IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PTGDS Ensembl ENSG00000107317 Chromosome 9 Start 138991777 End 138996014
Description Prostaglandin-H2 D-isomerase Precursor (EC 5.3.99.2)(Lipocalin-type prostaglandin-D synthase)(Glutathione-independent PGD synthetase)(Prostaglandin-D2 synthase)(PGD2 synthase)(PGDS2)(PGDS)(Beta-trace protein)(Cerebrin-28) [Source:UniProtKB/Swiss-Prot;Acc:P41222]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9592
     Entrez Gene : 5730
     UCSC : uc004cke.2
     GeneCards : 9592
     RefSeq : NM_000954
     CCDS : CCDS7019.1
     Uniprot : P41222
     Interpro : P41222
     OMIM : 176803
     GeneTests : PTGDS
     CGAP : PTGDS
     PMID : 1902577

< Top >


Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  216_at  -1.25  1.73e-12  3.57e-11  -1.74  1.92e-16  8.06e-15
 HG_U95  38406_f_at  -1.14  5.13e-13  1.17e-11  -1.42  1.58e-16  6.91e-15
 HG_U95  38407_r_at  -2.78  8.01e-15  2.46e-13  -4.04  8.63e-20  8.07e-18
 HG_U133A  211663_x_at  -1.79  3.17e-43  1.07e-41  -8.13  3.65e-129  5.83e-128
 HG_U133A  211748_x_at  -1.82  1.16e-29  1.75e-28  -4.96  1.26e-134  2.40e-133
 HG_U133A  212187_x_at  -1.70  2.35e-30  3.73e-29  1.34  1.32e-48  2.94e-48
 HG_U133_Plus2  211663_x_at  -1.45  4.83e-16  7.34e-15  -1.67  1.55e-17  1.63e-16
 HG_U133_Plus2  211748_x_at  -1.60  1.69e-14  2.15e-13  -2.42  3.86e-16  3.46e-15
 HG_U133_Plus2  212187_x_at  -1.50  1.88e-14  2.38e-13  -2.20  2.56e-15  2.09e-14
 Agilent_HS_21.6K  11  -0.48  4.30e-4  3.87e-3  -0.61  1.89e-7  3.78e-6

< Top >


Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  211663_x_at  1.34  6.90e-3  6.60e-1  -0.06  8.52e-1  1.00e+0
 HG_U133A  211748_x_at  1.35  1.02e-2  6.80e-1  -0.25  5.50e-1  1.00e+0
 HG_U133A  212187_x_at  1.18  1.49e-2  6.83e-1  -0.22  5.94e-1  1.00e+0

< Top >


Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 216_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 38406_f_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 38407_r_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211663_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211748_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 212187_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211663_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211748_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 212187_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 11    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

< Top >


Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
pgd2 human pancreatic carcinoma CONCLUSIONS: These results indicate that ketoconazole significantly reduced hepatic metastases from the human pancreatic carcinoma RWP-2 in the nude mouse model, and inhibited thromboxane B2 formation, potentiating a concomitant redirection of platelet en 12630766 Human
pgd2 hepatic metastases CONCLUSIONS: These results indicate that ketoconazole significantly reduced hepatic metastases from the human pancreatic carcinoma RWP-2 in the nude mouse model, and inhibited thromboxane B2 formation, potentiating a concomitant redirection of platelet en 12630766 Human
prostaglandin d synthase renal-cell carcinoma Prostaglandin D synthase does not produce prostate-specific antigen cross-reactivity in renal cell carcinoma. 11238325 Human
prostaglandin d synthase meningeal hemangiopericytoma Prostaglandin D synthase (beta-trace) in meningeal hemangiopericytoma. 11266526 Human
pgds mesenchymal chondrosarcoma Mesenchymal chondrosarcoma arises in the bones of the skull, and its histological pattern resembles that of HPC; however, it showed no immunoreactivity for PGDS. 11266526 Human
pgds choroid plexus papillomas Neither choroid plexus papillomas nor oligodendrogliomas were immunopositive for PGDS. 11266526 Human
lipocalin-type prostaglandin d synthase breast tumors Lipocalin-type prostaglandin D synthase (L-PGDS) has recently been shown to be expressed in human brain tumors and breast tumors. 11798075 Human
pgds invasive cancer Cytology, DNA index (including % hypertetraploid cells), cell cycle parameters (S phase fraction, % cells in G2/M), prostate-specific antigen (PSA), epidermal growth factor (EGF), testosterone, carcinoembryonic antigen (CEA) and prostaglandin D synthase ( 10584885 Human
prostaglandin d synthase invasive cancer Cytology, DNA index (including % hypertetraploid cells), cell cycle parameters (S phase fraction, % cells in G2/M), prostate-specific antigen (PSA), epidermal growth factor (EGF), testosterone, carcinoembryonic antigen (CEA) and prostaglandin D synthase ( 10584885 Human
prostaglandin d synthase breast cyst Quantification of pepsinogen C and prostaglandin D synthase in breast cyst fluid and their potential utility for cyst type classification. 10074890 Human
pgds breast cyst Immunoreactive PGDS levels were highly correlated with a low cation ratio and were associated with the transudative/flattened type of breast cyst (Type II) (p = 0.0003). 10074890 Human
pgd2 gingival carcinoma The inhibitory effects of various prostaglandins (PGA2, PGD2 and PGE2) on the growth of human gingival carcinoma cell line Ca 9-22 and human cervical carcinoma cell line HeLa were studied in vitro. 3162424 Human
pgd2 reticulosarcoma The five stable metabolites [prostaglandin F2 alpha (PGF2 alpha), prostaglandin D2 (PGD2), prostaglandin E2 (PGE2), thromboxane B2 (TXB2), and 6-ketoprostaglandin F1 alpha (6-keto-PGF1 alpha)] of arachidonic acid (AA) via the cyclooxygenase pathway were m 3100032 Human
pgd2 granuloma SB 203347 reduced both LTB4 and PAF, but not PGD2 levels measured in the day 6 granuloma. 9593866 Human
pgd2 hepatic metastasis These findings suggest that measuring the PGD2 in cancer tissue may be useful for detecting and predicting the hepatic metastasis from human colorectal cancer. 9697269 Human
pgds meningiomas Here, we report PGDS to be expressed consistently in 10 human arachnoid and arachnoid villi and in 21 meningiomas by immunohistochemistry, Western blot, and reverse transcription (RT)-PCR analyses. 9065498 Human
pgd2 b16 melanoma Cytotoxicity of combinations of prostaglandin D2 (PGD2) and antitumor drugs for B16 melanoma cells in culture. 3473056 Mouse
pgd2 murine leukemia L-1210 murine leukemia cells were exposed to prostaglandin D2 (PGD2), 10 micrograms/ml, in culture medium for various time, and subsequent cell growth was observed. 3857041 Human
pgd2 systemic mastocytosis In a patient with systemic mastocytosis associated with overproduction of PGD2, urinary excretion of 9 alpha, 11 beta-PGF 2 was 6634 ng/24 hr and a circulating plasma level as high as 490 ng/ml was found during a severe episode of systemic mast cell activ 3862115 Human
pgd2 dunn osteosarcoma These results suggest that PGD2 and 9-deoxy-delta 9-PGD2 are considered to have cytocidal activity on Dunn osteosarcoma cells in dosages which do not affect non-malignant cells. 3863195 Human
pgd2 mouse neuroblastoma The results indicate that PGD2 has growth-inhibitory effects on mouse neuroblastoma cells in vitro and in vivo. 6574994 Mouse
pgd2 metastatic pancreas carcinoma Platelet abnormality with no response to PGD2 in a patient with metastatic pancreas carcinoma and myeloproliferative disorder. 3473883 Human
pgd2 ewing's sarcoma The efficacy order for prostaglandins (PG) is PGE1 greater than PGI2 greater than PGE2 much greater than PGF2 alpha; 6-keto PGF1 alpha and PGD2 do not influence cAMP levels in Ewing's sarcoma cells. 2887164 Human
pgd2 benign meningiomas Compared to the slow-growing benign meningiomas, the rapidly-growing infiltrating gliomas had higher synthesis of TXA2 (reported as a procancer metabolite) and lower synthesis of PGD2 and PGI2 (reported as anticancer metabolites). 3126274 Human
pgd2 retinoblastoma Prostaglandin D2 (PGD2) and 64E, a derivative of PGs, were tested for their capacity to suppress the growth of retinoblastoma in the nude mouse. 3482290 Human
pgd2 melanoma Our interest in prostaglandins (PGs) as antitumor agents stemmed from the report of Bregman and Meyskens (Cancer Res., 43: 1642-1645, 1983) that PGA1, PGA2, and PGD2 inhibited colony formation by human melanoma cells obtained from fresh biopsies of melano 3456266 Human
pgd2 melanoma However, against human melanoma cells, PGD2 was much more active than PGA1, whereas PGA2 was inactive. 3456266 Human
pgd2 melanoma Towards the end of our study, we obtained PGJ2 and found that it was as cytotoxic as PGD2 for L1210 cells but was more lethal for human melanoma cells. 3456266 Human
pgd2 brain metastases All brain metastases from different carcinomas (n = 5) showed a prevalence of TXB2 and PGE2 and very low PGD2 synthesis. 2493982 Human
pgd2 human erythroleukemia In this study, we found that PGE1 could stimulate PLD in human erythroleukemia cells, as measured by phosphatidylethanol formation, with an ED50 of 3.5 x 10(-7) M. PGE2 was also active, but other PGs including prostacyclin, PGD2 and PGF2, had no effect. 1650837 Human
pgds dcis Cytology, DNA index (including % hypertetraploid cells), cell cycle parameters (S phase fraction, % cells in G2/M), prostate-specific antigen (PSA), epidermal growth factor (EGF), testosterone, carcinoembryonic antigen (CEA) and prostaglandin D synthase ( 10584885 Human
pds malignancy BACKGROUND: This study aimed to define PDS characteristics that predict malignancy and would thus invoke further diagnostic evaluation or aggressive treatment. 15150064 Human
pgd2 myeloproliferative disorders This enzyme activity was spectrophotometrically determined in the cytosol of platelets and platelet sensitivities to PGD2 were studied in patients with myeloproliferative disorders (MPD) as well as in normal subjects. 3457389 Human
pgd2 neuroepithelial tumors AA metabolism capacity well correlates with proliferative patterns in neuroepithelial tumors: the relationship depends preferentially on TxB2 and PGD2 synthesis capacity. 1910078 Human
pgds gross cystic disease CONCLUSIONS: Quantification of PEPC and PGDS in breast cyst fluid may be useful in the subclassification of cyst type in patients with gross cystic disease. 10074890 Human
pgds hemangiopericytomas In this study, we examined 25 meningeal hemangiopericytomas (HPCs) and found that 16 of the tumors (64%) showed immunoreactivity for PGDS in the perinuclear region. 11266526 Human
pgds oligodendrogliomas Neither choroid plexus papillomas nor oligodendrogliomas were immunopositive for PGDS. 11266526 Human
pgds polyposis In the nasal mucosa of subjects suffering from polyposis: (1) PGDS was detected in mast cells and other large infiltrating inflammatory cells, (2) both DP mRNA and CRTH2 were detected in eosinophils and (3) CRTH2 was detected on a subset of infiltrating T 15165034 Human
lipocalin-type prostaglandin d synthase brain tumors Lipocalin-type prostaglandin D synthase (L-PGDS) has recently been shown to be expressed in human brain tumors and breast tumors. 11798075 Human
lipocalin-type prostaglandin d synthase medulloblastoma Here we investigated the regulatory mechanism of lipocalin-type prostaglandin D synthase (L-PGDS) gene expression in human TE671 (medulloblastoma of cerebellum) cells. 15743775 Human
prostaglandin d synthase non-small cell lung cancer To investigate the components of the prostaglandin biosynthetic pathway, the characteristics of cyclooxygenase (COX)-1, COX-2, hematopoietic prostaglandin D synthase (hPGDS), microsomal prostaglandin E synthase (mPGES), and thromboxane synthase (TXS) were 15870920 Human
prostaglandin d synthase nsclc To investigate the components of the prostaglandin biosynthetic pathway, the characteristics of cyclooxygenase (COX)-1, COX-2, hematopoietic prostaglandin D synthase (hPGDS), microsomal prostaglandin E synthase (mPGES), and thromboxane synthase (TXS) were 15870920 Human
prostaglandin d synthase small cell lung cancer (sclc) To investigate the components of the prostaglandin biosynthetic pathway, the characteristics of cyclooxygenase (COX)-1, COX-2, hematopoietic prostaglandin D synthase (hPGDS), microsomal prostaglandin E synthase (mPGES), and thromboxane synthase (TXS) were 15870920 Human
pds skin tumors [Resorbable suture material in the human skin: tissue reaction and modified suture technic] Two-stage excision of skin tumors provided an opportunity for histological evaluation of implanted PDS or Vicryl suture material. 3128494 Human
pgd2 serous cystadenocarcinoma [Inhibition of human ovarian cancer cell growth by prostaglandin D2] The effects of prostaglandin D2 (PGD2) on human ovarian tumor growth were examined in vitro and in vivo by using a cell line, designated HR, derived from patients with serous cystadenoca 3029247 Human
pgd2 mpd We studied the potency of PGD2, PGI2 and PGE1 as inhibitors of platelet aggregation induced by threshold aggregating concentrations of arachidonic acid and U-46619-analogue of the cyclic endoperoxide PGH2 in 20 patients with MPD in comparison with healthy 3129810 Human
pgd2 glioma [Effects of prostaglandin D2 on cultured glioma cells] The cytotoxic and cytokinetic effects of prostaglandin (PG)D2 on human and rat glioma cells were studied in vitro, and the morphological changes occurring in glioma cells following PGD2 treatment were 3463248 Human
pgd2 glioma Glioma cells treated with PGD2 became round with cytoplasmic vacuolization and blebbing. 3463248 Human
pgd2 malignant glioma Thus, PGD2 appears to be useful as an adjuvant chemotherapeutic agent for malignant glioma. 3463248 Human
pgd2 chronic myeloid leukemia (cml) Scatchard analysis for pure (greater than 95%) chronic myeloid leukemia (CML) basophils revealed two classes of PGE1-binding sites differing in their affinity for the natural ligand (Bmax1 = 217 +/- 65 fmol/10(8) cells; Kd1 = 0.5 +/- 0.2 nM; Bmax2 = 2462 1377673 Human
pgd2 cml In addition, CML basophils exhibited a single class of PGD2-binding sites (Bmax = 378 +/- 98 fmol/10(8) cells; Kd = 13 +/- 4 nM; IC50: PGD2 less than PGI2 less than PGE1 less than PGE2 less than PGF2 alpha). 1377673 Human
pgd2 mastocytosis Until the etiology of mastocytosis is understood, the treatment is symptomatic: histamine antagonism by H1 +/- H2 blockade for flushing, itching, and gastric distress; cyclooxygenase inhibition to prevent prostaglandin D2 (PGD2)-induced hypotension when i 1490622 Human
pgd2 megakaryoblastic leukemia MEG-01s, an established human megakaryoblastic leukemia cell line, exhibited specific high-affinity binding sites for [3H]iloprost, a stable prostaglandin (PG) I2 analogue, for [3H]SQ-29548, a stable thromboxane (TX) A2 antagonist and, for [3H]PGE2/PGE1, 1718495 Human
prostaglandin d synthase ductal carcinoma in situ (dcis) Cytology, DNA index (including % hypertetraploid cells), cell cycle parameters (S phase fraction, % cells in G2/M), prostate-specific antigen (PSA), epidermal growth factor (EGF), testosterone, carcinoembryonic antigen (CEA) and prostaglandin D synthase ( 10584885 Human
prostaglandin d synthase renal cell carcinoma Prostaglandin D synthase does not produce prostate-specific antigen cross-reactivity in renal cell carcinoma. 11238325 Human
pgds ductal carcinoma in situ (dcis) Cytology, DNA index (including % hypertetraploid cells), cell cycle parameters (S phase fraction, % cells in G2/M), prostate-specific antigen (PSA), epidermal growth factor (EGF), testosterone, carcinoembryonic antigen (CEA) and prostaglandin D synthase ( 10584885 Human
pds differentiated thyroid cancer (dtc) We assessed the accuracy of real-time RT-PCR-based detection of a panel of thyroid-specific markers, including TG, TPO, TSHR, NIS and PDS, in comparison with serum TG measurements in a series of 55 patients operated for differentiated thyroid cancer (DTC) 15170676 Human
pgds nasal polyps METHODS: The study examined the expression of PGDS and PGES in nasal polyps of 22 CRS patients. 16911359 Human
pgds nasal polyps Levels of PGDS mRNA in nasal polyps were positively correlated with degree of infiltration by EG2+ eosinophils, whereas the levels of PGES were inversely correlated. 16911359 Human
pgds polyp CONCLUSIONS: These results suggest that PGDS and PGES display an opposite and important role in the pathophysiology of CRS such as polyp formation, and more specifically, a biased expression of these synthases might contribute to the development of CRS by 16911359 Human
pgd2 osteosarcoma The effects of PGD2 and 9-deoxy-delta 9-PGD2 on colony formation of murine osteosarcoma cells. 3863195 Mouse
pgd2 neuroblastoma PGE1, thought to be the most effective among all PGs in the therapy of neuroblastoma, was much less effective than PGD2. 6572553 Human
pgd2 leukemia [Antineoplastic action of prostaglandin D2--effect of PGD2 on proliferation of L1210 leukemic cells in culture] Prostaglandin D2 was found to have a potent cytotoxic effect on L1210 leukemia culture cells. 6964030 Human
pgd2 lymphoma Pharmacologically, rat CRTH2 stably transfected in mouse preB lymphoma L1.2 cells behaved very similar compared with the mouse and human orthologs, showing a binding affinity for PGD2 of 11 nM, a functional calcium mobilization when exposed to agonist, an 12975488 Mouse
pgd2 ibd The roles of PGD2, LTC4, PAF and mast cell cytokines in IBD were also discussed. 14760748 Human
pgd2 colon cancer The results from this animal model suggest that prolonged elevation of COX-2-derived PGD2 synthesis after resolution of colitis may contribute significantly to colitis-associated increases in colon cancer incidence. 16251413 Human
pgd2 mastocytoma HQL-79 selectively inhibited PGD2 production by H-PGDS-expressing human megakaryocytes and rat mastocytoma cells with an IC50 value of about 100 microm but only marginally affected the production of other prostanoids, suggesting the tight functional engag 16547010 Rat
pgd2 rat basophilic leukemia Rat basophilic leukemia cells (RBL-2H3) generate prostaglandin D2 (PGD2) after regulated upon activation, normal T-cell expressed and secreted (RANTES) activation. 17177158 Rat
beta-trace protein orbital cyst High beta-trace protein concentration in the fluid of an orbital cyst associated with bilateral colobomatous microphthalmos. 17510479 Human
beta-trace protein meningioma Based on the radiologic features of the left ON and the dissociated beta-trace protein concentrations in the CSF of the SAS of the ON and the lumbar CSF, the diagnosis of an ON sheath compartment syndrome due to an ON sheath meningioma was made. 17534836 Human
prostaglandin d synthase ovarian carcinomas In this study, we show that the embryonic male prostaglandin D synthase (Pgds)/SOX9 pathway is expressed at both the RNA and protein levels in different types of human ovarian tumors, pointing to Pgds and SOX9 as possible diagnostic markers for ovarian ca 17532558 Human
prostaglandin d synthase ovarian tumors In this study, we show that the embryonic male prostaglandin D synthase (Pgds)/SOX9 pathway is expressed at both the RNA and protein levels in different types of human ovarian tumors, pointing to Pgds and SOX9 as possible diagnostic markers for ovarian ca 17532558 Human
pgds ovarian carcinomas In this study, we show that the embryonic male prostaglandin D synthase (Pgds)/SOX9 pathway is expressed at both the RNA and protein levels in different types of human ovarian tumors, pointing to Pgds and SOX9 as possible diagnostic markers for ovarian ca 17532558 Human
pgds ovarian tumors In this study, we show that the embryonic male prostaglandin D synthase (Pgds)/SOX9 pathway is expressed at both the RNA and protein levels in different types of human ovarian tumors, pointing to Pgds and SOX9 as possible diagnostic markers for ovarian ca 17532558 Human
pgds ovarian cancer Using ovarian cancer cell lines, we found, first, that components of the Pgds/SOX9 pathway are expressed in these cells, and second, that treatment of these cells with prostaglandin D2 (PGD2) can inhibit their growth via its DP1 receptor and induce apopto 17532558 Human
lpgds ovarian tumors Recent studies have shown that LPGDS is anomalously expressed in ovarian tumors and that retinoid may have a role as an ovarian cancer chemotherapeutic agent. 12842099 Human
lpgds ovarian cancer Recent studies have shown that LPGDS is anomalously expressed in ovarian tumors and that retinoid may have a role as an ovarian cancer chemotherapeutic agent. 12842099 Human
lpgds laryngeal carcinoma Immunohistochemical expression of COX-1, COX-2, mPGES, LPGDS, and HPGDS was investigated in 24 laryngeal carcinoma samples. 16720448 Human
pgd2 ovarian cancer Using ovarian cancer cell lines, we found, first, that components of the Pgds/SOX9 pathway are expressed in these cells, and second, that treatment of these cells with prostaglandin D2 (PGD2) can inhibit their growth via its DP1 receptor and induce apopto 17532558 Human
lipocalin-type prostaglandin d synthase cervical carcinoma Decisive role of cyclooxygenase-2 and lipocalin-type prostaglandin D synthase in chemotherapeutics-induced apoptosis of human cervical carcinoma cells. 18071320 Human
prostaglandin d synthase small cell lung cancer To investigate the components of the prostaglandin biosynthetic pathway, the characteristics of cyclooxygenase (COX)-1, COX-2, hematopoietic prostaglandin D synthase (hPGDS), microsomal prostaglandin E synthase (mPGES), and thromboxane synthase (TXS) were 15870920 Human

< Top >


Download all image files.
Save all PNG files.    Save all PDF files.    Save all PS files.