IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ABO Ensembl ENSG00000175164 Chromosome 9 Start 135120384 End 135140451
Description Histo-blood group ABO system transferase (NAGAT)(Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase)(EC 2.4.1.40)(Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase)(Histo-blood group A transferase)(A transferase)(Glycoprotein-fucosylgalactoside alpha-galactosyltransferase)(EC 2.4.1.37)(Fucosylglycoprotein 3-alpha-galactosyltransferase)(Histo-blood group B transferase)(B transferase) [Contains Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form] [Source:UniProtKB/Swiss-Prot;Acc:P16442]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 79
     Entrez Gene : 28
     UCSC : uc004cda.1
     GeneCards : 79
     RefSeq : NM_020469
     Uniprot : Q99484
     Interpro : Q99484
     OMIM : 110300
     GeneTests : ABO
     CGAP : ABO
     PMID : 184030

< Top >


Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  34469_at  0.40  2.75e-6  1.62e-5  0.33  1.56e-2  3.38e-2
 HG_U133A  214504_at  -0.12  1.37e-1  1.74e-1  -1.64  4.35e-26  6.91e-26
 HG_U133A  216716_at  0.30  1.06e-2  1.66e-2  1.82  1.30e-35  2.36e-35
 HG_U133A  216929_x_at  -0.23  4.85e-2  6.76e-2  1.23  8.30e-18  1.17e-17
 HG_U133_Plus2  214504_at  0.08  5.88e-1  6.68e-1  -0.08  6.17e-1  6.70e-1
 HG_U133_Plus2  216716_at  0.43  6.17e-3  1.33e-2  0.73  8.21e-5  1.86e-4
 HG_U133_Plus2  216929_x_at  1.01  5.12e-8  2.83e-7  1.01  3.92e-5  9.26e-5
 Agilent_HS_21.6K  18589  0.01  7.66e-1  8.65e-1  0.00  9.01e-1  9.41e-1

< Top >


Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  214504_at  -0.15  5.29e-1  9.35e-1  0.24  9.44e-2  1.00e+0
 HG_U133A  216716_at  -0.39  3.57e-1  8.92e-1  0.43  1.21e-1  1.00e+0
 HG_U133A  216929_x_at  -0.43  1.20e-1  7.88e-1  -0.40  8.18e-2  1.00e+0

< Top >


Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 34469_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 214504_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 216716_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 216929_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 214504_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 216716_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 216929_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 18589    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

< Top >


Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
abo erythroleukaemia Mutation of this site abrogates binding of those factors and reduces the ability of the ABO promoter to function in erythroleukaemia cells and gastric cancer cells. 11856466 Human
abo gastric cancer Mutation of this site abrogates binding of those factors and reduces the ability of the ABO promoter to function in erythroleukaemia cells and gastric cancer cells. 11856466 Human
abo tumours Changes in ABO expression in tumours have, in some cases, been due to the A/B gene promoter, although little is known about the regulation of A, and B expression, in normal tissue. 11896825 Human
abo oral squamous-cell carcinoma Genetic and epigenetic alterations of the blood group ABO gene in oral squamous cell carcinoma. 14750174 Human
abo oral carcinomas Loss of histo-blood group A and B antigen expression is a frequent event in oral carcinomas and is associated with decreased activity of glycosyltransferases encoded by the ABO gene. 14750174 Human
abo tumors We also examined DNA from these tumors for loss of heterozygosity (LOH) at markers surrounding the ABO locus at chromosome 9q34, for loss of specific ABO alleles, and for hypermethylation of the ABO promoters. 14750174 Human
abo tumors Analysis of the proximal ABO promoter by methylation-specific PCR and melting curve analysis showed hypermethylation in 10 of 30 tumors (33.3%), which was associated with loss of A/B antigen expression. 14750174 Human
abo tumors ABO promoter hypermethylation was also found in hyperplastic or dysplastic tissues adjacent to the tumors, suggesting that it is an early event in tumorigenesis. 14750174 Human
abo gastric cancer Whereas constitutive transcriptional activity of the ABO gene promoter was demonstrated in both expressor and nonexpressor cell lines by transient transfection of reporter constructs containing the ABO gene promoter sequence, HhaI methylase-catalyzed in v 10601288 Human
abo gastric cancer On the other hand, in the nonexpressor gastric cancer cell line MKN28 cells, treatment with DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine resulted in demethylation of the ABO gene promoter and appearance of A-transferase messages, as well as 10601288 Human
abo transitional cell carcinoma ABO blood groups and their relationship to transitional cell carcinoma of the urinary bladder in 30 Jordanian patients. 3207084 Human
abo bladder neoplasms In bladder neoplasms the loss of A and B transferase activity is due to down-regulation of the ABO gene transcripts. 9506524 Human
abo tumor Normal and tumor DNA also were analyzed by PCR coupled with restriction enzyme analysis in order to establish the ABO genotype. 9506524 Human
abo tumors Our data indicate that the lack of ABO antigen expression in certain bladder tumors is due to the allelic loss of the ABO glycosyltransferase-encoding genes and that in some of these tumors the loss involves the surrounding chromosomal region at 9q34.1-4. 9506524 Human
abo bladder tumors Our data indicate that the lack of ABO antigen expression in certain bladder tumors is due to the allelic loss of the ABO glycosyltransferase-encoding genes and that in some of these tumors the loss involves the surrounding chromosomal region at 9q34.1-4. 9506524 Human
abo chronic myeloid leukemia Detection of histo-blood group ABO mRNA in human chronic myeloid leukemia cell lines using reverse transcription-polymerase chain reaction (RT-PCR). 10072169 Human
abo chronic myeloid leukemia (cml) In an attempt to verify the ABO mRNA expression in hemopoietic precursor cells, mRNAs were isolated from human chronic myeloid leukemia (CML) cell lines which are believed to be at the most immature level of hemopoietic differentiation among hemopoietic m 10072169 Human
abo chronic myeloid leukemia Both of the human chronic myeloid leukemia cell lines expressed ABO mRNA. 10072169 Human
abo hematologic malignancy Because the CML cell lines are presumed to be at the immature stem cell level of hematopoietic cell differentiation and because it is believed that the cultured cell lines from hematologic malignancy reflect the characteristics of normal corresponding hem 10072169 Human
abo gastric cancer We introduced the 5'-upstream sequence of ABO genes into the promoterless reporter vector and characterized the promoter activity of deletion constructs using transient transfection assays with gastric cancer cell line KATO III cells. 9325321 Human
abo gastric cancer The sequence just upstream of the transcription start site (cap site), and an enhancer element, which is located further upstream (between -3899 and -3618 base pairs (bp) from the transcription initiation site) and contains 4 tandem copies of a 43-bp repe 9325321 Human
abo bladder tumors The molecular mechanism that in human bladder tumors leads to the loss of blood group ABO glycosyltransferase activity and, thereby, the loss of ABO antigens was investigated. 8640757 Human
abo tumors In 15 tumors and 3 normal biopsies from blood group AB individuals and 7 tumors and 3 normal biopsies from blood group O individuals, mRNA was detected by a reverse transcription PCR (RT-PCR) assay, and the ABO blood group structure was determined by immu 8640757 Human
abo tumors The ABO mRNA was present in normal urothelium and low-grade tumors but disappeared from high grade tumors. 8640757 Human
abo low-grade tumors The ABO mRNA was present in normal urothelium and low-grade tumors but disappeared from high grade tumors. 8640757 Human
abo bladder cancer Loss of ABH antigen expression in bladder cancer is not caused by loss of heterozygosity of the ABO locus. 7591228 Human
abo tumor We have studied LOH of the ABO gene locus at 9q34.2 by means of polymerase chain reaction (PCR) genotyping of tumor preparations and leukocytes. 7591228 Human
abo tumors As all tumors were ABH antigen-negative, this study demonstrates that LOH of the ABO locus on chromosome 9q34 is not the cause of loss of blood-group ABH expression in human bladder cancer. 7591228 Human
abo human bladder cancer As all tumors were ABH antigen-negative, this study demonstrates that LOH of the ABO locus on chromosome 9q34 is not the cause of loss of blood-group ABH expression in human bladder cancer. 7591228 Human
abo leukaemia Blood group gene specified glycosyltransferases in rare ABO groups and in leukaemia. 418487 Human
abo angiomyolipoma One angiomyolipoma showed allele loss for the markers ABO, DBH and D9S66, but not for D9S149 or D9S67. 7849709 Human
abo cancer 1) Incomplete synthesis of carbohydrate chains (e.g. loss of ABO antigens) 2) accumulation of precursor carbohydrates (e.g. accumulation of I antigen which is one of the precursors of ABO) 3) synthesis of new carbohydrates (e.g. expression of A-like antig 3729459 Human
abo bladder tumors The blood group ABO gene transcript is down-regulated in human bladder tumors and growth-stimulated urothelial cell lines. 8640757 Human
abo epidermoid carcinoma [Role pf genetic and other biomarkers in the prognostication of postoperative course in patients with lung cancer] Relationships between genetic polymorphisms (ABO, RH, HP, TF, GC, Pi, ACP1, PGM1, GLO1, PTC) and some clinical, biochemical, and functional 9102077 Human
abo ca METHODS: The echocardiograms of all patients with ABO CA were evaluated for the screening sign and compared with those of age-matched control patients. 12835663 Human
abo hcc In comparison with the normal liver tissues from the healthy donors, it was found that while remained unmethylated the ABL, CAV, EPO, GATA3, LKB1, NEP, NFL, NIS and p27KIP1 genes, varying extents of the HCC specific hypermethylation were found associated 14672555 Human
abo hyperplastic ABO promoter hypermethylation was also found in hyperplastic or dysplastic tissues adjacent to the tumors, suggesting that it is an early event in tumorigenesis. 14750174 Human
abo cancer To explain the molecular basis of how the ABO genes are controlled in cell type-specific expression, during normal cell differentiation, and in cancer cells with invasive and metastatic potential that lack A/B antigens, it is essential to understand the r 15939654 Human
abo blood group tumors In 15 tumors and 3 normal biopsies from blood group AB individuals and 7 tumors and 3 normal biopsies from blood group O individuals, mRNA was detected by a reverse transcription PCR (RT-PCR) assay, and the ABO blood group structure was determined by immu 8640757 Human
abo blood group high grade tumors Studies of glycosylation genes have shown downregulation of the ABO gene, followed by loss of ABO blood group structures and accumulation of the Lewis cell adhesion molecules in high grade tumors. 9759995 Human
abo blood group hematologic malignancy Because the CML cell lines are presumed to be at the immature stem cell level of hematopoietic cell differentiation and because it is believed that the cultured cell lines from hematologic malignancy reflect the characteristics of normal corresponding hem 10072169 Human
abo blood group acute leukemia (al) A study was carried out in northeast peninsular Malaysia, where the population is predominantly Malay, to examine whether there was a difference in ABO blood group distribution between males and females with acute leukemia (AL). 10391104 Human
the abo gene tumor We have studied LOH of the ABO gene locus at 9q34.2 by means of polymerase chain reaction (PCR) genotyping of tumor preparations and leukocytes. 7591228 Human
the abo gene bladder neoplasms In bladder neoplasms the loss of A and B transferase activity is due to down-regulation of the ABO gene transcripts. 9506524 Human
the abo gene gastric cancer Whereas constitutive transcriptional activity of the ABO gene promoter was demonstrated in both expressor and nonexpressor cell lines by transient transfection of reporter constructs containing the ABO gene promoter sequence, HhaI methylase-catalyzed in v 10601288 Human
the abo gene gastric cancer On the other hand, in the nonexpressor gastric cancer cell line MKN28 cells, treatment with DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine resulted in demethylation of the ABO gene promoter and appearance of A-transferase messages, as well as 10601288 Human
the abo gene bladder cancer Loss of blood group A antigen expression in bladder cancer caused by allelic loss and/or methylation of the ABO gene. 15880137 Human
the abo mrna high grade tumors The ABO mRNA was present in normal urothelium and low-grade tumors but disappeared from high grade tumors. 8640757 Human
the abo mrna low-grade tumors The ABO mRNA was present in normal urothelium and low-grade tumors but disappeared from high grade tumors. 8640757 Human
the abo mrna chronic myeloid leukemia (cml) In an attempt to verify the ABO mRNA expression in hemopoietic precursor cells, mRNAs were isolated from human chronic myeloid leukemia (CML) cell lines which are believed to be at the most immature level of hemopoietic differentiation among hemopoietic m 10072169 Human

< Top >


Download all image files.
Save all PNG files.    Save all PDF files.    Save all PS files.