IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene DBH Ensembl ENSG00000123454 Chromosome 9 Start 135491306 End 135514287
Description Dopamine beta-hydroxylase (EC 1.14.17.1)(Dopamine beta-monooxygenase) [Contains Soluble dopamine beta-hydroxylase] [Source:UniProtKB/Swiss-Prot;Acc:P09172]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 2689
     Entrez Gene : 1621
     UCSC : uc004cel.2
     GeneCards : 2689
     RefSeq : NM_000787
     CCDS : CCDS6977.2
     Uniprot : P09172
     Interpro : P09172
     OMIM : 609312
     GeneTests : DBH
     CGAP : DBH

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  32943_at  -0.01  9.22e-1  9.43e-1  -0.08  7.25e-1  7.98e-1
 HG_U133A  206450_at  -0.17  3.01e-2  4.36e-2  4.19  2.34e-114  2.38e-113
 HG_U133_Plus2  206450_at  -0.39  1.73e-2  3.32e-2  -0.62  5.70e-4  1.14e-3
 HG_U133_Plus2  234916_at  -0.45  5.44e-3  1.19e-2  -0.43  2.37e-2  3.61e-2
 Agilent_HS_21.6K  15861  0.11  6.84e-2  1.81e-1  0.11  2.14e-2  6.49e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206450_at  0.04  9.02e-1  9.94e-1  0.11  5.77e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 32943_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206450_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206450_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 234916_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 15861    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
dbh hepatoma Using mammalian one-hybrid and two-hybrid systems, we demonstrate that recruitment of Arix to the positions of homeodomain core recognition sites 1 and 2 at -153 to -166 of the DBH gene restores complete responsiveness of the promoter to PKA in SHSY-5Y ne 10644760 Human
dbh neuroblastoma Using mammalian one-hybrid and two-hybrid systems, we demonstrate that recruitment of Arix to the positions of homeodomain core recognition sites 1 and 2 at -153 to -166 of the DBH gene restores complete responsiveness of the promoter to PKA in SHSY-5Y ne 10644760 Human
dbh glioblastoma Because non-neuronal cells in the central nervous system contained peptidyl alpha-amidating monooxygenase (PAM), to which cytochrome b561 donates its electrons, we used RT-PCR to document the coexpression of cytochrome b561 with PAM and dopamine beta-hydr 9778036 Human
dbh human neuroblastoma Protein kinase C (PKC) activation after treatment of human neuroblastoma SK-N-BE(2)C cells with phorbol 12-myristate 13-acetate (PMA) was found to enhance transcription of the human dopamine beta-hydroxylase (DBH) in those cells. 9427517 Human
dbh human neuroblastoma Stimulation of human DBH gene expression by prostaglandin E2 in human neuroblastoma SK-N-BE(2)C cells. 9481616 Human
dbh human neuroblastoma Prostaglandin E2 (PGE2) enhances transcription of the human dopamine beta-hydroxylase (DBH) gene in human neuroblastoma SK-N-BE(2)C cells. 9481616 Human
dbh human neuroblastoma Similarly, human neuroblastoma cells also secrete native DBH into the medium, but at a much lower level than recombinant Drosophila cells. 8546710 Human
dbh c6 glioma We have found that 1 kilobase of the DBH promoter can direct expression of the luciferase reporter gene in the DBH-expressing PC12, CATH.a, and SK-N-SH cell lines, but not in the non-DBH-expressing C6 glioma or CA77 cell lines. 9011768 Rat
dbh neuroblastoma Using the promoter proximal region of the rat DBH gene and nuclear extracts from SHSY-5Y neuroblastoma cells, a DNA-protein complex was identified that is competitive with oligonucleotides containing the recognition site of transcription factor AP-2. 7616204 Human
dbh tumor Dopamine-beta-hydroxylase (DBH) in membrane-bound (mDBH) and water-soluble (sDBH) forms was isolated from chromaffin granules of bovine adrenal medullae and a human pheochromocytoma tumor. sDBH was purified by concanavalin A-agarose column chromatography 3965617 Human
dopamine beta-monooxygenase myeloma Spleen cells from BALB/c mice immunized with rat dopamine beta-monooxygenase were fused to P3-X63-Ag8-653 mouse myeloma cells. 6733150 Human
dbh neuroblastoma We have studied serum DBH levels on 26 children with neuroblastoma and 58 age-matched controls. 6821627 NA
dbh neuroblastoma Serum DBH levels in children with neuroblastoma were unrelated to the response of this neoplasm to treatment or to urinary catecholamine output and thus are unlikely to have any value in diagnosis or as a marker of tumour activity. 6821627 Human
dbh neoplasm Serum DBH levels in children with neuroblastoma were unrelated to the response of this neoplasm to treatment or to urinary catecholamine output and thus are unlikely to have any value in diagnosis or as a marker of tumour activity. 6821627 Human
dbh tumour Serum DBH levels in children with neuroblastoma were unrelated to the response of this neoplasm to treatment or to urinary catecholamine output and thus are unlikely to have any value in diagnosis or as a marker of tumour activity. 6821627 Human
dbh tumor Biochemical differences in tumor groups probably reflected variations in the proportion of neuroepithelial components: trends suggested an increase of cAMP and an increased activity of TPH, AADC, TH and DBH in tumors with increased proportions of neuroepi 1140 Mouse
dbh tumors Biochemical differences in tumor groups probably reflected variations in the proportion of neuroepithelial components: trends suggested an increase of cAMP and an increased activity of TPH, AADC, TH and DBH in tumors with increased proportions of neuroepi 1140 Mouse
dbh tumors Significant correlations were observed between postoperative falls of individual DBH activities, urinary VMA and weight of the tumors, whereas there was correlation neither between preoperative DBH activity and urinary CA, nor between the rate of postoper 647977 Human
dbh tumor These findings suggest that pheochromocytoma is capable of secreting DBH, and wide variations in the rate of DBH output from these tumors may account for varying capacity of CA biosynthesis in the tumor. 647977 Human
dbh tumors These findings suggest that pheochromocytoma is capable of secreting DBH, and wide variations in the rate of DBH output from these tumors may account for varying capacity of CA biosynthesis in the tumor. 647977 Human
dbh parathyroid hyperplasia We determined the activity of DBH in the plasma of 8 patients with pheos, secondary to multiple endocrine neoplasia Type 2 (MEN II) (medullary carcinoma of the thyroid [MCT], pheochromocytoma(s), and parathyroid hyperplasia). 723634 Human
dbh medullary carcinoma We determined the activity of DBH in the plasma of 8 patients with pheos, secondary to multiple endocrine neoplasia Type 2 (MEN II) (medullary carcinoma of the thyroid [MCT], pheochromocytoma(s), and parathyroid hyperplasia). 723634 Human
dbh multiple endocrine neoplasia We determined the activity of DBH in the plasma of 8 patients with pheos, secondary to multiple endocrine neoplasia Type 2 (MEN II) (medullary carcinoma of the thyroid [MCT], pheochromocytoma(s), and parathyroid hyperplasia). 723634 Human
dbh neuroblastoma We have measured plasma levels of norepinephrine (NE), epinephrine (E), dopamine (DA) and 3,4-dihydroxyphenylalanine (DOPA), and plasma activities of dopamine beta-hydroxylase (DBH) and aromatic L-amino acid decarboxylase (ALAAD) in 18 patients with neuro 2503383 Human
dbh tumour NE, E and DBH were found not to reflect tumour activity. 2503383 Human
dbh human neuroblastoma We previously showed that ethanol regulates dopamine beta-hydroxylase (DBH) mRNA and protein levels in human neuroblastoma cells (Thibault, C., Lai, C., Wilke, N., Duong, B., Olive, M. F., Rahman, S., Dong, H., Hodge, C. W., Lockhart, D. J., and Miles, M. 12842874 Human
dbh neuroblastoma These results indicate that endogenous DA overload in neuroblastoma inhibits NE production by suppressing DBH activity as well as by forming VMA and MHPG. 2583066 Human
dbh nasal polyps Since the pathophysiological roles of neuropeptides depend on their presence in the target tissue, specimens of nasal polyps were removed from 20 patients and examined for the presence of vasoactive intestinal peptide (VIP), neuropeptide Y (NPY), dopamine 7521108 Human
dbh human neuroblastoma In the present study, we used DBH-expressing human neuroblastoma SK-N-BE(2)C and rat pheochromocytoma (PC12) cell lines to investigate the role of cAMP-dependent protein kinase (PKA) in transcriptional regulation of the DBH gene. 7525897 Human
dbh c6 glioma In DBH-nonexpressing HeLa and C6 glioma cell lines, coexpression of PKAc changed the transcriptional activity of the DBH promoter to a minimal degree, indicating that basal and PKA-mediated transcription of the DBH gene occur in a cell type-specific manne 7525897 Rat
dbh tumors As it is not clear whether these tumors contain specific enzymes for catecholamine synthesis, we aimed to detect catecholamine-synthesizing enzymes [tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine-N-methyltransferase (PN 12651811 Human
dbh midgut carcinoid tumors As it is not clear whether these tumors contain specific enzymes for catecholamine synthesis, we aimed to detect catecholamine-synthesizing enzymes [tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine-N-methyltransferase (PN 12651811 Human
dbh paraffin-embedded tumor METHODS: Paraffin-embedded tumor specimens from 21 midgut carcinoid patients and 20 pheochromocytoma patients (10 sporadic and 10 MEN type IIa-related tumors) were stained for TH, DBH, and PNMT, using a three-step biotin-avidin-peroxidase method. 12651811 NA
dbh tumors METHODS: Paraffin-embedded tumor specimens from 21 midgut carcinoid patients and 20 pheochromocytoma patients (10 sporadic and 10 MEN type IIa-related tumors) were stained for TH, DBH, and PNMT, using a three-step biotin-avidin-peroxidase method. 12651811 NA
dbh angiomyolipoma One angiomyolipoma showed allele loss for the markers ABO, DBH and D9S66, but not for D9S149 or D9S67. 7849709 Human
dbh neuroblastoma DBH expression in the neuroblastoma cell lines almost perfectly corresponded to Dlk1 expression. 12672031 Human
dbh human neuroblastoma A fragment of 1,247 bp directly 5' to the transcriptional start was progressively shortened, placed in front of a reporter gene, and tested in a human neuroblastoma cell line expressing DBH (SK-N-SH-TFM) and in a monkey kidney cell line (CV-1). 8380196 Human
dbh human neuroblastoma DNase I hypersensitive sites were found in the 5'-flanking region of the DBH gene in noradrenergic human neuroblastoma SK-N-BE(2)C cells, but not in DBH-nonexpressing HeLa cells. 7688735 Human
dbh neuroblastoma We used sympathetic neurons and SK-N-BE(2)M17 neuroblastoma cells to investigate CDF down-regulation of the norepinephrine synthetic enzyme dopamine-beta-hydroxylase (DBH). 12609984 Human
dbh tumours AADC and DBH were present universally in all functioning and non-functioning tumours, including TH-negative tumours. 1353277 Human
dbh tumor A number of cDNA clones for rat dopamine beta-hydroxylase (DBH) were isolated from a rat pheochromocytoma tumor cDNA library. 2325165 Human
dbh tumor In 4 patients both the DBH activity and plasma catecholamine concentrations rapidly increased during surgical manipulation of the tumor. 7084126 Human
dbh mouse neuroblastoma The distribution of the enzymatic activity of dopamine beta-hydroxylase (DBH) in linear sucrose gradients was studied for a soluble fraction of the C1300 mouse neuroblastoma tumor, for the serum of tumor-bearing A/J mice, and for adrenal tissue and serum 7119788 Mouse
dbh tumor The distribution of the enzymatic activity of dopamine beta-hydroxylase (DBH) in linear sucrose gradients was studied for a soluble fraction of the C1300 mouse neuroblastoma tumor, for the serum of tumor-bearing A/J mice, and for adrenal tissue and serum 7119788 Mouse
dbh tumor In tumor supernatants and in the serum of tumor-bearing mice, about 55% of the DBH activity was present as the 7.1 S species (DBHB), while only 35% was recovered as the high-molecular-weight form (DBHA). 7119788 Mouse
dbh tumor The three enzymically active forms of DBH in the C1300 tumor are considered to represent the tetrameric (DBHA), dimeric (DBHB), and monomeric (DBHC) forms of the enzyme. 7119788 Mouse
dbh neuroblastoma Recent reports have suggested that elevations of serum dopamine-B-hydroxylase (DBH) activity may correlate with diagnosis in neuroblastoma patients excreting vanillylmandelic acid (VMA). 460046 Human
dbh neuroblastoma We have serially studied serum DBH and urinary homovanillic acid (HVA) and VMA excretion during the disease course of five patients with neuroblastoma. 460046 Human
dbh neuroblastoma Dilution studies revealed an age-related alteration in DBH effectors and they suggest that these may be different in neuroblastoma. 460046 Human
dbh neuroblastoma Investigation of dopamine-beta-hydroxylase (DBH) serum activity as a potential diagnostic/prognostic tool for neuroblastoma did not confirm previous reports. 485096 Human
dbh neuroblastoma Additionally, these effectors may be variably affected by assay methodology, influencing DBH results obtained in neuroblastoma and other disease states. 485096 Human
dbh adrenal pheochromocytoma In the adrenal pheochromocytoma both DBH- and PNMT-positive cells were seen, whereas the two extra-adrenal tumors contained only DBH. 386355 Human
dbh tumors In the adrenal pheochromocytoma both DBH- and PNMT-positive cells were seen, whereas the two extra-adrenal tumors contained only DBH. 386355 Human
dbh pheochromocytomas Tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) activities, dopamine (DA), noradrenaline (NA), adrenaline (A), met 5-enkephalin (Met-Enk), leu5-enkephalin (Leu-Enk), dynorphin (Dyn) and beta-endorphin (beta-end) were measured simultaneously 6144074 Human
dbh pheochromocytomas E, NE, chromogranin, TH, DBH, and PNMT were found in the normal human adrenal medulla and in pheochromocytomas. 3777139 Human
dbh phaeochromocytoma A human cDNA clone for dopamine beta hydroxylase (DBH) has been isolated from a phaeochromocytoma library. 3180847 Human
dbh pheochromocytomas We also examined the gene expression of the messengers of other catecholamine synthesizing enzymes, dopamine beta-hydroxylase (DBH) and aromatic 1-amino acid decarboxylase (AADC) in pheochromocytomas. 7602797 Human
dbh pheochromocytomas These findings indicate that catecholamine overproduction in pheochromocytomas is mediated by the overexpression of genes coding for catecholamines synthesizing enzymes, TH, DBH, and AADC. 7602797 Human
dbh pheochromocytomas METHODS: We measured the concentrations of mRNA coding for the catecholamine-synthesizing enzymes tyrosine hydroxylase, aromatic L-amino acid decarboxylase (AADC), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyl transferase (PNMT) and for 9578504 NA
dbh pheochromocytomas However, the tyrosine hydroxylase, AADC and DBH mRNA concentrations in the pheochromocytomas were greater than those of the normal adrenal medullas. 9578504 Human
dbh pheochromocytomas The majority of patients with sporadic pheochromocytomas (pheos) have been noted to have normal plasma dopamine-beta-hydroxylase (DBH) activity. 723634 Human
dbh medullary carcinoma of the thyroid We determined the activity of DBH in the plasma of 8 patients with pheos, secondary to multiple endocrine neoplasia Type 2 (MEN II) (medullary carcinoma of the thyroid [MCT], pheochromocytoma(s), and parathyroid hyperplasia). 723634 Human
dbh pheochromocytomas We evaluated the activity of phenylethanolamine-N-methyltransferase (PNMT) and dopamine-beta-hydroxylase (DBH) in 16 pheochromocytomas. 7323441 Human
dbh pheochromocytomas All of the pheochromocytomas contained PNMT and DBH activity. 7323441 Human
dbh pheochromocytomas There was a significant correlation between PNMT activity and epinephrine concentration in the pheochromocytomas (r=0.61); there was no significant correlation between PNMT activity and norepinephrine concentration (r=0.38) or DBH activity and norepinephr 7323441 Human
dbh carcinoid METHODS: Paraffin-embedded tumor specimens from 21 midgut carcinoid patients and 20 pheochromocytoma patients (10 sporadic and 10 MEN type IIa-related tumors) were stained for TH, DBH, and PNMT, using a three-step biotin-avidin-peroxidase method. 12651811 NA
dbh pheochromocytomas RESULTS: TH was demonstrated in 9 (43%) of 21 carcinoids and in all (100%) of 20 pheochromocytomas, DBH in 8 (38%) carcinoids and in 15 (75%) pheochromocytomas, and PNMT in 7 (33%) carcinoids and in 13 (65%) pheochromocytomas. 12651811 Human
dbh pd RESULTS: The allelic frequency of A2 allele of DBH gene was significantly higher in PD patients than in controls(P<0.01).The risk of suffering from PD increased (OR=1.82) in the individual with A2 allele. 12778453 Human
dbh pd On the other hand, the allelic frequency of A1 allele and the genotypic frequency of A1/A2 genotype of DBH gene in PD patients were significantly lower(A1 alleles: OR=0.54, P<0.01; A1/A2 genotypes: OR=0.45, P<0.01). 12778453 Human
dbh pd CONCLUSION: The polymorphism in DBH gene might play an important role in the susceptibility of Shanghai Chinese Han population to PD. 12778453 Human
dbh neuroblastoma Treatment of neuroblastoma cultures with PD98059 increases the interaction of Arix with DBH and NET genes, but not the TH gene. 16156742 Human
dopamine beta-hydroxylase pheochromocytomas Tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) activities, dopamine (DA), noradrenaline (NA), adrenaline (A), met 5-enkephalin (Met-Enk), leu5-enkephalin (Leu-Enk), dynorphin (Dyn) and beta-endorphin (beta-end) were measured simultaneously 6144074 Human
dopamine beta-hydroxylase phaeochromocytoma Effect of fusaric acid (a dopamine beta-hydroxylase inhibitor) on phaeochromocytoma. 3987067 Human
dopamine beta-hydroxylase phaeochromocytoma Fusaric acid, an inhibitor of dopamine beta-hydroxylase, which converts dopamine to noradrenaline, lowered the blood pressure and induced a subjective improvement in patients with phaeochromocytoma. 3987067 Human
dopamine beta-hydroxylase neuroblastomas This suggests a dopamine-norepinephrine pathway block, which supports previous reports of deficiency of dopamine beta-hydroxylase activity in some neuroblastomas. 2702581 Human
dopamine beta-hydroxylase neuroblastoma We have measured plasma levels of norepinephrine (NE), epinephrine (E), dopamine (DA) and 3,4-dihydroxyphenylalanine (DOPA), and plasma activities of dopamine beta-hydroxylase (DBH) and aromatic L-amino acid decarboxylase (ALAAD) in 18 patients with neuro 2503383 Human
dopamine beta-hydroxylase carcinoma of the rectum The distribution of serotonin and dopamine beta-hydroxylase was examined in sigmoid colon specimens from patients with severe idiopathic constipation and control patients with carcinoma of the rectum or colon. 1691117 Human
dopamine beta-hydroxylase tumor A number of cDNA clones for rat dopamine beta-hydroxylase (DBH) were isolated from a rat pheochromocytoma tumor cDNA library. 2325165 Human
dopamine beta-hydroxylase pheochromocytomas Sixteen of 17 pheochromocytomas and all hyperplastic nodules stained positively for tyrosine hydroxylase and dopamine beta-hydroxylase, consistent with an ability to produce NE. 1695697 Human
dopamine beta-hydroxylase hyperplastic Sixteen of 17 pheochromocytomas and all hyperplastic nodules stained positively for tyrosine hydroxylase and dopamine beta-hydroxylase, consistent with an ability to produce NE. 1695697 Human
dopamine beta-hydroxylase cell tumors Our results indicate, that antibodies directed to neuron specific enolase, HISL 19, dopamine beta-hydroxylase, neurofilament, EGC, LK2H10 and leucocyte common antigen may be useful in discrimination of neuroblastomas from non-neuroendocrine round and smal 2080234 Human
dopamine beta-hydroxylase neuroblastomas Our results indicate, that antibodies directed to neuron specific enolase, HISL 19, dopamine beta-hydroxylase, neurofilament, EGC, LK2H10 and leucocyte common antigen may be useful in discrimination of neuroblastomas from non-neuroendocrine round and smal 2080234 Human
dopamine beta-hydroxylase carcinoma of the bladder Different regions of the prostate gland, namely the prostatic capsule, peripheral prostate, and proximal and distal central prostate, were obtained from 5 patients with carcinoma of the bladder and studied histochemically and immunohistochemically to loca 1873692 Human
dopamine beta-hydroxylase neuroblastoma Multiple forms of human dopamine beta-hydroxylase in SH-SY5Y neuroblastoma cells. 1929417 Human
dopamine beta-hydroxylase human neuroblastoma Dopamine beta-hydroxylase exists as three forms in human neuroblastoma (SH-SY5Y) cells. 1929417 Human
dopamine beta-hydroxylase tumors Antibodies to dopamine beta-hydroxylase and protein gene product (PGP) 9.5 reacted with all tumors except two NBLs. 1530805 Human
dopamine beta-hydroxylase cell tumors We conclude that antibodies directed to neuron-specific enolase, HISL19, dopamine beta-hydroxylase, neurofilaments, EGC, LK2H10, and leucocyte common antigen represent markers that might be useful in the discrimination of GNBLs from non-neuroendocrine rou 1530805 Human
dopamine beta-hydroxylase neuroblastoma The 5'-flanking region of the dopamine beta-hydroxylase gene is also responsive to cyclic AMP and phorbol ester treatment of SHSY-5Y neuroblastoma cells. 1382062 Human
dopamine beta-hydroxylase phaeochromocytoma The principal causes of variable pulse OH are therapeutic drugs, absolute or relative hypovolaemia, endocrine diseases (adrenal insufficiency, phaeochromocytoma), spinal quadriplegia and two congenital diseases including dopamine beta-hydroxylase deficien 1344926 Human
dopamine beta-hydroxylase pheochromocytomas We also examined the gene expression of the messengers of other catecholamine synthesizing enzymes, dopamine beta-hydroxylase (DBH) and aromatic 1-amino acid decarboxylase (AADC) in pheochromocytomas. 7602797 Human
dopamine beta-hydroxylase human neuroblastoma Protein kinase C (PKC) activation after treatment of human neuroblastoma SK-N-BE(2)C cells with phorbol 12-myristate 13-acetate (PMA) was found to enhance transcription of the human dopamine beta-hydroxylase (DBH) in those cells. 9427517 Human
dopamine beta-hydroxylase human neuroblastoma Prostaglandin E2 (PGE2) enhances transcription of the human dopamine beta-hydroxylase (DBH) gene in human neuroblastoma SK-N-BE(2)C cells. 9481616 Human
dopamine beta-hydroxylase pheochromocytomas METHODS: We measured the concentrations of mRNA coding for the catecholamine-synthesizing enzymes tyrosine hydroxylase, aromatic L-amino acid decarboxylase (AADC), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyl transferase (PNMT) and for 9578504 NA
dopamine beta-hydroxylase neoplasms However, all neoplasms were negative for the other neuroendocrine markers tested, including chromogranin A, tyrosine hydroxylase, and dopamine beta-hydroxylase, as well as for epithelial membrane antigen, S100, and p53. 9591731 Human
dopamine beta-hydroxylase glioblastoma Because non-neuronal cells in the central nervous system contained peptidyl alpha-amidating monooxygenase (PAM), to which cytochrome b561 donates its electrons, we used RT-PCR to document the coexpression of cytochrome b561 with PAM and dopamine beta-hydr 9778036 Human
dopamine beta-hydroxylase tumours It is concluded that some pheochromocytoma tumours are able to secrete dopamine beta-hydroxylase. 947638 Human
dopamine beta-hydroxylase adrenal tumor [Changes in serum dopamine beta-hydroxylase activities and hypertension during excision of adrenal tumor] 1034731 Human
dopamine beta-hydroxylase mouse neuroblastoma Concomitant elevation of tyrosine hydroxylase and dopamine beta-hydroxylase by cyclic AMP in cultured mouse neuroblastoma cells. 28385 Mouse
dopamine beta-hydroxylase neuroblastomas These results are consistent with the hypothesis that biochemically primitive neuroblastomas deficient in dopamine beta-hydroxylase are move virulent than their mature analogues which produce epinephrine, norepinephrine, and their metabolites. 683787 Human
dopamine beta-hydroxylase mouse neuroblastoma Induction of tyrosine hydroxylase and dopamine beta-hydroxylase in cultured mouse neuroblastoma by 8Br-cAMP. 34092 Mouse
dopamine beta-hydroxylase mouse neuroblastoma Multiple molecular forms of dopamine beta-hydroxylase in the C1300 mouse neuroblastoma tumor and in the serum of tumor-bearing mice. 7119788 Mouse
dopamine beta-hydroxylase tumor Multiple molecular forms of dopamine beta-hydroxylase in the C1300 mouse neuroblastoma tumor and in the serum of tumor-bearing mice. 7119788 Mouse
dopamine beta-hydroxylase mouse neuroblastoma The distribution of the enzymatic activity of dopamine beta-hydroxylase (DBH) in linear sucrose gradients was studied for a soluble fraction of the C1300 mouse neuroblastoma tumor, for the serum of tumor-bearing A/J mice, and for adrenal tissue and serum 7119788 Mouse
dopamine beta-hydroxylase tumor The distribution of the enzymatic activity of dopamine beta-hydroxylase (DBH) in linear sucrose gradients was studied for a soluble fraction of the C1300 mouse neuroblastoma tumor, for the serum of tumor-bearing A/J mice, and for adrenal tissue and serum 7119788 Mouse
dopamine beta-hydroxylase tumor Decreased expression of dopamine beta-hydroxylase in the tumor was considered a possible mechanism of producing a pathophysiological concentration of dopamine. 11206726 Human
dopamine beta-hydroxylase human neuroblastoma We previously showed that ethanol regulates dopamine beta-hydroxylase (DBH) mRNA and protein levels in human neuroblastoma cells (Thibault, C., Lai, C., Wilke, N., Duong, B., Olive, M. F., Rahman, S., Dong, H., Hodge, C. W., Lockhart, D. J., and Miles, M. 12842874 Human
dopamine beta-hydroxylase neuroblastoma We found that ciliary neurotrophic factor decreased the transcriptional activator Phox2a in neuroblastoma cells and cultured sympathetic neurons, suggesting that the loss of Phox2a is part of the mechanism by which CNTF suppresses tyrosine hydroxylase and 15106827 Human
the dbh gene human neuroblastoma DNase I hypersensitive sites were found in the 5'-flanking region of the DBH gene in noradrenergic human neuroblastoma SK-N-BE(2)C cells, but not in DBH-nonexpressing HeLa cells. 7688735 Human
the dbh gene human neuroblastoma In the present study, we used DBH-expressing human neuroblastoma SK-N-BE(2)C and rat pheochromocytoma (PC12) cell lines to investigate the role of cAMP-dependent protein kinase (PKA) in transcriptional regulation of the DBH gene. 7525897 Human
the dbh gene c6 glioma In DBH-nonexpressing HeLa and C6 glioma cell lines, coexpression of PKAc changed the transcriptional activity of the DBH promoter to a minimal degree, indicating that basal and PKA-mediated transcription of the DBH gene occur in a cell type-specific manne 7525897 Rat
the dbh gene hepatoma Using mammalian one-hybrid and two-hybrid systems, we demonstrate that recruitment of Arix to the positions of homeodomain core recognition sites 1 and 2 at -153 to -166 of the DBH gene restores complete responsiveness of the promoter to PKA in SHSY-5Y ne 10644760 Human
the dbh gene neuroblastoma Using mammalian one-hybrid and two-hybrid systems, we demonstrate that recruitment of Arix to the positions of homeodomain core recognition sites 1 and 2 at -153 to -166 of the DBH gene restores complete responsiveness of the promoter to PKA in SHSY-5Y ne 10644760 Human

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