IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CEL Ensembl ENSG00000170835 Chromosome 9 Start 134927201 End 134936972
Description Bile salt-activated lipase Precursor (BAL)(EC 3.1.1.3)(EC 3.1.1.13)(Bile salt-stimulated lipase)(BSSL)(Carboxyl ester lipase)(Sterol esterase)(Cholesterol esterase)(Pancreatic lysophospholipase)(Bucelipase) [Source:UniProtKB/Swiss-Prot;Acc:P19835]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 1848
     Entrez Gene : 1056
     UCSC : uc010naa.1
     GeneCards : 1848
     RefSeq : XM_002346209
     CCDS : CCDS43896.1
     Uniprot : P19835
     Interpro : P19835
     OMIM : 114840
     GeneTests : CEL
     CGAP : CEL
     PMID : 1676983

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  39176_f_at  0.72  2.14e-3  6.13e-3  3.42  9.15e-10  1.02e-8
 HG_U95  39177_r_at  0.37  2.44e-4  9.03e-4  1.35  5.57e-4  1.85e-3
 HG_U133A  205910_s_at  0.37  2.83e-2  4.12e-2  8.33  6.29e-185  9.94e-183
 HG_U133_Plus2  1553970_s_at  1.25  5.22e-6  2.10e-5  3.77  4.03e-18  4.52e-17
 HG_U133_Plus2  205910_s_at  0.82  2.31e-3  5.53e-3  2.99  2.07e-13  1.35e-12
 Agilent_HS_21.6K  6788  -0.14  6.53e-8  2.33e-6  -0.12  2.88e-5  2.78e-4

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205910_s_at  0.13  6.29e-1  9.56e-1  0.99  1.19e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 39176_f_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 39177_r_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205910_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1553970_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205910_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 6788    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
cel hepatoma Carboxyl ester lipase overexpression in rat hepatoma cells and CEL deficiency in mice have no impact on hepatic uptake or metabolism of chylomicron-retinyl ester. 10194331 Mouse
cel hepatoma To study the role of carboxyl ester lipase (CEL) in hepatic retinoid (vitamin A) metabolism, we investigated uptake and hydrolysis of chylomicron (CM)-retinyl esters (RE) by rat hepatoma (McArdle-RH7777) cells stably transfected with a rat CEL cDNA. 10194331 Rat
bsdl human hepatoma In this article, we report the nucleotide sequence of the cDNA encoding an isoform of bile-salt-dependent lipase (BSDL) expressed by human hepatoma cells. 10432315 Human
bsdl human hepatoma This isoform of BSDL was mainly associated with the cytosol of a human hepatoma cell line (HepG2), the remaining protein being found in the microsome fraction. 10432315 Human
bsdl hepatoma The actual intracellular function of this human BSDL hepatoma isoform remains to be elucidated. 10432315 Human
bsdl tumor BSDL has been detected in many cells including fetal and tumor cells, hepatocytes, macrophages and eosinophils and in tissues such as adrenal glands and testes. 9748640 Human
bsdl cancer Sequencing of fragments, obtained by mRNA reverse transcription and amplification, confirmed the presence of BSDL transcripts in these cancer cells. 9774442 Human
cholesterol esterase human hepatoma In the current study, the human hepatoma cell line HepG2 was used as a model to determine the role of cholesterol esterase on hepatic uptake of high density lipoprotein (HDL)-associated cholesteryl esters. 8639615 Human
fap cancer of the pancreas The diagnostic value of the foetoacinar pancreatic (FAP) protein in cancer of the pancreas; a comparative study with CA19/9. 3479995 Human
fap pancreatic cancer FAP protein levels superior to 10% inhibition were found in 86% of patients with pancreatic cancer, in 31% with non-pancreatic malignancy, in 69% with benign hepato-pancreato-biliary disease and in 20% with other benign diseases. 3479995 Human
fap pancreatic carcinoma Accordingly, sensitivity of FAP protein for pancreatic carcinoma was 86% and specificity, 66%. 3479995 Human
fap pancreatic cancer However, high FAP protein levels (greater than 30% inhibition) were almost exclusively seen in patients with pancreatic cancer. 3479995 Human
fap pancreatic cancer In pancreatic cancer 55 out of 57 patients had elevated levels of either FAP protein or CA19/9 (sensitivity; 96%). 3479995 Human
bile salt-dependent lipase pancreatic tumors Expression of a 46 kDa protein in human pancreatic tumors and its possible relationship with the bile salt-dependent lipase. 7889983 Human
fetoacinar pancreatic protein duodenal cancers A fetoacinar pancreatic protein (FAP) associated with the ontogenesis, differentiation and oncogenic transformation of the human exocrine pancreas has been purified from pancreatic juices of patients suffering from pancreatitis or duodenal cancers invadin 8424803 Human
fap duodenal cancers A fetoacinar pancreatic protein (FAP) associated with the ontogenesis, differentiation and oncogenic transformation of the human exocrine pancreas has been purified from pancreatic juices of patients suffering from pancreatitis or duodenal cancers invadin 8424803 Human
fap tumor Retention of the fetoacinar pancreatic (FAP) protein to the endoplasmic reticulum of tumor cells. 8462590 Human
fap cancer FAP expression is enhanced in cases of pancreatic exocrine cancer and it is found in relatively high concentrations in pathological pancreatic juices. 8462590 Human
fap tumor However, tumor cell lines do not secrete FAP into the culture medium. 8462590 Human
fap tumor The absence of reactivity of the tumoral FAP with wheat germ agglutinin lectin and its strong reactivity with concanavalin A is consistent with the idea that FAP in tumor cells does not reach the Golgi apparatus and it is consequently retained in the endo 8462590 Human
fap pancreatic adenocarcinoma FAP contained in hepatic metastasis derived from pancreatic adenocarcinoma appeared to be similar, if not identical, to that expressed by cell lines. 8462590 Human
fap hepatic metastasis FAP contained in hepatic metastasis derived from pancreatic adenocarcinoma appeared to be similar, if not identical, to that expressed by cell lines. 8462590 Human
fap cancer FAP expressed by cancer cell lines and metastases appeared by sodium dodecyl sulfate polyacrylamide gel electrophoresis a homogeneous protein with a M(r) of 120,000. 8462590 Human
fap metastases FAP expressed by cancer cell lines and metastases appeared by sodium dodecyl sulfate polyacrylamide gel electrophoresis a homogeneous protein with a M(r) of 120,000. 8462590 Human
bile salt-dependent lipase pancreatic cancer Is bile salt-dependent lipase concentration in serum of any help in pancreatic cancer diagnosis? 7508110 Human
bile salt-dependent lipase cancer Thirty percent of control subjects and 73% of cancer patients had a bile salt-dependent lipase serum level below the cutoff value of 0.5 microgram/L. 7508110 Human
bile salt-dependent lipase pancreatic cancer Accordingly, 36 of 38 patients with pancreatic cancer had either low serum levels of bile salt-dependent lipase (< 0.5 microgram/L) or high values of CA 19-9 antigen (> 37 U/ml; sensitivity 95%).(ABSTRACT TRUNCATED AT 250 WORDS) 7508110 Human
cholesterol esterase adrenal adenoma We have studied the nature and characteristics of cholesterol esterase (CEase) in human adrenal adenoma and hyperplasia tissues showing Cushing's syndrome, comparing with those in normal tissue. 7920899 Human
cholesterol esterase hyperplasia We have studied the nature and characteristics of cholesterol esterase (CEase) in human adrenal adenoma and hyperplasia tissues showing Cushing's syndrome, comparing with those in normal tissue. 7920899 Human
fap pancreatic tumors We describe the in vivo localization of radiolabeled mAb J28, a murine monoclonal antibody characterizing the oncodevelopmental human fetoacinar pancreatic (FAP) protein, at different stages of chemical induction of pancreatic tumors in the Syrian golden 1583067 others
fap pancreatic cancer It is concluded that FAP behaves as a marker of preneoplastic lesions, and therefore that radioimmunoimaging with mAb J28 might help with early diagnosis of pancreatic cancer. 1583067 Human
fap human tumor Expression of fetoacinar pancreatic (FAP) protein in the pancreatic human tumor cell line BxPC-3. 1994378 Human
fap cancer In order to set out a model for studies on the regulation of FAP, 47 established cell lines from human cancer of different origins were tested for FAP expression using the monoclonal antibody J28 (Mab J28). 1994378 Human
fap pancreatic adenocarcinoma An immunohistologic study of the feto-acinar pancreatic protein (FAP) in the normal pancreas, chronic pancreatitis, pancreatic adenocarcinoma, and intraabdominal metastases of adenocarcinomas. 2403740 Human
fap metastases An immunohistologic study of the feto-acinar pancreatic protein (FAP) in the normal pancreas, chronic pancreatitis, pancreatic adenocarcinoma, and intraabdominal metastases of adenocarcinomas. 2403740 Human
fap pancreatic adenocarcinoma In cases of primary pancreatic adenocarcinoma and metastatic tumors in the pancreas, a strong expression of FAP protein in the peritumoral acinar area was found. 2403740 Human
fap tumors The tumors themselves were FAP protein negative, as were the nonpancreatic tumors and normal organs. 2403740 Human
carboxyl ester lipase hepatoma Carboxyl ester lipase overexpression in rat hepatoma cells and CEL deficiency in mice have no impact on hepatic uptake or metabolism of chylomicron-retinyl ester. 10194331 Mouse
carboxyl ester lipase hepatoma To study the role of carboxyl ester lipase (CEL) in hepatic retinoid (vitamin A) metabolism, we investigated uptake and hydrolysis of chylomicron (CM)-retinyl esters (RE) by rat hepatoma (McArdle-RH7777) cells stably transfected with a rat CEL cDNA. 10194331 Rat
cel pd METHODS: CML and CEL were measured by tandem mass spectroscopy, MDA by HPLC, and VCAM-1 by ELISA in 37 stable PD patients (age 54 +/- 12 years; time on PD 25 +/- 18 months). 15031349 NA
cel ca OBJECTIVE: To determine the effect of interferon-beta-1b (IFNbeta-1b) treatment on total contrast-enhancing lesions (CEL), white matter lesion load (WMLL), and cerebral atrophy (CA) in patients with relapsing-remitting multiple sclerosis (RRMS) using seri 15007120 NA
fap malignancy FAP protein levels superior to 10% inhibition were found in 86% of patients with pancreatic cancer, in 31% with non-pancreatic malignancy, in 69% with benign hepato-pancreato-biliary disease and in 20% with other benign diseases. 3479995 Human
fap primary amyloidosis We examined 5 brains with dementia of the Alzheimer type (SDAT), a peripheral nerves of familial amyloidotic polyneuropathy (variant transthyretin type, FAP) and dorsal root ganglions of a primary amyloidosis with peripheral neuropathy (AL type, PA). 2663294 NA
fap metastatic tumors In cases of primary pancreatic adenocarcinoma and metastatic tumors in the pancreas, a strong expression of FAP protein in the peritumoral acinar area was found. 2403740 Human
fap cm METHODS: In May 1993, a prospective study was begun to evaluate the role of sulindac in prevention of polyp recurrence after resection of large (> 1 cm) duodenal polyps in FAP patients. 9112144 NA
fap polyposis MATERIAL AND METHODS: From November 1998 to November 2000, 32 individuals with putative familial/hereditary predisposition to colorectal cancer were investigated for adenomatous polyposis (attenuated or classical familial adenomatous polyposis coli, FAP) 11407044 NA
fap familial adenomatous polyposis coli MATERIAL AND METHODS: From November 1998 to November 2000, 32 individuals with putative familial/hereditary predisposition to colorectal cancer were investigated for adenomatous polyposis (attenuated or classical familial adenomatous polyposis coli, FAP) 11407044 NA
fap colorectal cancer MATERIAL AND METHODS: From November 1998 to November 2000, 32 individuals with putative familial/hereditary predisposition to colorectal cancer were investigated for adenomatous polyposis (attenuated or classical familial adenomatous polyposis coli, FAP) 11407044 NA
fap hereditary nonpolyposis colorectal cancer (hnpcc) MATERIAL AND METHODS: From November 1998 to November 2000, 32 individuals with putative familial/hereditary predisposition to colorectal cancer were investigated for adenomatous polyposis (attenuated or classical familial adenomatous polyposis coli, FAP) 11407044 NA
fap hcc This study tested the hypothesis that biallelic inactivation of the APC gene contributed to the development of HCC in a patient with FAP and a known germline mutation of the APC gene at codon 208, but no other risk factors for HCC. 11466687 NA
fap polyposis METHODS: Between 1993 and 1998, 84 patients underwent IAA without ileostomy: 51 for FAP, 30 for UC, 2 for non familial colonic polyposis and 1 for indeterminate colitis. 12434066 NA
fap skin tumors In this study, we describe the expression and enzyme activity of FAP in benign and malignant melanocytic skin tumors. 12542520 NA
fap adenomatosis METHODS: Between January 1994 and June 2002, 16 patients with FAP (mean age 55 years; eight men) were referred to a single surgeon for pylorus-preserving pancreaticoduodenal resection for Spigelman stage IV duodenal adenomatosis. 15449267 NA
fap polyposis PATIENTS AND METHODS: We examined desmoid risk dependent on germline APC mutation, sex, history of abdominal surgery, and family history in FAP patients from the St Mark's Hospital Polyposis Registry. 15542524 NA
fap adenoma METHODS: To elucidate the biological dysregulation underlying adenoma formation we examined global gene expression profiles of adenomas and corresponding normal mucosa from an FAP patient. 15982419 NA
fap adenomas METHODS: To elucidate the biological dysregulation underlying adenoma formation we examined global gene expression profiles of adenomas and corresponding normal mucosa from an FAP patient. 15982419 NA
fapp pancreatic tumors We attempted to determine whether pancreatic tumoral SOJ-6 cells are expressed at their surface FAPP antigens and to examine if specific antibodies directed against these FAPP epitopes could decrease the growth of pancreatic tumors in a mice model. 15720797 Human
fap cancer of the pancreas FAP protein is a serum marker for pancreatic pathologies and combined with CA 19-9 antigen assay it provides a serum test which is almost specific for cancer of the pancreas with near 100% sensitivity. 2317578 Human
cel malignancy Since pancreatic cancer is an aggressive and often incurable malignancy, we investigated if the carboxyl ester lipase gene (CEL) is specifically expressed in pancreatic tissues and its promoter can be used for a specific suicide gene approach. 16865281 Human
cel pancreatic cancer Since pancreatic cancer is an aggressive and often incurable malignancy, we investigated if the carboxyl ester lipase gene (CEL) is specifically expressed in pancreatic tissues and its promoter can be used for a specific suicide gene approach. 16865281 Human
cel tumor Twenty-five tumor samples, 24 samples of normal pancreatic tissue and control tissues from other organs were examined by radioactive in situ hybridization (ISH) to localize CEL mRNA. 16865281 Human
fetoacinar pancreatic protein oncogenic A fetoacinar pancreatic protein (FAP) associated with the ontogenesis, differentiation and oncogenic transformation of the human exocrine pancreas has been purified from pancreatic juices of patients suffering from pancreatitis or duodenal cancers invadin 8424803 Human
fetoacinar pancreatic protein metastases An immunohistologic study of the feto-acinar pancreatic protein (FAP) in the normal pancreas, chronic pancreatitis, pancreatic adenocarcinoma, and intraabdominal metastases of adenocarcinomas. 2403740 NA
fetoacinar pancreatic protein adenocarcinomas An immunohistologic study of the feto-acinar pancreatic protein (FAP) in the normal pancreas, chronic pancreatitis, pancreatic adenocarcinoma, and intraabdominal metastases of adenocarcinomas. 2403740 NA
fetoacinar pancreatic protein pancreatic adenocarcinoma An immunohistologic study of the feto-acinar pancreatic protein (FAP) in the normal pancreas, chronic pancreatitis, pancreatic adenocarcinoma, and intraabdominal metastases of adenocarcinomas. 2403740 NA
fetoacinar pancreatic protein fap The immunohistologic distribution of the feto-acinar pancreatic protein (FAP), detected by the monoclonal antibody (MoAb) J28 using an indirect immunoperoxidase technique, is described. 2403740 Human
fap oncogenic A fetoacinar pancreatic protein (FAP) associated with the ontogenesis, differentiation and oncogenic transformation of the human exocrine pancreas has been purified from pancreatic juices of patients suffering from pancreatitis or duodenal cancers invadin 8424803 Human
fap adenocarcinomas An immunohistologic study of the feto-acinar pancreatic protein (FAP) in the normal pancreas, chronic pancreatitis, pancreatic adenocarcinoma, and intraabdominal metastases of adenocarcinomas. 2403740 NA
cel lipomatosis We have recently described pancreatic atrophy and lipomatosis in diabetic subjects of two Norwegian families with a novel syndrome of diabetes and exocrine pancreatic dysfunction caused by heterozygous carboxyl-ester lipase (CEL) mutations. 17259390 Human
fetoacinar pancreatic protein tumor Monoclonal antibody 16D10 to the C-terminal domain of the feto-acinar pancreatic protein binds to membrane of human pancreatic tumoral SOJ-6 cells and inhibits the growth of tumor xenografts. 15720797 Human
cel npc To verify the results from pathway-based selection, reverse transcription-polymerase chain reaction (RT-PCR) and real-time RT-PCR were performed to detect the expression levels of RAN, CEL and RELA genes and it was found that the RAN and CEL genes were si 17151784 Human

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