IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene MLLT3 Ensembl ENSG00000171843 Chromosome 9 Start 20334968 End 20612514
Description Protein AF-9 (ALL1 fused gene from chromosome 9 protein)(Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein)(YEATS domain-containing protein 3) [Source:UniProtKB/Swiss-Prot;Acc:P42568]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 7136
     Entrez Gene : 4300
     UCSC : uc003zoe.2
     GeneCards : 7136
     RefSeq : NM_004529
     CCDS : CCDS6494.1
     Uniprot : P42568
     Interpro : P42568
     OMIM : 159558
     GeneTests : MLLT3
     CGAP : MLLT3
     PMID : 8506309

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  35975_at  -0.28  2.53e-1  3.53e-1  -0.79  1.59e-2  3.44e-2
 HG_U133A  204917_s_at  0.00  9.82e-1  9.85e-1  -2.33  2.22e-53  5.33e-53
 HG_U133A  204918_s_at  -0.19  2.13e-2  3.16e-2  -1.25  1.68e-23  2.56e-23
 HG_U133_Plus2  1569652_at  -0.10  5.27e-1  6.13e-1  -0.82  1.41e-8  5.22e-8
 HG_U133_Plus2  204917_s_at  0.05  6.41e-1  7.15e-1  -0.07  4.94e-1  5.54e-1
 HG_U133_Plus2  204918_s_at  0.18  9.80e-2  1.51e-1  -0.31  4.84e-3  8.34e-3
 Stanford  9589  -0.63  1.71e-1  3.52e-1  -1.17  1.16e-2  7.65e-2
 Agilent_HS_21.6K  12474  0.08  1.33e-1  2.85e-1  0.02  6.89e-1  7.96e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204917_s_at  -0.17  4.27e-1  9.11e-1  0.01  9.40e-1  1.00e+0
 HG_U133A  204918_s_at  -0.00  9.96e-1  1.00e+0  0.34  2.52e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 35975_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204917_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204918_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1569652_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204917_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204918_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 9589    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 12474    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
af9 acute myeloid leukemia (aml) The t(9;11) has been described in patients with acute myeloid leukemia (AML), and two genes [AF9 (at 9p21) and FBP17 (at 9q34)] have been cloned as fusion partners of the MLL gene. 14978793 Human
af9 leukemia Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia. 12242306 Mouse
af9 acute myeloid leukemia Chromosomal translocation t(9;11)(p22;q23) in acute myeloid leukemia fuses the MLL and AF9 genes. 12242306 Mouse
af9 acute myeloid leukemias This is analogous to the role of Mll, the murine homolog of human MLL, to which the Af9 gene fuses in acute myeloid leukemias. 12242306 Human
mllt3 human leukemias There is also conservation of the genomic structure, but not the promoter, between MLLT1 and MLLT3/AF9, a homologous gene that is also an MLL translocation partner in human leukemias with a predominant myeloid phenotype. 12367585 Human
af9 human leukemias There is also conservation of the genomic structure, but not the promoter, between MLLT1 and MLLT3/AF9, a homologous gene that is also an MLL translocation partner in human leukemias with a predominant myeloid phenotype. 12367585 Human
af9 acute leukemias The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias. 11439343 Human
af9 acute leukemias Here, data are presented demonstrating that MPc3 also interacts with AF9, a transcriptional activator implicated in the development of acute leukemias. 11439343 Human
af9 leukemias The carboxy-terminus of AF9 is fused to the MLL protein in leukemias characterized by t(9;11)(p22;q23) chromosomal translocations. 11439343 Human
af-9 acute leukemia Using in situ immunofluorescence microscopy, we addressed the interrelationships of modifications in nuclear morphology with the intranuclear distribution of leukemia-related regulatory factors (including ALL-1, PML, and AF-9) in cells from patients with 10679814 Human
af-9 leukemias Thus, the cellular AF-9 gene is alternatively expressed in a manner that reflects the presence of translocated, functionally active (oncogenic) AF-9 sequences in leukemias. 10834932 Mouse
af-9 acute leukemias GAS41 is related to the AF-9 and ENL proteins, which are putative transcription factors found as fusion proteins in some acute leukemias. 10913114 Human
af9 myeloid leukemias Two of these partners, ENL and AF9, code for proteins that are highly similar to each other and as fusions with HRX induce myeloid leukemias in mice as demonstrated by retroviral gene transfer and knock-in experiments, respectively. 9418860 Mouse
af9 acute myeloid leukemia (aml) The translocation t(9;11)(p22;q23), which results in the fusion of MLL to AF9, is the most common of the 11q23 chromosomal abnormalities observed in de novo acute myeloid leukemia (AML), in therapy related leukemia (t-AML), and rarely in acute lymphoblast 9331569 Human
af9 acute lymphoblastic leukemia (all) The translocation t(9;11)(p22;q23), which results in the fusion of MLL to AF9, is the most common of the 11q23 chromosomal abnormalities observed in de novo acute myeloid leukemia (AML), in therapy related leukemia (t-AML), and rarely in acute lymphoblast 9331569 Human
af9 therapy-related leukemia The translocation t(9;11)(p22;q23), which results in the fusion of MLL to AF9, is the most common of the 11q23 chromosomal abnormalities observed in de novo acute myeloid leukemia (AML), in therapy related leukemia (t-AML), and rarely in acute lymphoblast 9331569 Human
af9 leukemia Our data, when combined with those of others, suggest that the fusion point within the AF9 gene, and thus the amount of AF9 material included in the MLL-AF9 fusion gene product, may influence the phenotype of the resulting leukemia. 9331569 Human
af9 leukemias In infantile leukemias and therapy-related leukemias, the MLL gene is frequently found to be disrupted and fused to various translocation partner genes, such as AF4/FEL, LTG9/AF9 and LTG19/ENL as a result of 11q23 translocations. 9349501 Human
af9 therapy-related leukemias In infantile leukemias and therapy-related leukemias, the MLL gene is frequently found to be disrupted and fused to various translocation partner genes, such as AF4/FEL, LTG9/AF9 and LTG19/ENL as a result of 11q23 translocations. 9349501 Human
af9 acute myeloid leukemia Development of a real-time RT-PCR assay for the quantification of the most frequent MLL/AF9 fusion types resulting from translocation t(9;11)(p22;q23) in acute myeloid leukemia. 14506704 Human
mllt3 leukemia This is more evidence that the production of chimeric mRNA following the translocation of the LTG9 (MLLT3/AF9) gene at 9p22 to 11q is a critical event in this leukemia subtype. 8630974 Human
af9 leukemia This is more evidence that the production of chimeric mRNA following the translocation of the LTG9 (MLLT3/AF9) gene at 9p22 to 11q is a critical event in this leukemia subtype. 8630974 Human
af-9 acute leukemia TFG3 is significantly similar to ENL and AF-9, two proteins implicated in human acute leukemia. 8668146 Human
af-9 acute leukemia These results suggest that ENL and AF-9 proteins interact with the SNF5 component of the human SWI/SNF complex and raise the possibility that the SWI/SNF complex is involved in acute leukemia. 8668146 Human
af9 human leukemias AF9 sequences were fused into the mouse Mll gene so that expression of the Mll-AF9 fusion gene occurred from endogenous Mll transcription control elements, as in t(9;11) found in human leukemias. 8681380 Human
af9 acute leukemia The ALLI gene, located at chromosome band 11q23, is involved in acute leukemia through a series of chromosome translocations and fusion to a variety of genes, most frequently to A4 and AF9. 8618864 Human
af9 acute myeloid leukemia (aml) The translocation t(9;11)(p22;q23) is a recurring chromosomal abnormality in acute myeloid leukemia (AML) fusing two genes designated as MLL and AF9. 12619163 Human
mllt3 acute-lymphocytic leukemia MLLT3, one of the genes shown to be a translocation breakpoint partner for the acute lymphocytic leukemia (MLL) gene, has been mapped to 9p22. 8034324 Human
mllt3 leukemia MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13. 8414510 Human
mllt3 acute monocytic leukemia In the present study, we isolated chimeric cDNAs between the MLL and a gene designated MLLT3 at 9p22 from a cDNA library of an IMS-M1 cell line with a t(9;11)(p22;q23) translocation, a representative karyotypic abnormality seen in acute monocytic leukemia 8414510 Human
mllt3 leukemia The predicted MLLT3 protein demonstrated a significant homology to that of the MLLT1 gene at 19p13 involved in t(11;19) leukemia. 8414510 Human
af9 mixed-lineage leukemia The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor. 12776190 Human
af9 acute myeloid leukemia AF9 is a common MLL fusion partner in acute myeloid leukemia. 12776190 Human
af-9 treatment-related aml Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further pro 14627986 Human
af9 aml Interestingly, all of the breaks within the AF9 gene in AML patients occurred in the central AF9 exon, called Site A by others, whereas in the single ALL patient the breakpoint mapped to a more 3' region of the AF9 gene. 9331569 Human
af9 mrd The implications of MRD detection by MLL/AF9 fusion transcript quantification for the clinical management of t(9;11)-positive AML have to be determined in further studies. 14506704 Human
af9 aml The implications of MRD detection by MLL/AF9 fusion transcript quantification for the clinical management of t(9;11)-positive AML have to be determined in further studies. 14506704 Human
af9 acute myelogenous leukemia Cryptic insertion of MLL gene into 9p22 leads to MLL-MLLT3 (AF9) fusion in a case of acute myelogenous leukemia. 15188459 Human
af9 acute leukemias The AF4 protein interacts with the product of another gene, AF9, which is also fused to MLL in acute leukemias. 15269783 Human
af9 childhood all RESULTS: Of the 50 childhood ALL patients, 18 (36.0%) carried 11 types of fusion genes including E2A/PBX1, TEL/AML1, TLS/ERG, MLL/AF4, MLL/AF9, MLL/AF10, MLL/AFX, MLL/AF6, MLL/ELL, TAL1D, and HOX11, revealed by multiplex RT-PCR, and in 48 cases, 24 (57.1% 15355694 Human
af9 neoplasias Translocations between Mll and Enl or Af9 cause myeloid neoplasias, initiating in pluripotent stem cells or multipotent myeloid progenitors. 16096649 Human
the af9 gene aml Interestingly, all of the breaks within the AF9 gene in AML patients occurred in the central AF9 exon, called Site A by others, whereas in the single ALL patient the breakpoint mapped to a more 3' region of the AF9 gene. 9331569 Human
the af9 gene leukemia Our data, when combined with those of others, suggest that the fusion point within the AF9 gene, and thus the amount of AF9 material included in the MLL-AF9 fusion gene product, may influence the phenotype of the resulting leukemia. 9331569 Human
the af9 gene acute myeloid leukemias This is analogous to the role of Mll, the murine homolog of human MLL, to which the Af9 gene fuses in acute myeloid leukemias. 12242306 Human

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