IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene NFIB Ensembl ENSG00000147862 Chromosome 9 Start 14071847 End 14388630
Description Nuclear factor 1 B-type (Nuclear factor 1/B)(NF1-B)(NFI-B)(NF-I/B)(CCAAT-box-binding transcription factor)(CTF)(TGGCA-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:O00712]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 7785
     Entrez Gene : 4781
     UCSC : uc003zle.2
     GeneCards : 7785
     RefSeq : NM_005596
     CCDS : CCDS6474.1
     Uniprot : O00712
     Interpro : O00712
     OMIM : 600728
     GeneTests : NFIB
     CGAP : NFIB
     PMID : 7590749

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  34720_at  -0.55  7.12e-4  2.33e-3  -0.92  2.46e-5  1.13e-4
 HG_U95  40642_at  -0.79  6.03e-9  6.43e-8  -0.82  6.05e-6  3.21e-5
 HG_U95  41229_at  -0.70  4.76e-8  4.17e-7  -0.79  7.16e-6  3.73e-5
 HG_U95  462_at  0.30  1.40e-1  2.19e-1  0.26  2.52e-1  3.51e-1
 HG_U95  463_g_at  0.06  6.00e-1  6.93e-1  0.04  7.90e-1  8.50e-1
 HG_U133A  209289_at  -1.03  2.02e-29  3.02e-28  -5.02  3.22e-94  1.87e-93
 HG_U133A  209290_s_at  -0.87  4.26e-16  2.49e-15  0.45  4.65e-12  6.02e-12
 HG_U133A  211466_at  0.29  1.59e-1  1.99e-1  -1.25  2.42e-6  2.84e-6
 HG_U133A  211467_s_at  -0.50  1.80e-5  4.05e-5  -2.39  1.81e-38  3.43e-38
 HG_U133A  213029_at  -0.89  9.27e-28  1.23e-26  -1.61  4.40e-80  1.79e-79
 HG_U133A  213032_at  -0.57  2.23e-7  6.14e-7  -3.08  3.06e-71  1.02e-70
 HG_U133A  213033_s_at  -0.70  2.05e-4  4.08e-4  1.91  1.25e-32  2.17e-32
 HG_U133_Plus2  209289_at  -0.68  7.34e-10  5.22e-9  -0.97  7.60e-16  6.57e-15
 HG_U133_Plus2  209290_s_at  -0.48  1.28e-5  4.79e-5  -0.67  1.03e-8  3.87e-8
 HG_U133_Plus2  211466_at  -0.09  7.03e-1  7.69e-1  -1.52  3.33e-10  1.51e-9
 HG_U133_Plus2  211467_s_at  -0.81  2.83e-5  9.98e-5  -0.85  2.04e-6  5.74e-6
 HG_U133_Plus2  213029_at  -0.93  2.27e-17  4.03e-16  -1.23  2.87e-21  4.60e-20
 HG_U133_Plus2  213032_at  -0.37  3.03e-3  7.05e-3  -0.81  9.68e-9  3.66e-8
 HG_U133_Plus2  213033_s_at  -0.69  2.39e-3  5.70e-3  -1.35  5.19e-7  1.58e-6
 HG_U133_Plus2  230291_s_at  -1.44  3.93e-15  5.41e-14  -2.03  3.17e-18  3.60e-17
 HG_U133_Plus2  230791_at  -0.56  5.71e-4  1.56e-3  -1.41  2.68e-15  2.18e-14
 HG_U133_Plus2  233304_at  -1.13  9.57e-6  3.67e-5  -2.00  1.75e-12  1.04e-11
 Stanford  18959  -0.36  4.72e-1  6.58e-1  -0.66  7.26e-2  2.19e-1
 Agilent_HS_21.6K  7339  -0.09  3.28e-1  5.16e-1  -0.29  1.86e-4  1.34e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  209289_at  0.15  5.97e-1  9.52e-1  0.21  2.69e-1  1.00e+0
 HG_U133A  209290_s_at  0.34  2.97e-1  8.75e-1  0.15  4.70e-1  1.00e+0
 HG_U133A  211466_at  -0.58  3.77e-1  8.96e-1  0.36  3.64e-1  1.00e+0
 HG_U133A  211467_s_at  0.13  7.36e-1  9.74e-1  -0.25  4.92e-1  1.00e+0
 HG_U133A  213029_at  0.11  6.78e-1  9.66e-1  0.03  8.55e-1  1.00e+0
 HG_U133A  213032_at  0.02  9.43e-1  9.97e-1  0.14  5.61e-1  1.00e+0
 HG_U133A  213033_s_at  1.01  1.25e-1  7.93e-1  0.05  8.81e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 34720_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 40642_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 41229_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 462_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 463_g_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209289_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209290_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211466_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211467_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 213029_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 213032_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 213033_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209289_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209290_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211466_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211467_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 213029_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 213032_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 213033_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 230291_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 230791_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 233304_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 18959    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 7339    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
nfib squamous cell carcinoma of the esophagus A novel amplicon at 9p23 - 24 in squamous cell carcinoma of the esophagus that lies proximal to GASC1 and harbors NFIB. 11346465 Human
nfib pleomorphic adenomas Identification of NFIB as recurrent translocation partner gene of HMGIC in pleomorphic adenomas. 9484777 Human
nfib adenoma 3'-RACE analysis of a primary adenoma with an apparently normal karyotype revealed an HMGIC fusion transcript containing ectopic sequences derived from the human NFIB gene, previously mapped to chromosome band 9p24.1. 9484777 Human
nfib pleomorphic adenomas Since the chromosome segment 9p12-24 is repeatedly involved as translocation partner of chromosome 12q13-15 in pleomorphic adenomas, we tested whether NFIB might be a recurrent partner of HMGIC. 9484777 Human
nfib adenoma RT-PCR analysis of a second adenoma with an ins(9;12)(p23;q12q15) as the sole anomaly, revealed that also in this tumor an HMGIC/NFIB hybrid transcript was present. 9484777 Human
nfib tumor RT-PCR analysis of a second adenoma with an ins(9;12)(p23;q12q15) as the sole anomaly, revealed that also in this tumor an HMGIC/NFIB hybrid transcript was present. 9484777 Human
nfib tumors The reciprocal NFIB/HMGIC fusion transcript, however, could not be detected in any of these tumors. 9484777 Human
nfib tumors Nucleotide sequence analysis of the fusion transcripts indicated that the genetic aberration in both tumors resulted in the replacement of a carboxy-terminal segment of HMGIC by the last five amino acids of NFIB. 9484777 Human
nfib pleomorphic adenomas In conclusion, our results reveal the recurrent involvement of the NFIB gene as translocation partner gene of HMGIC in pleomorphic adenomas. 9484777 Human
nfib myeloproliferative disorders Decreased expression of c-MPL protein in platelets, increased expression of polycythemia rubra vera 1 (PRV-1) and nuclear factor I-B (NFIB) mRNA in granulocytes, and loss of heterozygosity on chromosome 9p (9pLOH) were described as molecular markers for m 12730106 Human

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