IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene NOTCH1 Ensembl ENSG00000148400 Chromosome 9 Start 138508717 End 138560135
Description Neurogenic locus notch homolog protein 1 Precursor (Notch 1)(hN1)(Translocation-associated notch protein TAN-1) [Contains Notch 1 extracellular truncation;Notch 1 intracellular domain] [Source:UniProtKB/Swiss-Prot;Acc:P46531]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 7881
     Entrez Gene : 4851
     UCSC : uc004chz.2
     GeneCards : 7881
     RefSeq : NM_017617
     CCDS : CCDS43905.1
     Uniprot : P46531
     Interpro : P46531
     OMIM : 190198
     GeneTests : NOTCH1
     CGAP : NOTCH1
     PMID : 1831692

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
11 2.51 439 5 1.85 271 4 9.30 43
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
1348374 AD c.4927G>C p.D1643H Substitution - Missense Heterozygous 9:138519040-13851904020007775
1348375 AD c.6982C>T p.R2328W Substitution - Missense Heterozygous 9:138511033-13851103320007775
1348379 AD c.7330_7330G>TGT p.V2444fs*35 Complex - frameshift Heterozygous 20007775
1348380 AD c.7330_7330G>TGT p.V2444fs*35 Complex - frameshift Heterozygous 20007775
16626 AD c.5014G>A p.V1672I Substitution - Missense Heterozygous 9:138518953-13851895318948947
1348376 SCC c.7330_7330G>TGT p.V2444fs*35 Complex - frameshift Heterozygous 20007775
1348377 SCC c.7330_7330G>TGT p.V2444fs*35 Complex - frameshift Heterozygous 20007775
1348378 SCC c.6824_6825insT p.H2276fs*79 Insertion - Frameshift Heterozygous 9:138511190-13851119120007775
1348381 SCC c.7330_7330G>TGT p.V2444fs*35 Complex - frameshift Unknown 20007775

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  218902_at  -0.64  1.51e-18  1.06e-17  -0.05  7.20e-1  7.29e-1
 HG_U133_Plus2  218902_at  -0.71  1.76e-17  3.19e-16  0.02  8.12e-1  8.44e-1
 HG_U133_Plus2  223508_at  -0.28  7.56e-2  1.20e-1  0.33  1.02e-1  1.37e-1
 Agilent_HS_21.6K  10780  0.02  5.77e-1  7.36e-1  0.13  1.84e-2  5.78e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  218902_at  0.38  7.65e-2  7.41e-1  0.21  2.12e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133A - 218902_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 218902_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 223508_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 10780    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
notch1 small-cell lung cancer Using recombinant adenoviruses expressing active Notch1 in small-cell lung cancer cells, we showed that the initial appearance of Notch1 coincided with the loss of hASH1 protein, preceding the full decay of hASH1 mRNA. 11940670 Human
notch1 anaplastic large-cell lymphoma Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma. 11964309 Human
notch1 tumor Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma. 11964309 Human
notch1 neoplasms In addition, truncated Notch1 alleles could be associated with 10% of all cases of human T lymphoblastic leukemia and, when introduced into mouse bone marrow stem cells, cause T-cell neoplasms. 11964309 Mouse
notch1 lymphoblastic leukemia In addition, truncated Notch1 alleles could be associated with 10% of all cases of human T lymphoblastic leukemia and, when introduced into mouse bone marrow stem cells, cause T-cell neoplasms. 11964309 Human
notch1 anaplastic large-cell lymphoma Here we show that Notch1 is highly expressed in B- and T-cell-derived tumor cells of Hodgkin and anaplastic large cell lymphoma. 11964309 Human
notch1 tumor Here we show that Notch1 is highly expressed in B- and T-cell-derived tumor cells of Hodgkin and anaplastic large cell lymphoma. 11964309 Human
notch1 tumor We demonstrate a novel mechanism for the oncogenic capacity of Notch1 by showing that the interaction between intact Notch1 on tumor cells and its ligand Jagged1 dramatically induces proliferation and inhibition of apoptosis in vitro. 11964309 Human
notch1 tumor Notch1 signaling may therefore be activated in tumor cells by Jagged1 through homotypic or heterotypic cell-cell interactions, and it seems likely that these interactions contribute to lymphomagenesis in vivo. 11964309 Human
notch1 anaplastic large-cell lymphoma Thus, our data suggest that activated Notch1 signaling plays an important role in the pathobiology of Hodgkin and anaplastic large cell lymphoma and that it might be a potential new target for treatment. 11964309 Human
notch1 cervical cancer Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. 12208848 Human
notch1 cervical carcinoma We now report that expression of the endogenous Notch1 gene is markedly reduced in a panel of cervical carcinoma cells whereas expression of Notch2 remains elevated, and Notch1 expression is similarly reduced or absent in invasive cervical cancers. 12208848 Human
notch1 invasive cervical cancers We now report that expression of the endogenous Notch1 gene is markedly reduced in a panel of cervical carcinoma cells whereas expression of Notch2 remains elevated, and Notch1 expression is similarly reduced or absent in invasive cervical cancers. 12208848 Human
notch1 cervical carcinoma Conversely, expression of activated Notch1 causes strong growth inhibition of HPV-positive, but not HPV-negative, cervical carcinoma cells, but exerts no such effects on other epithelial tumor cells. 12208848 Human
notch1 acute lymphoblastic leukemias Notch signaling was first linked to tumorigenesis through identification of a recurrent t(7;9)(q34;q34.3) chromosomal translocation involving the human Notch1 gene that is found in a small subset of human pre-T-cell acute lymphoblastic leukemias (T-ALL).( 12496471 Human
notch1 acute promyelocytic leukemia All-trans retinoid acid increases Notch1 transcript expression in acute promyelocytic leukemia. 15058751 Human
notch1 acute promyelocytic leukemia The effect of all-trans retinoid acid (ATRA) on the expression of Notch1 gene by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in acute promyelocytic leukemia cells (APL), NB4, and HL-60 lacking t(15;17) was studied. 15058751 Human
notch1 neoplasm As Notch1 gene is involved in the differentiation and leukemogenesis in lymphoid neoplasm, observations suggest that Notch1 is involved in ATRA-modulated differentiation process in APL. 15058751 Human
notch1 hyperplasia We show that keratinocyte-specific deletion of the Notch1 gene results in marked epidermal hyperplasia and deregulated expression of multiple differentiation markers. 11432830 Human
notch1 tumors Cervical tumors also consistently exhibit cytosolic and nuclear forms of Notch1, suggesting the possible persistent activation of the Notch pathway. 11448155 Human
notch1 human t-cell leukemias Mammalian Notch homologs were first identified from the involvement of Notch1 in a recurrent chromosomal translocation in a subset of human T-cell leukemias. 11561162 Human
notch1 t-cell leukemia Constitutive Notch signaling mediated by Notch1, Notch2, or Notch3 predisposes to T-cell leukemia. 11561162 Human
notch1 prostate cancer In situ hybridization and reverse transcription-PCR analyses revealed that Notch1 was expressed in prostate epithelial cells during normal development and in prostate cancer cells. 11585768 Human
notch1 prostate cancer Furthermore, overexpression of a constitutively active form of Notch1 inhibited the proliferation of various prostate cancer cells, including DU145, LNCaP, and PC3 cells. 11585768 Human
notch1 acute myeloid leukemia Expression of Notch1 and Jagged1 proteins in acute myeloid leukemia cells. 11699411 Human
notch1 burkitt's lymphoma Intracellular forms of human NOTCH1 functionally activate essential Epstein-Barr virus major latent promoters in the Burkitt's lymphoma BJAB cell line but repress these promoters in Jurkat cells. 10627560 Human
notch1 t-cell leukemia Two distinct Notch1 mutant alleles are involved in the induction of T-cell leukemia in c-myc transgenic mice. 10805726 Mouse
notch1 tumor These data suggest that both type I and type II mutations generate two structurally distinct Notch1 N(EC) and N(IC) proteins that may participate in tumor formation, in collaboration with the c-myc oncogene, through distinct mechanisms. 10805726 Human
notch1 cervical cancers Activation of the Notch1 signaling pathway has been proposed as one of the cellular changes that cooperate with the E6 and E7 proteins to cause cervical cancers. 14695182 Human
notch1 cancers This proposition is based on: (a) the detection of active Notch1 in high-grade cervical lesions and cancers; (b) the synergism between Notch1 and E6 and E7 to transform immortalized cells; and (c) the obliteration of neoplastic properties of a cervical ca 14695182 Human
notch1 cervical cancer This proposition is based on: (a) the detection of active Notch1 in high-grade cervical lesions and cancers; (b) the synergism between Notch1 and E6 and E7 to transform immortalized cells; and (c) the obliteration of neoplastic properties of a cervical ca 14695182 Human
notch1 cervical cancer However, this view was put in doubt by a recent report that showed Notch1 expression is markedly reduced in cervical cancer cells, and this was attributed to the ability of Notch1 to repress the expression of the HPV E6 and E7 proteins. 14695182 Human
notch1 cervical cancer In addition, we show that activated Notch1 is readily detected in all cervical cancer cell lines tested. 14695182 Human
notch1 cervical cancer Together, these results show that not only do cervical cancer cells express Notch1, but also that Notch1 signaling, in synergy with other cellular changes, can participate in the transformation of primary cells expressing E6 and E7 proteins. 14695182 Human
notch1 metastatic cancer Here we show that notch1 expression is increased 4-5 times in C4-2B and MDA PCa 2b cells (osteoblastic skeletal prostate metastatic cancer cell lines) when compared with nonskeletal metastatic cell lines (LNCaP and DU145). 14602722 Human
notch1 bone metastases Immunohistochemical studies demonstrate that Notch1 is present in both human clinical samples from prostate cancer bone metastases and the C4-2B cell line. 14602722 Human
notch1 prostate cancer Immunohistochemical studies demonstrate that Notch1 is present in both human clinical samples from prostate cancer bone metastases and the C4-2B cell line. 14602722 Human
notch1 tumors Retroviral insertions in the Notch1 gene were observed in 88% of tumors arising with a shortened latency. 10961893 Mouse
notch1 t-cell lymphomas Identification of Notch1 as a frequent target for provirus insertional mutagenesis in T-cell lymphomas induced by leukemogenic mutants of mouse mammary tumor virus. 11000255 Mouse
notch1 t-cell lymphomas In 30% of T-cell lymphomas arising in BALB/c mice infected with MLA-MMTV, a leukemogenic MMTV mutant, we have found that MMTV proviruses were integrated into a short region of the Notch1 genome, so that truncated Notch1 transcripts encoding the transmembr 11000255 Mouse
notch1 t-cell lymphomas Thus, Notch1 is a major target of provirus insertional mutagenesis in these T-cell lymphomas. 11000255 Mouse
notch1 t-cell leukemia Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1. 11003647 Mouse
notch1 human hepatocellular carcinoma Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis. 14678992 Human
notch1 human t-cell leukemia As Notch1 is disrupted via a chromosomal translocation in a subset of human T-cell leukemia, leading to a truncated polypeptide resembling N(IC), deregulated chromatin remodeling and transcription may fuel uncontrolled cell proliferation in this hematopoi 11389531 Human
notch1 mouse mammary tumors Involvement of Notch1 in the development of mouse mammary tumors. 10557086 Mouse
notch1 tumors In Notch1-rearranged tumors, the Notch1 gene was interrupted by the MMTV provirus insertion upstream of the exons coding for the TM domain. 10557086 Mouse
notch1 invasive cervical carcinomas We find that activated MAPK signaling cooperates with deregulated Notch1 signaling to recreate features of HPV-driven invasive cervical carcinomas. 15140991 Human
notch1 t-cell lymphomas The Notch1 gene was previously found to be targetted by provirus insertion in a high proportion of T-cell lymphomas arising in Moloney MuLV-inoculated MMTV(D)/myc transgenic mice. 9484841 Mouse
notch1 tumors The high levels of truncated Notch1 RNA and proteins in these tumors are thought to be involved in the oncogenic transformation. 9484841 Mouse
notch1 tumors However, in addition to these truncated RNA and proteins, high level expression of full-length Notch1 RNA and proteins was also observed in several tumors, suggesting that they could also contribute to the transformation process. 9484841 Mouse
notch1 tumors Notch1 was rearranged at similar frequencies in both groups, indicating that the full-length Notch1 allele is dispensable in tumors harboring an activated Notch1 allele. 9484841 Human
notch1 t-cell acute lymphoblastic leukemia Three human disorders including a neoplasia (a T-cell acute lymphoblastic leukemia/lymphoma), a late onset neurological disease (CADASIL) and a developmental disorder (the Alagille syndrome) are associated with mutations in, respectively, the Notch1, Notc 10075489 Human
notch1 human t-cell leukemia-lymphoma Truncated forms of the NOTCH1 transmembrane receptor engineered to resemble mutant forms of NOTCH1 found in certain cases of human T cell leukemia/lymphoma (T-ALL) efficiently induce T-ALL when expressed in the bone marrow of mice. 9111040 Mouse
notch1 t-cell leukaemia Members of the Notch family (e.g. Notch1 and Notch3) have been recently described to play a critical role in T cell development and their constitutive activation has been related to T cell leukaemia in both animal models and human disease. 12651099 Human
tan1 tumors All tumors overexpressed truncated TAN1 of the size and subcellular localization predicted from the structure of the gene. 8642337 Mouse
tan1 tumors Moreover, the murine tumors caused by TAN1 in the bone marrow transplant model are very similar to the TAN1-associated human tumors and suggest that TAN1 may be specifically oncotropic for T cells. 8642337 Mouse
tan1 human tumors Moreover, the murine tumors caused by TAN1 in the bone marrow transplant model are very similar to the TAN1-associated human tumors and suggest that TAN1 may be specifically oncotropic for T cells. 8642337 Mouse
notch1 tumors We found that Notch1 was mutated in a high proportion (52%) of these tumors. 8756350 Mouse
notch1 tumors In addition, many Notch1-rearranged tumors showed elevated levels of full-length Notch1 transcripts, whereas nearly all showed increased levels of full-length (330-kD) or close to full-length (280-kD) Notch1 proteins. 8756350 Mouse
notch1 tumors Several new CISs were identified, including one CIS that mapped near Notch1, a gene that has been causally associated with human T-cell tumors. 12502872 Human
notch1 salivary-gland carcinomas Truncation of Notch1 has been shown to cause a subtype of acute leukemia, and activation of Notch4 has been associated with mammary and salivary gland carcinomas of mice. 12539049 Human
notch1 acute leukemia Truncation of Notch1 has been shown to cause a subtype of acute leukemia, and activation of Notch4 has been associated with mammary and salivary gland carcinomas of mice. 12539049 Human
notch1 tumor Notch1 functions as a tumor suppressor in mouse skin. 12590261 Mouse
notch1 tumors Unexpectedly, ablation of Notch1 results in epidermal and corneal hyperplasia followed by the development of skin tumors and facilitated chemical-induced skin carcinogenesis. 12590261 Mouse
notch1 hyperplasia Unexpectedly, ablation of Notch1 results in epidermal and corneal hyperplasia followed by the development of skin tumors and facilitated chemical-induced skin carcinogenesis. 12590261 Mouse
notch1 tumors Notch1 deficiency in skin and in primary keratinocytes results in increased and sustained expression of Gli2, causing the development of basal-cell carcinoma-like tumors. 12590261 Mouse
notch1 tumor Given this genetic link between NOTCH1 and tumor formation, it is of interest to establish the chromosomal positions of the other two homologs. 7698746 Human
notch1 tumor Activated Notch1 (AcN1) alleles cooperate with oncogenes from DNA tumor viruses in transformation of epithelial cells. 12768030 Human
notch1 thymic lymphomas Radiation-induced deletions in the 5' end region of Notch1 lead to the formation of truncated proteins and are involved in the development of mouse thymic lymphomas. 12807718 Mouse
notch1 thymic lymphomas To elucidate the effect of Notch1 abnormalities in radiation-induced lymphomagenesis, we determined the structure of the Notch1 gene and examined the frequency and the sites of Notch1 rearrangements in radiation-induced mouse thymic lymphomas. 12807718 Mouse
notch1 thymic lymphomas More than 50% of radiation-induced thymic lymphomas exhibited Notch1 rearrangements, suggesting that Notch1 acts as a major oncogene in radiation-induced lymphomagenesis. 12807718 Mouse
notch-1 thymomas We identified the constitutively active intracellular fragment of murine Notch-1 as capable of rendering thymomas resistant to glucocorticoid-induced apoptosis. 9881968 Human
notch-1 murine erythroleukemia Notch-1 inhibits apoptosis in murine erythroleukemia cells and is necessary for differentiation induced by hybrid polar compounds. 10227380 Mouse
notch-1 tumor This novel function of notch-1 may play a role in regulating apoptosis susceptibility in notch-1 expressing tumor cells. 10227380 Mouse
notch-1 mesotheliomas Notch-1 upregulation is maintained in SV40-transformed human mesothelial clones and in SV40-positive mesotheliomas and derived cell lines. 12527910 Human
notch-1 microinvasive carcinoma Moreover, the main cellular localization of Notch-1 protein changes from cytoplasmic to nuclear with the transition from CIN III to microinvasive carcinoma. 12548555 Human
notch-1 cervical carcinoma Since the E6 and E7 proteins encoded by human papilloma virus (HPV) are a causative agent of cervical carcinoma, this study determined whether E6 and E7 protein expression causes the observed upregulation in Notch-1 expression. 12548555 Human
notch-1 cervical carcinoma Downregulation of Notch-1 expression in a human cervical carcinoma cell line expressing E6/E7 caused striking inhibition of proliferation in vitro and tumorigenicity in vivo. 12548555 Human
notch-1 breast cancers ERalpha/PR+ breast cancers exhibit loss of the two key regulators of asymmetric cell division, Musashi-1 and Notch-1 and thus may arise from symmetric division of the ERalpha/PR+ stem cell. 14521515 Human
notch-1 murine erythroleukemia Notch-1 regulates cell death independently of differentiation in murine erythroleukemia cells through multiple apoptosis and cell cycle pathways. 15095289 Mouse
notch-1 murine erythroleukemia We had previously shown that Notch-1 prevents apoptosis and is necessary for pharmacologically induced differentiation in murine erythroleukemia (MEL) cells. 15095289 Mouse
notch-1 myeloma Involvement of Notch-1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines. 14670925 Human
notch-1 tumor However, activation of only Notch-1, but not Notch-2, resulted in protection of tumor cells from melphalan- and mitoxantrone-induced apoptosis. 14670925 Human
notch-1 myeloma Overexpression of Notch-1 in Notch-1(-) U266 myeloma cells up-regulated p21 and resulted in protection from drug-induced apoptosis. 14670925 Human
notch-1 tumour The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer. 15492845 Human
notch-1 human breast cancer The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer. 15492845 Human
notch-1 breast cancer We quantified Notch-1 and Notch-2 expression, in association with clinical outcome, in tissue samples from breast cancer patients (normal specimens n=24, breast cancer specimens n=97). 15492845 Human
notch-1 breast cancer Our results show that there are aberrant levels of Notch-1 and Notch-2 in breast cancer tissues compared with normal breast tissue. 15492845 Human
notch-1 breast cancer Examination of the breast cancer patients' clinicopathological parameters reported that a high level of Notch-1 may be associated with a poorer outlook for the breast cancer patient, while a high level of Notch-2 correlated to a higher chance of surv 15492845 Human
notch-1 breast tumour Notch-1 and Notch-2 also appear to play crucial and contrasting roles in breast tumour differentiation. 15492845 Human
notch-1 tumours Notch-1 expression was low in grade 1 tumours and increased in poorly-differentiated tumours, whereas, Notch-2 expression was high in well-differentiated tumours and reduced in breast tumours with poor differentiation. 15492845 Human
notch-1 breast tumours Notch-1 expression was low in grade 1 tumours and increased in poorly-differentiated tumours, whereas, Notch-2 expression was high in well-differentiated tumours and reduced in breast tumours with poor differentiation. 15492845 Human
notch-1 human breast cancer Therefore, Notch-1 may possess tumour-promoting functions, while Notch-2 could play a tumour-suppressive role in human breast cancer. 15492845 Human
notch-1 glioma Expression of notch-1 and its ligands, delta-like-1 and jagged-1, is critical for glioma cell survival and proliferation. 15781650 Human
notch-1 gliomas We show that Notch-1 and its ligands, Delta-like-1 and Jagged-1, are overexpressed in many glioma cell lines and primary human gliomas. 15781650 Human
notch-1 glioma We show that Notch-1 and its ligands, Delta-like-1 and Jagged-1, are overexpressed in many glioma cell lines and primary human gliomas. 15781650 Human
notch-1 glioma Immunohistochemistry of a primary human glioma tissue array shows the presence in the nucleus of the Notch-1 intracellular domain, indicating Notch-1 activation in situ. 15781650 Human
notch-1 glioma Down-regulation of Notch-1, Delta-like-1, or Jagged-1 by RNA interference induces apoptosis and inhibits proliferation in multiple glioma cell lines. 15781650 Human
notch-1 glioma In addition, pretreatment of glioma cells with Notch-1 or Delta-like-1 small interfering RNA significantly prolongs survival in a murine orthotopic brain tumor model. 15781650 Human
notch-1 brain tumor In addition, pretreatment of glioma cells with Notch-1 or Delta-like-1 small interfering RNA significantly prolongs survival in a murine orthotopic brain tumor model. 15781650 Human
notch-1 glioma Notch-1 and its ligands may present novel therapeutic targets in the treatment of glioma. 15781650 Human
notch-1 cholangiocarcinoma Results: Notch-1, but not other Notch receptors, were up-regulated by cholangiocytes in primary sclerosing cholangitis and cholangiocarcinoma. 15887117 Human
notch1 thymomas Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis. 8756350 Mouse
notch1 t-all Truncated forms of the NOTCH1 transmembrane receptor engineered to resemble mutant forms of NOTCH1 found in certain cases of human T cell leukemia/lymphoma (T-ALL) efficiently induce T-ALL when expressed in the bone marrow of mice. 9111040 Mouse
notch1 neoplasia Three human disorders including a neoplasia (a T-cell acute lymphoblastic leukemia/lymphoma), a late onset neurological disease (CADASIL) and a developmental disorder (the Alagille syndrome) are associated with mutations in, respectively, the Notch1, Notc 10075489 Human
notch1 thymomas We have previously characterized a large panel of provirus insertion Notch1 mutant alleles and their products arising in thymomas of MMTV(D)/myc transgenic mice. 10805726 Mouse
notch1 t-all Several mammalian Notch receptors are oncogenic when constitutively active, including Notch1, a gene initially identified based on its involvement in a (7;9) chromosomal translocation found in sporadic T-cell lymphoblastic leukemias and lymphomas (T-ALL). 11003647 Human
notch1 t-all Induction of T-ALL correlated with the transactivation activity of each Notch1 polypeptide when fused to the DNA-binding domain of GAL4, with the exception of polypeptides deleted of the ankyrin repeats, which lacked transforming activity while retaining 11003647 Mouse
notch1 cervical tumors Cervical tumors also consistently exhibit cytosolic and nuclear forms of Notch1, suggesting the possible persistent activation of the Notch pathway. 11448155 Human
notch1 metastatic tumors Examination of the transgenic adenocarcinoma of the mouse prostate showed that expression of Notch1 was elevated in malignant prostatic epithelial cells of primary and metastatic tumors. 11585768 Mouse
notch1 aml As the first step to clarify this, we examined the expression of Notch1 and Jagged1 proteins in eight AML cell lines and 15 fresh AML samples by immunoblotting. 11699411 Human
notch1 aml In the Notch1 protein, two bands, a 300 kDa band and a 120 kDa band, which appeared to be a full-length protein and a transmembrane fragment, respectively, were recognized in five AML cell lines and six fresh samples. 11699411 Human
notch1 aml We showed that Notch1 and Jagged1 proteins are widely expressed in AML cells. 11699411 Human
notch1 t-cell neoplasms In addition, truncated Notch1 alleles could be associated with 10% of all cases of human T lymphoblastic leukemia and, when introduced into mouse bone marrow stem cells, cause T-cell neoplasms. 11964309 Mouse
notch1 epithelial tumor Conversely, expression of activated Notch1 causes strong growth inhibition of HPV-positive, but not HPV-negative, cervical carcinoma cells, but exerts no such effects on other epithelial tumor cells. 12208848 Human
notch1 skin tumors Unexpectedly, ablation of Notch1 results in epidermal and corneal hyperplasia followed by the development of skin tumors and facilitated chemical-induced skin carcinogenesis. 12590261 Human
notch1 neoplasia The function of Notch signaling during lymphopoiesis and T cell neoplasia, based on gain-of-function and conditional loss-of-function approaches for the Notch1 receptor, indicates Notch1 is essential in T cell lineage commitment. 14985712 Human
notch1 apl The effect of all-trans retinoid acid (ATRA) on the expression of Notch1 gene by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in acute promyelocytic leukemia cells (APL), NB4, and HL-60 lacking t(15;17) was studied. 15058751 Human
notch1 apl The expression of Notch1 gene might be specific for APL cells. 15058751 Human
notch1 lymphoid neoplasm As Notch1 gene is involved in the differentiation and leukemogenesis in lymphoid neoplasm, observations suggest that Notch1 is involved in ATRA-modulated differentiation process in APL. 15058751 Human
notch1 apl As Notch1 gene is involved in the differentiation and leukemogenesis in lymphoid neoplasm, observations suggest that Notch1 is involved in ATRA-modulated differentiation process in APL. 15058751 Human
notch1 thymic lymphomas Defective expression of Notch1 and Notch2 in connection to alterations of c-Myc and Ikaros in gamma-radiation-induced mouse thymic lymphomas. 14976135 Mouse
notch1 thymic lymphomas In the present work we present evidence that gamma-radiation-induced thymic lymphomas in (C57BL/6 J x BALB/c) F1 hybrid mice often exhibit increased levels of Notch1 expression, but, contrary to what was expected, they also exhibit a clearly reduced Notch 14976135 Mouse
notch1 primary tumours These results represent the first reported instance for the involvement of Notch2 inactivation in the development of thymic primary tumours while confirming the role of Notch1 as an activated oncogene. 14976135 Mouse
notch1 t-cell acute lymphoblastic leukemia Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. 15472075 Human
notch1 tumors Here, we report that more than 50% of human T-ALLs, including tumors from all major molecular oncogenic subtypes, have activating mutations that involve the extracellular heterodimerization domain and/or the C-terminal PEST domain of NOTCH1. 15472075 Human
notch1 t-all These findings greatly expand the role of activated NOTCH1 in the molecular pathogenesis of human T-ALL and provide a strong rationale for targeted therapies that interfere with NOTCH signaling. 15472075 Human
notch1 breast cancer We show here that 17 beta-estradiol promoted a 6-fold increase in Jagged1 expression and an 8-fold increase in Notch1 expression by cDNA arrays in breast cancer MCF7 cells. 15192074 Mouse
notch1 tumor Inoculation of MCF7 cells in 17 beta-estradiol-treated nude mice resulted in up-regulation of Notch1 expression as well as increased number of tumor microvessels in comparison to placebo-treated mice. 15192074 Mouse
notch1 t-cell leukemia Notch transmembrane receptors are known to play a critical role in cell-fate decisions, with Notch1 shown to enhance self-renewal of hematopoietic stem cells and cause T-cell leukemia. 15231576 Human
notch1 brain tumor Notch1 and notch2 have opposite effects on embryonal brain tumor growth. 15520184 Human
notch1 tumor The role of Notch signaling in tumorigenesis can vary; Notch1 acts as an oncogene in some neoplasms, and a tumor suppressor in others. 15520184 Human
notch1 tumor Expression of truncated, constitutively active Notch1 or Notch2 in embryonal brain tumor cell lines caused antagonistic effects on tumor growth. 15520184 Human
notch1 brain tumor Expression of truncated, constitutively active Notch1 or Notch2 in embryonal brain tumor cell lines caused antagonistic effects on tumor growth. 15520184 Human
notch1 medulloblastomas We also found that Notch2 receptor transcripts are highly expressed in progenitor cell-derived brain tumors such as medulloblastomas, whereas Notch1 is scarce or undetectable. 15520184 Human
notch1 brain tumors We also found that Notch2 receptor transcripts are highly expressed in progenitor cell-derived brain tumors such as medulloblastomas, whereas Notch1 is scarce or undetectable. 15520184 Human
notch1 human tumors Our data indicate that Notch1 and Notch2 can have opposite effects on the growth of a single tumor type, and show that Notch2 can be overexpressed after gene amplification in human tumors. 15520184 Human
notch1 tumor Our data indicate that Notch1 and Notch2 can have opposite effects on the growth of a single tumor type, and show that Notch2 can be overexpressed after gene amplification in human tumors. 15520184 Human
notch1 mouse mammary tumors The vertebrate Notch1 and Notch4 homologs are involved in normal development of the mammary gland, and mutated forms of these genes are associated with development of mouse mammary tumors. 15535842 Human
notch1 t-all Kick it up a Notch: NOTCH1 activation in T-ALL. 15542425 Human
notch1 tumors While the human NOTCH1 gene initially was cloned as part of a translocation breakpoint in T cell acute lymphoblastic leukemia (T-ALL) tumors, this translocation is present in only a small percentage of T-ALL patients. 15542425 Human
notch1 t-all While the human NOTCH1 gene initially was cloned as part of a translocation breakpoint in T cell acute lymphoblastic leukemia (T-ALL) tumors, this translocation is present in only a small percentage of T-ALL patients. 15542425 Human
notch1 t-all (2004) demonstrates that novel types of activating mutations in the NOTCH1 gene occur in more than half of all T-ALL cases, implicating NOTCH1 as a major player in the etiology of T-ALL. 15542425 Human
notch1 cancer T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling. 15548998 Human
notch1 t-cell acute lymphoblastic leukemia T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling. 15548998 Human
notch1 tumors PURPOSE OF REVIEW: Although constitutively activated forms of the NOTCH1 receptor are potent inducers of T cell acute lymphoblastic leukemia/lymphoma when expressed in the bone marrow stem cells of mice, the known involvement of NOTCH1 in human T cell acu 15548998 Mouse
notch1 t-cell acute lymphoblastic leukemia PURPOSE OF REVIEW: Although constitutively activated forms of the NOTCH1 receptor are potent inducers of T cell acute lymphoblastic leukemia/lymphoma when expressed in the bone marrow stem cells of mice, the known involvement of NOTCH1 in human T cell acu 15548998 Human
notch1 t-cell acute lymphoblastic leukemia This picture has changed dramatically in the past year with the discovery of frequent mutations involving NOTCH1 in human T cell acute lymphoblastic leukemia/lymphoma. 15548998 Human
notch1 tumors RECENT FINDINGS: NOTCH1 point mutations, insertions, and deletions producing aberrant increases in NOTCH1 signaling are frequently present in both childhood and adult T cell acute lymphoblastic leukemia/lymphoma and are detected in tumors from all major m 15548998 Human
notch1 t-cell acute lymphoblastic leukemia RECENT FINDINGS: NOTCH1 point mutations, insertions, and deletions producing aberrant increases in NOTCH1 signaling are frequently present in both childhood and adult T cell acute lymphoblastic leukemia/lymphoma and are detected in tumors from all major m 15548998 Human
notch1 t-cell acute lymphoblastic leukemia These observations are particularly important in the light of experiments using human and murine T cell acute lymphoblastic leukemia/lymphoma cell lines indicating that NOTCH1 signals are required for sustained growth and, in a subset of lines, survival. 15548998 Human
notch1 t-cell acute lymphoblastic leukemia This inference is based in part on experiments conducted with small molecule inhibitors of gamma-secretase, a protease required for normal NOTCH signal transduction and the activity of the mutated forms of NOTCH1 found commonly in human T cell acute lymph 15548998 Human
notch1 thymic lymphomas Involvement of illegitimate v(d)j recombination or microhomology-mediated nonhomologous end-joining in the formation of intragenic deletions of the notch1 gene in mouse thymic lymphomas. 15604248 Mouse
notch1 thymic lymphomas We describe three pathways for the formation of 5'-deletions of the Notch1 gene in thymic lymphomas of wild-type or V(D)J recombination-defective severe combined immune deficiency (scid) mice. 15604248 Mouse
notch1 cancers NOTCH1 pathway: a molecular target in T-cell cancers? 15652588 Human
notch1 acute leukemia A wide role for NOTCH1 signaling in acute leukemia. 15694671 Human
notch1 t-acute lymphoblastic leukemia NOTCH1 is involved in the pathogenesis of T-acute lymphoblastic leukemia (T-ALL) carrying the very rare translocation t(7;9)(q34;q34.3). 15694671 Human
notch1 t-all NOTCH1 is involved in the pathogenesis of T-acute lymphoblastic leukemia (T-ALL) carrying the very rare translocation t(7;9)(q34;q34.3). 15694671 Human
notch1 acute lymphoblastic leukemia NOTCH1 pathway activation represents a common feature of T-ALL when compared to acute myelogenous leukemia (AML) and B-cell precursor acute lymphoblastic leukemia. 15694671 Human
notch1 t-all NOTCH1 pathway activation represents a common feature of T-ALL when compared to acute myelogenous leukemia (AML) and B-cell precursor acute lymphoblastic leukemia. 15694671 Human
notch1 aml AML primary samples show high levels of JAGGED1 expression despite the low NOTCH1 pathway activation, consistent with an autonomous JAGGED1 signaling in myeloid leukemogenesis. 15694671 Human
notch1 nodular regenerative hyperplasia Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice. 15723439 Mouse
notch1 nodular regenerative hyperplasia In conclusion, within weeks after Notch1 inactivation, the mice developed nodular regenerative hyperplasia without vascular changes in the liver. 15723439 Mouse
notch1 cervical cancer Constitutively active Notch1 induces growth arrest of HPV-positive cervical cancer cells via separate signaling pathways. 15817159 Human
notch1 tumor However, in primary keratinocytes, Notch1 can function as a tumor suppressor. 15817159 Human
notch1 cervical cancer Similarly, in HPV-positive cervical cancer cells, constitutively active Notch1 signaling was found to cause growth suppression. 15817159 Human
notch1 cervical cancer Here we show that in cervical cancer cell lines in which Notch1 ability to repress AP-1 activity is impaired, Notch1-enforced expression elicits an alternative pathway leading to growth arrest. 15817159 Human
notch1 cervical cancer Finally, we show that inhibition of endogenous Notch1 signaling, although results in a proliferative advantage, sensitizes cervical cancer cell lines to drug-induced apoptosis. 15817159 Human
notch1 myeloma Shortly after co-culture with osteoclasts, we found that the Notch2 receptor was activated in myeloma cells but Notch1 was not. 15485809 Human
notch1 enteropathy-type t-cell lymphoma Amplification of NOTCH1 and ABL1 gene loci is a frequent aberration in enteropathy-type T-cell lymphoma. 15756589 Human
notch1 epithelial tumors Whereas much is known about the role of Notch1 in human cancer, the role of Notch3 in epithelial tumors, such as lung carcinomas, has not been well established. 15867348 Human
notch1 cancer Whereas much is known about the role of Notch1 in human cancer, the role of Notch3 in epithelial tumors, such as lung carcinomas, has not been well established. 15867348 Human
notch1 cervical carcinoma Moreover, in a human cervical carcinoma cell line, CaSki, in which Notch1 is spontaneously activated, suppression of Notch1 expression with small interfering RNA significantly restores the responsiveness to TGF-beta. 15904468 Human
notch1 meningiomas We have shown that the transcript and protein levels of HES1, the Notch2 and Notch1 receptors and the Jagged1 ligand are induced in meningiomas of all grades, whereas induction of TLE2 and TLE3 occurs specifically in higher-grade meningiomas. 15958550 Human
notch1 tumor In keratinocytes, the cyclin/CDK inhibitor p21(WAF1/Cip1) is a direct transcriptional target of Notch1 activation; loss of either the p21 or Notch1 genes expands stem cell populations and facilitates tumor development. 15964998 Human
notch1 colorectal cancer Remarkably, unlike the case of APP, CTFs derived from Notch1, Jagged2, deleted in colorectal cancer (DCC), and N-cadherin remain largely detergent-soluble, indicative of their spatial segregation in non-raft domains. 15886206 Human
notch1 cyst Embryonic as well as postnatal inactivation of Notch1 shortly after birth or in adult mice results in almost complete hair loss followed by cyst formation. 15978571 Mouse
notch1 thymic tumors Gene expression profiling of thymic tumors that developed in OLIG2/LMO1 mice revealed up-regulation of Notch1 as well as Deltex1 (Dtx1) and pre T-cell antigen receptor alpha (Ptcra), two genes that are considered to be downstream of Notch1. 16103065 Mouse
notch1 thymic tumors Of note, we found mutations in the Notch1 heterodimerization or proline-, glutamic acid-, serine-, and threonine-rich domain in three of six primary thymic tumors. 16103065 Human
notch1 carcinoid Conservation of the Notch1 signaling pathway in gastrointestinal carcinoid cells. 16160079 Human
notch1 carcinoid We were interested in determining whether activation of the Notch1 signal transduction pathway in carcinoid cells could modulate production of NE markers and hormones. 16160079 Human
notch1 carcinoid Human pancreatic carcinoid cells (BON cells) were stably transduced with an estrogen-inducible Notch1 construct, creating BON-NIER cells. 16160079 Human
notch1 human breast cancer High-level Coexpression of JAG1 and NOTCH1 Is Observed in Human Breast Cancer and Is Associated with Poor Overall Survival. 16166334 Human
notch1 tumors High levels of JAG1 and NOTCH1 were noted in a subset of tumors with poor prognosis pathologic features (P < 0.05). 16166334 Human
notch1 tumors Patients with tumors expressing high levels of JAG1 or NOTCH1 had a significantly poorer overall survival compared with patients expressing low levels of these genes [5-year survival rate of 42% versus 65% and median survival of 50 versus 83 months, respe 16166334 Human
notch 1 burkitt's lymphoma An estrogen receptor fusion protein of the intracellular part of mouse Notch 1 (mNotch1-IC), mimicking in the presence of estrogen a constitutively active Notch receptor, was stably transfected into the Burkitt's lymphoma cell lines BL41-P3HR1 and HH 10644343 Mouse
notch 1 testicular germ cell tumors METHODS: Northern blot analysis and immunohistochemical staining for Notch 1 and Jagged 2 were done in 139 samples of testicular germ cell tumors. 15361705 Human
notch 1 embryonal carcinomas However, the expressions of transcript and protein were negative for both Jagged 2 and Notch 1 in seminomas, they were negative for Jagged 2 but were positive for Notch 1 in embryonal carcinomas and choriocarcinomas, and they were positive for Jagged 2 an 15361705 Human
notch 1 teratomas However, the expressions of transcript and protein were negative for both Jagged 2 and Notch 1 in seminomas, they were negative for Jagged 2 but were positive for Notch 1 in embryonal carcinomas and choriocarcinomas, and they were positive for Jagged 2 an 15361705 Human
notch 1 seminomas However, the expressions of transcript and protein were negative for both Jagged 2 and Notch 1 in seminomas, they were negative for Jagged 2 but were positive for Notch 1 in embryonal carcinomas and choriocarcinomas, and they were positive for Jagged 2 an 15361705 Human
notch 1 choriocarcinomas However, the expressions of transcript and protein were negative for both Jagged 2 and Notch 1 in seminomas, they were negative for Jagged 2 but were positive for Notch 1 in embryonal carcinomas and choriocarcinomas, and they were positive for Jagged 2 an 15361705 Human
notch 1 osteosarcoma In this immunohistochemical examination, the expression of Notch1 peptide was detected in neoplastic cells in a case of osteosarcoma of the maxilla of a 31-year-old Indonesian male patient. 15649865 Human
tan-1 t-all In t(7;9)(q34;q34.3) translocations from three cases of T-ALL, the breakpoints occur within 100 bp of an intron in TAN-1, resulting in truncation of TAN-1 transcripts. 1831692 Human
tan-1 t-cell neoplasms These observations suggest that TAN-1 may be important for normal lymphocyte function and that alteration of TAN-1 may play a role in the pathogenesis of some T cell neoplasms. 1831692 Human
tan-1 t-cell leukemia Cloning and sequencing of the PCR products identified this Notch homologue as TAN-1, a member of the Notch family previously cloned from a T-cell leukemia with a translocation involving this gene. 7512837 Human
tan-1 human t-cell leukemia Translocation-associated Notch homologue (TAN-1), a gene originally cloned from the translocation breakpoint of a human T cell leukemia carrying a 9:7(q34.3) translocation, encodes a protein belonging to the Notch/Lin-12/Glp-1 receptor family. 8642313 Human
tan-1 endometrial cancers Imbalanced expression of TAN-1 and human Notch4 in endometrial cancers. 11078798 Human
tan-1 other cancers By contrast, 18 MSI+ colorectal cancers (13 cancer cell lines and five primary tumors) with mismatch repair defects exhibited six mutations in three of the 17 genes (SREBP-2, TAN-1, GR6) (P<0.000003 compared to all other cancers tested). 11314036 Human
tan-1 cancer By contrast, 18 MSI+ colorectal cancers (13 cancer cell lines and five primary tumors) with mismatch repair defects exhibited six mutations in three of the 17 genes (SREBP-2, TAN-1, GR6) (P<0.000003 compared to all other cancers tested). 11314036 Human
tan-1 colorectal cancers By contrast, 18 MSI+ colorectal cancers (13 cancer cell lines and five primary tumors) with mismatch repair defects exhibited six mutations in three of the 17 genes (SREBP-2, TAN-1, GR6) (P<0.000003 compared to all other cancers tested). 11314036 Human
hn1 tumor RESULTS: The 3-fold up-regulated genes were examined and four genes [Notch homologue 3 (NOTCH3), E2F transcription factor 3 (E2F3), GTPase activating protein (RACGAP1), and hematological and neurological expressed 1 (HN1)] distinguished all tumor samples 15161682 Human
tan-1 endometrial cancers Our results showed that: a) Both human Notch4 and translocation-associated Notch homologue-1 (TAN-1), another human homologue of Drosophila Notch, are expressed in the normal endometrium, mainly in the endometrial glandular cells. b) The level of expressi 11078798 Human
tan-1 endometrial cancer These results suggest that human Notch4 and/or TAN-1 are involved in the changes of the endometrium during the menstrual cycle, and also in the development of endometrial cancer. 11078798 Human
notch1 cancer RESULTS: Autoradiographic analysis showed that of the 588 genes analyzed, 61 were found up-regulated in cancer, including cdc25B, Notch1, MMP, MET etc, and 22 down regulated in cancer, including cytokeratin4, BAD, IL-1 RECEPTOR ANTAGONIST, IL-6, etc. 10514537 Human
notch1 tumor However, mice transgenic for both the E2A-PBX1 and Notch1(DeltaC) genes displayed a substantially shortened latency for tumor development compared with E2A-PBX1 single transgenic mice. 10961893 Mouse
notch1 sclc Recombinant adenoviruses were used to overexpress active forms of Notch1, Notch2, or the Notch effector protein human hairy enhancer of split-1 (HES1) in DMS53 and NCI-H209 SCLC cells. 11306509 Human
notch1 anaplastic large cell lymphoma Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma. 11964309 Human
notch1 anaplastic large cell lymphoma Here we show that Notch1 is highly expressed in B- and T-cell-derived tumor cells of Hodgkin and anaplastic large cell lymphoma. 11964309 Human
notch1 anaplastic large cell lymphoma Thus, our data suggest that activated Notch1 signaling plays an important role in the pathobiology of Hodgkin and anaplastic large cell lymphoma and that it might be a potential new target for treatment. 11964309 Human
notch1 salivary gland carcinomas Truncation of Notch1 has been shown to cause a subtype of acute leukemia, and activation of Notch4 has been associated with mammary and salivary gland carcinomas of mice. 12539049 Human
notch1 thymoma Consistent with other recent reports, these data suggest a role for Notch1 during the DN to DP stage of thymocyte maturation and suggest a cellular mechanism by which Notch1IC oncogenes could contribute to thymoma development and maintenance. 12928374 Human
notch1 thymoma We found that Notch1 expression and activation were negatively regulated by p53in several thymoma lines. 14991602 Mouse
notch1 t cell acute lymphoblastic leukemia Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. 15472075 Human
notch1 t cell acute lymphoblastic leukemia (t-all) Very rare cases of human T cell acute lymphoblastic leukemia (T-ALL) harbor chromosomal translocations that involve NOTCH1, a gene encoding a transmembrane receptor that regulates normal T cell development. 15472075 Human
notch1 t cell acute lymphoblastic leukemia (t-all) While the human NOTCH1 gene initially was cloned as part of a translocation breakpoint in T cell acute lymphoblastic leukemia (T-ALL) tumors, this translocation is present in only a small percentage of T-ALL patients. 15542425 Human
notch1 t cell acute lymphoblastic leukemia T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling. 15548998 Human
notch1 t cell acute lymphoblastic leukemia PURPOSE OF REVIEW: Although constitutively activated forms of the NOTCH1 receptor are potent inducers of T cell acute lymphoblastic leukemia/lymphoma when expressed in the bone marrow stem cells of mice, the known involvement of NOTCH1 in human T cell acu 15548998 Human
notch1 t cell acute lymphoblastic leukemia This picture has changed dramatically in the past year with the discovery of frequent mutations involving NOTCH1 in human T cell acute lymphoblastic leukemia/lymphoma. 15548998 Human
notch1 t cell acute lymphoblastic leukemia RECENT FINDINGS: NOTCH1 point mutations, insertions, and deletions producing aberrant increases in NOTCH1 signaling are frequently present in both childhood and adult T cell acute lymphoblastic leukemia/lymphoma and are detected in tumors from all major m 15548998 Human
notch1 t cell acute lymphoblastic leukemia These observations are particularly important in the light of experiments using human and murine T cell acute lymphoblastic leukemia/lymphoma cell lines indicating that NOTCH1 signals are required for sustained growth and, in a subset of lines, survival. 15548998 Human
notch1 t cell acute lymphoblastic leukemia This inference is based in part on experiments conducted with small molecule inhibitors of gamma-secretase, a protease required for normal NOTCH signal transduction and the activity of the mutated forms of NOTCH1 found commonly in human T cell acute lymph 15548998 Human
notch1 osteosarcoma In this immunohistochemical examination, the expression of Notch1 peptide was detected in neoplastic cells in a case of osteosarcoma of the maxilla of a 31-year-old Indonesian male patient. 15649865 Human
notch1 osteosarcoma Notch1 peptide appeared in the cytoplasm of neoplastic cells of comparatively well-differentiated areas of the osteosarcoma, an osteoblastic area containing osteoid and/or immature bone tissues. 15649865 Human
notch1 osteosarcoma The results suggest that Notch1 is closely related to cytological differentiation or acquisition of cytological characteristics in neoplastic cells of osteosarcoma. 15649865 Human
notch1 acute myelogenous leukemia (aml) NOTCH1 pathway activation represents a common feature of T-ALL when compared to acute myelogenous leukemia (AML) and B-cell precursor acute lymphoblastic leukemia. 15694671 Human
notch1 t-cell acute lymphoblastic leukemia Mutations of the Notch1 gene in T-cell acute lymphoblastic leukemia: analysis in adults and children. 16079893 Human
notch1 astrocytoma ASCL1 upregulation in progressive astrocytoma is accompanied by inhibition of Notch signaling as seen by uninduced levels of HES1, a transcriptional target of Notch1, increased levels of HES6, a dominant-negative inhibitor of HES1-mediated repression of A 16103883 Human
notch1 t-cell acute lymphoblastic leukemia (t-all) It was reported that GSI suppressed growth of T-cell acute lymphoblastic leukemia (T-ALL) cell lines, which frequently had NOTCH1 mutations. 16780947 Human
notch1 t-cell acute lymphoblastic leukemia c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. 16847353 Human
notch1 acute t-cell lymphoblastic leukemias Human acute T-cell lymphoblastic leukemias and lymphomas (T-ALL) are commonly associated with gain-of-function mutations in Notch1 that contribute to T-ALL induction and maintenance. 16847353 Human
notch1 t-all Human acute T-cell lymphoblastic leukemias and lymphomas (T-ALL) are commonly associated with gain-of-function mutations in Notch1 that contribute to T-ALL induction and maintenance. 16847353 Human
notch1 t-all Starting from an expression-profiling screen, we identified c-myc as a direct target of Notch1 in Notch-dependent T-ALL cell lines, in which Notch accounts for the majority of c-myc expression. 16847353 Human
notch1 t-all In functional assays, inhibitors of c-myc interfere with the progrowth effects of activated Notch1, and enforced expression of c-myc rescues multiple Notch1-dependent T-ALL cell lines from Notch withdrawal. 16847353 Human
notch1 t-all The existence of a Notch1-c-myc signaling axis was bolstered further by experiments using c-myc-dependent murine T-ALL cells, which are rescued from withdrawal of c-myc by retroviral transduction of activated Notch1. 16847353 Mouse
notch1 t-all Together, these data implicate c-myc as a developmentally regulated direct downstream target of Notch1 that contributes to the growth of T-ALL cells. 16847353 Human
notch-1 mouse erythroleukemia (mel) We investigated whether endogenously expressed notch-1 controls cell fate determination in mouse erythroleukemia (MEL) cells during pharmacologically induced differentiation. 10227380 Human
notch-1 cin Notch-1 receptor expression is increased during the progression from cervical intraepithelial lesions (CIN) to invasive cervical carcinoma. 12548555 Human
notch-1 cin Moreover, the main cellular localization of Notch-1 protein changes from cytoplasmic to nuclear with the transition from CIN III to microinvasive carcinoma. 12548555 Human
notch-1 multiple myeloma The results showed that multiple myeloma cells expressed the Notch-1 and its related molecules. 15228662 Human
notch-1 ks In this report, we demonstrate elevated levels of activated Notch-1, -2, and -4 in KS tumor cells in vivo and in vitro compared to endothelial cells, the precursor of the KS cell. 15940249 Human
notch-1 tumor In this report, we demonstrate elevated levels of activated Notch-1, -2, and -4 in KS tumor cells in vivo and in vitro compared to endothelial cells, the precursor of the KS cell. 15940249 Human
notch 1 testicular germ cell tumors OBJECTIVES: The expression of Notch 1 and its ligand Jagged 2, critical factors in cell type specification, in testicular germ cell tumors was examined in order to evaluate its possible relationship with their pathogenesis. 15361705 Human
notch 1 adenomas Quantitative PCR revealed decreased Notch 1 mRNA in ovarian adenocarcinomas compared with adenomas. 16136053 Human
notch 1 ovarian adenocarcinomas Quantitative PCR revealed decreased Notch 1 mRNA in ovarian adenocarcinomas compared with adenomas. 16136053 Human
notch1 oncogenic Any of the identified targets, Cyclin E, c-Myc, c-Jun, Notch1/4 and Aurora-A may have oncogenic properties when accumulated in tumors with FBXW7 loss. 17326833 Human
notch1 human tumor Thus, the Notch1 gene is a p53 target with a role in human tumor suppression through negative regulation of Rho effectors. 17344417 Human
tan-1 human t cell leukemia Translocation-associated Notch homologue (TAN-1), a gene originally cloned from the translocation breakpoint of a human T cell leukemia carrying a 9:7(q34.3) translocation, encodes a protein belonging to the Notch/Lin-12/Glp-1 receptor family. 8642313 Human
notch1 human t cell leukemia Truncated forms of the NOTCH1 transmembrane receptor engineered to resemble mutant forms of NOTCH1 found in certain cases of human T cell leukemia/lymphoma (T-ALL) efficiently induce T-ALL when expressed in the bone marrow of mice. 9111040 Mouse
notch1 acute lymphoblastic t-cell leukemia In human acute lymphoblastic T-cell leukemia, a chromosomal translocation damages the NOTCH1 gene. 9343387 Human
notch1 t-cell lymphoblastic leukemias Several mammalian Notch receptors are oncogenic when constitutively active, including Notch1, a gene initially identified based on its involvement in a (7;9) chromosomal translocation found in sporadic T-cell lymphoblastic leukemias and lymphomas (T-ALL). 11003647 Human
notch1 hematopoietic malignancy As Notch1 is disrupted via a chromosomal translocation in a subset of human T-cell leukemia, leading to a truncated polypeptide resembling N(IC), deregulated chromatin remodeling and transcription may fuel uncontrolled cell proliferation in this hematopoi 11389531 Human
notch1 cell leukaemia Members of the Notch family (e.g. Notch1 and Notch3) have been recently described to play a critical role in T cell development and their constitutive activation has been related to T cell leukaemia in both animal models and human disease. 12651099 Human
notch1 invasive cervical carcinomas (icc) Intracellular Notch1 protein is detected in invasive cervical carcinomas (ICC), and truncated Notch1 alleles complement the function of E6/E7 in the transformation of human epithelial cells. 15280477 Human
notch-1 acute lymphoblastic t-cell leukemias In many cases of human acute lymphoblastic T-cell leukemias, chromosomal translocations fuse a part of the Notch-1 gene to the T-cell receptor-beta locus (Ellison et al., 1991, Cell 66:649-661). 11056013 Human
notch-1 invasive cervical carcinoma Notch-1 receptor expression is increased during the progression from cervical intraepithelial lesions (CIN) to invasive cervical carcinoma. 12548555 Human
tan1 t-cell lymphoblastic leukemias A human homologue of Notch, TAN1, was initially identified at the chromosomal breakpoint of a subset of T-cell lymphoblastic leukemias/lymphomas containing a t(7;9) chromosomal translocation; however, its role in oncogenesis has been unclear. 8642337 Human
notch1 t-all Activating Notch1 mutations in mouse models of T-ALL. 16166587 Mouse
notch1 t-cell acute lymphocytic leukemia (t-all) Recent studies have demonstrated that most patients with T-cell acute lymphocytic leukemia (T-ALL) have activating mutations in NOTCH1. 16166587 Human
notch1 tumors We sequenced the heterodimerization domain and the PEST domain of Notch1 in our mouse model of TAL1-induced leukemia and found that 74% of the tumors harbor activating mutations in Notch1. 16166587 Mouse
notch1 thymic lymphomas In addition, we found activating Notch1 mutations in 31% of thymic lymphomas that occur in mice deficient for various combinations of the H2AX, Tp53, and Rag2 genes. 16166587 Mouse
notch1 nasopharyngeal carcinoma (npc) [Expression and Significance of Notch1, P21WAF1 and involucrin in nasopharyngeal carcinoma] BACKGROUND & OBJECTIVE: Abnormal expression of Notch1 protein was often found in many kinds of primary tumors, but its correlation with nasopharyngeal carcinoma (N 16219138 Human
notch1 carcinoma The positive rates of Notch1, P21(WAF1), and Involucrin were significantly higher in keratinizing squamous cell carcinoma (KSCC) than in differentiated nonkeratinizing carcinoma (DNKC) and undifferentiated carcinoma (UDC) (P<0.05), and were significantly 16219138 Human
notch1 keratinizing squamous cell carcinoma (kscc) The positive rates of Notch1, P21(WAF1), and Involucrin were significantly higher in keratinizing squamous cell carcinoma (KSCC) than in differentiated nonkeratinizing carcinoma (DNKC) and undifferentiated carcinoma (UDC) (P<0.05), and were significantly 16219138 Human
notch1 tumor Delta-like 4 (Dll4), a membrane-bound ligand for Notch1 and Notch4, is selectively expressed in the developing endothelium and in some tumor endothelium, and it is induced by vascular endothelial growth factor (VEGF)-A and hypoxia. 16219802 Human
notch1 melanoma Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression. 16239965 Human
notch1 melanoma Here we show that the Notch1 pathway is activated in human melanoma. 16239965 Human
notch1 melanoma Blocking Notch signaling suppressed whereas constitutive activation of the Notch1 pathway enhanced primary melanoma cell growth both in vitro and in vivo yet had little effect on metastatic melanoma cells. 16239965 Human
notch1 metastatic melanoma Blocking Notch signaling suppressed whereas constitutive activation of the Notch1 pathway enhanced primary melanoma cell growth both in vitro and in vivo yet had little effect on metastatic melanoma cells. 16239965 Human
notch1 melanoma Activation of Notch1 signaling enabled primary melanoma cells to gain metastatic capability. 16239965 Human
notch1 melanoma Furthermore, the oncogenic effect of Notch1 on primary melanoma cells was mediated by beta-catenin, which was upregulated following Notch1 activation. 16239965 Human
notch1 melanoma Our data therefore suggest a beta-catenin-dependent, stage-specific role for Notch1 signaling in promoting the progression of primary melanoma. 16239965 Human
notch1 t-all Association with other oncogene expression (TAL1, HOXAs, or TLX3/HOX11L2), NOTCH1 activating mutations, and/or CDKN2A/p16/ARF deletion, showed that cyclin D2 dysregulation could contribute to multi-event oncogenesis in various T-ALL groups. 16270038 Human
notch1 t-cell lymphoblastic leukemia NOTCH1 is frequently mutated in human precursor T-cell lymphoblastic leukemia/lymphoma (pre-T LBL). 16282337 Human
notch1 tumors Thymocytes from clinically healthy SCL/LMO1 mice aged 5 weeks did not have Notch1 mutations, whereas thymocytes from clinically healthy SCL/LMO1 mice aged 8 to 12 weeks did have Notch1 mutations and formed tumors upon transplantation into nude mice. 16282337 Mouse
notch1 acute t-cell lymphoblastic leukemias Recent work has shown that the majority of human acute T-cell lymphoblastic leukemias and lymphomas (T-ALL) have gain-of-function mutations in NOTCH1, a type I transmembrane receptor that normally signals through a gamma-secretase-dependent mechanism that 16298817 Human
notch1 t-all Recent work has shown that the majority of human acute T-cell lymphoblastic leukemias and lymphomas (T-ALL) have gain-of-function mutations in NOTCH1, a type I transmembrane receptor that normally signals through a gamma-secretase-dependent mechanism that 16298817 Human
notch1 hyperplastic Notch1, Notch3, Delta1, and Jagged1 were overexpressed in the synovial lining and sublining cells on synovial hyperplastic lesions in all samples. 16307184 Human
notch1 osteosarcoma In this immunohistochemical examination, the expression of Runx2, Notch1, Delta and Osteopontin peptides were detected in neoplastic cells in 10 Japanese cases of osteosarcoma. 16354601 Human
notch1 osteosarcoma However, Notch1 peptide expression appeared in the cytoplasm of neoplastic cells in the localized and comparatively well-differentiated area of osteosarcoma, which osteoblastic and chondroblastic containing osteoid and/or chondroid tissues. 16354601 Human
notch1 osteosarcomas Therefore, these results suggest that Runx2, Notch1, and Delta peptides are closely related to cytological differentiation or acquisition of tissue specific characteristics in neoplastic cells in osteosarcomas. 16354601 Human
notch1 acute myeloid leukemia Observation of high frequencies of mutations in NOTCH1, NPM and JAK2 in T-cell acute lymphoblastic leukemia, acute myeloid leukemia with normal karyotype and myeloproliferative disorders (polycythemia vera, essential thrombocythemia and idiopathic myelofi 16357566 Human
notch1 essential thrombocythemia Observation of high frequencies of mutations in NOTCH1, NPM and JAK2 in T-cell acute lymphoblastic leukemia, acute myeloid leukemia with normal karyotype and myeloproliferative disorders (polycythemia vera, essential thrombocythemia and idiopathic myelofi 16357566 Human
notch1 idiopathic myelofibrosis Observation of high frequencies of mutations in NOTCH1, NPM and JAK2 in T-cell acute lymphoblastic leukemia, acute myeloid leukemia with normal karyotype and myeloproliferative disorders (polycythemia vera, essential thrombocythemia and idiopathic myelofi 16357566 Human
notch1 myeloproliferative disorders Observation of high frequencies of mutations in NOTCH1, NPM and JAK2 in T-cell acute lymphoblastic leukemia, acute myeloid leukemia with normal karyotype and myeloproliferative disorders (polycythemia vera, essential thrombocythemia and idiopathic myelofi 16357566 Human
notch1 polycythemia vera Observation of high frequencies of mutations in NOTCH1, NPM and JAK2 in T-cell acute lymphoblastic leukemia, acute myeloid leukemia with normal karyotype and myeloproliferative disorders (polycythemia vera, essential thrombocythemia and idiopathic myelofi 16357566 Human
notch1 t-cell acute lymphoblastic leukemia Observation of high frequencies of mutations in NOTCH1, NPM and JAK2 in T-cell acute lymphoblastic leukemia, acute myeloid leukemia with normal karyotype and myeloproliferative disorders (polycythemia vera, essential thrombocythemia and idiopathic myelofi 16357566 Human
notch1 prostate adenocarcinomas Furthermore, expression of Notch1 and its effector Hey-1 gene in human prostate adenocarcinomas were found significantly down-regulated compared to normal control tissues. 16360140 Human
notch1 carcinoid tumor Hairy Enhancer of Split-1 (HES-1), a Notch1 effector, inhibits the growth of carcinoid tumor cells. 16360401 Human
notch1 carcinoid tumors However, the molecules that mediate Notch1 signaling, as well as their potential roles in regulating the growth of carcinoid tumors, have not been characterized. 16360401 Human
notch1 t-all The relevance of these findings is discussed in the context of activating NOTCH1 mutations and the other genetic lesions implicated in the multistep transformation process of TLX1(+) T-ALL. 16398656 Human
notch1 tumor BACKGROUND: To better understand the possibilities of antiangiogenic tumor therapy and to assess possible side effects, we investigated the effect of tumour necrosis factor (TNF)-alpha and curcumin on the expression of vascular endothelial growth factor ( 16438902 Human
notch1 t cell lymphomas Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms. 16449526 Human
notch1 t cell lymphomas Our findings indicate that the activation of Notch1 is an important "second hit" for the transformation of E2A(-/-) T cell lymphomas and that Notch1 promotes survival through pre-TCR-dependent and -independent mechanisms. 16449526 Human
notch1 human breast carcinomas Here, we show accumulation of the intracellular domain of Notch1 and hence increased Notch signaling in a wide variety of human breast carcinomas. 16452208 Human
notch1 t cell acute lymphoblastic leukemia Alternatively, dissociation of the Notch heterodimer with consequent activation can also be mediated experimentally by calcium chelators or by mutations that destabilize the Notch1 heterodimer, such as in the human disease T cell acute lymphoblastic leuke 16492672 Human
notch1 mammary tumors Overexpression of activated murine notch1 and notch3 in transgenic mice blocks mammary gland development and induces mammary tumors. 16507912 Mouse
notch1 mammary tumors The mouse mammary tumor virus (MMTV) provirus was found to target the Notch1 gene, producing insertional mutations in mammary tumors of MMTV/neu transgenic (Tg) mice. 16507912 Mouse
notch1 mammary tumors In these mammary tumors, the Notch1 gene is truncated upstream of the transmembrane domain, and the resulting Notch1 intracellular domain (Notch1(intra)), deleted of most extracellular sequences, is overexpressed. 16507912 Mouse
notch1 mammary gland tumor Although Notch1(intra) transforms mammary epithelial cells in vitro, its role in mammary gland tumor formation in vivo was not studied. 16507912 Mouse
notch1 mammary gland tumors The MMTV/Notch1(intra) Tg females developed mammary gland tumors, confirming the oncogenic potential of Notch1(intra) in vivo. 16507912 Mouse
notch1 t-all Recent studies, however, have identified a large fraction of T-ALL cases carrying mutations in one of these genes, Notch1, suggesting for the first time that many cases may share a common pathogenic etiology, and perhaps may allow the development of targe 16556027 Human
notch1 tongue carcinoma Growth suppression induced by Notch1 activation involves Wnt-beta-catenin down-regulation in human tongue carcinoma cells. 16608439 Human
notch1 cancers BACKGROUND INFORMATION: Involvement of Notch1 signalling in several cancers is well known, but its role in human tongue squamous cell carcinoma, one of the most common carcinomas of the human oral cavity, remains poorly characterized. 16608439 Human
notch1 common carcinomas BACKGROUND INFORMATION: Involvement of Notch1 signalling in several cancers is well known, but its role in human tongue squamous cell carcinoma, one of the most common carcinomas of the human oral cavity, remains poorly characterized. 16608439 Human
notch1 tongue squamous cell carcinoma BACKGROUND INFORMATION: Involvement of Notch1 signalling in several cancers is well known, but its role in human tongue squamous cell carcinoma, one of the most common carcinomas of the human oral cavity, remains poorly characterized. 16608439 Human
notch1 tongue cancer RESULTS: Our studies demonstrated that constitutively over-expressed active Notch1, via stable transfection of exogenous ICN (intracellular fragment of Notch), resulted in growth suppression of the human tongue cancer cell line Tca8113 in vitro and in viv 16608439 Human
notch1 t-all The recent discovery of novel activating mutations in NOTCH1 in more than 50% of human T-ALL samples has made it clear that Notch 1 is far more important in human T-ALL pathogenesis than previously suspected. 16612405 Human
notch1 t-cell lymphoblastic leukemia Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia. 16614245 Human
notch1 t-all Activating mutations of the transmembrane receptor NOTCH1 are common in precursor T-cell lymphoblastic leukemia (T-ALL). 16614245 Human
notch1 t-cell lymphoblastic leukemia Activating mutations of the transmembrane receptor NOTCH1 are common in precursor T-cell lymphoblastic leukemia (T-ALL). 16614245 Human
notch1 t-all We systematically analyzed the impact of activating NOTCH1 mutations on early treatment response and long-term outcome in 157 patients with T-ALL of the pediatric ALL-Berlin-Frankfurt-Munster (BFM) 2000 study. 16614245 Human
notch1 t-all We confirm previous results that NOTCH1 mutations occur in more than 50% of T-ALL in children. 16614245 Human
notch1 minimal residual disease The presence of NOTCH1 mutations was significantly correlated with a good prednisone response and favorable minimal residual disease (MRD) kinetics, which was independent from sex, age, white blood cell count, and T-cell immunophenotype at the time of dia 16614245 Human
notch1 mrd The presence of NOTCH1 mutations was significantly correlated with a good prednisone response and favorable minimal residual disease (MRD) kinetics, which was independent from sex, age, white blood cell count, and T-cell immunophenotype at the time of dia 16614245 Human
notch1 t-all These findings indicate that in the context of the ALL-BFM 2000 treatment strategy, NOTCH1 mutations predict a more rapid early treatment response and a favorable long-term outcome in children with T-ALL. 16614245 Human
notch1 melanoma Notch1 Signaling Promotes Primary Melanoma Progression by Activating Mitogen-Activated Protein Kinase/Phosphatidylinositol 3-Kinase-Akt Pathways and Up-regulating N-Cadherin Expression. 16618740 Human
notch1 melanoma Here, we show that Notch1 signaling drives the vertical growth phase (VGP) of primary melanoma toward a more aggressive phenotype. 16618740 Human
notch1 melanoma Constitutive activation of Notch1 by ectopic expression of the Notch1 intracellular domain enables VGP primary melanoma cell lines to proliferate in a serum-independent and growth factor-independent manner in vitro and to grow more aggressively with metas 16618740 Human
notch1 tumor Notch1 activation also enhances tumor cell survival when cultured as three-dimensional spheroids. 16618740 Human
notch1 melanoma Both pathways are activated in melanoma cells following Notch1 pathway activation. 16618740 Human
notch1 tumor Inhibition of either the MAPK or the phosphatidylinositol 3-kinase (PI3K)-Akt pathway reverses the Notch1 signaling-induced tumor cell growth. 16618740 Human
notch1 tumor We further showed that Notch1 activation increases tumor cell adhesion and up-regulates N-cadherin expression. 16618740 Human
notch1 tumors Several tumors exhibit aberrant expression of Notch signaling component genes, such as Notch1/2/3 and Hath1. 16647036 Human
notch1 gastric cancer (gc) In this study, we investigated the mRNA expression of seven Notch-related genes, Notch1/2/3, Hes1/2/3, and Hath1, and then compared it with the expression of gastric mucin genes, MUC5AC and MUC6, in eight gastric cancer (GC) cell lines. 16647036 Human
notch1 breast cancer Finally, we show that MCF7 (breast cancer) and MOLT4 (T-cell acute lymphoblastic leukemia) cells having aberrant Notch1 signaling are chemoresistant, which can be reversed by both PI3K and mTOR inhibitors. 16651424 Human
notch1 t-cell acute lymphoblastic leukemia Finally, we show that MCF7 (breast cancer) and MOLT4 (T-cell acute lymphoblastic leukemia) cells having aberrant Notch1 signaling are chemoresistant, which can be reversed by both PI3K and mTOR inhibitors. 16651424 Human
notch1 t-all Episomal NUP214-ABL1 amplification and activating mutations in NOTCH1, two other recently identified 9q34 abnormalities in T-ALL, were also detected in our patient cohort. 16673019 Human
notch1 human t-cell lymphoma CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to gamma-secretase inhibitors. 16688224 Human
notch1 t-all Activating mutations in NOTCH1 are present in over 50% of human T-cell lymphoblastic leukemia (T-ALL) samples and inhibition of NOTCH1 signaling with gamma-secretase inhibitors (GSI) has emerged as a potential therapeutic strategy for the treatment of thi 16688224 Human
notch1 t-cell lymphoblastic leukemia Activating mutations in NOTCH1 are present in over 50% of human T-cell lymphoblastic leukemia (T-ALL) samples and inhibition of NOTCH1 signaling with gamma-secretase inhibitors (GSI) has emerged as a potential therapeutic strategy for the treatment of thi 16688224 Human
notch1 human t-cell lymphoma Here, we report a new human T-cell lymphoma line CUTLL1, which expresses high levels of activated NOTCH1 and is extremely sensitive to gamma-secretase inhibitors treatment. 16688224 Human
notch1 t-all In contrast with most human T-ALL cell lines with activating mutations in NOTCH1, CUTLL1 cells showed a robust cellular phenotype upon GSI treatment characterized by G1 cell cycle arrest and increased apoptosis. 16688224 Human
notch1 t-all These results show that the CUTLL1 cell line has a strong dependence on NOTCH1 signaling for proliferation and survival and supports that T-ALL patients whose tumors harbor t(7;9) should be included in clinical trials testing the therapeutic efficacy NOTC 16688224 Human
notch1 tumors These results show that the CUTLL1 cell line has a strong dependence on NOTCH1 signaling for proliferation and survival and supports that T-ALL patients whose tumors harbor t(7;9) should be included in clinical trials testing the therapeutic efficacy NOTC 16688224 Human
notch1 pel In this report, we show that the activated intracellular domain of Notch1 (ICN) is aberrantly accumulated in KSHV latently infected pleural effusion lymphoma (PEL) cells. 16701788 Human
notch1 t-cell acute lymphoblastic leukemia NOTCH1 mutations in T-cell acute lymphoblastic leukemia: prognostic significance and implication in multifactorial leukemogenesis. 16707600 Human
notch1 t-cell acute lymphoblastic leukemia (t-all) PURPOSE: NOTCH signaling pathway is essential in T-cell development and NOTCH1 mutations are frequently present in T-cell acute lymphoblastic leukemia (T-ALL). 16707600 Human
notch1 t-all To gain insight into its clinical significance, NOTCH1 mutation was investigated in 77 patients with T-ALL. 16707600 Human
notch1 t-all Interestingly, the statistically significant difference of survival according to NOTCH1 mutations was only observed in adult patients (>18 years) but not in pediatric patients (< or = 18 years), possibly due to the relatively good overall response of chil 16707600 Human
notch1 t-all CONCLUSION: NOTCH1 mutation is an important prognostic marker in T-ALL and its predictive value could be even further increased if coevaluated with other T-cell-related regulatory genes. 16707600 Human
notch1 glioma Polypyrimidine tract binding protein and Notch1 are independently re-expressed in glioma. 16729017 Human
notch1 gliomas To do this, we performed an immunohistochemical analysis for expression of PTB, activated Notch1 (Notch1IC), Hes1 (a Notch target), and GFAP on an extensive human tissue microarray that included 246 gliomas, 10 gliosarcomas, and 10 normal brains. 16729017 Human
notch1 glioma We conclude that PTB, and Notch1 serve as independent and functionally unlinked markers of glioma progression. 16729017 Human
notch1 t-cell acute lymphoblastic leukemia (t-all) Because mutations in the heterodimerization domain of NOTCH1 occur frequently in human T-cell acute lymphoblastic leukemia (T-ALL), we assessed the effect of 16 putative tumor-associated mutations on Notch1 signaling and HD domain stability. 16738328 Human
notch1 breast cancer To explore the potential involvement of aberrant Notch1 signaling in breast cancer pathogenesis, we have used a transgenic mouse model. 16751266 Mouse
notch1 invasive adenocarcinomas In these animals, mouse mammary tumor virus LTR-driven expression of the constitutively active intracellular domain of the Notch1 receptor (N1(IC)) causes development of lactation-dependent mammary tumors that regress upon gland involution but progress to 16751266 Mouse
notch1 mammary tumors In these animals, mouse mammary tumor virus LTR-driven expression of the constitutively active intracellular domain of the Notch1 receptor (N1(IC)) causes development of lactation-dependent mammary tumors that regress upon gland involution but progress to 16751266 Mouse
notch1 tumors Up-regulation of Myc in these tumors prompted a genetic investigation of a potential Notch1/Myc functional relationship in breast carcinogenesis. 16751266 Mouse
notch1 human breast carcinomas Consistent with this mechanistic link, Notch1 and Myc expression is positively correlated by immunostaining in 38% of examined human breast carcinomas. 16751266 Mouse
notch1 t-all Intriguingly, enforced Notch1 signaling up-regulates expression of Notch3, which has also been implicated in the pathogenesis of T-ALL. 16838279 Human
notch1 t-all In summary, we anticipate this new animal model will help to further elucidate the role of Notch1 in the pathogenesis of T-ALL. 16838279 Mouse
notch1 t-all Recent work has shown that human T-ALL is frequently associated with C-terminal NOTCH1 truncations, which uniformly remove sequences lying between residues 2524 and 2556. 16880534 Human
notch1 metastasis Structurally distinct ligand-binding or ligand-independent notch1 mutants are leukemogenic but affect thymocyte development, apoptosis, and metastasis differently. 16887975 Mouse
notch1 cell tumors We previously found that provirus insertion in T cell tumors of mouse mammary tumor virus/c-myc transgenic (Tg) mice induced two forms of Notch1 mutations. 16887975 Mouse
notch1 thymomas Both Notch1(IC) and Notch1(DeltaCT), but not Notch1(EC), Tg mice developed double-positive (DP) thymomas. 16887975 Mouse
notch1 human leukemias Because these two Notch1 mutations are very similar to those described in some forms of human T cell leukemia, these Tg mice may represent relevant models of these human leukemias. 16887975 Mouse
notch1 melanoma Transcriptional regulation of human MAP2 gene in melanoma: role of neuronal bHLH factors and Notch1 signaling. 16916793 Human
notch-1 tumors MN1-TEL-positive T-lymphoid tumors showed elevated expression of the Notch-1, Hes-1, c-Myc, and Lmo-2 genes while their Ink4a/pRB and Arf/p53 pathways were impaired, suggesting that these alterations cooperatively transform T progenitors. 16081688 Human
notch-1 tumor Increased Protein Expression of the PTEN Tumor Suppressor in the Presence of Constitutively Active Notch-1. 16096376 Human
notch-1 tumor In other cell lineages, however, studies have indicated that cooperation with cellular signaling pathways, such as Ras, is necessary for Notch-mediated oncogenesis and in some settings, Notch-1 has been reported to function as a tumor suppressor. 16096376 Human
notch-1 prostatic cancer The selective outgrowth of the normal transit-amplifying versus prostatic cancer cells is due to the differential effect of low-Ca2+ medium on the structure of Notch-1 and E-cadherin signaling molecules. 16230388 Human
notch-1 prostatic cancer Additional results document that, at physiologic levels of Ca2+ (i.e., >600 micromol/L), prostatic cancer cells are not contact inhibited by E-cadherin interactions and Notch-1 signaling is no longer required for survival but instead becomes one of multip 16230388 Human
notch-1 pancreatic cancer Inhibition of nuclear factor kappab activity by genistein is mediated via Notch-1 signaling pathway in pancreatic cancer cells. 16284950 Human
notch-1 pancreatic cancer From these results, we conclude that the inhibition of Notch-1 and NF-kappaB activity and their cross talk provides a novel mechanism by which genistein inhibits cell growth and induces apoptotic processes in pancreatic cancer cells. 16284950 Human
notch-1 tumor Activation of this signaling pathway by constitutive Notch-1 mutants and by Jagged-1 causes an angiogenic and invasive tumor phenotype. 16327489 Human
notch-1 melanocytic nevi Here, we have investigated, for the first time, the expression of Notch-1, Notch-2, Jagged-1, Jagged-2 and Delta-like 1 proteins, by immunohistochemistry, in a series of benign and malignant human melanocytic lesions: five common melanocytic nevi, five &a 16341148 Human
notch-1 melanomas Here, we have investigated, for the first time, the expression of Notch-1, Notch-2, Jagged-1, Jagged-2 and Delta-like 1 proteins, by immunohistochemistry, in a series of benign and malignant human melanocytic lesions: five common melanocytic nevi, five &a 16341148 Human
notch-1 metastatic melanomas Here, we have investigated, for the first time, the expression of Notch-1, Notch-2, Jagged-1, Jagged-2 and Delta-like 1 proteins, by immunohistochemistry, in a series of benign and malignant human melanocytic lesions: five common melanocytic nevi, five &a 16341148 Human
notch-1 melanocytic nevi We found that the expression of Notch-1 and Notch-2, as well as Notch ligands, was upregulated in 'dysplastic nevi' and melanomas as compared with common melanocytic nevi. 16341148 Human
notch-1 melanomas We found that the expression of Notch-1 and Notch-2, as well as Notch ligands, was upregulated in 'dysplastic nevi' and melanomas as compared with common melanocytic nevi. 16341148 Human
notch-1 melanoma Compared with proliferating normal human melanocytes, melanoma cell lines are characterized by markedly enhanced levels of activated Notch-1 receptor. 16363061 Human
notch-1 t-cell acute lymphoblastic leukemia High incidence of Notch-1 mutations in adult patients with T-cell acute lymphoblastic leukemia. 16424867 Human
notch-1 pancreatic cancer Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. 16510599 Human
notch-1 tumor Notch signaling plays a critical role in the pathogenesis and progression of human malignancies but the precise role and mechanism of Notch-1 for tumor invasion remains unclear. 16510599 Human
notch-1 metastasis Because NF-kappaB, VEGF, and MMPs are critically involved in the processes of tumor cell invasion and metastasis, we investigated the role and mechanism(s) by which Notch-1 down-regulation (using molecular approaches) may lead to the down-regulation of NF 16510599 Human
notch-1 pancreatic cancer Because NF-kappaB, VEGF, and MMPs are critically involved in the processes of tumor cell invasion and metastasis, we investigated the role and mechanism(s) by which Notch-1 down-regulation (using molecular approaches) may lead to the down-regulation of NF 16510599 Human
notch-1 tumor Because NF-kappaB, VEGF, and MMPs are critically involved in the processes of tumor cell invasion and metastasis, we investigated the role and mechanism(s) by which Notch-1 down-regulation (using molecular approaches) may lead to the down-regulation of NF 16510599 Human
notch-1 tumor We found that the down-regulation of Notch-1 by small interfering RNA decreased cell invasion, whereas Notch-1 overexpression by cDNA transfection led to increased tumor cell invasion. 16510599 Human
notch-1 metastasis Taken together, we conclude that the down-regulation of Notch-1 could be an effective approach for the down-regulation and inactivation of NF-kappaB and its target genes, such as MMP-9 and VEGF expression, resulting in the inhibition of invasion and metas 16510599 Human
notch-1 pancreatic cancer Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. 16546962 Human
notch-1 pancreatic cancer To characterize Notch pathway function in pancreatic cancer cells, we explored the consequences of down-regulation of Notch-1 in BxPC-3, HPAC, and PANC-1 pancreatic cancer cells. 16546962 Human
notch-1 pancreatic cancer Using multiple cellular and molecular approaches such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, apoptosis assay, flow cytometry, gene transfection, real-time reverse transcription-PCR (RT-PCR), Western blotting, and electropho 16546962 Human
notch-1 pancreatic cancer In addition, Notch-1 down-regulation also induced apoptosis, which could be due to decreased Bcl-2 and Bcl-X(L) protein expression in pancreatic cancer cells. 16546962 Human
notch-1 pancreatic cancer These findings suggest that Notch-1 down-regulation, especially by genistein, could be a novel therapeutic approach for the treatment of pancreatic cancer. 16546962 Human
notch-1 pancreatic cancer Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells. 16628653 Human
notch-1 pancreatic cancer However, to the authors' knowledge to date, no studies have determined whether the down-regulation of Notch-1 signaling, resulting in the inactivation of NF-kappaB activity, contributes to curcumin-induced cell growth inhibition and apoptosis in panc 16628653 Human
notch-1 pancreatic cancer This was accompanied by increased apoptosis and concomitant attenuation of Notch-1 and NF-kappaB and down-regulation of NF-kappaB downstream genes, such as matrix metalloproteinase-9 and vascular endothelial growth factor, resulting in the inhibition of p 16885366 Human
tan1 t-cell acute lymphoblastic leukaemia (t-all) The chromosomal translocation t(7;9) in human T-cell acute lymphoblastic leukaemia (T-ALL) results in deregulated expression of a truncated, activated form of Notch 1 (TAN1) under the control of the T-cell receptor-beta (TCRB) locus. 16612405 Human
tan1 t-all Although TAN1 efficiently induces T-ALL in mouse models, t(7;9) is present in less than 1% of human T-ALL cases. 16612405 Mouse
notch 1 t-cell acute lymphoblastic leukaemia Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. 16612405 Human
notch 1 t-cell acute lymphoblastic leukaemia (t-all) The chromosomal translocation t(7;9) in human T-cell acute lymphoblastic leukaemia (T-ALL) results in deregulated expression of a truncated, activated form of Notch 1 (TAN1) under the control of the T-cell receptor-beta (TCRB) locus. 16612405 Human
notch 1 t-all The recent discovery of novel activating mutations in NOTCH1 in more than 50% of human T-ALL samples has made it clear that Notch 1 is far more important in human T-ALL pathogenesis than previously suspected. 16612405 Human
notch1 nonkeratinizing carcinoma The positive rates of Notch1, P21(WAF1), and Involucrin were significantly higher in keratinizing squamous cell carcinoma (KSCC) than in differentiated nonkeratinizing carcinoma (DNKC) and undifferentiated carcinoma (UDC) (P<0.05), and were significantly 16219138 Human
notch1 human t cell leukemia Because these two Notch1 mutations are very similar to those described in some forms of human T cell leukemia, these Tg mice may represent relevant models of these human leukemias. 16887975 Mouse
tan-1 oncogenes Two mammalian Notch family members, TAN-1 and int-3, are proto-oncogenes. 9043073 Human
tan-1 neoplasms TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. 1831692 Human
tan-1 neoplasms These observations suggest that TAN-1 may be important for normal lymphocyte function and that alteration of TAN-1 may play a role in the pathogenesis of some T cell neoplasms. 1831692 Human
notch1 neoplasia The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation. 7698746 Human
notch1 leukemia This notion is supported by the previous finding of a truncated, translocated form of the human NOTCH1 gene (formerly TAN1) in three cases of leukemia. 7698746 Human
notch1 neoplasms Mammalian Notch1 is expressed at high levels in thymus and is mutated in a subset of human T-cell acute lymphoblastic neoplasms, suggesting a role in T-cell differentiation. 8704256 Human
notch1 oncogenic Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription. 9111040 Human
notch1 lymphoma Truncated forms of the NOTCH1 transmembrane receptor engineered to resemble mutant forms of NOTCH1 found in certain cases of human T cell leukemia/lymphoma (T-ALL) efficiently induce T-ALL when expressed in the bone marrow of mice. 9111040 Mouse
notch1 oncogenic The high levels of truncated Notch1 RNA and proteins in these tumors are thought to be involved in the oncogenic transformation. 9484841 Mouse
notch1 lymphoma Three human disorders including a neoplasia (a T-cell acute lymphoblastic leukemia/lymphoma), a late onset neurological disease (CADASIL) and a developmental disorder (the Alagille syndrome) are associated with mutations in, respectively, the Notch1, Notc 10075489 Human
tan1 leukemia This notion is supported by the previous finding of a truncated, translocated form of the human NOTCH1 gene (formerly TAN1) in three cases of leukemia. 7698746 Human
tan1 lymphomas A human homologue of Notch, TAN1, was initially identified at the chromosomal breakpoint of a subset of T-cell lymphoblastic leukemias/lymphomas containing a t(7;9) chromosomal translocation; however, its role in oncogenesis has been unclear. 8642337 Human
tan1 oncogenic Using a bone marrow reconstitution assay with cells containing retrovirally transduced TAN1 alleles, we analyzed the oncogenic potential of both nuclear and extranuclear forms of truncated TAN1 in hematopoietic cells. 8642337 Human
tan1 leukemia Although the Moloney leukemia virus long terminal repeat drives expression in most hematopoietic cell types, retroviruses encoding either form of the TAN1 protein induced clonal leukemias of exclusively immature T cell phenotypes in approximately 50% of t 8642337 Mouse
tan1 leukemias Although the Moloney leukemia virus long terminal repeat drives expression in most hematopoietic cell types, retroviruses encoding either form of the TAN1 protein induced clonal leukemias of exclusively immature T cell phenotypes in approximately 50% of t 8642337 Mouse
tan1 oncoprotein These results show that TAN1 is an oncoprotein and suggest that truncation and overexpression are important determinants of transforming activity. 8642337 Mouse
notch 1 gbm METHODS: Western blot analysis of Notch 1 expression and activation showed that Notch 1 protein was overexpressed and/or activated in Ras-transformed astrocytes, in three of four GBM cell lines, and in four of five primary GBM samples. 17367064 Human
notch 1 lymphomas Of particular interest, recent findings indicate that a high fraction of T-cell acute lymphoblastic leukemias and lymphomas have activating mutations in the Notch 1 receptor, and that Notch signaling might have a role in the maintenance of normal and mali 17178457 Human
notch 1 t-cell acute lymphoblastic leukemias Of particular interest, recent findings indicate that a high fraction of T-cell acute lymphoblastic leukemias and lymphomas have activating mutations in the Notch 1 receptor, and that Notch signaling might have a role in the maintenance of normal and mali 17178457 Human
notch-1 neuroblastomas Here, we describe the presence of the Notch-1 intracellular domain (N1(ICD)) in sub-nuclear bodies in SH-SY5Y neuroblastomas and in primary rat cortical neurons as well as several other mammalian cell lines. 17300869 Rat
notch-1 tumor antigen In this study, we genetically modified human umbilical cord blood-derived hematopoietic stem cells (HSCs) to express tumor antigen-specific T-cell receptor (TCR) genes and generated T lymphocytes by coculture with a murine cell line expressing Notch-1 lig 17363559 Human
notch-1 neuroblastomas The Notch-1 intracellular domain is found in sub-nuclear bodies in SH-SY5Y neuroblastomas and in primary cortical neurons. 17300869 Human
notch-1 pancreatic tumors Immunohistochemical study using specific antibodies revealed that Notch-1 and Hes-1 were expressed in lesions ranging from tubular complexes to carcinoma in these chemically induced pancreatic tumors. 17297654 Human
notch-1 carcinoma Semiquantitative reverse transcription-polymerase chain reaction with microdissection demonstrated that Notch-1 expression was continuous from precursor lesions to carcinoma cells, whereas Pdx-1 expression was attenuated in carcinoma cells compared to pre 17297654 Human
notch1 cancers FBXW7 (F-box and WD40 domain protein 7) is an F-box protein with 7 tandem WDs (tryptophan-aspartic acid) that functions as a phosphoepitope-specific substrate recognition component of SCF (Skp1-Cul1-F-box protein) ubiquitin ligases and catalyzes the ubiqu 17274947 Human
notch1 cervical cancer [Effect of CRE-dependent RNA interference targeting Notch1 on proliferation of cervical cancer cell line HeLa] BACKGROUND & OBJECTIVE: Notch signal transduction pathway mediates cell differentiation and proliferation. 17298743 Human
notch-1 carcinoma Immunohistochemical study using specific antibodies revealed that Notch-1 and Hes-1 were expressed in lesions ranging from tubular complexes to carcinoma in these chemically induced pancreatic tumors. 17297654 Human
notch1 all ABL gene amplification and NOTCH1 gene mutations in subsets of pre-T ALL/LBL suggest patients may benefit from therapy with tyrosine kinase and gamma-secretase inhibitors, respectively. 17369128 Human
notch1 cancer Here we show that Notch1 gene expression and activity are substantially down-modulated in keratinocyte cancer cell lines and tumors, with expression of this gene being under p53 control in these cells. 17344417 Human
notch1 human tumors Little is known about the regulation and function of the Notch1 gene in negative control of human tumors. 17344417 Human
notch1 tumors Here we show that Notch1 gene expression and activity are substantially down-modulated in keratinocyte cancer cell lines and tumors, with expression of this gene being under p53 control in these cells. 17344417 Human
notch1 tumor Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases. 17344417 Human
notch1 t-all The ability of this model to detect a strong interaction between NOTCH1 and bcl2 suggests that genetic modifier screens have a high likelihood of revealing other genes that can cooperate with NOTCH1 to induce T-ALL. 17252014 Zebrafish
notch1 t-cell leukemia In order to study the molecular mechanisms by which altered Notch signaling induces leukemia, a zebrafish model of human NOTCH1-induced T-cell leukemia was generated. 17252014 Human
notch1 leukemias Reverse transcription-polymerase chain reaction analysis showed that Notch target genes such as her6 and her9 were highly expressed in NOTCH1-induced leukemias. 17252014 Zebrafish
notch1 leukemia In order to study the molecular mechanisms by which altered Notch signaling induces leukemia, a zebrafish model of human NOTCH1-induced T-cell leukemia was generated. 17252014 Zebrafish
notch1 human prostate cancer RNA profiling of human prostate cancer cell lines with various degrees of AAV transduction indicated a correlation of the amount of Notch1 with rAAV transgene expression. 17151095 Human
notch1 cervical cancer RESULTS: Features of Notch1 activation as measured by intracellular Notch1, high levels of Jagged1, Hes1 and Cdk9 were paralleled by nuclear translocation of both NF-kappaB p50 and p65 with target gene expression (IkappaB-alpha, Bcl-2, and CyclinD1) in hu 17098279 Human
notch1 cervical cancers CONCLUSIONS: Results from this study suggest that there is a co-activation of Notch1 and NF-kappaB signaling pathways at the cellular level in the majority of human cervical cancers, with Notch as an upstream regulator. 17098279 Human
notch1 t-cell leukemia NOTCH1-induced T-cell leukemia in transgenic zebrafish. 17252014 Mouse
notch1 t-all These findings identify NF-kappaB as one of the major mediators of Notch1-induced transformation and suggest that the NF-kappaB pathway is a potential target of future therapies of T-ALL. 17173050 Human
notch1 cervical cancer Coexpression of Notch1 and NF-kappaB signaling pathway components in human cervical cancer progression. 17098279 Human
notch1 cervical cancers OBJECTIVES: Features of deregulated Notch1 signaling and NF-kappaB activation have independently been reported in cervical cancers. 17098279 Human
notch1 t-cell acute lymphoblastic leukemia (t-all) T-cell acute lymphoblastic leukemia (T-ALL), unlike other ALL types, is only infrequently associated with chromosomal aberrations, but it was recently shown that most individuals with T-ALL carry activating mutations in the NOTCH1 gene. 17173050 Human
notch1 ovarian cancer CD8+ T cells expressing TCRs which specifically recognized peptides Notch1 (2112-2120) and Numb1 (87-95) were presented in the ascites of ovarian cancer patients. 17332928 Human
notch1 tumor The natural immunogenicity of Notch1 and particularly of Numb1 suggests a mechanism of immunosurveillance which is overcome during tumor progression. 17332928 Human
notch1 lung adenocarcinoma We over-expressed the active form of Notch1 (NIC) in A549 cells by constitutive transfection to evaluate the effects of the Notch signaling on lung adenocarcinoma cells. 17342326 Human
notch1 tumorigenesis Thus, combined Notch1 and Ikaros dysfunction can be a significant early event in T-cell proliferation and tumorigenesis. 16870249 Mouse
notch1 oncogenic A Notch1/Myc oncogenic association was also observed in T-cell acute lymphoblastic leukemia. 17329972 Human
notch1 t-cell acute lymphoblastic leukemia A Notch1/Myc oncogenic association was also observed in T-cell acute lymphoblastic leukemia. 17329972 Human
notch1 t-all Analysis revealed Notch1 activating mutations in 12 of 17 Plstc/+ lymphomas (70%), analogous to those in human T-ALL. 16870249 Mouse
notch1 lymphomas Analysis revealed Notch1 activating mutations in 12 of 17 Plstc/+ lymphomas (70%), analogous to those in human T-ALL. 16870249 Mouse
notch1 human breast cancer A medically-relevant correlative observation based on immunophenotyping was the coexpression of Notch1 and Myc in a significant fraction of human breast cancer specimens. 17329972 Human
notch1 t-all T-cell acute lymphoblastic leukemia (T-ALL), unlike other ALL types, is only infrequently associated with chromosomal aberrations, but it was recently shown that most individuals with T-ALL carry activating mutations in the NOTCH1 gene. 17173050 Human
notch1 malignancy Activating Notch1 mutations are an early event in T-cell malignancy of Ikaros point mutant Plastic/+ mice. 16870249 Mouse
notch1 t-all We believe that these findings could be important for the understanding of Notch1 signaling and the therapeutic treatment of T-ALL. 17329966 Human
notch1 mammary tumors Recently, a Notch/Myc relationship in oncogenesis was revealed from a mouse model, in which mammary tumors are induced by the intracellular domain of Notch1 (N1(IC)). 17329972 Mouse
notch1 t-all Using parallel studies in T cell progenitors and established T-ALL lines we have demonstrated that the NFkappaB signaling pathway is targeted and induced by Notch1 activation. 17329966 Human
notch1 oncogene Recent findings suggested that the transmembrane receptor NOTCH1 is the major oncogene for the majority of T-ALL cases. 17329966 Human
notch1 t-all Recent findings suggested that the transmembrane receptor NOTCH1 is the major oncogene for the majority of T-ALL cases. 17329966 Human
notch1 tumors Any of the identified targets, Cyclin E, c-Myc, c-Jun, Notch1/4 and Aurora-A may have oncogenic properties when accumulated in tumors with FBXW7 loss. 17326833 Human
notch1 cervical cancer Overall, our results suggest that NF-kappaB inhibition may contribute partially to cell cycle arrest and apoptosis induced by Notch1 activation in human cervical cancer cells. 17316355 Human
notch1 cervical cancer Our studies demonstrated that constitutively overexpressed active Notch1 via stable transfection with exogenous intracellular domain of Notch1 (ICN) resulted in growth inhibition of the human cervical cancer cell line HeLa by inducing G(2)-M arrest and ap 17316355 Human
notch1 oral squamous cell carcinomas CONCLUSION: Comparing with the alterations at 9q33 to 34.2 regions, LOH at 9q34.3 and methylation of the Notch1 gene was less involved in oral squamous cell carcinomas. 17305639 Human
notch1 cervical cancer Notch1 induces cell cycle arrest and apoptosis in human cervical cancer cells: involvement of nuclear factor kappa B inhibition. 17316355 Human
notch1 oral carcinoma RESULTS: We found LOH at 9q34.3 in three patients and methylation of the Notch1 gene only in two patients with oral carcinoma. 17305639 Human
notch1 t-cell leukemia Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. 17173050 Human
notch1 all T-cell acute lymphoblastic leukemia (T-ALL), unlike other ALL types, is only infrequently associated with chromosomal aberrations, but it was recently shown that most individuals with T-ALL carry activating mutations in the NOTCH1 gene. 17173050 Human
notch1 oral squamous cell carcinomas LOH at chromosome 9q34.3 and the Notch1 gene methylation are less involved in oral squamous cell carcinomas. 17305639 Human
notch1 cervical cancer This study was to construct a course recombination enzyme(CRE)-dependent short hairpin RNA (shRNA) expression plasmid targeting Notch1, and investigate its effect on proliferation of cervical cancer cell line HeLa. 17298743 Human
tan-1 carcinogenesis Our observations suggest that SEL1L is presumably implicated in pancreatic and gastric carcinogenesis and that, along with TAN-1, it is very important for normal cell function. 10763137 Human
tan-1 oncogenes Moreover, the TAN-1 and int-3 oncogenes represent activated versions of Notch1 and Notch4, respectively. 11230145 Human
tan-1 primary tumors By contrast, 18 MSI+ colorectal cancers (13 cancer cell lines and five primary tumors) with mismatch repair defects exhibited six mutations in three of the 17 genes (SREBP-2, TAN-1, GR6) (P<0.000003 compared to all other cancers tested). 11314036 Human
tan-1 oncoproteins We have examined two types of truncated Notch oncoproteins that arise from proviral insertion into the Notch4 gene (Notch4/int-3) or a chromosomal translocation involving the Notch1 gene (TAN-1). 15123653 Human
tan-1 oncoproteins Both Notch4/int-3 and TAN-1 oncoproteins lack most or all of their ectodomain. 15123653 Human
notch1 tumorigenesis The suggested role of Notch1 or its mutants in thymocyte differentiation and T cell tumorigenesis raises the question of how the different members of the Notch family influence distinct steps in T cell development and the role played by Notch ligands in t 10383933 Human
notch1 lymphoma Murine leukemia provirus-mediated activation of the Notch1 gene leads to induction of HES-1 in a mouse T lymphoma cell line, DL-3. 10437788 Mouse
notch1 lymphoma In a mouse T lymphoma cell line, DL-3, we found that a murine leukemia provirus was inserted in the Notch1 locus, which led to marked expression of a virus-Notch1 fusion mRNA encoding an intracellular portion of the Notch1 protein. 10437788 Human
notch1 neuroblastoma RESULTS: We observed that N2a neuroblastoma cells expressing an activated form of Notch, Notch1(IC), produced shorter neurites compared with controls, whereas N2a cell lines expressing a dominant-negative Notch1 or a dominant-negative Delta1 construct ext 10607588 Human
notch1 oncogene These data suggest that both type I and type II mutations generate two structurally distinct Notch1 N(EC) and N(IC) proteins that may participate in tumor formation, in collaboration with the c-myc oncogene, through distinct mechanisms. 10805726 Human
notch1 oncogenes These studies reveal a novel mechanism for oncogenic activation of Notch1 and demonstrate a collaborative relationship between 2 cellular oncogenes that also contribute to cell fate determination during embryonic development. 10961893 Human
notch1 oncogenic These studies reveal a novel mechanism for oncogenic activation of Notch1 and demonstrate a collaborative relationship between 2 cellular oncogenes that also contribute to cell fate determination during embryonic development. 10961893 Human
notch1 oncogenic Several mammalian Notch receptors are oncogenic when constitutively active, including Notch1, a gene initially identified based on its involvement in a (7;9) chromosomal translocation found in sporadic T-cell lymphoblastic leukemias and lymphomas (T-ALL). 11003647 Human
notch1 lymphomas Several mammalian Notch receptors are oncogenic when constitutively active, including Notch1, a gene initially identified based on its involvement in a (7;9) chromosomal translocation found in sporadic T-cell lymphoblastic leukemias and lymphomas (T-ALL). 11003647 Human
notch1 neuroblastoma Induced neuroblastoma cell differentiation, associated with transient HES-1 activity and reduced HASH-1 expression, is inhibited by Notch1. 11054669 Human
notch1 neuroblastoma Constitutive expression of the intracellular domain of Notch1, which activates the HES-1 promoter in SH-SY5Y cells, inhibited spontaneous and induced morphological differentiation of these neuroblastoma cells. 11054669 Human
notch1 oncogenes Moreover, the TAN-1 and int-3 oncogenes represent activated versions of Notch1 and Notch4, respectively. 11230145 Human
notch1 oncogenes Activated Notch1 signaling cooperates with papillomavirus oncogenes in transformation and generates resistance to apoptosis on matrix withdrawal through PKB/Akt. 11448155 Human
notch1 oncogenes Here we show that activated Notch1 synergizes with papillomavirus oncogenes in transformation of immortalized epithelial cells and leads to the generation of resistance to anoikis, an apoptotic response induced on matrix withdrawal. 11448155 Human
notch1 oncogenic Oncogenic forms of Notch1, Notch2, and Notch4 appear to mimic signaling intermediates of Notch1 and suggest that the role of proteolysis in Notch signaling has been conserved. 11518718 Human
notch1 adenocarcinoma Examination of the transgenic adenocarcinoma of the mouse prostate showed that expression of Notch1 was elevated in malignant prostatic epithelial cells of primary and metastatic tumors. 11585768 Mouse
notch1 oncogenic We demonstrate a novel mechanism for the oncogenic capacity of Notch1 by showing that the interaction between intact Notch1 on tumor cells and its ligand Jagged1 dramatically induces proliferation and inhibition of apoptosis in vitro. 11964309 Human
notch1 tumor We further provide evidence that in Hodgkin and anaplastic large cell lymphoma, Jagged1 is expressed in malignant and in bystander cells colocalizing with Notch1-positive tumor cells. 11964309 Human
notch1 anaplastic large cell lymphoma We further provide evidence that in Hodgkin and anaplastic large cell lymphoma, Jagged1 is expressed in malignant and in bystander cells colocalizing with Notch1-positive tumor cells. 11964309 Human
notch1 lymphomagenesis Notch1 signaling may therefore be activated in tumor cells by Jagged1 through homotypic or heterotypic cell-cell interactions, and it seems likely that these interactions contribute to lymphomagenesis in vivo. 11964309 Human
notch1 malignant transformation Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. 12208848 Human
notch1 carcinogenesis Thus, Notch1 exerts specific protective effects against HPV-induced transformation through suppression of E6/E7 expression, and down-modulation of Notch1 expression is likely to play an important role in late stages of HPV-induced carcinogenesis. 12208848 Human
notch1 tumorigenesis Notch signaling was first linked to tumorigenesis through identification of a recurrent t(7;9)(q34;q34.3) chromosomal translocation involving the human Notch1 gene that is found in a small subset of human pre-T-cell acute lymphoblastic leukemias (T-ALL).( 12496471 Human
notch1 neoplasms Notch signaling was first linked to tumorigenesis through identification of a recurrent t(7;9)(q34;q34.3) chromosomal translocation involving the human Notch1 gene that is found in a small subset of human pre-T-cell acute lymphoblastic leukemias (T-ALL).( 12496471 Human
notch1 t-all We demonstrate here that the blockade of Notch signaling at two independent steps suppresses the growth and survival of NOTCH1-transformed T-ALL cells. 12509463 Human
notch1 carcinogenesis Unexpectedly, ablation of Notch1 results in epidermal and corneal hyperplasia followed by the development of skin tumors and facilitated chemical-induced skin carcinogenesis. 12590261 Human
notch1 basal-cell carcinoma Notch1 deficiency in skin and in primary keratinocytes results in increased and sustained expression of Gli2, causing the development of basal-cell carcinoma-like tumors. 12590261 Human
notch1 tumor Our results indicate that Notch1 functions as a tumor-suppressor gene in mammalian skin. 12590261 Human
notch1 oncoproteins Active forms of Notch1 consisting of a transmembrane domain and an intracellular domain (Notch1TM) or only an intracellular domain (Notch1IC) function as oncoproteins. 12807718 Human
notch1 lymphomagenesis To elucidate the effect of Notch1 abnormalities in radiation-induced lymphomagenesis, we determined the structure of the Notch1 gene and examined the frequency and the sites of Notch1 rearrangements in radiation-induced mouse thymic lymphomas. 12807718 Mouse
notch1 oncogene More than 50% of radiation-induced thymic lymphomas exhibited Notch1 rearrangements, suggesting that Notch1 acts as a major oncogene in radiation-induced lymphomagenesis. 12807718 Mouse
notch1 lymphomagenesis More than 50% of radiation-induced thymic lymphomas exhibited Notch1 rearrangements, suggesting that Notch1 acts as a major oncogene in radiation-induced lymphomagenesis. 12807718 Mouse
notch1 oncogenic These results indicate that in addition to Hes1 expression, other Notch1 pathway(s) have a role in thymic lymphomagenesis and suggest the presence of a novel mechanism for oncogenic activation of Notch1 by 5' deletion. 12807718 Mouse
notch1 lymphomagenesis These results indicate that in addition to Hes1 expression, other Notch1 pathway(s) have a role in thymic lymphomagenesis and suggest the presence of a novel mechanism for oncogenic activation of Notch1 by 5' deletion. 12807718 Mouse
notch1 oncogenes Consistent with other recent reports, these data suggest a role for Notch1 during the DN to DP stage of thymocyte maturation and suggest a cellular mechanism by which Notch1IC oncogenes could contribute to thymoma development and maintenance. 12928374 Mouse
notch1 hcc We constitutively overexpressed active Notch1 in human HCC to explore the effects of Notch1 signaling on HCC cell growth and to investigate the underlying molecular mechanisms. 14678992 Human
notch1 hcc We show here that overexpression of Notch1 was able to inhibit the growth of HCC cells in vitro and in vivo. 14678992 Human
notch1 hcc Biochemical analysis revealed the involvement of cell cycle regulated proteins in Notch1-mediated G(0)/G(1) arrest of HCC cells. 14678992 Human
notch1 hcc These findings suggest that Notch1 signaling may participate in the development of HCC cells, affecting multiple pathways that control both cell proliferation and apoptosis. 14678992 Human
notch1 oncogenic Here we report that although exaggerated levels of Notch1 can, indeed, adversely affect HPV E6 and E7 expression, and cellular proliferation in general, moderate levels of Notch1, together with active phosphoinositide 3 kinase, can, instead, exhibit oncog 14695182 Human
notch1 oncogene These results represent the first reported instance for the involvement of Notch2 inactivation in the development of thymic primary tumours while confirming the role of Notch1 as an activated oncogene. 14976135 Mouse
notch1 leukemogenesis As Notch1 gene is involved in the differentiation and leukemogenesis in lymphoid neoplasm, observations suggest that Notch1 is involved in ATRA-modulated differentiation process in APL. 15058751 Human
notch1 oncoproteins We have examined two types of truncated Notch oncoproteins that arise from proviral insertion into the Notch4 gene (Notch4/int-3) or a chromosomal translocation involving the Notch1 gene (TAN-1). 15123653 Human
notch1 neoplasms Here we describe a transgenic mouse model, which demonstrates that expression of a constitutively active form of the Notch1 receptor in the mammary epithelium induces the rapid development of pregnancy/lactation-dependent neoplasms that consistently exhib 15277242 Mouse
notch1 tumorigenesis In mice, the Notch1 and Notch4 genes are both targets for insertion and rearrangement by the mouse mammary tumor virus and these mutations promote epithelial mammary tumorigenesis. 15288259 Mouse
notch1 carcinogenesis In parallel with the pro-differentiation function of Notch1 in keratinocytes, we discuss recent evidence pointing to a tumor suppressor function of this gene in both mouse skin and human cervical carcinogenesis. 15288263 Human
notch1 oncogenic Here, we report that more than 50% of human T-ALLs, including tumors from all major molecular oncogenic subtypes, have activating mutations that involve the extracellular heterodimerization domain and/or the C-terminal PEST domain of NOTCH1. 15472075 Human
notch1 oncogene The role of Notch signaling in tumorigenesis can vary; Notch1 acts as an oncogene in some neoplasms, and a tumor suppressor in others. 15520184 Human
notch1 tumorigenesis The role of Notch signaling in tumorigenesis can vary; Notch1 acts as an oncogene in some neoplasms, and a tumor suppressor in others. 15520184 Human
notch1 neoplasms The role of Notch signaling in tumorigenesis can vary; Notch1 acts as an oncogene in some neoplasms, and a tumor suppressor in others. 15520184 Human
notch1 lymphoma T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling. 15548998 Human
notch1 lymphoma PURPOSE OF REVIEW: Although constitutively activated forms of the NOTCH1 receptor are potent inducers of T cell acute lymphoblastic leukemia/lymphoma when expressed in the bone marrow stem cells of mice, the known involvement of NOTCH1 in human T cell acu 15548998 Human
notch1 lymphoma This picture has changed dramatically in the past year with the discovery of frequent mutations involving NOTCH1 in human T cell acute lymphoblastic leukemia/lymphoma. 15548998 Human
notch1 lymphoma RECENT FINDINGS: NOTCH1 point mutations, insertions, and deletions producing aberrant increases in NOTCH1 signaling are frequently present in both childhood and adult T cell acute lymphoblastic leukemia/lymphoma and are detected in tumors from all major m 15548998 Human
notch1 lymphoma These observations are particularly important in the light of experiments using human and murine T cell acute lymphoblastic leukemia/lymphoma cell lines indicating that NOTCH1 signals are required for sustained growth and, in a subset of lines, survival. 15548998 Human
notch1 lymphoma This inference is based in part on experiments conducted with small molecule inhibitors of gamma-secretase, a protease required for normal NOTCH signal transduction and the activity of the mutated forms of NOTCH1 found commonly in human T cell acute lymph 15548998 Human
notch1 lymphomagenesis Recombination signal sequence-mediated deletions were present clonally in the thymocyte population, suggesting that thymocytes with a 5'-deletion of the Notch1 gene have a growth advantage and are involved in lymphomagenesis. 15604248 Human
notch1 osteosarcoma In this immunohistochemical examination, the expression of Notch1 peptide was detected in neoplastic cells in a case of osteosarcoma of the maxilla of a 31-year-old Indonesian male patient. 15649865 Human
notch1 osteosarcoma Notch1 peptide appeared in the cytoplasm of neoplastic cells of comparatively well-differentiated areas of the osteosarcoma, an osteoblastic area containing osteoid and/or immature bone tissues. 15649865 Human
notch1 osteosarcoma The results suggest that Notch1 is closely related to cytological differentiation or acquisition of cytological characteristics in neoplastic cells of osteosarcoma. 15649865 Human
notch1 leukemogenesis AML primary samples show high levels of JAGGED1 expression despite the low NOTCH1 pathway activation, consistent with an autonomous JAGGED1 signaling in myeloid leukemogenesis. 15694671 Human
notch1 oncoprotein Notch1 oncoprotein antagonizes TGF-beta/Smad-mediated cell growth suppression via sequestration of coactivator p300. 15904468 Human
notch1 oncogenic Complementation of human papillomavirus type 16 E6 and E7 by Jagged1-specific Notch1-phosphatidylinositol 3-kinase signaling involves pleiotropic oncogenic functions independent of CBF1;Su(H);Lag-1 activation. 15919944 Human
notch1 tumor The Notch1 tumor-suppressor function was associated with down-regulation of Wnt signaling. 15964998 Human
notch1 gi carcinoid tumor In the present study, we found that Notch1 is not detectable in human GI carcinoid tumor cells. 16160079 Human
notch1 carcinoid The induction of Notch1 in human BON carcinoid cells led to high levels of functional Notch1, as measured by CBF-1 binding studies, resulting in activation of the Notch1 pathway. 16160079 Human
notch1 carcinoid syndrome Most interestingly, activation of the Notch1 pathway caused a significant reduction in 5-hydroxytryptamine, an important bioactive hormone in carcinoid syndrome. 16160079 Human
notch1 carcinoid tumors Therefore, manipulation of the Notch1 signaling pathway may be useful for expanding the targets for therapeutic and palliative treatment of patients with carcinoid tumors. 16160079 Human
notch1 leukemia We sequenced the heterodimerization domain and the PEST domain of Notch1 in our mouse model of TAL1-induced leukemia and found that 74% of the tumors harbor activating mutations in Notch1. 16166587 Mouse
notch1 primary tumors [Expression and Significance of Notch1, P21WAF1 and involucrin in nasopharyngeal carcinoma] BACKGROUND & OBJECTIVE: Abnormal expression of Notch1 protein was often found in many kinds of primary tumors, but its correlation with nasopharyngeal carcinoma (N 16219138 Human
notch1 nasopharyngeal carcinoma [Expression and Significance of Notch1, P21WAF1 and involucrin in nasopharyngeal carcinoma] BACKGROUND & OBJECTIVE: Abnormal expression of Notch1 protein was often found in many kinds of primary tumors, but its correlation with nasopharyngeal carcinoma (N 16219138 Human
notch1 npc This study was designed to investigate the expression of Notch1 and its downstream proteins P21(WAF1) and Involucrin in NPC, and analyze their correlations with the differentiation of NPC cells. 16219138 Human
notch1 npc METHODS: The expression of Notch1, P21(WAF1), and Involucrin in 101 specimens of NPC and 20 specimens of chronic inflammatory nasopharyngeal mucosa were detected by SP immunohistochemistry. 16219138 Human
notch1 npc RESULTS: The positive rates of Notch1, P21(WAF1), and Involucrin were 100%, 90.0%, and 100% in chronic inflammatory nasopharyngeal mucosa, and were 77.2%, 89.1%, and 80.1% in NPC, respectively. 16219138 Human
notch1 npc The expression of Notch1, P21(WAF1), and Involucrin were significantly suppressed along with descending differentiation of NPC (P=0.000, P=0.026, and P=0.000). 16219138 Human
notch1 undifferentiated carcinoma The positive rates of Notch1, P21(WAF1), and Involucrin were significantly higher in keratinizing squamous cell carcinoma (KSCC) than in differentiated nonkeratinizing carcinoma (DNKC) and undifferentiated carcinoma (UDC) (P<0.05), and were significantly 16219138 Human
notch1 npc The expression of Notch1 in NPC was positively correlated with the expression of P21(WAF1) (r=0.306, P=0.002) and Involucrin (r=0.325, P=0.001). 16219138 Human
notch1 npc CONCLUSION: The expression of Notch1, P21(WAF1), and Involucrin are closely correlated to the differentiation of NPC cells. 16219138 Human
notch1 oncogenic Furthermore, the oncogenic effect of Notch1 on primary melanoma cells was mediated by beta-catenin, which was upregulated following Notch1 activation. 16239965 Human
notch1 metastasis Inhibiting beta-catenin expression reversed Notch1-enhanced tumor growth and metastasis. 16239965 Human
notch1 tumor Inhibiting beta-catenin expression reversed Notch1-enhanced tumor growth and metastasis. 16239965 Human
notch1 oncogene Association with other oncogene expression (TAL1, HOXAs, or TLX3/HOX11L2), NOTCH1 activating mutations, and/or CDKN2A/p16/ARF deletion, showed that cyclin D2 dysregulation could contribute to multi-event oncogenesis in various T-ALL groups. 16270038 Human
notch1 lymphoma Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma. 16282337 Mouse
notch1 leukemia Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma. 16282337 Mouse
notch1 lymphoma NOTCH1 is frequently mutated in human precursor T-cell lymphoblastic leukemia/lymphoma (pre-T LBL). 16282337 Human
notch1 primary tumors In the current study, we found that 13 of 19 cell lines and 29 of 49 primary tumors from SCL/LMO1, OLIG2/LMO1, OLIG2, LMO1, NUP98/HOXD13, and p27(-/-)/SMAD3(+/-) mice had Notch1 mutations in either the heterodimerization (HD) or the glutamic acid/serine/t 16282337 Mouse
notch1 lymphomas Recent work has shown that the majority of human acute T-cell lymphoblastic leukemias and lymphomas (T-ALL) have gain-of-function mutations in NOTCH1, a type I transmembrane receptor that normally signals through a gamma-secretase-dependent mechanism that 16298817 Human
notch1 osteosarcoma In this immunohistochemical examination, the expression of Runx2, Notch1, Delta and Osteopontin peptides were detected in neoplastic cells in 10 Japanese cases of osteosarcoma. 16354601 Human
notch1 osteosarcoma However, Notch1 peptide expression appeared in the cytoplasm of neoplastic cells in the localized and comparatively well-differentiated area of osteosarcoma, which osteoblastic and chondroblastic containing osteoid and/or chondroid tissues. 16354601 Human
notch1 osteosarcomas Therefore, these results suggest that Runx2, Notch1, and Delta peptides are closely related to cytological differentiation or acquisition of tissue specific characteristics in neoplastic cells in osteosarcomas. 16354601 Human
notch1 carcinoid tumor BACKGROUND: The Notch1-signaling pathway has been shown to regulate the differentiation and growth of carcinoid tumor cells. 16360401 Human
notch1 carcinoid tumors We hypothesized that HES-1 may be the essential downstream factor in Notch1-mediated growth regulation of carcinoid tumors. 16360401 Human
notch1 oncogenes c-Myc substitutes for Notch1-CBF1 functions in cooperative transformation with papillomavirus oncogenes. 16378632 Human
notch1 lymphoma Loss of E2A transcription factor activity or activation of the intracellular form of Notch1 (ICN) leads to the development of leukemia or lymphoma in humans or mice, respectively. 16449526 Mouse
notch1 leukemia Loss of E2A transcription factor activity or activation of the intracellular form of Notch1 (ICN) leads to the development of leukemia or lymphoma in humans or mice, respectively. 16449526 Human
notch1 lymphomas Here we show that lymphomas arising in E2A(-/-) mice require the activation of Notch1 for their survival and have accumulated mutations in, or near, the Notch1 PEST domain, resulting in increased stability and signaling. 16449526 Mouse
notch1 lymphomas In contrast, lymphomas arising in p53(-/-) mice show the activation of Notch1, but no mutations were identified in ICN. 16449526 Mouse
notch1 lymphomas The requirement for Notch1 signaling in E2A(-/-) lymphomas cannot be overcome by ectopic expression of pTalpha; however, pTalpha is required for optimal survival and expansion of these cells. 16449526 Mouse
notch1 lymphomagenesis Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling. 16507772 Mouse
notch1 oncogenic The MMTV/Notch1(intra) Tg females developed mammary gland tumors, confirming the oncogenic potential of Notch1(intra) in vivo. 16507912 Mouse
notch1 lymphoma In this report, we show that the activated intracellular domain of Notch1 (ICN) is aberrantly accumulated in KSHV latently infected pleural effusion lymphoma (PEL) cells. 16701788 Human
notch1 leukemogenesis NOTCH1 mutations in T-cell acute lymphoblastic leukemia: prognostic significance and implication in multifactorial leukemogenesis. 16707600 Human
notch1 tumor Because mutations in the heterodimerization domain of NOTCH1 occur frequently in human T-cell acute lymphoblastic leukemia (T-ALL), we assessed the effect of 16 putative tumor-associated mutations on Notch1 signaling and HD domain stability. 16738328 Human
notch1 tumorigenesis Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice. 16751266 Mouse
notch1 carcinogenesis Up-regulation of Myc in these tumors prompted a genetic investigation of a potential Notch1/Myc functional relationship in breast carcinogenesis. 16751266 Human
notch1 lymphoma Here we show that the activated intracellular domain of Notch1 (ICN) is aberrantly accumulated in latently KSHV-infected pleural effusion lymphoma cells and results in increased proliferation. 16775329 Human
notch1 prostate cancer Validation revealed that Notch1 is a substrate of both granzyme B and caspases, whereas FGFR1 is a caspase-independent substrate of granzyme B. Proteolysis of FGFR1 in prostate cancer cells has functionally relevant consequences that indicate its cleavage 16798735 Human
notch1 lymphoma c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. 16847353 Human
notch1 lymphomas Human acute T-cell lymphoblastic leukemias and lymphomas (T-ALL) are commonly associated with gain-of-function mutations in Notch1 that contribute to T-ALL induction and maintenance. 16847353 Human
notch1 oncogenic However, the oncogenic pathway of Notch1-induced transformation is not known. 16885355 Human
notch1 oncogenes Therefore, Notch1(IC) and Notch1(DeltaCT) behave as oncogenes for T cells. 16887975 Mouse
notch1 t-cell leukemia Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc. 16954387 Mouse
notch1 t-cell acute lymphoblastic leukemia (t-all) Recent work with mouse models and human leukemic samples has shown that gain-of-function mutation(s) in Notch1 is a common genetic event in T-cell acute lymphoblastic leukemia (T-ALL). 16954387 Mouse
notch1 leukemia To identify Notch1 target genes in leukemia, we developed mouse T-cell leukemic lines that express intracellular Notch1 in a doxycycline-dependent manner. 16954387 Mouse
notch1 tumors Using gene expression profiling and chromatin immunoprecipitation, we identified c-myc as a novel, direct, and critical Notch1 target gene in T-cell leukemia. c-myc mRNA levels are increased in primary mouse T-cell tumors that harbor Notch1 mutations, and 16954387 Mouse
notch1 t-cell leukemia Using gene expression profiling and chromatin immunoprecipitation, we identified c-myc as a novel, direct, and critical Notch1 target gene in T-cell leukemia. c-myc mRNA levels are increased in primary mouse T-cell tumors that harbor Notch1 mutations, and 16954387 Mouse
notch1 t-cell leukemia Consistent with these findings, retroviral insertional mutagenesis screening of our T-cell leukemia mouse model revealed common insertions in either notch1 or c-myc genes. 16954387 Mouse
notch1 t-all These studies define the Notch1 molecular signature in mouse T-ALL and importantly provide mechanistic insight as to how Notch1 contributes to human T-ALL. 16954387 Mouse
notch1 leukemias Activating mutations in NOTCH1 in acute myeloid leukemia and lineage switch leukemias. 17008890 Human
notch1 acute myeloid leukemia Activating mutations in NOTCH1 in acute myeloid leukemia and lineage switch leukemias. 17008890 Human
notch1 t-cell lymphoblastic leukemias Activating mutations in NOTCH1 are found in over 50% of human T-cell lymphoblastic leukemias (T-ALLs). 17008890 Human
notch1 acute myeloid leukemia (aml) Here, we report the analysis for activating NOTCH1 mutations in a large number of acute myeloid leukemia (AML) primary samples and cell lines. 17008890 Human
notch1 leukemia We found activating mutations in NOTCH1 in a single M0 primary AML sample, in three (ML1, ML2 and CTV-1) out of 23 AML cell lines and in the diagnostic (myeloid) and relapsed (T-lymphoid) clones in a patient with lineage switch leukemia. 17008890 Human
notch1 aml We found activating mutations in NOTCH1 in a single M0 primary AML sample, in three (ML1, ML2 and CTV-1) out of 23 AML cell lines and in the diagnostic (myeloid) and relapsed (T-lymphoid) clones in a patient with lineage switch leukemia. 17008890 Human
notch1 t-all Overall, these results demonstrate that activating mutations in NOTCH1 are mostly restricted to T-ALL and are rare in AMLs. 17008890 Human
notch1 leukemias The presence of NOTCH1 mutations in myeloid and T-lymphoid clones in lineage switch leukemias establishes the common clonal origin of the diagnostic and relapse blast populations and suggests a stem cell origin of NOTCH1 mutations during the molecular pat 17008890 Human
notch1 tumors The presence of NOTCH1 mutations in myeloid and T-lymphoid clones in lineage switch leukemias establishes the common clonal origin of the diagnostic and relapse blast populations and suggests a stem cell origin of NOTCH1 mutations during the molecular pat 17008890 Human
notch1 t-all Other molecular and/or cytogenetic aberrations frequently found in subtypes of T-ALL (SIL-TAL1, CALM-AF10, HOX11, HOX11L2) were not detected in the TCRbeta-HOXA rearranged cases except for deletion 9p21 and NOTCH1 activating mutations, which were present 17039236 Human
notch1 sil Other molecular and/or cytogenetic aberrations frequently found in subtypes of T-ALL (SIL-TAL1, CALM-AF10, HOX11, HOX11L2) were not detected in the TCRbeta-HOXA rearranged cases except for deletion 9p21 and NOTCH1 activating mutations, which were present 17039236 Human
notch1 hyperplasia Expression of constitutively active Notch1 in male genital tracts results in ectopic growth and blockage of efferent ducts, epididymal hyperplasia and sterility. 17046738 Mouse
notch1 hyperplastic In situ hybridization with a Notch1-specific probe lacked sensitivity to detect expression in normal-appearing cells, but demonstrated expression in hyperplastic epithelial cells of the vas deferens, epididymis and efferent ducts. 17046738 Human
notch1 hyperplastic Finally, the presence of ectopic hyperplastic efferent duct tubules was observed within the testicular parenchyma itself, outside their normal territory, suggesting that Notch1 signaling is involved in the establishment of these borders. 17046738 Human
notch1 medullary thyroid cancer Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells. 17090547 Human
notch1 oncogene The role of NOTCH1 as an oncogene or tumor suppressor appears to be cell type-specific. 17090547 Human
notch1 tumor The role of NOTCH1 as an oncogene or tumor suppressor appears to be cell type-specific. 17090547 Human
notch1 tumor In this study, we show that the active NOTCH1 intracellular domain is absent in human MTC tumor tissue samples and MTC-TT cells. 17090547 Human
notch1 acute myeloid leukemia NOTCH1 mutations are rare in acute myeloid leukemia. 17107915 Human
notch1 acute myeloid leukemia (aml) Mutations in the NOTCH1 gene were investigated in 12 primary acute myeloid leukemia (AML) cell samples and eight AML cell lines. 17107915 Human
notch1 aml Mutations in the NOTCH1 gene were investigated in 12 primary acute myeloid leukemia (AML) cell samples and eight AML cell lines. 17107915 Human
notch1 aml This is the first paper to present an AML case with NOTCH1 mutation. 17107915 Human
notch1 lymphoblastic leukemia The NOTCH1 signaling pathway directly links extracellular signals with transcriptional responses in the cell nucleus and plays a critical role during T cell development and in the pathogenesis over 50% of human T cell lymphoblastic leukemia (T-ALL) cases. 17114293 Human
notch1 t-all The NOTCH1 signaling pathway directly links extracellular signals with transcriptional responses in the cell nucleus and plays a critical role during T cell development and in the pathogenesis over 50% of human T cell lymphoblastic leukemia (T-ALL) cases. 17114293 Human
notch1 t-all Inhibition of NOTCH1 signaling in T-ALL cells led to a reduction in cell size and elicited a gene expression signature dominated by down-regulated biosynthetic pathway genes. 17114293 Human
notch1 t-all Reverse engineering of regulatory networks from expression profiles showed that NOTCH1 and c-MYC govern two directly interconnected transcriptional programs containing common target genes that together regulate the growth of primary T-ALL cells. 17114293 Human
notch1 oncogenic These results identify c-MYC as an essential mediator of NOTCH1 signaling and integrate NOTCH1 activation with oncogenic signaling pathways upstream of c-MYC. 17114293 Human
notch-1 neuroblastoma Furthermore, a constitutively active form of Notch-1 inhibits induced differentiation of neuroblastoma cells. 15013216 Human
notch-1 tumour Therefore, Notch-1 may possess tumour-promoting functions, while Notch-2 could play a tumour-suppressive role in human breast cancer. 15492845 Human
notch-1 carcinogenesis Inducible nitric oxide synthase up-regulates Notch-1 in mouse cholangiocytes: implications for carcinogenesis. 15887117 Mouse
notch-1 hcc All HCC samples had relatively increased levels of Notch-1 and HES-1 gene expression. 16871543 Human
notch-1 neuroblastomas In this study, by the use of reporter-gene assays, we demonstrate that C-promoter binding factor-1 (CBF-1)-dependent gene transcription driven by the Notch-1 intracellular domain (N1(ICD)) is potently antagonized by exogenously expressed transactivating ( 17076661 Human
notch-1 cancer Fractionated doses of irradiation increased activation of Notch-1 (untreated, mean = 10.7, versus treated, mean = 15.1, difference = 4.4, 95% CI = 2.7 to 6.1, P = .002) and the percentage of the cancer stem/initiating cells in the nonadherent cell populat 17179479 Human
notch1 t-cell acute lymphoblastic leukemia (t-all) Activating mutations in the NOTCH1 gene have been found in about 60% of patients with T-cell acute lymphoblastic leukemia (T-ALL). 17252014 Human

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