IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene LAMC3 Ensembl ENSG00000050555 Chromosome 9 Start 132874325 End 132958267
Description Laminin subunit gamma-3 Precursor (Laminin 12 gamma 3 subunit) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y6N6]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6494
     Entrez Gene : 10319
     UCSC : uc004caa.1
     GeneCards : 6494
     RefSeq : NM_006059
     CCDS : CCDS6938.1
     Uniprot : Q9Y6N6
     Interpro : Q9Y6N6
     OMIM : 604349
     GeneTests : LAMC3
     CGAP : LAMC3
     PMID : 10225960

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  219407_s_at  -2.55  1.47e-36  3.37e-35  1.25  1.45e-23  2.22e-23
 HG_U133_Plus2  219407_s_at  -1.70  4.52e-22  1.31e-20  -1.56  1.33e-14  1.00e-13
 HG_U133_Plus2  232558_at  0.60  1.31e-3  3.32e-3  0.84  2.12e-4  4.51e-4
 Agilent_HS_21.6K  15570  -0.16  3.64e-6  7.42e-5  -0.17  6.11e-6  7.41e-5

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  219407_s_at  -0.45  4.65e-1  9.20e-1  -0.09  8.17e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133A - 219407_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 219407_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 232558_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 15570    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
lamc3 breast cancer Seven genes undergoing abnormal epigenetic regulation in breast cancer, SEMA6B, BIN1, VCPIP1, LAMC3, KCNH2, CACNG4 and PSMF1, have been identified by this method. 17936981 Human
lamc3 breast cancer Downregulation of SEMA6B, BIN1, VCPIP1, LAMC3, KCNH2, CACNG4 and PSMF1 in breast cancer was as frequent as 44-94% by real-time PCR expression assay. 17936981 Human
lamc3 carcinogenesis The most pronounced functional alterations were demonstrated for SEMA6B and LAMC3 genes, which allows recommending their inclusion into the panels of carcinogenesis diagnostic panels. 17936981 Human
lamc3 breast cancer Fine methylation mapping was performed for the genes most frequently methylated in breast cancer (SEMA6B, BIN1, LAMC3), providing a fundamental basis for the development of effective methylation tests for these genes. 17936981 Human

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