IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SMARCA2 Ensembl ENSG00000080503 Chromosome 9 Start 2005342 End 2183624
Description Probable global transcription activator SNF2L2 (EC 3.6.1.-)(ATP-dependent helicase SMARCA2)(SNF2-alpha)(SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2)(hBRM) [Source:UniProtKB/Swiss-Prot;Acc:P51531]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11098
     Entrez Gene : 6595
     UCSC : uc003zhc.2
     GeneCards : 11098
     RefSeq : NM_003070
     CCDS : CCDS34977.1
     Uniprot : P51531
     Interpro : P51531
     OMIM : 600014
     GeneTests : SMARCA2
     CGAP : SMARCA2
     PMID : 8012116

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40961_at  -0.88  1.88e-12  3.83e-11  -0.48  1.13e-2  2.58e-2
 HG_U95  40962_s_at  -0.79  1.48e-8  1.44e-7  -0.25  2.07e-1  2.98e-1
 HG_U133A  206542_s_at  -0.79  5.00e-20  3.93e-19  -1.90  6.57e-51  1.52e-50
 HG_U133A  206543_at  0.17  2.58e-1  3.08e-1  1.84  7.22e-26  1.14e-25
 HG_U133A  206544_x_at  -0.52  1.70e-5  3.85e-5  -0.90  1.08e-15  1.48e-15
 HG_U133A  212257_s_at  -0.19  2.37e-3  4.08e-3  -0.42  4.85e-9  5.99e-9
 HG_U133A  212258_s_at  -0.61  3.54e-6  8.64e-6  3.84  3.83e-92  2.10e-91
 HG_U133A  217707_x_at  -1.04  4.20e-39  1.09e-37  0.31  1.22e-3  1.35e-3
 HG_U133_Plus2  206542_s_at  -0.85  3.83e-19  8.28e-18  -0.40  1.40e-4  3.07e-4
 HG_U133_Plus2  206543_at  -0.35  8.37e-2  1.32e-1  -0.05  7.80e-1  8.15e-1
 HG_U133_Plus2  206544_x_at  -0.81  7.56e-7  3.49e-6  -0.10  4.89e-1  5.49e-1
 HG_U133_Plus2  212257_s_at  -0.33  1.51e-2  2.95e-2  0.18  1.48e-1  1.92e-1
 HG_U133_Plus2  212258_s_at  0.53  1.23e-3  3.13e-3  0.56  2.57e-3  4.63e-3
 HG_U133_Plus2  217707_x_at  -0.52  3.18e-6  1.33e-5  0.13  2.70e-1  3.27e-1
 HG_U133_Plus2  228926_s_at  0.12  4.72e-1  5.61e-1  0.89  2.40e-6  6.68e-6
 Stanford  17437  -0.80  4.14e-3  3.62e-2  -0.55  1.38e-1  3.37e-1
 Agilent_HS_21.6K  4034  -0.20  2.34e-2  8.51e-2  -0.21  8.61e-2  1.86e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206542_s_at  0.55  4.07e-2  7.08e-1  0.07  7.34e-1  1.00e+0
 HG_U133A  206543_at  -0.18  7.90e-1  9.82e-1  0.03  9.38e-1  1.00e+0
 HG_U133A  206544_x_at  0.73  2.11e-1  8.38e-1  -0.08  8.28e-1  1.00e+0
 HG_U133A  212257_s_at  0.16  5.12e-1  9.33e-1  0.03  8.47e-1  1.00e+0
 HG_U133A  212258_s_at  -0.37  3.37e-1  8.87e-1  -0.27  4.25e-1  1.00e+0
 HG_U133A  217707_x_at  0.47  1.02e-1  7.76e-1  0.08  6.81e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40961_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 40962_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206542_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206543_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206544_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 212257_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 212258_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 217707_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206542_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206543_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206544_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 212257_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 212258_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 217707_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 228926_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 17437    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 4034    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
hbrm pancreatic carcinoma In this study, we identified the first cell line negative for the BAF57 protein as well as a pancreatic carcinoma cell line negative for both the BRG-1 and hBRM proteins. 11147808 Human
hbrm human synovial sarcoma Furthermore, association of SYT-SSX1 with the chromatin remodeling factor hBRM/hSNF2 alpha, which regulates transcription, was demonstrated in both SYT-SSX1-expressing 3Y1 cells and in the human synovial sarcoma cell line HS-SY-II. 11274403 Human
hbrm cancer These data clearly demonstrate transforming activity of human oncogene SYT-SSX1 and also involvement of chromatin remodeling factor hBRM/hSNF2 alpha in human cancer. 11274403 Human
hbrm tumour SWI2/SNF2 is an ATPase whose homologues, BRG1 and hBRM, mediate cell-cycle arrest; the SNF5 homologue, INI1/hSNF5, appears to be a tumour suppressor. 10319872 Human
hbrm cancer The proto-oncoprotein SYT, involved in the unique translocation t(X;18) found in synovial sarcoma, is known to interact with human BRM (hBRM), thus providing a link between chromatin remodelling factors and human cancer. 14603256 Human
hbrm synovial sarcoma The proto-oncoprotein SYT, involved in the unique translocation t(X;18) found in synovial sarcoma, is known to interact with human BRM (hBRM), thus providing a link between chromatin remodelling factors and human cancer. 14603256 Human
hbrm adenocarcinoma Interaction between the hBRG1/hBRM family with the pRB family likely influences cellular proliferation, as both hBRG1 and hBRM, but not mutants of these proteins unable to bind to pRB family members, inhibit the formation of drug-resistant colonies when t 8657132 Human
hbrm human tumors Mutation of BRG1, hBRM, and their associated factors, INI1 and BAF57, in primary human tumors has suggested that inactivation of human SWI/SNF (hSWI/SNF) complexes may be involved in neoplastic transformation. 16135788 Human

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