IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ASS1 Ensembl ENSG00000130707 Chromosome 9 Start 132309915 End 132366482
Description Argininosuccinate synthase (EC 6.3.4.5)(Citrulline--aspartate ligase) [Source:UniProtKB/Swiss-Prot;Acc:P00966]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 758
     Entrez Gene : 445
     UCSC : uc004bzm.2
     GeneCards : 758
     RefSeq : NM_000050
     CCDS : CCDS6933.1
     Uniprot : P00966
     Interpro : P00966
     OMIM : 603470
     GeneTests : ASS1
     CGAP : ASS1
     PMID : 3513483

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40541_at  0.58  8.43e-6  4.46e-5  0.30  4.88e-2  8.99e-2
 HG_U133A  207076_s_at  0.55  7.97e-6  1.87e-5  -3.05  9.20e-120  1.11e-118
 HG_U133_Plus2  207076_s_at  0.25  9.72e-2  1.50e-1  -0.15  3.88e-1  4.50e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207076_s_at  0.04  9.05e-1  9.94e-1  -0.19  4.80e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40541_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207076_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207076_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
argininosuccinate synthetase melanomas Melanomas and HCCs did not express argininosuccinate synthetase mRNA but did express argininosuccinate lyase mRNA, suggesting that the arginine auxotrophy of these cells was a result of an inability to produce argininosuccinate synthetase. 12359751 Human
argininosuccinate synthetase melanomas Human melanomas and HCCs were transfected with an expression plasmid containing argininosuccinate synthetase cDNA. 12359751 Human
argininosuccinate synthetase tumors These data indicate that sensitivity of melanoma and HCC is due to the absence of argininosuccinate synthetase in these cells and that an effective formulation of ADI, which causes a sustained decrease in arginine, may be a useful treatment for arginine a 12359751 Human
argininosuccinate synthetase melanoma These data indicate that sensitivity of melanoma and HCC is due to the absence of argininosuccinate synthetase in these cells and that an effective formulation of ADI, which causes a sustained decrease in arginine, may be a useful treatment for arginine a 12359751 Human
argininosuccinate synthetase cancers Incidence and distribution of argininosuccinate synthetase deficiency in human cancers: a method for identifying cancers sensitive to arginine deprivation. 14770441 Human
argininosuccinate synthetase glioma However, when the glioma cells were treated with either bacterial lipopolysaccharide, interferon-gamma, or a combination of both, argininosuccinate synthetase immunoreactivity was increased. 9049064 Mouse
argininosuccinate synthetase insulinoma The enzymes involved in citrulline-arginine metabolism, argininosuccinate synthetase (ASS), argininosuccinate lyase (ASL), and NOS were expressed in rat islets and insulinoma HIT T15 cells. 9207208 others
argininosuccinate synthetase human tumor This study demonstrates that argininosuccinate synthetase and GTP-cyclohydrolase-I, which catalyze rate-limiting steps in the synthesis of iNOS substrate (arginine) and cofactor (tetrahydrobiopterin), respectively, are coinduced with iNOS expression in tw 8616812 Human
argininosuccinate synthetase hepatocellular carcinomas Some tumour cell lines, notably the vast majority of melanomas and hepatocellular carcinomas, tend to be deficient in argininosuccinate synthetase (EC 6.5.4.3.), and therefore cannot recycle citrulline to arginine. 12888832 Human
argininosuccinate synthetase tumour Some tumour cell lines, notably the vast majority of melanomas and hepatocellular carcinomas, tend to be deficient in argininosuccinate synthetase (EC 6.5.4.3.), and therefore cannot recycle citrulline to arginine. 12888832 Human
argininosuccinate synthetase melanomas Some tumour cell lines, notably the vast majority of melanomas and hepatocellular carcinomas, tend to be deficient in argininosuccinate synthetase (EC 6.5.4.3.), and therefore cannot recycle citrulline to arginine. 12888832 Human
argininosuccinate synthetase adult t leukemia Elevated argininosuccinate synthetase activity in adult T leukemia cell lines. 2259230 Human
argininosuccinate synthetase tumor Comparison of cases with subchromosomal LOH implicated the region between the D9S55 locus on 9p12 and the argininosuccinate synthetase (ASS) locus on 9q34.1 as the location of a tumor suppressor gene relevant to TCC. 7902161 Human
argininosuccinate synthetase leukemias Argininosuccinate synthetase gene expression in leukemias: potential diagnostic marker for blastic crisis of chronic myelocytic leukemia. 1625473 Human
argininosuccinate synthetase chronic myelocytic leukemia Argininosuccinate synthetase gene expression in leukemias: potential diagnostic marker for blastic crisis of chronic myelocytic leukemia. 1625473 Human
the ass gene leukemia In this study, we examined the ASS gene expression of various leukemia cells by a polymerase-chain-reaction method. 1625473 Human
the ass gene adult t leukemia We demonstrate here that (a) acute lymphocytic and acute myelocytic leukemia cells exhibit the highly elevated expression of the ASS gene and (b) chronic myelocytic leukemia (CML) in blastic crisis also exhibits the increase of ASS gene expression while C 1625473 Human
the ass gene chronic myelocytic leukemia (cml) We demonstrate here that (a) acute lymphocytic and acute myelocytic leukemia cells exhibit the highly elevated expression of the ASS gene and (b) chronic myelocytic leukemia (CML) in blastic crisis also exhibits the increase of ASS gene expression while C 1625473 Human
the ass gene chronic lymphocytic leukemia We demonstrate here that (a) acute lymphocytic and acute myelocytic leukemia cells exhibit the highly elevated expression of the ASS gene and (b) chronic myelocytic leukemia (CML) in blastic crisis also exhibits the increase of ASS gene expression while C 1625473 Human
the ass gene acute myelocytic leukemia We demonstrate here that (a) acute lymphocytic and acute myelocytic leukemia cells exhibit the highly elevated expression of the ASS gene and (b) chronic myelocytic leukemia (CML) in blastic crisis also exhibits the increase of ASS gene expression while C 1625473 Human
the ass gene leukemia These results suggest that the ASS gene expression is of value as a diagnostic marker of acute type leukemia, particularly for blastic crisis of CML. 1625473 Human
argininosuccinate synthetase melanoma Five melanoma cell lines tested also exhibited reduced argininosuccinate synthetase (ASS) gene expression--being almost absent in four cell lines and at low level in one cell line. 1450673 Human
argininosuccinate synthetase tumor In tumor DNA an additional hybridization fragment was detected by pAS-1 probe, which recognizes multiple pseudogenes of argininosuccinate synthetase dispersed in various chromosomes. 1969328 Human
argininosuccinate synthetase hepatoma Regulation of glucocorticoids of arginase and argininosuccinate synthetase in cultured rat hepatoma cells. 7061421 Rat
argininosuccinate synthetase hepatoma We have examined and characterized the regulation by glucocorticoids of the levels of arginase and argininosuccinate synthetase in two rat hepatoma cell lines (H4-II-E-C3 and MH1C1). 7061421 Rat
argininosuccinate synthetase hcc These data indicate that sensitivity of melanoma and HCC is due to the absence of argininosuccinate synthetase in these cells and that an effective formulation of ADI, which causes a sustained decrease in arginine, may be a useful treatment for arginine a 12359751 Human
ass human tumor Previous studies demonstrated that several human tumor cell lines were auxotrophic for arginine due to an inability to express ASS. 14770441 Human
ass malignant tumors The purpose of these experiments was to determine the frequency of ASS deficiency and arginine auxotrophy in a variety of human malignant tumors. 14770441 Human
ass human tumor METHODS: The authors analyzed the expression of ASS by immunohistochemistry with a monoclonal antibody in a variety of human tumor biopsies. 14770441 Human
ass tumor They found that the incidence of ASS deficiency varied greatly with the tumor type and tissue of origin. 14770441 Human
ass hepatocellular carcinoma RESULTS: Melanoma, hepatocellular carcinoma, and prostate carcinoma were most frequently deficient in ASS. 14770441 Human
ass melanoma RESULTS: Melanoma, hepatocellular carcinoma, and prostate carcinoma were most frequently deficient in ASS. 14770441 Human
ass prostate carcinoma RESULTS: Melanoma, hepatocellular carcinoma, and prostate carcinoma were most frequently deficient in ASS. 14770441 Human
ass cancers Some human cancers were almost always positive for ASS (e.g., lung and colon carcinomas). 14770441 Human
ass colon carcinomas Some human cancers were almost always positive for ASS (e.g., lung and colon carcinomas). 14770441 Human
ass cancers However, other human cancers, including sarcomas, invasive breast carcinoma, and renal cell carcinoma, also were sometimes ASS deficient. 14770441 Human
ass invasive breast carcinoma However, other human cancers, including sarcomas, invasive breast carcinoma, and renal cell carcinoma, also were sometimes ASS deficient. 14770441 Human
ass renal cell carcinoma However, other human cancers, including sarcomas, invasive breast carcinoma, and renal cell carcinoma, also were sometimes ASS deficient. 14770441 Human
ass human tumors CONCLUSIONS: These data indicated that immunohistochemical detection of ASS may prove an effective means for determining ASS deficiency in malignant human tumors and for identifying patients most likely to respond to arginine deprivation therapy. 14770441 Human
ass necrosis ASS and EST-1 exhibited greater sensitivity and specificity toward I/R liver injury as compared with alanine aminotransferase (ALT), an established marker of hepatocellular necrosis. 16908442 Human
argininosuccinate synthetase cml Recent studies using fluorescence in situ hybridization (FISH) have shown that in a subset of patients with CML, deletions of 9q34 involving the argininosuccinate synthetase region occur at the time of the Philadelphia translocation and are associated wit 15474149 Human
ass tumors Up-regulated genes in post-CT tumors included substantial number of genes with previously known implication in mechanisms of chemoresistance (TOP2A, ETV4, ABCF2, PRDX2, COX2, COX7B, MUC1, MT3, MT2A), and tumorigenesis (SCGB2A2, S100A9, YWHAE, SFN, ATP6AP1 16773180 NA
argininosuccinate synthetase tumours These tumours that are sensitive to arginine depletion do not express argininosuccinate synthetase, a key enzyme in the synthesis of arginine from citrulline. 16787144 Human
the ass gene cml We demonstrate here that (a) acute lymphocytic and acute myelocytic leukemia cells exhibit the highly elevated expression of the ASS gene and (b) chronic myelocytic leukemia (CML) in blastic crisis also exhibits the increase of ASS gene expression while C 1625473 Human
the ass gene cml These results suggest that the ASS gene expression is of value as a diagnostic marker of acute type leukemia, particularly for blastic crisis of CML. 1625473 Human
ass tumor Comparison of cases with subchromosomal LOH implicated the region between the D9S55 locus on 9p12 and the argininosuccinate synthetase (ASS) locus on 9q34.1 as the location of a tumor suppressor gene relevant to TCC. 7902161 Human
ass tcc Comparison of cases with subchromosomal LOH implicated the region between the D9S55 locus on 9p12 and the argininosuccinate synthetase (ASS) locus on 9q34.1 as the location of a tumor suppressor gene relevant to TCC. 7902161 Human
ass recurrent tumours Nineteen paired blood and MB DNA specimens from 16 patients (11 primary tumours, two primary with recurrent tumours, one primary tumour and cell line, two cell lines) were studied by PCR analysis of microsatellites at D9S55 (9p12), D9S15 (9q13-q21.1), D9S 8208343 Human
ass primary tumour Nineteen paired blood and MB DNA specimens from 16 patients (11 primary tumours, two primary with recurrent tumours, one primary tumour and cell line, two cell lines) were studied by PCR analysis of microsatellites at D9S55 (9p12), D9S15 (9q13-q21.1), D9S 8208343 Human
ass primary tumours Nineteen paired blood and MB DNA specimens from 16 patients (11 primary tumours, two primary with recurrent tumours, one primary tumour and cell line, two cell lines) were studied by PCR analysis of microsatellites at D9S55 (9p12), D9S15 (9q13-q21.1), D9S 8208343 Human
ass insulinoma The enzymes involved in citrulline-arginine metabolism, argininosuccinate synthetase (ASS), argininosuccinate lyase (ASL), and NOS were expressed in rat islets and insulinoma HIT T15 cells. 9207208 others
ass oncogene (1992), several classical systems previously assigned to chromosome 9q, and polymorphisms for the genes tenacin (HXB), gelsolin (GSN), adenylate kinase 1 (AK1), arginosuccinate synthetase (ASS), ABL oncogene (ABL1), ABO blood group (ABO), and dopamine bet 1427899 Human
ass melanoma Five melanoma cell lines tested also exhibited reduced argininosuccinate synthetase (ASS) gene expression--being almost absent in four cell lines and at low level in one cell line. 1450673 Human
ass melanomas Based on the tissue-specific regulation of ASS gene, the feature of melanomas suggests that it might be possible to develop agents with strong AD activity for chemotherapeutic use for human melanomas in vivo. 1450673 Human
ass chronic lymphocytic leukemia We demonstrate here that (a) acute lymphocytic and acute myelocytic leukemia cells exhibit the highly elevated expression of the ASS gene and (b) chronic myelocytic leukemia (CML) in blastic crisis also exhibits the increase of ASS gene expression while C 1625473 Human
ass acute myelocytic leukemia We demonstrate here that (a) acute lymphocytic and acute myelocytic leukemia cells exhibit the highly elevated expression of the ASS gene and (b) chronic myelocytic leukemia (CML) in blastic crisis also exhibits the increase of ASS gene expression while C 1625473 Human
ass chronic myelocytic leukemia (cml) We demonstrate here that (a) acute lymphocytic and acute myelocytic leukemia cells exhibit the highly elevated expression of the ASS gene and (b) chronic myelocytic leukemia (CML) in blastic crisis also exhibits the increase of ASS gene expression while C 1625473 Human
ass cml We demonstrate here that (a) acute lymphocytic and acute myelocytic leukemia cells exhibit the highly elevated expression of the ASS gene and (b) chronic myelocytic leukemia (CML) in blastic crisis also exhibits the increase of ASS gene expression while C 1625473 Human
ass adult t leukemia We demonstrate here that (a) acute lymphocytic and acute myelocytic leukemia cells exhibit the highly elevated expression of the ASS gene and (b) chronic myelocytic leukemia (CML) in blastic crisis also exhibits the increase of ASS gene expression while C 1625473 Human
ass leukemia We demonstrate here that (a) human normal T and B lymphocytes did not express ASS activity, (b) however, three adult T leukemia (ATL) cell lines tested here exhibited significant elevation of ASS activity, and (c) ASL activity remained relatively constant 2259230 Human
ass adult t leukemia (atl) We demonstrate here that (a) human normal T and B lymphocytes did not express ASS activity, (b) however, three adult T leukemia (ATL) cell lines tested here exhibited significant elevation of ASS activity, and (c) ASL activity remained relatively constant 2259230 Human
ass leukemia These results suggest that the ASS expression of peripheral blood lymphocytes is of value as a diagnostic marker of leukemia including ATL. 2259230 Human
ass sarcomas However, other human cancers, including sarcomas, invasive breast carcinoma, and renal cell carcinoma, also were sometimes ASS deficient. 14770441 Human
ass tumorigenesis Up-regulated genes in post-CT tumors included substantial number of genes with previously known implication in mechanisms of chemoresistance (TOP2A, ETV4, ABCF2, PRDX2, COX2, COX7B, MUC1, MT3, MT2A), and tumorigenesis (SCGB2A2, S100A9, YWHAE, SFN, ATP6AP1 16773180 Human
ass hepatocellular carcinoma Recently, pegylated arginine deiminase (ADI; EC 3.5.3.6) has been used to treat the patients with hepatocellular carcinoma or melanoma, in which the level of argininosuccinate synthetase (ASS) activity is low or undetectable. 17096330 Human
ass melanoma Recently, pegylated arginine deiminase (ADI; EC 3.5.3.6) has been used to treat the patients with hepatocellular carcinoma or melanoma, in which the level of argininosuccinate synthetase (ASS) activity is low or undetectable. 17096330 Human
ass tumor The efficacy of its antitumor activity largely depends on the level of intracellular ASS, which enables tumor cells to recycle citrulline to arginine. 17096330 Human
ass cancer Thus, we examined the expression levels of ASS in various cancer cells and found that it is low in renal cell carcinoma (RCC) cells, rendering the cells highly sensitive to arginine deprivation by ADI treatment. 17096330 Human
ass renal cell carcinoma (rcc) Thus, we examined the expression levels of ASS in various cancer cells and found that it is low in renal cell carcinoma (RCC) cells, rendering the cells highly sensitive to arginine deprivation by ADI treatment. 17096330 Human
ass tumor Immunohistochemical analysis revealed that in biopsy specimens from RCC patients (n = 98), the expression of ASS is highly demonstrated in the epithelium of normal proximal tubule but not seen in tumor cells. 17096330 Human
ass rcc Immunohistochemical analysis revealed that in biopsy specimens from RCC patients (n = 98), the expression of ASS is highly demonstrated in the epithelium of normal proximal tubule but not seen in tumor cells. 17096330 Human
ass hepatocellular carcinoma (hcc) Hepatocellular carcinoma (HCC) is believed to be auxotrophic for arginine through the lack of expression of argininosuccinate synthetase (ASS). 17210712 Human
ass tumors The successful use of the arginine-depleting enzyme arginine deiminase (ADI) to treat ASS-deficient tumors has opened up new possibilities for effective cancer therapy. 17210712 Human
ass cancer The successful use of the arginine-depleting enzyme arginine deiminase (ADI) to treat ASS-deficient tumors has opened up new possibilities for effective cancer therapy. 17210712 Human
ass hcc Nevertheless, many ASS-positive HCC cell lines are found to be resistant to ADI treatment, although most require arginine for proliferation. 17210712 Human
ass tumors Thus far, an arginine-depleting enzyme for killing ASS-positive tumors has not been reported. 17210712 Human
ass hccs Here, we provide direct evidence that recombinant human arginase (rhArg) inhibits ASS-positive HCCs. 17210712 Human
ass hcc Thus, OTC expression alone may be sufficient to induce rhArg resistance in ASS-positive HCC cells. 17210712 Human
ass hccs This surprising correlation between the lack of OTC expression and sensitivity of ASS-positive HCC cells shows that OTC-deficient HCCs are sensitive to rhArg-mediated arginine depletion. 17210712 Human
ass hcc This surprising correlation between the lack of OTC expression and sensitivity of ASS-positive HCC cells shows that OTC-deficient HCCs are sensitive to rhArg-mediated arginine depletion. 17210712 Human
ass tumor Therefore, pretreatment tumor gene expression profiling of ASS and OTC could aid in predicting tumor response to arginine depletion with arginine-depleting enzymes. 17210712 Human
ass tumor Furthermore, the growth of the OTC-deficient Hep3B tumor cells (ASS-positive and ADI-resistant) in mice was inhibited by treatment with rhArg-peg(5,000mw), which is active alone and is synergistic in combination with 5-fluorouracil. 17210712 Mouse
argininosuccinate synthetase hccs Melanomas and HCCs did not express argininosuccinate synthetase mRNA but did express argininosuccinate lyase mRNA, suggesting that the arginine auxotrophy of these cells was a result of an inability to produce argininosuccinate synthetase. 12359751 Human
argininosuccinate synthetase hccs Human melanomas and HCCs were transfected with an expression plasmid containing argininosuccinate synthetase cDNA. 12359751 Human
argininosuccinate synthetase renal cell carcinoma Renal cell carcinoma does not express argininosuccinate synthetase and is highly sensitive to arginine deprivation via arginine deiminase. 17096330 Human
argininosuccinate synthetase hepatocellular carcinoma Recently, pegylated arginine deiminase (ADI; EC 3.5.3.6) has been used to treat the patients with hepatocellular carcinoma or melanoma, in which the level of argininosuccinate synthetase (ASS) activity is low or undetectable. 17096330 Human
argininosuccinate synthetase melanoma Recently, pegylated arginine deiminase (ADI; EC 3.5.3.6) has been used to treat the patients with hepatocellular carcinoma or melanoma, in which the level of argininosuccinate synthetase (ASS) activity is low or undetectable. 17096330 Human
argininosuccinate synthetase tumor Both bioconjugates exhibited potent growth inhibition of several cultured tumor lines that are deficient in the anabolic enzyme, argininosuccinate synthetase. 17105223 Human
argininosuccinate synthetase malignant pleural mesothelioma In vivo loss of expression of argininosuccinate synthetase in malignant pleural mesothelioma is a biomarker for susceptibility to arginine depletion. 17145837 Human
argininosuccinate synthetase hepatocellular carcinoma (hcc) Hepatocellular carcinoma (HCC) is believed to be auxotrophic for arginine through the lack of expression of argininosuccinate synthetase (ASS). 17210712 Human
argininosuccinate synthetase human epithelial ovarian cancer Aberrant regulation of argininosuccinate synthetase by TNF-alpha in human epithelial ovarian cancer. 17354225 Human
argininosuccinate synthetase carcinogenesis Here, we show that TNF-alpha also induces expression of arate-limiting enzyme in arginine synthesis, argininosuccinate synthetase (AS), thereby linking inflammation with several arginine-dependent metabolic pathways, implicated in accelerated carcinogenes 17354225 Human
argininosuccinate synthetase tumour Here, we show that TNF-alpha also induces expression of arate-limiting enzyme in arginine synthesis, argininosuccinate synthetase (AS), thereby linking inflammation with several arginine-dependent metabolic pathways, implicated in accelerated carcinogenes 17354225 Human
ass retinoblastoma Expression of argininosuccinate synthetase (ASS) was detected in human retinoblastoma tissues. 17982619 Human
ass retinoblastoma Even with a high expression of ASS, ADI effectively inhibited the proliferation of retinoblastoma cells and induced retinoblastoma cell death in a dose-dependent manner. 17982619 Human
ass retinoblastoma These results indicate that arginine deprivation via ADI could be another treatment option for retinoblastoma due to low ASS activity in retinoblastoma cells. 17982619 Human
ass tumors Arginine deprivation is a novel approach to target tumors which lack argininosuccinate synthetase (ASS) expression. 18473854 Human
ass hepatocellular carcinoma Tumors which usually do not express ASS include melanoma, hepatocellular carcinoma, some mesotheliomas and some renal cell cancers. 18473854 Human
ass melanoma Tumors which usually do not express ASS include melanoma, hepatocellular carcinoma, some mesotheliomas and some renal cell cancers. 18473854 Human
ass mesotheliomas Tumors which usually do not express ASS include melanoma, hepatocellular carcinoma, some mesotheliomas and some renal cell cancers. 18473854 Human
ass tumors Tumors which usually do not express ASS include melanoma, hepatocellular carcinoma, some mesotheliomas and some renal cell cancers. 18473854 Human
ass renal cell cancers Tumors which usually do not express ASS include melanoma, hepatocellular carcinoma, some mesotheliomas and some renal cell cancers. 18473854 Human
ass melanoma However, arginine deprivation can also induce ASS expression in certain melanoma cell lines which can lead to in vitro drug resistance. 18473854 Human
ass cancers It has been observed that ASS is underexpressed in various types of cancers ASS, for which arginine become auxotrophic. 18661517 Human
ass hepatoma Arginine deiminase (ADI) is a prokaryotic enzyme that metabolizes arginine to citrulline and has been found to inhibit melanoma and hepatoma cancer cells deficient of ASS. 18661517 Human
ass melanoma Arginine deiminase (ADI) is a prokaryotic enzyme that metabolizes arginine to citrulline and has been found to inhibit melanoma and hepatoma cancer cells deficient of ASS. 18661517 Human
ass cancer Arginine deiminase (ADI) is a prokaryotic enzyme that metabolizes arginine to citrulline and has been found to inhibit melanoma and hepatoma cancer cells deficient of ASS. 18661517 Human
ass pancreatic cancers We tested the hypothesis that pancreatic cancers have low ASS expression and therefore arginine deprivation by ADI will inhibit cell growth. 18661517 Human
ass human pancreatic cancer ASS expression was examined in 47 malignant and 20 non-neoplastic pancreatic tissues as well as a panel of human pancreatic cancer cell lines. 18661517 Human
ass tumors Eighty-seven percent of the tumors lacked ASS expression; 5 of 7 cell lines similarly lacked ASS expression. 18661517 Human
ass pancreatic cancer Reduced expression of ASS occurs in pancreatic cancer and predicts sensitivity to arginine deprivation achieved by PEG-ADI treatment. 18661517 Human
argininosuccinate synthetase retinoblastoma Expression of argininosuccinate synthetase (ASS) was detected in human retinoblastoma tissues. 17982619 Human
argininosuccinate synthetase tumors Arginine deprivation is a novel approach to target tumors which lack argininosuccinate synthetase (ASS) expression. 18473854 Human
argininosuccinate synthetase pancreatic cancer Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase. 18661517 Human
the ass gene chronic myelocytic leukemia We demonstrate here that (a) acute lymphocytic and acute myelocytic leukemia cells exhibit the highly elevated expression of the ASS gene and (b) chronic myelocytic leukemia (CML) in blastic crisis also exhibits the increase of ASS gene expression while C 1625473 Human
ass chronic myelocytic leukemia We demonstrate here that (a) acute lymphocytic and acute myelocytic leukemia cells exhibit the highly elevated expression of the ASS gene and (b) chronic myelocytic leukemia (CML) in blastic crisis also exhibits the increase of ASS gene expression while C 1625473 Human
ass renal cell carcinoma Thus, we examined the expression levels of ASS in various cancer cells and found that it is low in renal cell carcinoma (RCC) cells, rendering the cells highly sensitive to arginine deprivation by ADI treatment. 17096330 Human
ass tumor Citrulline can be recycled back to arginine in normal cells which express ASS, whereas ASS(-) tumor cells cannot. 18473854 Human
ass adult t leukemia We demonstrate here that (a) human normal T and B lymphocytes did not express ASS activity, (b) however, three adult T leukemia (ATL) cell lines tested here exhibited significant elevation of ASS activity, and (c) ASL activity remained relatively constant 2259230 Human

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