IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene RPS6 Ensembl ENSG00000137154 Chromosome 9 Start 19366254 End 19385742
Description 40S ribosomal protein S6 (Phosphoprotein NP33) [Source:UniProtKB/Swiss-Prot;Acc:P62753]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 10429
     Entrez Gene : 6194
     UCSC : uc003znv.1
     GeneCards : 10429
     RefSeq : NM_001010
     CCDS : CCDS6492.1
     Uniprot : P62753
     Interpro : P62753
     OMIM : 180460
     GeneTests : RPS6
     CGAP : RPS6
     PMID : 1577483

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  35125_at  0.10  1.62e-1  2.46e-1  0.21  3.76e-2  7.21e-2
 HG_U133A  200081_s_at  0.22  1.75e-6  4.40e-6  -0.86  4.16e-60  1.12e-59
 HG_U133A  201254_x_at  -0.04  2.73e-1  3.24e-1  -2.54  8.65e-130  1.42e-128
 HG_U133A  209134_s_at  0.02  4.85e-1  5.39e-1  -11.26  2.45e-239  1.82e-235
 HG_U133A  211690_at  0.00  9.71e-1  9.76e-1  3.64  1.46e-96  8.97e-96
 HG_U133_Plus2  200081_s_at  -0.04  4.56e-1  5.45e-1  -0.19  1.85e-3  3.40e-3
 HG_U133_Plus2  201254_x_at  -0.05  1.11e-1  1.68e-1  -0.07  8.32e-2  1.14e-1
 HG_U133_Plus2  209134_s_at  0.03  4.70e-1  5.58e-1  0.09  4.01e-2  5.85e-2
 HG_U133_Plus2  211690_at  -0.32  3.96e-2  6.87e-2  -0.36  3.35e-2  4.95e-2
 HG_U133_Plus2  238156_at  -0.64  1.71e-7  8.74e-7  -0.89  8.11e-10  3.50e-9
 Stanford  92  0.76  4.84e-2  1.52e-1  0.02  9.58e-1  9.82e-1
 Stanford  22157  0.52  3.00e-1  5.03e-1  0.44  3.80e-1  6.17e-1
 Stanford  22688  0.27  3.97e-1  5.94e-1  -0.01  9.63e-1  9.84e-1
 Stanford  22870  -0.39  3.97e-1  5.94e-1  -0.95  4.64e-2  1.62e-1
 Agilent_HS_21.6K  16590  0.32  1.30e-4  1.50e-3  0.29  7.73e-5  6.42e-4

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  200081_s_at  0.15  5.25e-1  9.34e-1  -0.03  8.44e-1  1.00e+0
 HG_U133A  201254_x_at  0.15  4.15e-1  9.07e-1  0.00  9.75e-1  1.00e+0
 HG_U133A  209134_s_at  0.12  5.14e-1  9.34e-1  -0.01  9.52e-1  1.00e+0
 HG_U133A  211690_at  0.31  2.19e-1  8.42e-1  0.09  7.50e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 35125_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 200081_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201254_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209134_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211690_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 200081_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201254_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209134_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211690_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 238156_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 92    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 22157    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 22688    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 22870    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 16590    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ribosomal protein s6 ascites hepatoma Heat shock, protein synthesis and ribosomal protein S6 phosphorylation in vitro in Yoshida AH 130 ascites hepatoma cells. 2852063 Human
ribosomal protein s6 human hepatoma Injection of this inhibitory antibody resulted in a decreased ability of insulin to stimulate the uptake of 2-deoxyglucose in Chinese hamster ovary cells and freshly isolated rat adipocytes, ribosomal protein S6 phosphorylation in CHO cells, and glycogen 3540958 Human
ribosomal protein s6 chronic myelogenous leukemia Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin. 14522890 Human
ribosomal protein s6 ascites tumor Protein synthesis, ribosomal protein S6 phosphorylation in vitro and the effects of amiloride: SDS gel electrophoresis studies in the Yoshida ascites tumor (AH 130) grown in vivo. 3022947 Rat
ribosomal protein s6 ascites hepatoma The present experiments support the hypothesis that the regulation of protein synthesis is not tightly coupled to phosphorylation-dephosphorylation cycles, at least of ribosomal protein S6, in cells characterized by a rather uncontrolled growth such as th 3022947 Rat
ribosomal protein s6 hepatoma Other studies utilizing microinjection of antibodies to inhibit the receptor kinase have extended this conclusion to include a critical role for the receptor kinase in insulin's ability to stimulate ribosomal protein S6 phosphorylation in CHO cells, 3472760 Human
ribosomal protein s6 hepatoma The relative abilities of insulin and the phorbol ester tumor promoter 12-O-tetradecanoyl phorbol 13-acetate (TPA) to lead to the phosphorylation of ribosomal protein S6 in vivo were compared in a Reuber H35 hepatoma cell line shown previously to be highl 3156132 Human
ribosomal protein s6 tumour Ribosomal protein S6 phosphorylation and morphological changes in response to the tumour promoter 12-O-tetradecanoylphorbol 13-acetate in primary human tumour cells, established and transformed cell lines. 2996613 Human
ribosomal protein s6 tumour The phosphorylation of ribosomal protein S6 in fibroblasts, primary human tumour cells, established and SV40-transformed human cell lines was compared after the addition of 12-O-tetradecanoylphorbol 13-acetate (TPA). 2996613 Human
ribosomal protein s6 hepatoma Tumor-promoting phorbol esters stimulate the phosphorylation of ribosomal protein S6 in quiescent Reuber H35 hepatoma cells. 6319390 Human
ribosomal protein s6 tumor We have analyzed the phosphorylation of the ribosomal protein S6 in several cultures of normal cells and cells transformed with RNA or DNA tumor viruses. 6328026 NA
ribosomal protein s6 melanoma Insulin-mediated phosphorylation of ribosomal protein S6 in mouse melanoma cells and melanoma x fibroblast hybrid cells in relation to cell proliferation. 6347262 Human
ribosomal protein s6 melanoma The possible role of insulin-mediated phosphorylation of ribosomal protein S6 in the control of cell proliferation was examined in insulin-unresponsive mouse melanoma calls (PG19) and insulin-responsive melanoma x fibroblast clone 100A. 6347262 Human
ribosomal protein s6 meningioma Influence of hyperthermia on the phosphorylation of ribosomal protein S6 from human skin fibroblasts and meningioma cells. 6617858 Human
ribosomal protein s6 ehrlich ascites tumor Enhanced phosphorylation of ribosomal protein s6 and other cytoplasmic proteins after mengovirus infection of Ehrlich ascites tumor cells. 208946 Human
ribosomal protein s6 ehrlich ascites tumor After mengovirus infection of Ehrlich ascites tumor cells, an increased incorporation of radioactive phosphate into ribosomal protein S6 was detected. 208946 Human
ribosomal protein s6 epidermoid carcinoma Herpes simplex virus type-1-induced stimulation of ribosomal protein S6 phosphorylation is inhibited in neomycin-treated human epidermoid carcinoma 2 cells and in ras-transformed cells. 2174778 Human
rps6 tumor The mammalian RPS6 gene, homolog of the Drosophila air8 tumor suppressor gene: is it an oncosuppressor gene? 8600571 Human
rps6 hepatoma In mouse hepatoma cells (BWTG3), the Rps6 gene is hemizygously deleted but the remaining copy shows no sequence anomaly in the coding region, indicating that Rps6 is not oncosuppressor and that another gene acting as an oncosuppressor is located in its vi 8600571 Mouse
rps6 human tumor In human tumor cells, the RPS6 gene is retained in cells showing deletion of the near-by gene, IFNB. 8600571 Human
ribosomal protein s6 t-47d human breast cancer We have cloned a cDNA for ribosomal protein S6 from T-47D human breast cancer cells by immunoscreening a lambda gt11 expression library with antibody raised against the mitochondrial Ca(2+)-binding ATPase inhibitor protein (CaBI) of bovine heart mitochond 1837589 Human
ribosomal protein s6 tumour The extent of phosphorylation of ribosomal protein S6 in the livers of mice carrying the Krebs II ascites tumour has been examined by two-dimensional gel electrophoresis. 7260893 Human
ribosomal protein s6 ehrlich ascites tumor Phosphorylation of ribosomal protein S6 in the Ehrlich ascites tumor cell. 7317434 Human
ribosomal protein s6 human tumour Ribosomal protein S6 phosphorylation and morphological changes in response to the tumour promoter 12-O-tetradecanoylphorbol 13-acetate in primary human tumour cells, established and transformed cell lines. 2996613 Human
ribosomal protein s6 human tumour The phosphorylation of ribosomal protein S6 in fibroblasts, primary human tumour cells, established and SV40-transformed human cell lines was compared after the addition of 12-O-tetradecanoylphorbol 13-acetate (TPA). 2996613 Human
ribosomal protein s6 breast cancer Several autoantigens including annexin XI-A, the p80 subunit of the Ku antigen, ribosomal protein S6, and other unknown autoantigens could significantly discriminate between breast cancer and non-cancer control sera. 15289310 Human
ribosomal protein s6 dcis In addition, partial sequences identical to annexin XI-A, nucleolar protein interacting with the forkhead-associated (FHA) domain of pKi-67, the KIAA1671 gene product, ribosomal protein S6, cyclin K, elongation factor-2, Grb2-associated protein 2, and oth 15289310 Human
ribosomal protein s6 breast cancer In addition, partial sequences identical to annexin XI-A, nucleolar protein interacting with the forkhead-associated (FHA) domain of pKi-67, the KIAA1671 gene product, ribosomal protein S6, cyclin K, elongation factor-2, Grb2-associated protein 2, and oth 15289310 Human
ribosomal protein s6 lung cancer D.m. L27a is closely related to the mammalian protein that has been found differentially expressed in lung cancer tissues and therefore could be involved in the control of cell proliferation such as the ribosomal protein S6. 15560371 Human
rps6 tumor Immunofluorescent analysis of tumor vasculature from BMK1-knockout and control animals revealed a strong correlation between the presence of BMK1 and the phosphorylation of rpS6 in tumor-associated endothelial cells of blood vessels. 16140937 Human

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