IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene NUP214 Ensembl ENSG00000126883 Chromosome 9 Start 132990802 End 133098909
Description Nuclear pore complex protein Nup214 (Nucleoporin Nup214)(214 kDa nucleoporin)(Protein CAN) [Source:UniProtKB/Swiss-Prot;Acc:P35658]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 8064
     Entrez Gene : 8021
     UCSC : uc004cag.2
     GeneCards : 8064
     RefSeq : NM_005085
     CCDS : CCDS6940.1
     Uniprot : P35658
     Interpro : P35658
     OMIM : 114350
     GeneTests : NUP214
     CGAP : NUP214
     PMID : 8108440

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40768_s_at  -0.38  1.51e-5  7.54e-5  -0.41  6.81e-5  2.83e-4
 HG_U95  40769_r_at  0.21  1.94e-1  2.85e-1  0.14  5.60e-1  6.56e-1
 HG_U133A  202155_s_at  -0.20  1.72e-7  4.80e-7  -0.46  6.59e-7  7.81e-7
 HG_U133A  211261_at  -0.07  5.31e-1  5.83e-1  -2.64  2.61e-41  5.17e-41
 HG_U133_Plus2  202155_s_at  -0.17  9.06e-3  1.87e-2  0.18  1.77e-2  2.76e-2
 HG_U133_Plus2  211261_at  0.18  1.15e-1  1.73e-1  0.63  7.45e-7  2.22e-6
 HG_U133_Plus2  228902_at  -0.25  1.87e-3  4.56e-3  -0.04  6.83e-1  7.29e-1
 Stanford  1803  -0.11  7.04e-1  8.30e-1  -0.39  2.82e-1  5.23e-1
 Stanford  12357  0.34  6.88e-2  1.93e-1  0.02  9.33e-1  9.71e-1
 Stanford  23922  0.13  5.53e-1  7.23e-1  0.12  6.93e-1  8.45e-1
 Agilent_HS_21.6K  13885  0.00  9.34e-1  9.63e-1  0.05  1.32e-1  2.55e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202155_s_at  0.05  7.41e-1  9.74e-1  -0.07  5.39e-1  1.00e+0
 HG_U133A  211261_at  0.60  1.88e-1  8.25e-1  0.08  7.21e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40768_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 40769_r_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202155_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211261_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202155_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211261_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 228902_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 1803    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 12357    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 23922    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 13885    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
nup214 tumors Immunoblots of the same tumors with antibodies to 2 other Nups (Nup214 and Nup153) showed no comparable enhancement. 12094380 Human
nup214 acute myeloid leukemia (aml) Genes encoding the Phe-Gly (FG) repeat-containing nucleoporins NUP98 and CAN/NUP214 are at the breakpoints of several chromosomal translocations associated with human acute myeloid leukemia (AML), but their role in oncogenesis is unclear. 9858599 Human
the can gene acute undifferentiated leukemia TAF-I beta corresponds to the protein encoded by the set gene, which was found in an acute undifferentiated leukemia as a fusion version with the can gene via chromosomal translocation. 9597000 Human
nup214 human myeloid leukaemia These studies identify HOXA9 as an important human myeloid leukaemia gene and suggest an important role for nucleoporins in human myeloid leukaemia given that a second nucleoporin, NUP214, has also been implicated in human myeloid leukaemia. 8563753 Human
nup214 myeloid leukemia N-terminal and internal amino acid sequencing indicated that I2PP2A was a truncated form of SET, a largely nuclear protein that is fused to nucleoporin Nup214 in acute non-lymphocytic myeloid leukemia. 8626647 Human
nup214 myeloid leukemia One of its components, CAN/Nup214, is an FXFG repeat-containing protein known to be involved in myeloid leukemia in humans. 8896451 Human
the can gene leukemia Fusion genes encoding the 3' part of the can gene are implicated in two types of leukemia. 7753551 Human
the can gene acute undifferentiated leukemia Nucleotide sequence analysis revealed that the 39-kDa polypeptide corresponds to the protein encoded by the set gene, which is the part of the putative oncogene associated with acute undifferentiated leukemia when translocated to the can gene. 7753797 Human
the can gene leukemia Breakpoints in both the dek gene on chromosome 6 and the can gene on chromosome 9 appear to occur in defined regions, which allows us to diagnose this type of leukemia at the molecular level. 1586743 Human
the can gene acute myeloid leukemia (aml) The t(6;9) associated with a subtype of acute myeloid leukemia (AML) was shown to generate a fusion between the 3' part of the CAN gene on chromosome 9 and the 5' part of the DEK gene on chromosome 6. 1384675 Human
the can gene acute undifferentiated leukemia (aul) The same part of the CAN gene appeared to be involved in a case of acute undifferentiated leukemia (AUL) as well, where it was fused to the SET gene. 1384675 Human
nup214 myeloid leukemia CRM1 binds to CAN/NUP214, one of nucleopore proteins, which has been suggested to be involved in myeloid leukemia. 9702053 Human
nup214 t-cell acute lymphoblastic leukemia Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia. 15361874 Human
nup214 cancer We identified a previously undescribed mechanism for activation of tyrosine kinases in cancer: the formation of episomes resulting in a fusion between NUP214 and ABL1. 15361874 Human
nup214 acute myelogenous leukemia (aml) The t(6;9)(p23;q34) is a recurrent chromosomal abnormality observed in 1% of acute myelogenous leukemia (AML), which generates a fusion transcript between DEK and CAN/NUP214 genes. 15973457 Human
nup214 t-all Fusion of NUP214 to ABL1 on amplified episomes in T-ALL--implications for treatment. 16015385 Human
the can gene anll Analysis of 17 t(6;9) ANLL cases showed that the translocation breakpoints occur in a single intron of 7.5 kb in the CAN gene (ICB9) and in a single intron of 9 kb in the DEK gene (ICB6). 1308167 Human

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