IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene GRIN1 Ensembl ENSG00000176884 Chromosome 9 Start 139152663 End 139183028
Description Glutamate [NMDA] receptor subunit zeta-1 Precursor (N-methyl-D-aspartate receptor subunit NR1) [Source:UniProtKB/Swiss-Prot;Acc:Q05586]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 4584
     Entrez Gene : 2902
     UCSC : uc004clk.2
     GeneCards : 4584
     RefSeq : NM_000832
     CCDS : CCDS7031.1
     Uniprot : Q5VSF6
     Interpro : Q5VSF6
     OMIM : 138249
     GeneTests : GRIN1
     CGAP : GRIN1
     PMID : 1350383

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37134_f_at  0.50  5.29e-4  1.80e-3  0.13  4.73e-1  5.77e-1
 HG_U95  37135_f_at  0.62  1.57e-4  6.11e-4  0.86  1.07e-5  5.35e-5
 HG_U133A  205914_s_at  -0.38  3.81e-5  8.34e-5  4.38  2.70e-123  3.60e-122
 HG_U133A  205915_x_at  0.01  9.24e-1  9.35e-1  2.36  5.60e-50  1.28e-49
 HG_U133A  210781_x_at  -0.28  4.44e-5  9.65e-5  2.17  2.66e-35  4.80e-35
 HG_U133A  210782_x_at  1.03  1.45e-14  7.58e-14  1.43  1.27e-25  2.00e-25
 HG_U133A  211125_x_at  -0.25  3.02e-2  4.37e-2  5.95  1.99e-127  2.99e-126
 HG_U133_Plus2  205914_s_at  0.28  5.41e-2  9.01e-2  -0.26  6.55e-2  9.15e-2
 HG_U133_Plus2  205915_x_at  0.39  1.57e-2  3.05e-2  0.76  1.48e-4  3.23e-4
 HG_U133_Plus2  210781_x_at  0.17  1.53e-1  2.20e-1  0.11  4.41e-1  5.03e-1
 HG_U133_Plus2  210782_x_at  0.21  1.31e-1  1.93e-1  0.53  4.46e-4  9.06e-4
 HG_U133_Plus2  211125_x_at  0.47  6.23e-3  1.34e-2  0.40  6.57e-2  9.18e-2
 Stanford  7847  -0.49  2.81e-1  4.83e-1  0.01  9.82e-1  9.92e-1
 Agilent_HS_21.6K  3145  0.05  6.05e-1  7.56e-1  0.06  4.97e-1  6.45e-1
 Agilent_HS_21.6K  4942  0.03  7.46e-1  8.52e-1  0.06  4.87e-1  6.37e-1
 Agilent_HS_21.6K  5745  0.03  4.42e-1  6.24e-1  0.03  3.31e-1  4.90e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205914_s_at  0.25  4.03e-1  9.02e-1  0.06  7.71e-1  1.00e+0
 HG_U133A  205915_x_at  -0.27  2.79e-1  8.68e-1  -0.01  9.39e-1  1.00e+0
 HG_U133A  210781_x_at  -0.27  2.07e-1  8.33e-1  0.04  7.94e-1  1.00e+0
 HG_U133A  210782_x_at  -0.06  8.64e-1  9.89e-1  0.18  4.60e-1  1.00e+0
 HG_U133A  211125_x_at  -0.01  9.78e-1  9.99e-1  0.04  8.85e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37134_f_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 37135_f_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205914_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205915_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210781_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210782_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211125_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205914_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205915_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210781_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210782_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211125_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 7847    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 3145    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 4942    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 5745    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
nmdar1 tumors We have examined the immunohistochemical expression of BDNF, full-length TrkB receptor and the NMDAR subunit 1 and subunit 2A/B proteins (NMDAR1 and NMDAR2A/B) in glioneuronal tumors (gangliogliomas, GG, n = 40; dysembryoplastic neuroepithelial tumors, DN 11355310 Human
nmdar1 dysembryoplastic neuroepithelial tumors We have examined the immunohistochemical expression of BDNF, full-length TrkB receptor and the NMDAR subunit 1 and subunit 2A/B proteins (NMDAR1 and NMDAR2A/B) in glioneuronal tumors (gangliogliomas, GG, n = 40; dysembryoplastic neuroepithelial tumors, DN 11355310 Human
nmdar1 tumors In addition, since these neurons contain both NMDAR1 and NMDAR2A/B subunits, the BDNF-TrkB pathway may also contribute through a modulation of glutamatergic transmission to the intrinsic epileptogenicity of glioneuronal tumors. 11355310 Human
nr1 embryonal carcinoma However, we also found that two nonneuronal cell lines (C6 glioma and P19 embryonal carcinoma) that lack NRSF/REST-binding activity, manifest only small amounts of NR1 mRNA compared to neuronal cell lines (PC12 pheochromocytoma and neuronally differentiat 10640675 Human
nr1 c6 glioma However, we also found that two nonneuronal cell lines (C6 glioma and P19 embryonal carcinoma) that lack NRSF/REST-binding activity, manifest only small amounts of NR1 mRNA compared to neuronal cell lines (PC12 pheochromocytoma and neuronally differentiat 10640675 Rat
nmdar1 neuroblastoma NG108-15 neuroblastoma cells differentiated with 0.1 M of all-trans retinoic acid (RA) were processed for immunohistochemical analysis using polyclonal antisera against the delta opioid receptor (DOR) and the N-Methyl-D-Aspartate receptor (NMDAR1) to dete 8981241 Human
nmdar1 glioma In the present study, we provide immunochemical evidence for the expression of both the NMDAR1 and NMDAR2A/B receptor subunits in PC12W cells, that express only the angiotensin type-2 (AT2) receptor subtype, and in NG108-15 (NG108) cells, a murine neurobl 9332716 Mouse
nmdar1 murine neuroblastoma In the present study, we provide immunochemical evidence for the expression of both the NMDAR1 and NMDAR2A/B receptor subunits in PC12W cells, that express only the angiotensin type-2 (AT2) receptor subtype, and in NG108-15 (NG108) cells, a murine neurobl 9332716 Mouse
nr1 oligodendroglioma The NR1 positivity and the recently reported generation of action potentials in oligodendroglioma cells are consistent with neuronal differentiation and may contribute to the high epileptogenic potential of oligodendrogliomas. 9386775 Human
nmdar1 glioma We determined the effects of all-trans retinoic acid (RA) on the levels of delta opioid receptor (DOR) mRNA and N-Methyl-D-Aspartate receptor (NMDAR1) mRNA in neuroblastoma x glioma hybrid cells (NG108-15) by use of quantitative solution hybridization ass 8866697 Human
nmdar1 neuroblastoma We determined the effects of all-trans retinoic acid (RA) on the levels of delta opioid receptor (DOR) mRNA and N-Methyl-D-Aspartate receptor (NMDAR1) mRNA in neuroblastoma x glioma hybrid cells (NG108-15) by use of quantitative solution hybridization ass 8866697 Human
nr1 rat insulinoma Rat insulinoma cells expressed GluR5 and KA-2 non-NMDA and NR1 and NR2D NMDA GluR mRNAs. 8915893 Rat
nr1 human neuroblastoma The four human neuroblastoma lines all expressed mRNAs encoding GluR2-4, 6, 7 and KA-1 non-NMDA and NR1 NMDA GluR, and the three human medulloblastoma cell lines all expressed mRNAs encoding GluR1, 6 and KA-1, but none of the NMDA GluRs. 8915893 Human
nr1 embryonic carcinoma Following neuronal differentiation of P19 embryonic carcinoma cells, the NR1 transcription rate and mRNA level were significantly increased, while the nuclear level of the repressor RE1 silencing transcription factor (REST)/neuron-restriction silencer fac 12887696 Human
nmdar1 necrosis The tissue analysis demonstrated that following kindling induced seizures, 1) hippocampal and extrahippocampal neurons die, 2) some neurons die through apoptosis, others through necrosis, and 3) some of the diseased neurons express somatostatin, others th 9150799 Human
nmdar1 necrosis The possible implications of molecular mechanism underlying the neurotoxicity in association with necrosis, apoptosis, nitric oxide synthases (nNos and iNOS) and glutamate receptors (NMDAR1 and GluR2) related genes and their expression in DA-induced neuro 15325963 Human
nmdar1 oral squamous-cell carcinoma (oscc) Therefore, NMDA receptor 1 (NMDAR1) expression along with its clinical significance was examined in patients with oral squamous cell carcinoma (OSCC). 15357673 Human
nmdar1 tumour METHODS: Eighty-one tumour specimens from OSCC patients were used to determine the NMDAR1 expression level by immunohistochemical staining. 15357673 Human
nmdar1 tumour NMDAR1 expression was significantly associated with a lymph node metastasis (P = 0.008), the tumour size (P < 0.001), and the cancer stage (P = 0.034). 15357673 Human
nmdar1 cancer NMDAR1 expression was significantly associated with a lymph node metastasis (P = 0.008), the tumour size (P < 0.001), and the cancer stage (P = 0.034). 15357673 Human
nmdar1 lymph-node metastasis NMDAR1 expression was significantly associated with a lymph node metastasis (P = 0.008), the tumour size (P < 0.001), and the cancer stage (P = 0.034). 15357673 Human
nmdar1 tumours The patients whose tumours expressed NMDAR1 had a significantly poorer survival than the patients who were NMDAR1-negative (log-rank = 6.45, d.f. = 1, P = 0.011). 15357673 Human
nr1 medulloblastoma The four human neuroblastoma lines all expressed mRNAs encoding GluR2-4, 6, 7 and KA-1 non-NMDA and NR1 NMDA GluR, and the three human medulloblastoma cell lines all expressed mRNAs encoding GluR1, 6 and KA-1, but none of the NMDA GluRs. 8915893 Human
nr1 oligodendrogliomas To better characterize and distinguish the two entities we examined 25 oligodendrogliomas and 16 DNT immunohistochemically for the presence of the proliferation-associated Ki-67 antigen and the following neural antigens: the alpha 1 subunit of the GABAA r 9386775 Human
nr1 oligodendrogliomas The NR1 positivity and the recently reported generation of action potentials in oligodendroglioma cells are consistent with neuronal differentiation and may contribute to the high epileptogenic potential of oligodendrogliomas. 9386775 Human
nr1 necrosis Neurons pretreated with BDNF exhibited increased levels of the NMDA receptor subunits NR1 and NR2A, which was associated with increased calcium responses to NMDA and vulnerability to excitotoxic necrosis and reduced vulnerability to apoptosis. 10686066 Human
nr1 pd At a cellular level, a subpopulation of small and medium neurons in the superficial layers of the prefrontal cortex of the PD group showed a decreased expression of NMDA NR1 mRNA, with the maximal decrease in cortical layer IV. 10340300 Human
nr1 pd In the striatum, levels of glutamate binding to the NMDA receptor detected by receptor autoradiodgraphy were significantly reduced in the PD group, while no change could be detected at a macroscopical level in NMDA NR1 mRNA expression. 10340300 Human
nr1 pd Consequently, we suggest that the important decrease in agonist binding to the NMDA receptor observed in this study in the caudate and putamen of PD brains, in the absence of any major change in NMDA NR1 mRNA levels might reflect the degeneration of pre-s 10340300 Human
nr1 pd (3)H-Ro 25-6981 binding to the NR1/NR2B NMDA receptor was increased in the putamen of PD patients experiencing motor complications compared to those who did not (+53%) and compared to controls (+18%) whereas binding remained unchanged in the caudate nucle 14678757 Human
nr1 pd Caudate and putamen (3)H-CGP39653 binding to NR1/NR2A NMDA receptor and NR1 subunit mRNA levels measured by in situ hybridization were unchanged in subgroups of PD patients compared to controls. 14678757 Human
nr1 pd The decreased NR1 expression may be a compensatory response to overactive glutamatergic inputs, which appear to occur in response to striatal dopamine denervation in animal models of PD. 15081590 others

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