IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene RXRA Ensembl ENSG00000186350 Chromosome 9 Start 136358137 End 136472250
Description Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha)(Nuclear receptor subfamily 2 group B member 1) [Source:UniProtKB/Swiss-Prot;Acc:P19793]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 10477
     Entrez Gene : 6256
     UCSC : uc004cfb.2
     GeneCards : 10477
     RefSeq : NM_002957
     CCDS : CCDS35172.1
     Uniprot : P19793
     Interpro : P19793
     OMIM : 180245
     GeneTests : RXRA
     CGAP : RXRA
     PMID : 2159111

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Experimental Evidence        (help)
Expression Sample Number Method Clinical information PubMed Reference
down 17.8/22.1(88) qRT-PCR- 11839661 Clin Cancer Res. 2002 Feb;8(2):438-43.

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  32800_at  -0.69  2.45e-13  5.87e-12  -0.62  5.11e-6  2.76e-5
 HG_U95  405_at  -0.19  2.36e-1  3.35e-1  0.23  3.69e-1  4.75e-1
 HG_U133A  202426_s_at  0.01  9.28e-1  9.38e-1  4.85  3.46e-118  3.95e-117
 HG_U133A  202449_s_at  -0.67  4.06e-21  3.47e-20  0.66  1.01e-12  1.32e-12
 HG_U133_Plus2  202426_s_at  0.07  4.91e-1  5.78e-1  0.63  9.73e-8  3.25e-7
 HG_U133_Plus2  202449_s_at  -0.20  4.35e-2  7.47e-2  0.28  2.16e-2  3.32e-2
 Stanford  17890  -0.48  1.55e-1  3.31e-1  -0.08  8.15e-1  9.15e-1
 Agilent_HS_21.6K  12533  -0.07  2.14e-2  8.00e-2  -0.03  4.84e-1  6.35e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202426_s_at  -0.06  8.83e-1  9.92e-1  -0.10  7.52e-1  1.00e+0
 HG_U133A  202449_s_at  -0.02  9.40e-1  9.97e-1  -0.21  2.88e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 32800_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 405_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202426_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202449_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202426_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202449_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 17890    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 12533    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
retinoid x receptor alpha osteosarcoma We have studied the role of retinoid X receptor alpha (RXR alpha) in vitamin D receptor (VDR) responsive interactions using nuclear extracts from human osteoblast-like MG-63 osteosarcoma cells and its specific response element from human osteocalcin gene 7705332 Human
retinoid x receptor alpha acute promyelocytic leukemia (apl) Promyelocytic leukemia zinc finger-retinoic acid receptor a (PLZF-RARalpha), a fusion receptor generated as a result of a variant t(11;17) chromosomal translocation that occurs in a small subset of acute promyelocytic leukemia (APL) patients, has been sho 8622986 Human
retinoid x receptor alpha tumors In the majority of these tumors, the alpha6beta4 integrin and retinoid X receptor alpha transcripts were detected suprabasally, indicating an advanced state of premalignant progression. 9537245 Human
retinoid x receptor alpha embryonal carcinoma Deregulated expression of the retinoid X receptor alpha prevents muscle differentiation in P19 embryonal carcinoma cells. 9751115 Mouse
retinoid x receptor alpha human leukemia We evaluated the biological activity of two sets of ring A stereoisomers of 2-methyl-1alpha,25-dihydroxyvitamin D(3) (2-methyl-1alpha,25(OH)(2)D(3)) and 2-methyl-20-epi-1alpha, 25-dihydroxyvitamin D(3) (2-methyl-20-epi-1alpha,25(OH)(2)D(3)) in terms of th 10677586 Human
retinoid x receptor alpha carcinoma We evaluated the biological activity of two sets of ring A stereoisomers of 2-methyl-1alpha,25-dihydroxyvitamin D(3) (2-methyl-1alpha,25(OH)(2)D(3)) and 2-methyl-20-epi-1alpha, 25-dihydroxyvitamin D(3) (2-methyl-20-epi-1alpha,25(OH)(2)D(3)) in terms of th 10677586 Human
retinoid x receptor alpha human osteosarcoma We evaluated the biological activity of two sets of ring A stereoisomers of 2-methyl-1alpha,25-dihydroxyvitamin D(3) (2-methyl-1alpha,25(OH)(2)D(3)) and 2-methyl-20-epi-1alpha, 25-dihydroxyvitamin D(3) (2-methyl-20-epi-1alpha,25(OH)(2)D(3)) in terms of th 10677586 Human
retinoid x receptor alpha acute monocytic leukemia We studied the effects of peroxisome proliferator-activated receptor (PPAR) gamma, alpha, and retinoid X receptor alpha (RXRalpha) ligands on MCP-1-directed migration and matrix metalloproteinase expression of a human acute monocytic leukemia cell line (T 10936484 Human
retinoid x receptor alpha embryonal carcinoma To test this hypothesis directly, we have analyzed the activity of 4HPR on a panel of F9 embryonal carcinoma cell lines, which includes wild-type and mutant lines that lack expression of retinoic acid receptor gamma, retinoid X receptor alpha, or both. 9892176 Human
retinoid x receptor alpha lung carcinoma Increased retinoic acid responsiveness in lung carcinoma cells that are nonresponsive despite the presence of endogenous retinoic acid receptor (RAR) beta by expression of exogenous retinoid receptors retinoid X receptor alpha, RAR alpha, and RAR gamma. 11212249 Human
retinoid x receptor alpha human hepatocellular carcinoma Phosphorylation of retinoid X receptor alpha at serine 260 impairs its metabolism and function in human hepatocellular carcinoma. 11606411 Human
retinoid x receptor alpha hepatocellular carcinoma (hcc) Retinoid X receptor alpha (RXRalpha) has emerged as an important nuclear receptor involved in hepatocarcinogenesis, because its ligand suppresses the development of hepatocellular carcinoma (HCC) in both experimental and clinical studies. 11826406 Human
retinoid x receptor alpha prostatic intraepithelial neoplasia Prostatic intraepithelial neoplasia in mice with conditional disruption of the retinoid X receptor alpha allele in the prostate epithelium. 12183441 Mouse
retinoid x receptor alpha pancreatic cancer Growth inhibition of pancreatic cancer cells through activation of peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha pathway. 12851681 Human
retinoid x receptor alpha non-small cell lung cancer METHODOLOGY: Using semiquantitative conventional reverse transcriptase polymerase chain reaction (RT-PCR), quantitative real-time RT-PCR, in situ hybridization and immunostaining, we evaluated the expression and the distribution of retinoic acid receptor 12911822 Human
retinoid x receptor alpha pancreatic adenocarcinoma Thiazolidinediones inhibit growth of gastrointestinal, biliary, and pancreatic adenocarcinoma cells through activation of the peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha pathway. 12941612 Human
retinoid x receptor alpha gastric cancer Degradation of retinoid X receptor alpha by TPA through proteasome pathway in gastric cancer cells. 12970875 Human
retinoid x receptor alpha embryonal carcinoma To test this hypothesis directly, we have analyzed the activity of these phenylretinamides in vitro on a panel of F9 murine embryonal carcinoma cell lines, which includes wild-type (F9-WT) and mutant cells that have disrupted genes for both retinoid X rec 14555536 Mouse
retinoid x receptor alpha colon cancer To better understand their role, we studied the expression levels of all PPAR-isoforms and transcriptional partners such as the retinoid X receptor alpha (RXRalpha) and PPARgamma-coactivator-1 (PGC-1) by means of real-time PCR in 17 patients with colon ca 14670614 Human
retinoid x receptor alpha hcc HCC in cirrhotic patients contains lower levels of endogenous retinoids and simultaneously is insensitive to retinoic acid (RA) because of malfunction of its nuclear receptor, retinoid X receptor alpha (RXRalpha). 15010815 Human
retinoid x receptor alpha human breast cancer Altered localization of retinoid X receptor alpha coincides with loss of retinoid responsiveness in human breast cancer MDA-MB-231 cells. 15082790 Human
retinoid x receptor alpha breast cancer Retinoid X receptor alpha (RXR alpha) localized throughout the nucleoplasm in retinoid-sensitive normal human mammary epithelial cells and in retinoid-responsive breast cancer cell line (MCF-7), whereas it was found in the splicing factor compartment (SFC 15082790 Human
retinoid x receptor alpha human breast carcinoma Retinoid X receptor alpha (RXR alpha) localized throughout the nucleoplasm in retinoid-sensitive normal human mammary epithelial cells and in retinoid-responsive breast cancer cell line (MCF-7), whereas it was found in the splicing factor compartment (SFC 15082790 Human
retinoid x receptor alpha apl Reduced intranuclear mobility of APL fusion proteins accompanies their mislocalization and results in sequestration and decreased mobility of retinoid X receptor alpha. 15121864 Human
retinoid x receptor alpha neuroblastoma We present evidence that in neuroblastoma CHP126 cells, CAK interacts with and phosphorylates retinoblastoma tumor suppressor protein (pRb) and retinoid X receptor alpha (RXRalpha). 15126328 Human
retinoid x receptor alpha cancer IGFBP-3 has an important role in cancer cell apoptosis mediated via the nuclear retinoid X receptor alpha (RXRalpha). 15140235 Human
retinoid x receptor alpha breast cancer Ubiquitinated or sumoylated retinoic acid receptor alpha determines its characteristic and interacting model with retinoid X receptor alpha in gastric and breast cancer cells. 15171703 Human

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