IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PAEP Ensembl ENSG00000122133 Chromosome 9 Start 137593425 End 137598622
Description Glycodelin Precursor (GD)(Pregnancy-associated endometrial alpha-2 globulin)(PAEG)(PEG)(Placental protein 14)(PP14)(Progesterone-associated endometrial protein)(Progestagen-associated endometrial protein) [Source:UniProtKB/Swiss-Prot;Acc:P09466]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 8573
     Entrez Gene : 5047
     UCSC : uc004cgd.1
     GeneCards : 8573
     RefSeq : NM_001018049
     CCDS : CCDS35173.1
     Uniprot : P09466
     Interpro : P09466
     OMIM : 173310
     GeneTests : PAEP
     CGAP : PAEP
     PMID : 3320533

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37633_s_at  1.32  1.03e-5  5.32e-5  0.35  5.58e-2  1.00e-1
 HG_U95  37634_at  0.46  5.68e-2  1.03e-1  -0.17  3.69e-1  4.75e-1
 HG_U133A  206859_s_at  2.05  1.10e-9  3.80e-9  2.58  5.22e-87  2.51e-86
 HG_U133_Plus2  206859_s_at  2.74  6.88e-10  4.92e-9  0.45  5.90e-2  8.33e-2
 Stanford  7817  0.91  3.68e-1  5.67e-1  -0.73  1.57e-1  3.65e-1
 Agilent_HS_21.6K  17837  0.05  5.58e-1  7.21e-1  -0.01  6.41e-1  7.60e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206859_s_at  1.32  2.17e-1  8.39e-1  0.12  5.07e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37633_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 37634_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206859_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206859_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 7817    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 17837    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
pp14 invasive moles Serial determinations of PP14 have been performed in 31 patients with trophoblastic tumour (20 hydatidiform moles, 4 invasive moles and 7 choriocarcinomas). 2844125 Human
pp14 choriocarcinoma In patients with choriocarcinoma the PP14 values were moderately elevated (66.4 +/- 25.7 micrograms/l), and declined following the remission of disease. 2844125 Human
pp14 endometrial cancer MFE-280 endometrial cancer cells express PP14 (placental protein 14) in vitro. 9615781 Human
pp14 tumor In tumor tissue the expression of PP14 was not dependent on progestins. 9615781 Human
pp14 endometrial adenocarcinoma In post-menopausal women, the concentrations of PP14 (mean +/- SEM) in both plasma and flushing were significantly higher (P < 0.001) in women with endometrial adenocarcinoma (46.9+/-7.5 ng/ml plasma; 3350+/-1711 ng/ml flushing) than in the controls (7.6+ 9804252 Human
pp14 endometrial adenocarcinoma Elevated PP14 concentrations are also associated with the presence of endometrial adenocarcinoma and may have a potential to be used as a marker for this disease. 9804252 Human
pp 14 ovarian cancer Elevated levels of PP 14, found in one endometroid ovarian cancer, decreased during successful treatment. 3661128 Human
pp 14 tumor PP 14 could also be found in the blood of nude mice grafted with this tumor. 3661128 Mouse
pp 14 tumor One patient with serous kystadenocarcinoma had a slightly elevated level of PP 14 at diagnosis, increasing as the tumor progressed. 3661128 Human
pp 14 tumor PP 14 was demonstrated histochemically in both the original tumor and the grafted. 3661128 Human
pp 14 ovarian tumours In seven benign ovarian tumours, low PP 14 serum levels were found. 3661128 Human
pp 14 ovarian cancer The conclusion drawn from this study is that PP 14 can constitute a tumor marker in ovarian cancer. 3661128 Human
pp 14 tumor The conclusion drawn from this study is that PP 14 can constitute a tumor marker in ovarian cancer. 3661128 Human
paep leukemia Untreated K562 leukemia cells did not contain PAEP, whereas treatment of the cells with tetradecanoylphorbol acetate (TPA) induced strong expression of PAEP mRNA and synthesis of the intact protein that was found both in the cytoplasm of the differentiati 8025274 Human
paep adenoma We also found that the PAEP gene was expressed in endometriosis and in a borderline endometrioid adenoma. 8452641 Human
pp14 ovarian cyst This paper reports the detection and characterization of endometrial placental protein 14 (PP14) in human ovarian cyst fluids. 1626182 Human
pp14 ovarian cyst PP14 from ovarian cyst fluid has the same molecular size as PP14 purified from human amniotic fluid. 1626182 Human
pp14 ovarian cyst No clear difference was found in the PP14 concentrations between benign, borderline and malignant cyst fluids, but serous ovarian cyst fluids had significantly higher PP14 concentrations (median 253.3 micrograms/l) than mucinous cyst fluids (median 17.5 m 1626182 Human
pp14 cyst No clear difference was found in the PP14 concentrations between benign, borderline and malignant cyst fluids, but serous ovarian cyst fluids had significantly higher PP14 concentrations (median 253.3 micrograms/l) than mucinous cyst fluids (median 17.5 m 1626182 Human
pp14 hydatidiform moles The clinical applications of PP12, PP14 and PAPP-A measurements are not only limited to uterine pathologies but also include cancer (tumour markers) and pregnancy (hydatidiform moles and extra-uterine pregnancies). 2444151 Human
pp14 tumour The clinical applications of PP12, PP14 and PAPP-A measurements are not only limited to uterine pathologies but also include cancer (tumour markers) and pregnancy (hydatidiform moles and extra-uterine pregnancies). 2444151 Human
pp14 cancer The clinical applications of PP12, PP14 and PAPP-A measurements are not only limited to uterine pathologies but also include cancer (tumour markers) and pregnancy (hydatidiform moles and extra-uterine pregnancies). 2444151 Human
pp14 malignancy Beta lactoglobulin homologue placental protein 14 (PP14) in serum of patients with trophoblastic disease and non-trophoblastic gynecologic malignancy. 2844125 Human
pp14 trophoblastic tumour Serial determinations of PP14 have been performed in 31 patients with trophoblastic tumour (20 hydatidiform moles, 4 invasive moles and 7 choriocarcinomas). 2844125 Human
pp14 cervical carcinoma Glycodelin, previously known as PP14, has been localized in endometrial, ovarian and cervical carcinoma cells. 15706409 Human
pp 14 ovarian tumors Placental proteins (PP 5, PP 12 and PP 14) in ovarian tumors. 3661128 Human
pp 14 benign ovarian tumours In seven benign ovarian tumours, low PP 14 serum levels were found. 3661128 Human
gda ovarian carcinoma BACKGROUND: Glycodelin A (GdA), also known as placental protein 14 (PP14), has been detected in endometrial, cervical and ovarian carcinoma cells. 17649816 Human
gda tumour CONCLUSION: These results indicate that determination of GdA is not sensitive or specific enough for use as a tumour marker. 17649816 Human
pp14 ovarian carcinoma BACKGROUND: Glycodelin A (GdA), also known as placental protein 14 (PP14), has been detected in endometrial, cervical and ovarian carcinoma cells. 17649816 Human

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