IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene RALGDS Ensembl ENSG00000160271 Chromosome 9 Start 134962928 End 135014542
Description Ral guanine nucleotide dissociation stimulator (RalGDS)(RalGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q12967]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9842
     Entrez Gene : 5900
     UCSC : uc004cco.2
     GeneCards : 9842
     RefSeq : NM_001042368
     CCDS : CCDS6959.1
     Uniprot : Q12967
     Interpro : Q12967
     OMIM : 601619
     GeneTests : RALGDS
     CGAP : RALGDS
     PMID : 7972015

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  34254_at  -0.40  3.70e-2  7.17e-2  -0.82  3.97e-3  1.03e-2
 HG_U133A  209050_s_at  -0.32  9.00e-7  2.33e-6  -4.68  9.73e-97  6.04e-96
 HG_U133A  209051_s_at  -0.20  2.90e-3  4.94e-3  -4.60  1.84e-127  2.77e-126
 HG_U133_Plus2  209050_s_at  -1.10  1.39e-23  4.76e-22  -1.13  1.44e-21  2.38e-20
 HG_U133_Plus2  209051_s_at  -0.92  6.18e-12  5.72e-11  -0.48  5.79e-6  1.53e-5
 Stanford  552  0.53  1.50e-1  3.25e-1  0.31  4.30e-1  6.60e-1
 Agilent_HS_21.6K  8511  -0.34  1.70e-9  8.99e-8  -0.28  1.19e-4  9.22e-4
 Agilent_HS_21.6K  20825  -0.21  7.18e-4  5.86e-3  -0.19  1.64e-2  5.27e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  209050_s_at  -0.01  9.51e-1  9.98e-1  0.12  3.50e-1  1.00e+0
 HG_U133A  209051_s_at  -0.39  1.47e-1  8.07e-1  -0.01  9.49e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 34254_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209050_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209051_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209050_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209051_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 552    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 8511    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 20825    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ralgds squamous-cell carcinoma We have previously identified the oncogene rgr (ralGDS related) in DNA derived from a rabbit squamous cell carcinoma. 12140761 Human
ralgef metastasis Here we investigated the contribution of RalGEF and ERK activation to the development of experimental metastasis in vivo and associated invasive properties in vitro. 11486034 Human
ralgef metastasis In contrast, 3T3 cells transformed by Ras(12V,37G), a Ras effector mutant that activates RalGEF but not Raf or P13 kinase, formed aggressive, infiltrative metastasis. 11486034 Human
ralgef metastasis Dominant negative RalB inhibited Ras(12V,37G)-activated invasion and metastasis, demonstrating the necessity of the RalGEF pathway for a fully transformed phenotype. 11486034 Human
ralgef tumors Moreover, 3T3 cells constitutively expressing a membrane-associated form of RalGEF (RalGDS-CAAX) formed invasive tumors as well, demonstrating that activation of a RalGEF pathway is sufficient to initiate the invasive phenotype. 11486034 Human
ralgef metastasis The generality of the role of the RalGEF pathway in metastasis is supported by the finding that Ras(12V,37G) increased the invasiveness of epithelial cells as well as fibroblasts. 11486034 Human
ralgds myeloid leukemia JAK/STAT3-dependent activation of the RalGDS/Ral pathway in M1 mouse myeloid leukemia cells. 11432872 Human
ralgds leukemia To identify new leukemia inhibitory factor-induced genes, we have performed representational difference analysis using M1 mouse myeloid leukemia cells and cloned RalGDS. 11432872 Human
ralgds myeloid leukemia To identify new leukemia inhibitory factor-induced genes, we have performed representational difference analysis using M1 mouse myeloid leukemia cells and cloned RalGDS. 11432872 Human
ralgef embryonal carcinoma Interdependent action of RalGEF and Erk in Ras-induced primitive endoderm differentiation of F9 embryonal carcinoma cells. 10442634 Human
ralgds mammary carcinoma Most notably, a Ras effector loop mutant that lacks affinity with PI3K and RalGDS but retains affinity with Raf (E38-V12-Ras) is relatively similar in potency to V12-Ras for mammary carcinoma induction. 12538354 Human
ralgds carcinoma Two other Ras effector loop mutants, each lacking affinity with Raf, one retaining affinity with PI3K (C40-V12-Ras), the other with RalGDS (G37-V12-Ras), resulted in much longer tumor latency than E38-V12-Ras and V12-Ras and a reduced carcinoma frequency. 12538354 Human
ralgds tumor Two other Ras effector loop mutants, each lacking affinity with Raf, one retaining affinity with PI3K (C40-V12-Ras), the other with RalGDS (G37-V12-Ras), resulted in much longer tumor latency than E38-V12-Ras and V12-Ras and a reduced carcinoma frequency. 12538354 Human
ralgds tumour Additionally, some TPA-induced genes, such as Sprr1A, Saa3, JunB, Il4ralpha, Gp38, RalGDS and Slpi exhibit high basal level in advanced stages of skin carcinogenesis, suggesting that at least a subgroup of the identified TPA-regulated genes may contribute 12640676 Human
ralgds metastasis Additionally, some TPA-induced genes, such as Sprr1A, Saa3, JunB, Il4ralpha, Gp38, RalGDS and Slpi exhibit high basal level in advanced stages of skin carcinogenesis, suggesting that at least a subgroup of the identified TPA-regulated genes may contribute 12640676 Human
ralgds tumors Mice lacking RalGDS are defective in tumor formation, possibly because of increased apoptosis in Ras-driven tumors. 15766656 Human
ralgds tumor Mice lacking RalGDS are defective in tumor formation, possibly because of increased apoptosis in Ras-driven tumors. 15766656 Human
ralgds cancer The hunt for a clear role for RalGDS activation in human cancer is on. 15766656 Human
ralgds tumor RalGDS is required for tumor formation in a model of skin carcinogenesis. 15766660 Human
ralgds tumor Lack of RalGDS results in reduced tumor incidence, size, and progression to malignancy in multistage skin carcinogenesis, and reduced transformation by Ras in tissue culture. 15766660 Human
ralgds malignancy Lack of RalGDS results in reduced tumor incidence, size, and progression to malignancy in multistage skin carcinogenesis, and reduced transformation by Ras in tissue culture. 15766660 Human
ralgds skin tumors Experiments performed in cells isolated from skin tumors suggest that RalGDS mediates cell survival through the activation of the JNK/SAPK pathway. 15766660 Human

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