcinoma of the larynx Simultaneous expression of cyclooxygenase-2 and microsomal prostaglandin E synthase in squamous cell carcinoma of the larynx. 16720448 Human
prostaglandin e synthase gliomas In contrast, the role of prostaglandin E synthase in influencing the biological behavior of human gliomas has not been established. 16891468 Human
pges tcc We aimed to characterize cPLA(2), cyclooxygenase 2 (COX2) and prostaglandine E synthase (PGES) expression in human transitional carcinoma (TCC) of the urinary bladder and correlate with the Ki-67 proliferating marker. 14499677 Human
pges tcc METHODS: Formalin-fixed human TCC tissues (n=54) obtained from TURB or cystectomies were evaluated for cPLA(2), COX2, PGES and Ki-67 expression using specific antibodies. 14499677 Human
pges tcc CONCLUSIONS: These results suggest that (i). not only COX2 is involved in the tumorogenesis of the TCC but also cPLA(2) and PGES, (ii). there is relationship between the AA metabolic PGE(2) pathway expression and the aggressiveness of the TCC of the urina 14499677 Human
pges primary adenocarcinomas METHODS: Expression of cyclo-oxygenase (COX) 1 and 2, prostaglandin E synthase (PGES), TGF-beta1 and vascular endothelial growth factor (VEGF) A and C genes was analysed in 54 primary adenocarcinomas of the small intestine and corresponding normal intesti 17022010 Human
pges tumours COX-1, COX-2, VEGF-A, VEGF-C, PGES and TGF-beta1 mRNA expression varied markedly in different tumours, but all were overexpressed compared with levels in normal intestinal mucosa. 17022010 Human
pges primary adenocarcinomas CONCLUSION: Correlations between levels of mRNA for COX-1, COX-2, TGF-beta1 and PGES and those for proangiogenic factors VEGF-A and VEGF-C suggest a role for these factors in the propagation of primary adenocarcinomas of the small intestine. 17022010 Human
prostaglandin e synthase tumorigenesis To investigate the role of PGE2 in gastric tumorigenesis, we constructed transgenic mice simultaneously expressing COX-2 and microsomal prostaglandin E synthase (mPGES)-1 in the gastric epithelial cells. 15014433 Human
prostaglandin e synthase primary adenocarcinoma Expression of cyclo-oxygenase 1 and 2, prostaglandin E synthase and transforming growth factor beta1, and their relationship with vascular endothelial growth factors A and C, in primary adenocarcinoma of the small intestine. 17022010 Human
prostaglandin e synthase primary adenocarcinomas METHODS: Expression of cyclo-oxygenase (COX) 1 and 2, prostaglandin E synthase (PGES), TGF-beta1 and vascular endothelial growth factor (VEGF) A and C genes was analysed in 54 primary adenocarcinomas of the small intestine and corresponding normal intesti 17022010 Human

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