IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene FUT7 Ensembl ENSG00000180549 Chromosome 9 Start 139044447 End 139047283
Description Alpha-(1,3)-fucosyltransferase (EC 2.4.1.-)(Galactoside 3-L-fucosyltransferase)(Fucosyltransferase 7)(FucT-VII)(Selectin-ligand synthase) [Source:UniProtKB/Swiss-Prot;Acc:Q11130]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 4018
     Entrez Gene : 2529
     UCSC : uc004ckq.2
     GeneCards : 4018
     RefSeq : NM_004479
     CCDS : CCDS7022.1
     Uniprot : Q11130
     Interpro : Q11130
     OMIM : 602030
     GeneTests : FUT7
     CGAP : FUT7
     PMID : 8207002

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Experimental Evidence        (help)
Expression Sample Number Method Clinical information PubMed Reference
up 220/333(66%) IHC- 8542587 Cancer Res. 1996 Jan 15;56(2):325-9.

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  36322_at  -0.08  6.02e-1  6.95e-1  -0.14  3.45e-1  4.50e-1
 HG_U133A  210506_at  0.53  3.68e-5  8.06e-5  3.04  1.37e-101  9.66e-101
 HG_U133A  217696_at  0.30  1.75e-2  2.64e-2  -1.46  1.41e-20  2.06e-20
 HG_U133_Plus2  210506_at  -0.13  5.07e-1  5.94e-1  -0.51  1.57e-2  2.47e-2
 HG_U133_Plus2  217696_at  0.43  8.41e-3  1.75e-2  0.44  1.42e-2  2.25e-2
 Agilent_HS_21.6K  20762  0.04  1.62e-1  3.26e-1  0.06  4.63e-2  1.16e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  210506_at  0.29  5.34e-1  9.35e-1  -0.45  1.91e-1  1.00e+0
 HG_U133A  217696_at  0.04  9.19e-1  9.95e-1  0.11  6.65e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 36322_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210506_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 217696_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210506_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 217696_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 20762    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
fut7 cancer The transcription of genes for fucosyltransferase VII (FUT7), sialyltransferase ST3Gal-I (ST3O), and UDP-galactose transporter-1 (UGT1), which are all known to be involved in the synthesis of the carbohydrate ligands for E-selectin, was significantly indu 15141079 Human
fut7 carcinoma Transcripts of FUT1, FUT2, FUT3, FUT4, FUT5, and FUT7 were detected by RT-PCR in carcinoma cell lines as well as in normal and tumoral tissues. 9592127 NA

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