IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene AGPAT2 Ensembl ENSG00000169692 Chromosome 9 Start 138687416 End 138701732
Description 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (EC 2.3.1.51)(1-AGP acyltransferase 2)(1-AGPAT 2)(Lysophosphatidic acid acyltransferase beta)(LPAAT-beta)(1-acylglycerol-3-phosphate O-acyltransferase 2) [Source:UniProtKB/Swiss-Prot;Acc:O15120]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 325
     Entrez Gene : 10555
     UCSC : uc004cii.1
     GeneCards : 325
     RefSeq : NM_001012727
     CCDS : CCDS7003.1
     Uniprot : O15120
     Interpro : O15120
     OMIM : 603100
     GeneTests : AGPAT2
     CGAP : AGPAT2
     PMID : 9242711

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  32837_at  0.15  1.53e-1  2.35e-1  -0.38  9.08e-4  2.85e-3
 HG_U133A  210678_s_at  1.07  4.88e-14  2.44e-13  0.85  3.62e-5  4.17e-5
 HG_U133A  32837_at  0.05  4.98e-1  5.51e-1  -2.95  2.39e-56  6.06e-56
 HG_U133_Plus2  210678_s_at  0.16  2.28e-1  3.09e-1  -0.16  2.28e-1  2.81e-1
 HG_U133_Plus2  32837_at  0.44  3.55e-4  1.01e-3  0.27  2.13e-2  3.28e-2
 Agilent_HS_21.6K  7608  -0.10  2.37e-1  4.19e-1  -0.22  3.36e-2  9.15e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  210678_s_at  -0.63  9.82e-2  7.71e-1  0.33  3.21e-1  1.00e+0
 HG_U133A  32837_at  -0.67  1.88e-2  6.83e-1  -0.10  3.88e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 32837_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210678_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 32837_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210678_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 32837_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 7608    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
lpaat-beta neoplasm Enhanced transcription of LPAAT-beta is suggested for neoplasm of the female genital tract. 11487472 Human
lysophosphatidic acid acyltransferase beta tumor Inhibition of lysophosphatidic acid acyltransferase beta disrupts proliferative and survival signals in normal cells and induces apoptosis of tumor cells. 14578472 others
lpaat-beta tumors Given that PA is a cofactor in a number of signaling cascades that are constitutively active in tumors, we evaluated the role of PA produced by LPAAT-beta in Xenopus oocyte meiotic maturation assays and an isoform-specific inhibitor of LPAAT-beta in mamma 14578472 Human
lpaat-beta tumor When LPAAT-beta activity is suppressed by CT32228 (N-(4-bromo-phenyl)-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazine-2,4-diamine), an isoform-specific noncompetitive inhibitor, tumor cells undergo mitotic catastrophe while most normal cells simply arrest or 14578472 others
lpaat-beta tumor The data presented here suggest that PA produced by LPAAT-beta plays an important role in signaling pathways critical to tumor cell survival. 14578472 others
lpaat-beta human tumours The expression and activity of the LPAAT-beta isoform are elevated in human tumours, and the respective gene displays transforming capacity when overexpressed in vitro. 14498826 Human
lpaat-beta tumour Furthermore, the small-molecule inhibitors of LPAAT-beta are not cytotoxic to a number of normal cell types, including primary bone marrow progenitors, indicating a differential dependence of tumour cells on LPAAT-beta function. 14498826 Human
lpaat-beta cancer These discoveries indicate that LPAAT-beta represents a potential novel cancer therapy target. 14498826 Human
lpaat-beta tumour Expression of lysophosphatidic acid acyltransferase beta (LPAAT-beta) in ovarian carcinoma: correlation with tumour grading and prognosis. 15841084 Human
lpaat-beta ovarian carcinoma Expression of lysophosphatidic acid acyltransferase beta (LPAAT-beta) in ovarian carcinoma: correlation with tumour grading and prognosis. 15841084 Human
lpaat-beta tumour Lysophosphatidic acid acyltransferase beta (LPAAT-beta) is an enzyme involved in lipid biosynthesis whose role in tumour progression has been of emerging interest in the last few years. 15841084 Human
lpaat-beta ovarian tumours We investigated the expression of LPAAT-beta by reverse transcriptase-polymerase chain reaction and immunohistochemistry in 10 ovarian cell lines as well as in a cohort of 106 ovarian tumours and normal ovaries. 15841084 Human
lpaat-beta ovarian carcinomas Expression of LPAAT-beta protein was significantly increased in ovarian carcinomas compared to benign ovarian tissue (chi2 test P-value=0.001, Kruskal-Wallis test P-value <0.0001). 15841084 Human
lpaat-beta tumour Furthermore, LPAAT-beta expression was positively associated with higher tumour grade (P=0.044), higher mitotic index (P<0.0001) and tumour stage (P=0.032). 15841084 Human
lpaat-beta tumours Our study shows that LPAAT-beta is upregulated in ovarian cancer and is more prevalent in poorly differentiated tumours. 15841084 Human
lpaat-beta ovarian cancer Our study shows that LPAAT-beta is upregulated in ovarian cancer and is more prevalent in poorly differentiated tumours. 15841084 Human
lpaat-beta cancer Our study shows that LPAAT-beta is upregulated in ovarian cancer and is more prevalent in poorly differentiated tumours. 15841084 Human
lpaat-beta lymphoma EXPERIMENTAL DESIGN: LPAAT-beta may be a novel target for anticancer therapy, and, thus, we examined the effects of a series of inhibitors of LPAAT-beta on multiple human non-Hodgkin's lymphoma cell lines in vitro and in vivo. 16000584 Human
lpaat-beta non-hodgkin's lymphoma EXPERIMENTAL DESIGN: LPAAT-beta may be a novel target for anticancer therapy, and, thus, we examined the effects of a series of inhibitors of LPAAT-beta on multiple human non-Hodgkin's lymphoma cell lines in vitro and in vivo. 16000584 Human
lpaat-beta non-hodgkin's lymphoma The LPAAT-beta inhibitors induced caspase-mediated apoptosis at 50 to 100 nmol/L in up to 90% of non-Hodgkin's lymphoma cells. 16000584 Human
lpaat-beta lymphoma To assess the combination of Rituximab and a LPAAT-beta inhibitor in vivo, groups of athymic mice bearing s.c. human Ramos lymphoma xenografts were treated with the LPAAT-beta inhibitor CT-32228 i.p. 16000584 Human
lpaat-beta non-hodgkin's lymphoma Apoptotic effects of the LPAAT-beta inhibitors were evaluated either alone or in combination with the anti-CD20 antibody, Rituximab. 16000584 Human
lpaat-beta lymphoma The LPAAT-beta inhibitors induced caspase-mediated apoptosis at 50 to 100 nmol/L in up to 90% of non-Hodgkin's lymphoma cells. 16000584 Human
lpaat-beta non-hodgkin's lymphoma To assess the combination of Rituximab and a LPAAT-beta inhibitor in vivo, groups of athymic mice bearing s.c. human Ramos lymphoma xenografts were treated with the LPAAT-beta inhibitor CT-32228 i.p. 16000584 Human
lysophosphatidic acid acyltransferase beta tumour Expression of lysophosphatidic acid acyltransferase beta (LPAAT-beta) in ovarian carcinoma: correlation with tumour grading and prognosis. 15841084 Human
lysophosphatidic acid acyltransferase beta ovarian carcinoma Expression of lysophosphatidic acid acyltransferase beta (LPAAT-beta) in ovarian carcinoma: correlation with tumour grading and prognosis. 15841084 Human
lysophosphatidic acid acyltransferase beta tumour Lysophosphatidic acid acyltransferase beta (LPAAT-beta) is an enzyme involved in lipid biosynthesis whose role in tumour progression has been of emerging interest in the last few years. 15841084 Human
lysophosphatidic acid acyltransferase beta ovarian tumours Lysophosphatidic acid acyltransferase beta mRNA was found in all cell lines and ovarian tumours examined. 15841084 Human

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