IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene DOCK8 Ensembl ENSG00000107099 Chromosome 9 Start 263048 End 455255
Description Dedicator of cytokinesis protein 8 [Source:UniProtKB/Swiss-Prot;Acc:Q8NF50]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 19191
     Entrez Gene : 81704
     UCSC : uc003zgf.2
     GeneCards : 19191
     RefSeq : NM_203447
     CCDS : CCDS6440.1
     Uniprot : Q9BYJ5
     Interpro : Q9BYJ5
     OMIM : 611432
     GeneTests : DOCK8
     CGAP : DOCK8
     PMID : 11214971

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133_Plus2  225502_at  -0.90  1.62e-14  2.07e-13  -1.58  8.30e-18  8.99e-17
 HG_U133_Plus2  232842_at  -0.39  3.18e-4  9.16e-4  -0.31  1.38e-3  2.59e-3
 HG_U133_Plus2  232843_s_at  -0.94  1.33e-13  1.52e-12  -1.80  7.61e-21  1.16e-19
 HG_U133_Plus2  239027_at  -0.51  1.90e-3  4.63e-3  -1.39  1.06e-9  4.53e-9
 Agilent_HS_21.6K  19051  -0.08  3.70e-1  5.57e-1  -0.23  4.99e-3  2.04e-2

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133_Plus2 - 225502_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 232842_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 232843_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 239027_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 19051    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
dedicator of cytokinesis 8 lung cancer A homozygous deletion of the DOCK8 (dedicator of cytokinesis 8) locus at chromosome 9p24 was found in a lung cancer cell line by array-CGH analysis. 16391785 Human
dock8 human lung cancer Homozygous deletion and reduced expression of the DOCK8 gene in human lung cancer. 16391785 Human
dock8 lung cancer A homozygous deletion of the DOCK8 (dedicator of cytokinesis 8) locus at chromosome 9p24 was found in a lung cancer cell line by array-CGH analysis. 16391785 Human
dock8 lung cancer DOCK8 was expressed in a variety of human organs, including the lungs, and was also expressed in type II alveolar, bronchiolar epithelial and bronchial epithelial cells, which are considered as being progenitors for lung cancer cells. 16391785 Human
dock8 lung cancer DOCK8 expression was reduced in 62/71 (87%) primary lung cancers compared with normal lung tissue, and the reduction occurred irrespective of the histological type of lung cancer. 16391785 Human
dock8 primary lung cancers DOCK8 expression was reduced in 62/71 (87%) primary lung cancers compared with normal lung tissue, and the reduction occurred irrespective of the histological type of lung cancer. 16391785 Human
dock8 lung cancer 5-aza-2'-deoxy-cytidine and/or Trichostatin A treatments induced DOCK8 expression in lung cancer cell lines with reduced DOCK8 expression. 16391785 Human
dock8 lung cancer Therefore, epigenetic mechanisms, including DNA methylation and histone deacetylation, were indicated to be involved in DOCK8 down-regulation in lung cancer cells. 16391785 Human
dock8 breast cancer Further screening revealed homozygous deletions of the DOCK8 gene in a gastric and a breast cancer cell line. 16391785 Human
dock8 other cancers Thus, the present results suggest that genetic and epigenetic inactivation of DOCK8 is involved in the development and/or progression of lung and other cancers by disturbing such regulations. 16391785 Human

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