IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ANAPC2 Ensembl ENSG00000176248 Chromosome 9 Start 139189057 End 139202878
Description Anaphase-promoting complex subunit 2 (APC2)(Cyclosome subunit 2) [Source:UniProtKB/Swiss-Prot;Acc:Q9UJX6]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 19989
     Entrez Gene : 29882
     UCSC : uc004clr.1
     GeneCards : 19989
     RefSeq : NM_013366
     CCDS : CCDS7033.1
     Uniprot : Q9UJX6
     Interpro : Q9UJX6
     OMIM : 606946
     GeneTests : ANAPC2
     CGAP : ANAPC2
     PMID : 11739784

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  218555_at  -0.20  7.06e-4  1.32e-3  -2.86  3.16e-75  1.15e-74
 HG_U133_Plus2  218555_at  0.19  8.42e-2  1.32e-1  0.73  2.90e-8  1.03e-7
 Agilent_HS_21.6K  19413  -0.02  6.75e-1  8.06e-1  -0.00  9.70e-1  9.84e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  218555_at  0.01  9.75e-1  9.99e-1  0.06  6.93e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133A - 218555_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 218555_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 19413    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
apc2 tumor These results are consistent with the hypothesis that the abnormal expression of genes involved in maintaining the mitotic spindle checkpoint and genomic stability, e.g., hBUB3, hZW10, and APC2, contribute to the molecular pathogenesis and tumor progressi 12036940 Human
apc2 adenocarcinoma of the lung These results are consistent with the hypothesis that the abnormal expression of genes involved in maintaining the mitotic spindle checkpoint and genomic stability, e.g., hBUB3, hZW10, and APC2, contribute to the molecular pathogenesis and tumor progressi 12036940 Human
apc2 tumour Here, we report that the tumour suppressor homologue APC2 and its binding partner Armadillo both play roles in spindle anchoring during the syncytial mitoses of early Drosophila embryos. 11584277 Human
apc2 adenomatous polyposis coli A second adenomatous polyposis coli (APC)-like gene, APC2/APCL, was recently described and localized to chromosome 19. 11691822 Human
apc2 cancers We have fine mapped APC2 to a small region of chromosome 19p13.3 containing markers D19S883 and WI-19632, a region commonly lost in a variety of cancers, particularly ovarian cancer. 11691822 Human
apc2 ovarian cancer We have fine mapped APC2 to a small region of chromosome 19p13.3 containing markers D19S883 and WI-19632, a region commonly lost in a variety of cancers, particularly ovarian cancer. 11691822 Human
apc2 ovarian cancers Interphase fluorescence in situ hybridization analysis revealed an APC2 allelic imbalance in 19 of 20 ovarian cancers screened and indicates that APC2 could be a potential tumor suppressor gene in ovarian cancer. 11691822 Human
apc2 tumor Interphase fluorescence in situ hybridization analysis revealed an APC2 allelic imbalance in 19 of 20 ovarian cancers screened and indicates that APC2 could be a potential tumor suppressor gene in ovarian cancer. 11691822 Human
apc2 ovarian cancer Interphase fluorescence in situ hybridization analysis revealed an APC2 allelic imbalance in 19 of 20 ovarian cancers screened and indicates that APC2 could be a potential tumor suppressor gene in ovarian cancer. 11691822 Human
apc2 ovarian cancer When overexpressed in SKOV3 ovarian cancer cells, which express low levels of APC2, exogenous APC2 localized to the Golgi apparatus, actin-containing structures, and occasionally to microtubules. 11691822 Human
apc2 lung adenomas Analysis yielded 20 novel genes differentially expressed in both lung adenomas and ACs versus normal lungs, including the tumor suppressor APC2 and the oncogene Ros 1. 14647414 Human
apc2 tumor Analysis yielded 20 novel genes differentially expressed in both lung adenomas and ACs versus normal lungs, including the tumor suppressor APC2 and the oncogene Ros 1. 14647414 Human
apc2 adenomatous polyposis coli Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. 10021369 Human
apc2 tumour Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. 10021369 Human
apc2 colon carcinoma Like APC, APC2 regulates the formation of active betacatenin-Tcf complexes, as demonstrated using transient transcriptional activation assays in APC -/- colon carcinoma cells. 10021369 Human
apc2 cancer APC and APC2 may therefore have comparable functions in development and cancer. 10021369 Human
apc2 adenomatous polyposis coli Assignment of the murine adenomatous polyposis coli 2 (Apc2) gene to mouse chromosome band 10B5-C2 by in situ hybridisation. 10516441 Mouse
apc-2 adenomatous polyposis coli (apc) In order to detect the presence or absence of wild-type adenomatous polyposis coli (APC) gene protein (APC) in human colonic tissues, we immunoaffinity purified two polyclonal rabbit antibodies (APC-1 and APC-2) directed against defined epitopes in the mi 7645991 Human
apc2 tumor APC2 (previously known as APCL), a molecule closely related to the adenomatous polyposis coli (APC) tumor suppressor, can deplete cytoplasmic beta-catenin, like APC itself. 15018807 Human
apc2 adenomatous polyposis coli (apc) APC2 (previously known as APCL), a molecule closely related to the adenomatous polyposis coli (APC) tumor suppressor, can deplete cytoplasmic beta-catenin, like APC itself. 15018807 Human

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