IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CARD9 Ensembl ENSG00000187796 Chromosome 9 Start 138378229 End 138387954
Description Caspase recruitment domain-containing protein 9 (hCARD9) [Source:UniProtKB/Swiss-Prot;Acc:Q9H257]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 16391
     Entrez Gene : 64170
     UCSC : uc004chg.3
     GeneCards : 16391
     RefSeq : NM_052813
     CCDS : CCDS6997.1
     Uniprot : Q9H257
     Interpro : Q9H257
     OMIM : 607212
     GeneTests : CARD9
     CGAP : CARD9
     PMID : 11053425

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  220162_s_at  -0.27  1.80e-2  2.70e-2  3.27  5.48e-73  1.89e-72
 HG_U133_Plus2  220162_s_at  -0.38  6.13e-3  1.32e-2  -0.90  5.22e-7  1.59e-6
 Agilent_HS_21.6K  18357  -0.17  4.66e-3  2.56e-2  -0.08  3.83e-1  5.43e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  220162_s_at  0.07  8.22e-1  9.84e-1  0.20  4.29e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133A - 220162_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 220162_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 18357    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
card9 b-cell lymphoma Overexpression of caspase recruitment domain (CARD) membrane-associated guanylate kinase 1 (CARMA1) and CARD9 in primary gastric B-cell lymphoma. 16177990 Human
card9 (malt) lymphoma BACKGROUND: Although caspase recruitment domain (CARD) membrane-associated guanylate kinase (MAGUK) protein 1 (CARMA1) and CARD9 play important roles in lymphocyte activation, the significance of CARMA1 and CARD9 in the pathogenesis of gastric mucosa-asso 16177990 NA
card9 b-cell lymphoma METHODS: By using reverse transcription-polymerase chain reaction analysis, the expression levels of mRNA of CARMA1, CARD9, Bcl10, and the apoptosis inhibitor 2 (API2)-MALT1 chimeric transcript were determined in tissue specimens from 65 patients with pri 16177990 NA
card9 diffuse large b-cell lymphoma METHODS: By using reverse transcription-polymerase chain reaction analysis, the expression levels of mRNA of CARMA1, CARD9, Bcl10, and the apoptosis inhibitor 2 (API2)-MALT1 chimeric transcript were determined in tissue specimens from 65 patients with pri 16177990 NA
card9 malt lymphoma METHODS: By using reverse transcription-polymerase chain reaction analysis, the expression levels of mRNA of CARMA1, CARD9, Bcl10, and the apoptosis inhibitor 2 (API2)-MALT1 chimeric transcript were determined in tissue specimens from 65 patients with pri 16177990 Human
card9 b-cell lymphoma CONCLUSIONS: The overexpression of CARMA1 and CARD9 presumably is associated with the development or progression of gastric B-cell lymphoma, especially among patients who have disease in which the pathogenesis is not related to H. pylori. 16177990 Human
card9 lymphoma The positive rates for CARD9, Bcl10, and API2-MALT1 chimeric transcript in the lymphoma patients were 48%, 98%, and 8%, respectively, whereas the 3 molecules were not detected in any specimens from patients with chronic gastritis. 16177990 Human
card9 malt lymphoma Moreover, our findings suggest that genomic gain of genes that modulate NFkappaB activation, such as MALT1, TRAF2 and CARD9, may play a role in the pathogenesis of the translocation-negative MALT lymphoma. 16512826 Human
card9 cancer Furthermore, downregulation of Card9 in VHL(-/-) cancer cells reduced their tumorigenic potential. 17936701 Human
card9 tumorigenesis The latter activity, which promotes Card9 phosphorylation, links pVHL to control of NF-kappaB activity and tumorigenesis. 17936701 Human
card9 crohn's disease Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. 18439550 Human

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