IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ABCA2 Ensembl ENSG00000107331 Chromosome 9 Start 139021507 End 139043195
Description ATP-binding cassette sub-family A member 2 (ATP-binding cassette transporter 2)(ATP-binding cassette 2) [Source:UniProtKB/Swiss-Prot;Acc:Q9BZC7]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 32
     Entrez Gene : 20
     UCSC : uc011mel.1
     GeneCards : 32
     RefSeq : NM_001606
     CCDS : CCDS43909.1
     Uniprot : Q9BZC7
     Interpro : Q9BZC7
     OMIM : 600047
     GeneTests : ABCA2
     CGAP : ABCA2
     PMID : 8088782

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  31725_s_at  0.44  2.83e-4  1.03e-3  0.25  9.11e-2  1.52e-1
 HG_U95  38313_at  -0.07  6.80e-1  7.62e-1  -0.61  1.96e-2  4.12e-2
 HG_U95  918_at  0.47  6.04e-4  2.02e-3  0.61  9.38e-4  2.93e-3
 HG_U133A  210099_at  0.05  3.79e-1  4.34e-1  3.55  1.96e-109  1.72e-108
 HG_U133A  210100_s_at  0.38  2.58e-4  5.08e-4  -0.88  1.37e-8  1.68e-8
 HG_U133A  212772_s_at  0.03  5.28e-1  5.80e-1  1.13  1.62e-42  3.26e-42
 HG_U133_Plus2  210099_at  -0.01  9.59e-1  9.71e-1  -0.14  3.85e-1  4.46e-1
 HG_U133_Plus2  210100_s_at  0.46  1.26e-2  2.50e-2  0.52  2.20e-2  3.38e-2
 HG_U133_Plus2  212772_s_at  0.41  5.18e-4  1.43e-3  0.82  2.56e-8  9.19e-8
 Agilent_HS_21.6K  3126  0.05  3.91e-1  5.77e-1  0.04  4.85e-1  6.36e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  210099_at  -0.04  8.46e-1  9.88e-1  0.24  1.34e-1  1.00e+0
 HG_U133A  210100_s_at  -0.37  1.90e-1  8.25e-1  -0.24  2.26e-1  1.00e+0
 HG_U133A  212772_s_at  -0.01  9.74e-1  9.99e-1  0.08  6.69e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 31725_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 38313_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 918_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210099_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210100_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 212772_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210099_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210100_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 212772_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 3126    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
abc2 neuroblastoma This was confirmed by immunocolocalization of ABC2 and lysosomal markers in a neuroblastoma cell line. 11157071 Human
abc2 cervical cancer Re "ABC2"; several paces forward but a big leap back for cervical cancer audit. 11284960 Human
abca2 tumor Analysis of mRNA expression levels indicated that ABCA2 is highest in human brain and has a broad expression pattern in a panel of tumor cell lines. 11309290 Human
abca2 small-cell lung cancer Mitoxantrone resistance in a small cell lung cancer cell line is associated with ABCA2 upregulation. 15150577 Human
abca2 neuroblastoma When increasing amounts of EGR-1 were transfected into the BE(2)-M17 neuroblastoma cells we observed a dose-dependent decrease in expression of the ABCA2 promoter, although expression of the endogenous ABCA2 gene increased following transfection of EGR-1. 12560508 Human
abca2 hcc We think monitoring of ABCA2, C1 and G1 gene expression levels in PBL will be useful for selection of anti-cancer agents and monitoring of drug resistance of HCC. 15182435 Human
abca2 prostate carcinoma Cytotoxicity assays suggested a role for ABCA2 in estramustine and estradiol resistance, and overexpression of ABCA2 is seen in an estramustine-resistant prostate carcinoma line. 15093135 Human
abca2 vestibular schwannoma Expression of ABCA2 protein in human vestibular schwannoma and peripheral nerve. 15850583 Human
abca2 schwannomas Here, we demonstrate by immunoblot and immunohistochemistry that ABCA2 is expressed in benign vestibular schwannomas, which contain neither axons nor compact myelin. 15850583 Human
abca2 schwannomas The expression patterns of ABCA2 in combination with other markers showed phenotypic heterogeneity in schwannomas. 15850583 Human
abca2 schwannomas These data suggest that ABCA2 may be useful as a marker for cellular characterization of schwannomas. 15850583 Human

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