IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene EDF1 Ensembl ENSG00000107223 Chromosome 9 Start 138876392 End 138880559
Description Endothelial differentiation-related factor 1 (EDF-1)(Multiprotein-bridging factor 1)(MBF1) [Source:UniProtKB/Swiss-Prot;Acc:O60869]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 3164
     Entrez Gene : 8721
     UCSC : uc004cjt.1
     GeneCards : 3164
     RefSeq : NM_003792
     CCDS : CCDS7011.1
     Uniprot : O60869
     Interpro : O60869
     OMIM : 605107
     GeneTests : EDF1
     CGAP : EDF1
     PMID : 9813014

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  209058_at  0.10  6.25e-2  8.52e-2  -4.14  4.21e-115  4.38e-114
 HG_U133A  209059_s_at  0.58  1.49e-20  1.22e-19  -5.42  1.54e-92  8.52e-92
 HG_U133_Plus2  209058_at  -0.19  3.39e-3  7.80e-3  -0.41  4.37e-7  1.34e-6
 HG_U133_Plus2  209059_s_at  -0.12  1.08e-1  1.63e-1  -0.53  2.66e-7  8.42e-7
 Agilent_HS_21.6K  14441  0.04  3.89e-1  5.75e-1  0.06  2.34e-1  3.84e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  209058_at  -0.11  5.89e-1  9.50e-1  0.13  3.16e-1  1.00e+0
 HG_U133A  209059_s_at  0.04  8.51e-1  9.88e-1  -0.05  6.61e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133A - 209058_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209059_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209058_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209059_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 14441    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
edf-1 tumors Because EDF-1 has been isolated as a gene differentially expressed by exposure of endothelial cells to the Tat protein of HIV, we evaluated mEDF-1 expression in different cell lines derived from tumors which spontaneously develop in Tat transgenic mice. 11587857 Human
edf-1 leiomyosarcomas Cells isolated from adenocarcinomas and leiomyosarcomas express very high amounts of EDF-1, independently from their capability to secrete Tat. 11587857 Mouse
edf-1 adenocarcinomas Cells isolated from adenocarcinomas and leiomyosarcomas express very high amounts of EDF-1, independently from their capability to secrete Tat. 11587857 Mouse
edf-1 sarcoma Since Kaposi spindle cells, which are the proliferative component of the sarcoma, differentiate from an endothelial precursor, it is noteworthy that spindle cells derived from Kaposi-like lesions of the Tat transgenic mice downregulate EDF-1 when compared 11587857 Mouse

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