IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene IFNA1 Ensembl ENSG00000197919 Chromosome 9 Start 21430440 End 21431315
Description Interferon alpha-1/13 Precursor (Interferon alpha-D)(LeIF D) [Source:UniProtKB/Swiss-Prot;Acc:P01562]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 5417
     Entrez Gene : 3439
     UCSC : uc003zpd.1
     GeneCards : 5417
     RefSeq : NM_024013
     CCDS : CCDS6508.1
     Uniprot : P01562
     Interpro : P01562
     OMIM : 147660
     GeneTests : IFNA1
     CGAP : IFNA1
     PMID : 1385305

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  208344_x_at  -0.04  7.19e-1  7.58e-1  -0.62  2.14e-9  2.66e-9
 HG_U133A  208375_at  -0.05  7.16e-1  7.55e-1  -0.07  5.99e-1  6.08e-1
 HG_U133_Plus2  208344_x_at  0.79  1.82e-5  6.64e-5  1.37  8.35e-9  3.18e-8
 HG_U133_Plus2  208375_at  0.24  2.64e-1  3.49e-1  -0.07  7.77e-1  8.13e-1
 Agilent_HS_21.6K  20687  0.09  9.45e-3  4.41e-2  0.09  1.53e-1  2.83e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  208344_x_at  -0.28  4.03e-1  9.02e-1  0.27  2.56e-1  1.00e+0
 HG_U133A  208375_at  0.48  3.89e-1  8.96e-1  -0.40  1.88e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133A - 208344_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208375_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208344_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208375_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 20687    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ifn recurrent ovarian cancer The purpose of this study was to estimate the response rate of 26-h continuous infusion cyclosporine A (CSA) combined with carboplatin (CBDCA) and subcutaneous alpha-interferon (IFN), in recurrent ovarian cancer (OC), and to measure their effects on CBDCA 17362315 Human
ifn recurrent hepatocellular carcinoma A complete response was obtained by interferon (IFN) therapy for hepatitis C virus (HCV)-related advanced chronic hepatitis after curative treatment of initial and recurrent hepatocellular carcinoma (HCC). 11929181 Human
ifn-alpha primary plasma-cell leukemia Long-term disease-free survival in a primary plasma cell leukemia treated by VAD, autologous PBSC transplantation, and IFN-alpha. 12221683 Human
ifn-alpha invasive carcinoma To study the prevalence of the oncogenes c-myc, IFN-alpha; c-erbB2; H-ras codon 12, 13, and 61; c-fos; and E6/E7 oncogenes of human papillomavirus (HPV) 16 in patients with invasive carcinoma of the cervix and their prognostic significance, genomic DNA an 12366664 Human
ifn-alpha waldenstrom's macroglobulinemia IFN-alpha is an effective agent for the induction and maintenance treatment of Waldenström's macroglobulinemia patients. 12433280 Human
ifn-alpha sezary syndrome METHODS: Suppression of IL-5 production by IFN-alpha and IL-12 was assessed by comparing IL-5 production by PBMCs from patients with Sezary syndrome and eosinophilia when cultured alone or in the presence of either IFN-alpha or IL-12. 11148473 Human
ifn-alpha chronic myeloid leukemia Expression of interferon-alpha (IFN-alpha) receptor 2c at diagnosis is associated with cytogenetic response in IFN-alpha-treated chronic myeloid leukemia. 11369652 Human
ifn-alpha chronic phase cml In this study, the levels of expression of both BCR-ABL and subunit 2c of IFN-alpha receptor (IFN-alphaR2c) genes were analyzed at diagnosis in 74 patients with chronic phase CML treated with an IFN-alpha monotherapy. 11369652 Human
ifn-alpha human endometrial adenocarcinoma We observed that treatment of human endometrial adenocarcinoma cell, Ishikawa, with IFN-gamma or IFN-alpha markedly induced the expression of GBP1 mRNA. 11397834 Human
ifn stage iv follicular lymphoma Between 1984 and 1994, 204 patients with newly diagnosed Stage III or Stage IV follicular lymphoma were randomized to receive either, Chlorambucil (CB): 10 mg daily for 6 weeks, followed by a 2-week interval, with 3 subsequent 2-week treatment periods at 11437398 Human
ifn-alpha meningioma PURPOSE: In meningioma patients with postoperative residual masses, recurrent or primarily inoperable tumors, positron emission tomography (PET) with [(11)C]-L-methionine was used to evaluate treatment efficacy of IFN-alpha. 11489801 Human
ifn-alpha meningiomas No correlation was found between histopathological diagnosis (PAD) WHO grading I-III of meningiomas and response to IFN-alpha treatment. 11489801 Human
ifn breast adenocarcinoma After single-step selection of breast adenocarcinoma cells in paclitaxel, differential display and single gene analysis demonstrated that transcriptional activation of IRF9 and other IFN-responsive genes, independent of IFN, corresponded with resistance t 11522652 Human
ifn-alpha metastatic prostate cancer BACKGROUND: We determined whether treatment of metastatic prostate cancer cells with doxorubicin (DOX) and interferon-alpha (IFN-alpha) prevented the emergence of highly undifferentiated tumor cells. 11550207 Human
ifnalpha stage iv melanoma In light of the lack of impact on OS and the considerable to serious dose-dependent toxicity of IFNalpha, we do not have a clearly dose- and schedule-defined role for IFNalpha in the adjuvant setting and have no evidence for a benefit of IFNalpha in stage 11677100 Human
ifn-alpha myeloid metaplasia Large scale randomized clinical trials in PV are proposed, which should aim not only for clinical and hematological response, safety, efficacy, but should also assess toxicity, the need for phlebotomy and whether the development of progressive disease suc 10674896 Human
ifnalpha relapsed cml Successful treatment of relapsed CML after cord blood transplantation with donor leukocyte infusion IL-2 and IFNalpha. 10673686 Human
ifn laryngeal cancer Laryngeal cancer cell line HlaC79 was incubated with interferon (IFN) alpha and beta. bFGF quantification was performed by ELISA, and antiproliferative effects were determined by BrdU assay. 10679908 Human
ifn-alpha lymphoid tumor Furthermore, IFN-alpha augments the FasL-mediated cytotoxicity of normal PBMC against Fas-sensitive lymphoid tumor cells. 10866129 Human
ifn recurrent tumor In mice with curative resection, when comparison was made among control, IFN 5 x 10(5) U/kg/day, 1 x 10(6) U/kg/day, 4 x 10(6) U/kg/day, 7.5 x 10(6) U/kg/day, 1.5 x 10(7) U/kg/day, and 3 x 10(7) U/kg/day for treated groups; incidence of recurrent tumor wa 10869287 Mouse
ifn-alpha lymphomatoid papulosis CONCLUSIONS: The current results indicate that the treatment with IFN-alpha of patients with lymphomatoid papulosis alters the clinical course of the disease with fewer side effects than previous regimens; however, short term treatment does not induce sta 11013377 Human
ifn alpha hairy-cell leukemia (hcl) Recombinant human IFN alpha (rhIFN-alpha) plays an important role in the treatment of hairy cell leukemia (HCL). 11034083 Human
ifn-alpha acute leukemia We found that IFN-alpha rapidly (commonly within 4 hours) and significantly down-regulates the expression of hTERT and telomerase activity in a number of human malignant hematopoietic cell lines, primary leukemic cells from patients with acute leukemia as 11110707 Human
ifn metastatic prostate cancer Adjuvant Interferon (IFN) was given to increase tumor antigen expression and enhance localization with 131I-labeled CC49 radioimmunotherapy in a Phase II trial for hormone resistant metastatic prostate cancer. 10541372 Human
ifn-alpha primary-effusion lymphoma (pel) Primary effusion lymphoma (PEL) cell lines infected with human herpesvirus type 8 required IFN-alpha to potentiate AZT-induced apoptosis. 10554028 Human
ifnalpha systemic mastocytosis IFNalpha treatment in systemic mastocytosis. 10550562 Human
ifn-alpha recurrent tumors Interferon alpha (IFN-alpha) is indicated for methotrexate failures and recurrent tumors following TSEB therapy. 10559573 Human
ifn alpha relapsed cml The literature review identified 108 patients treated with IFN alpha as sole therapy for relapsed CML. 10100563 Human
ifn-alpha sezary syndrome We studied 51 patients (one stage Ia, seven stage Ib, one stage IIa, 30 stage IIb, 11 stage III (Sezary syndrome) and one stage IV) who received low-dose IFN-alpha as monotherapy for ECTL (mean daily dose of IFN-alpha 2.7 x 106 units for 14.9 months), giv 10233261 Human
ifn alpha spleen metastases We conclude that IFN alpha/beta was particularly effective in inhibiting the development of liver and spleen metastases and in increasing mouse survival time after iv inoculation of FLCs. 3422696 Human
ifn ependymoblastoma The effects of interleukin 2 (IL2) and interferon (IFN) on the generation and lytic activation of syngeneic murine malignant glioma (a methylcholanthrene-induced ependymoblastoma of C57BL/6 mouse origin, 203-glioma)-specific cytotoxic T-lymphocyte (G-CTL) 3259157 Human
ifn malignant glioma The effects of interleukin 2 (IL2) and interferon (IFN) on the generation and lytic activation of syngeneic murine malignant glioma (a methylcholanthrene-induced ependymoblastoma of C57BL/6 mouse origin, 203-glioma)-specific cytotoxic T-lymphocyte (G-CTL) 3259157 Human
ifn-alpha kaposi's sarcoma 21 patients with AIDS and Kaposi's sarcoma were enrolled in an open therapeutic trial to determine the in vivo anti-retroviral activity of recombinant interferon-alpha (IFN-alpha). 2903954 Human
ifn-alpha embryonal carcinoma We report here that human recombinant gamma-interferon (IFN-gamma) induced the expression of major histocompatibility complex Class I (HLA-A, B, C) antigens and beta 2-microglobulin in the two human embryonal carcinoma cell lines, 2102Ep cl.4D3 and NTERA- 3026615 Human
ifn-alpha malignant pleural mesothelioma The combination of high dose MTX and IFN-alpha and IFN-gamma is active against malignant pleural mesothelioma and well-tolerated. 10468296 Human
ifn-alpha skin squamous cell carcinoma Expression of dnSTAT2 suppressed cell growth inhibition with a pharmacologically achievable concentration (100 IU/ml) of IFN-alpha in the IFN-alpha-sensitive skin squamous cell carcinoma cell line SRB12-p9. dnSTAT2 also suppressed the IFN-alpha-induced ph 12748307 Human
ifn-alpha human bladder cancer These data suggest that in addition to its well-documented antiproliferative effects, IFN-alpha can inhibit the growth of human bladder cancer cells by inhibition of angiogenesis. 9485039 Human
ifn prostate adenocarcinoma We have previously shown that the type I IFN IFN alpha induces the expression of the cyclin-dependent kinase inhibitor p21WAF1 and inhibits the cell cycle of the human prostate adenocarcinoma cell line, DU145, that carries mutations in the tumor suppresso 9639405 Human
ifn alpha prostate adenocarcinoma We have previously shown that the type I IFN IFN alpha induces the expression of the cyclin-dependent kinase inhibitor p21WAF1 and inhibits the cell cycle of the human prostate adenocarcinoma cell line, DU145, that carries mutations in the tumor suppresso 9639405 Human
ifn-alpha leptomeningeal metastasis Immunotherapeutic approaches to leptomeningeal metastasis (LM) include the intrathecal application of cytokines such as interleukin-2 (IL-2) and interferon-alpha (IFN-alpha), and lymphokine-activated killer cells (LAK cells). 9696377 Human
ifn classic kaposi's sarcoma In the present report, we summarize the results of our experience with subcutaneous low-dose IFN alfa treatment of 11 patients with extensive classic Kaposi's sarcoma and review the literature. 9693183 Human
ifn classic kaposi's sarcoma CONCLUSION: Whereas in AIDS-related Kaposi's sarcoma patients become refractory to IFN, this was not observed in our patients with classic Kaposi's sarcoma. 9693183 Human
ifn-alpha vin 3 Because chronic and recurrent HPV-linked vulvar intraepithelial neoplasia 3 (VIN 3) have a high risk of invasion, we evaluated combined therapy of IFN-alpha with 13-cis-retinoic acid (13 cRA) in the treatment of two VIN 3 cases of this type. 9749422 Human
ifn-alpha vulvar intraepithelial neoplasia Because chronic and recurrent HPV-linked vulvar intraepithelial neoplasia 3 (VIN 3) have a high risk of invasion, we evaluated combined therapy of IFN-alpha with 13-cis-retinoic acid (13 cRA) in the treatment of two VIN 3 cases of this type. 9749422 Human
ifn-alpha vin 3 CASE: Two patients with chronic and recurrent VIN 3 were treated with combined therapy of IFN-alpha (4.5 x 10(6) five times a week) and 13 cRA (1 mg/kg/d) for six months. 9749422 Human
ifn-alpha vin 3 CONCLUSION: These data demonstrate the ineffectiveness of the combined regimen of IFN-alpha and 13 cRA with this schedule for a period of six months in recurrent and chronic VIN 3. 9749422 Human
ifn second malignancy The treatment is based on recombinant IFN: we discuss the interest and the risks of second malignancy related to the prescription of the purine analogues. 9766918 Human
ifnalpha gastric adenocarcinoma Here we report a gastric adenocarcinoma cell line, AGS, that is defective in its response to either IFNalpha or IFNgamma. 9769120 Human
ifn-alpha idiopathic myelofibrosis Whether IFN-alpha therapy can prevent the progression of idiopathic myelofibrosis to leukemia has not yet been determined. 9787320 Human
ifn-alpha pancreatic carcinoid tumor The purpose of this study was to determine the effect of IFN-alpha and IFN-gamma on the Stat pathway using a unique human pancreatic carcinoid tumor, BON, established in our laboratory. 9831114 Human
ifn endocrine tumors Delineating the signaling pathways altered by IFN treatment will provide a better understanding of downstream gene targets and mechanisms for IFN-mediated growth inhibition of endocrine tumors. 9831114 Human
ifn-alpha unresectable pancreatic carcinoma The purpose of this trial was to examine the feasibility and tolerability of a combination therapy of 13-cis RA and IFN-alpha in patients with advanced unresectable pancreatic carcinoma. 9840531 Human
ifn seminoma The purpose of this study was to investigate the effect of natural interferon (IFN) on the expression of placental alkaline phosphatase (PLAP) in a human seminoma xenograft in severe combined immunodeficient mice. 9879816 Human
ifn seminoma A radiolabeled anti-PLAP monoclonal antibody (MAb) was intravenously injected on the first day of IFN administration in order to determine if IFN has the potential to enhance the efficacy of an anti-PLAP MAb in the detection of seminoma. 9879816 Human
ifn seminoma Thus, IFN treatment appears to have some effect on the efficacy of the anti-PLAP MAb in the detection of seminoma xenografts. 9879816 Human
ifn primary myelofibrosis A 14-year-old boy presenting with primary myelofibrosis (MMM) was treated with alpha-interferon (IFN). 9949632 Human
ifn-alpha human endometrial adenocarcinoma In the present study, we have investigated the effects of interferons-alpha (IFN-alpha) and -gamma (IFN-gamma), interleukin-10 (IL-10) and -13 (IL-13), transforming growth factor-beta1 (TGF-beta1), granulocyte-macrophage colony-stimulating factor (GM-CSF) 10367939 Human
ifn alpha vulvar carcinoma All cytokines, with the exception of IFN alpha, showed inhibitory effects on DNA synthesis by vulvar carcinoma cells. 9067409 Human
ifn alpha metastatic carcinoma BACKGROUND: Recent clinical trials with a combination of interferon (IFN alpha) and 13 cis-retinoic acid resulted in high response rates among women with locally advanced and metastatic carcinoma of the uterine cervix. 9118041 Human
ifn-alpha sezary syndrome We report the effect of long-term (more than 12 months) IFN-alpha treatment on triglyceride levels in 43 patients suffering from hairy cell leukemia (18), multiple myeloma (10), chronic myelogenous leukemia (6), cryoglobulinemia (5), non-Hodgkin's ly 9181461 Human
ifn acute promyelocytic leukemia In a cell line (NB4) derived from a patient with acute promyelocytic leukemia, all-trans-retinoic acid (ATRA) and interferon (IFN) induce the expression of a novel gene we call RIG-G (for retinoic acid-induced gene G). 9207104 Human
ifn gastric adenocarcinoma The combined effects of different classes of interferon (IFN) on human gastric adenocarcinoma cell line HPE-GAC-2 (GAC-2) were investigated in vitro. 9234070 Human
ifn-alpha stage iv melanoma PATIENTS AND METHODS: In the first EORTC-MCG phase III trial, stage IV melanoma patients were stratified on the basis of serum lactate dehydrogenase levels and tumor burden and randomized to receive rIL-2 (decrescendo regimen) plus interferon-alpha (IFN-a 9457389 Human
ifn high-grade lymphomas The results obtained with IFN in patients with intermediate and high-grade lymphomas are disappointing. 9468038 Human
ifn-alpha tumor associated glycoprotein Preclinical studies have demonstrated that recombinant IFN-alpha (rIFN-alpha) can enhance the tumor associated glycoprotein 72 (TAG-72) on tumors. 9815842 Human
ifn metastatic carcinoid tumors We feel that currently the activity of IFN in metastatic carcinoid tumors compares favorably with that of systemic chemotherapy in patients with progressive disease. 8740722 Human
ifn second cancers A recent report found an 18.8% incidence of second cancers and suggested a possible role for alpha-interferon (IFN) in their pathogenesis. 8724535 Human
ifn second cancer However, when compared to age- and sex- matched population data this represents no increase in relative risk of second cancer in patients with HCL and provides no evidence of a role for IFN in the pathogenesis of these second malignancies. 8724535 Human
ifn tumor disease Optimal use of interferons (IFNs) for the treatment of tumor disease requires experimental work in order to precisely define IFN actions. 8813333 Human
ifn tumor disease Further experimental work, undertaken in these and additional IFN areas, is mandatory for the most effective clinical use of IFNs for the treatment of tumor disease. 8813333 Human
ifn-alpha invasive carcinoma We analyzed biopsies from three cervical invasive carcinoma patients treated with interferon-alpha (IFN-alpha) administered both topically and i.m. for 15 days. 8887059 Human
ifn graft-versus leukemia (gvl) The efficacy of IFN appears to be due to an anti-malignancy effect, not to graft versus leukemia (GVL) effect. 8923790 Human
ifn-alpha breast and ovarian cancer The aim of the present study was to assess the effectiveness of IFN-alpha in the treatment of 25 patients with malignant pleural or peritoneal effusions caused by lung, and metastatic breast and ovarian cancer. 9042270 Human
ifn primary glioblastoma Using this probe, FISH analysis of primary glioblastoma tumors revealed homozygous deletions of the CDKN2 region in 6 of 9 tumors (67%) whereas a yeast artificial chromosome probe containing the interferon type I (IFN) gene cluster was deleted in only 4 c 7867008 Human
ifn murine neuroblastoma Clone NS20Y/MS of the murine neuroblastoma C1300 persistently infected with the wild-type Edmonston strain of MV secretes relatively high levels of alpha/beta interferon (IFN). 7884896 Human
ifn-alpha non-melanoma skin cancers Interferon-alpha (IFN-alpha) is a cytokine that is effective in the treatment of a variety of cancers, including non-melanoma skin cancers. 7705922 Human
ifn-alpha renal carcinoma We investigated the influence of interferons alpha, beta, and gamma (IFN-alpha, -beta, and -gamma) on the production of basic fibroblast growth factor (bFGF) by human renal carcinoma cells. 7753843 Human
ifn-alpha renal carcinoma The human renal carcinoma cell metastatic line SN12PM6 was established in culture from a lung metastasis and SN12PM6-resistant cells were selected in vitro for resistance to the antiproliferative effects of IFN-alpha or IFN-beta. 7753843 Human
ifn-alpha breast carcinoma The incubation of human bladder, prostate, colon, and breast carcinoma cells with noncytostatic concentrations of IFN-alpha or IFN-beta also produced down-regulation of bFGF production. 7753843 Human
ifn-alpha pleural malignant mesothelioma The aim of this study was to assess the response of four mesothelioma cell lines, derived from diffuse asbestos-related pleural malignant mesothelioma, to methotrexate alone and in combination with recombinant IFN-alpha and IFN-gamma. 7756687 Human
ifn gastrointestinal tract cancer BACKGROUND: Based on encouraging treatment results with FU/FA or FU/IFN in gastrointestinal tract cancer, a phase II study was conducted to evaluate the effects and toxicity of combination FU/FA/IFN in patients (pts) with inoperable/metastatic gastric can 7540418 Human
ifn alpha primary colorectal cancer In this study, the induction by interferon alpha (IFN alpha) of two tumor surface antigens was evaluated in six patients with primary colorectal cancer. 7600563 Human
ifn alpha colon cancer Interferon-alpha (IFN alpha) potentiates the antitumor activity of 5-fluorouracil (FUra) in colon cancer in vitro, in vivo, and clinically. 7642571 Human
ifn-alpha urticaria pigmentosa These findings indicate that IFN-alpha is highly effective in the control of symptoms, but otherwise does not influence the cutaneous lesions of urticaria pigmentosa. 7669648 Human
ifn-alpha accelerated phase chronic myelogenous leukaemia Twenty-nine late chronic and accelerated phase chronic myelogenous leukaemia (CML) patients were entered in a pilot study designed to test the therapeutic efficacy of treatment with interferon-alpha (IFN-alpha) and low-dose cytosine arabinoside (ARA-C). 7672091 Human
ifn alpha relapsed cml Guillain Barre syndrome, a possible side effect of buffy coat transfusion and IFN alpha therapy in relapsed CML after bone marrow transplantation. 8573544 Human
ifn-alpha metastatic breast cancer To determine the effect of IFN-alpha on biodistribution and tumor uptake of 131I-labeled CC49, patients with metastatic breast cancer were randomized to either receive or not receive IFN-alpha (3 million units daily for 14 days) by s.c. injection. 7493372 Human
ifn alpha pancreatic adenocarcinoma Based on in vitro evidence of synergy and observed clinical activity, we conducted a pilot phase II trial of 13-cis-retinoic acid (1 mg/kg/day) and IFN alpha (6 million units/day) in patients with advanced pancreatic adenocarcinoma. 8526197 Human
ifn-alpha burkitt's lymphoma We show here that in Daudi Burkitt's lymphoma cells, IFN-alpha produces a five- to sevenfold reduction in c-myc mRNA through a decreased rate of c-myc gene transcription. 3881681 Human
ifn schwannoma The growth-inhibitory effect of IFN was most pronounced on three glioblastoma lines and least on fetal brain and oligodendroglioma cells; IFN growth inhibition of one schwannoma and one anaplastic cell line was intermediate between the two other groups. 2578869 Human
ifn oligodendroglioma The growth-inhibitory effect of IFN was most pronounced on three glioblastoma lines and least on fetal brain and oligodendroglioma cells; IFN growth inhibition of one schwannoma and one anaplastic cell line was intermediate between the two other groups. 2578869 Human
ifn reticulum-cell sarcoma Although reticulum cell sarcoma cell extracts had no detectable effect in vitro, they were capable of inducing transient IFN production in vivo. 6420599 Human
ifn oral cancer The streptococcal preparation OK-432 was used by intradermal administration as an immunotherapy in 18 patients with oral cancer, and the sera from patients during OK-432 treatment were serially assayed for interferon (IFN) activity by the plaque-reduction 6203858 Human
ifn teratomas A Phase 2 trial was conducted using intramuscular lymphoblastoid interferon (IFN, Wellcome Research Laboratories), 4 MU per day, in 10 patients with chemotherapy-resistant teratomas. 6498061 Human
ifn teratoma There was stabilisation of disease in 2 patients both of whom were in retrospect considered to have had differentiated teratoma at the time of IFN administration. 6498061 Human
ifn teratoma One of these patients, a 15-year-old boy with biopsy proven differentiated teratoma has received 2 courses of lymphoblastoid IFN and 1 course of recombinant leukocyte A IFN (Roche Products Ltd.) lasting 5 1/2, 8 and 8+ months respectively. 6498061 Human
ifn teratoma Lymphoblastoid IFN does not appear to be active against anaplastic germ cell tumours but both lymphoblastoid and recombinant leukocyte A IFN may be useful in the treatment of unresectable differentiated teratoma. 6498061 Human
ifn bladder carcinoma The in vitro antiproliferative effects of interferons (IFN) against the human bladder carcinoma cell lines T24, RT4, HT1197, and 647V were evaluated at temperatures ranging from 37-41 degrees. 6498814 Human
ifn lymphoid tumor These data indicate that IFN-activated allogeneic PBMC are able to lyse both myeloid and lymphoid tumor cells, whereas higher concentrations of IFN are required to enhance lytic activity against autologous tumor cells. 6831042 Human
ifn human endometrial adenocarcinoma Two cloned cell lines, HEC-IC and HEC-ID, derived from the human endometrial adenocarcinoma cell line HEC-I, were found to be as resistant to the antiviral and anticellular activities of interferon (IFN) as were the parental cells, and 2'-5' oli 6299971 Human
ifn malignant brain tumors Our pilot study has shown that IFN alone will not be effective against progressive malignant brain tumors by general administration. 6839290 Human
ifn metastatic adenocarcinoma Nineteen patients with metastatic adenocarcinoma of the colon or rectum were treated with alpha (human leukocyte) interferon (alpha IFN). 6850664 Human
ifn human teratocarcinoma It appears that human teratocarcinoma cell lines can thus differ greatly in their ability to produce IFN and to respond to it. 2440957 Human
ifn-alpha metastatic carcinoma The significance of these findings in terms of the clinical usefulness of IFNs is discussed and it is postulated that IFN-alpha (wellferon) might be effective in the treatment of metastatic carcinoma of the prostate in selected patients. 2442423 Human
ifn-alpha pleural carcinomatosis Seven patients with ipsilateral pleural carcinomatosis from breast cancer were treated by intrapleural application of a crude interferon-alpha (IFN-alpha) preparation (HLI). 3668305 Human
ifn leukoplakia The interferon (IFN) assay of the sera from the 26 patients with premalignant lesions such as lichen planus and leukoplakia arising in oral mucosa was performed by the plaque-reduction assay with vesicular stomatitis virus in FL cells derived from human a 2420904 Human
ifn leiomyosarcoma The synthetic polyribonucleotide polyinosinate:polycytidylate [poly(I):poly(C)] was used to induce interferon (IFN) production in a rat leiomyosarcoma cell line. 3745988 Human
ifn-alpha b-cell prolymphocytic leukemia In two cases of resistance to IFN-alpha administration, we diagnosed variant HCL, a form of HCL with intermediate features between typical HCL and B cell prolymphocytic leukemia. 3530350 Human
ifn-alpha lymphosarcoma The antitumor activity of IFN-alpha Con 1 and natural human IFN-alpha was assessed in hamsters inoculated with lethal TBD932 lymphosarcoma. 3021874 Human
ifn-alpha lymphosarcoma Unlike the natural human subtype IFN-alpha A, IFN-alpha Con 1 did not diminish the efficacy of cyclophosphamide (2.5 mg/hamster for 3 days) against the lymphosarcoma. 3021874 Human
ifn-alpha hepatic metastases We have previously shown that interleukin 2 (IL-2) synergizes with interferon alpha (IFN-alpha) in mediating the regression of established pulmonary and hepatic metastases and the reduction of intradermal tumor in various murine tumor models. 2386960 Human
ifn-alpha eosinophilic leukemia The effects of interferon-alpha (IFN-alpha), INF-gamma, transforming growth factor beta (TGF-beta) and dexamethasone on low-affinity Fc receptors for IgE (Fc epsilon R2/CD23) expression on a human eosinophilic leukemia cell line, Eol-3, were examined. 1701160 Human
ifn-alpha prolymphocytic leukemia Leu-13 density, determined by flow cytometry, was upregulated in vitro and in vivo by IFN-alpha on malignant B cells from patients with HCL, chronic lymphocytic leukemia, and prolymphocytic leukemia. 2265250 Human
ifn epidermoid cervical carcinomas The authors studied the effects of recombinant interferons (IFN), doxorubicin, and cisplatin against three cell lines derived from human epidermoid cervical carcinomas. 2491828 Human
ifn-alpha chronic myelocytic leukemia Sequential therapy with recombinant interferons gamma and alpha in patients with unfavorable prognosis of chronic myelocytic leukemia: clinical responsiveness to recombinant IFN-alpha correlates with the degree of receptor down-regulation. 2521842 Human
ifn tumor diseases Exogenous IFN therapy has been used since 1970 and some viral and tumor diseases respond to such therapy. 2471026 Human
ifn accelerated phase cml Among them, 187 patients had newly diagnosed, early chronic phase CML; 351 patients had chronic phase CML after interferon alpha (IFN) failure; 133 patients had accelerated phase CML; and 76 patients had blastic phase CML. 12973833 Human
ifn b-cell lymphoma A stable subline of 38C13 B-cell lymphoma (SIR-1) resistant to the antiproliferative effects of alpha-interferon (IFN) was isolated. 2787203 Human
ifn carcinomatosis Only one out of 20 animals receiving TNF or TNF in combination with IFN was found to have intraperitoneal tumor at the time of laparotomy, whereas all the untreated controls had gross intraabdominal carcinomatosis. 2504653 Human
ifn oligodendroglioma The interactive effects of interferons (IFN) in the induction of class II major histocompatibility complex (MHC) antigens in a murine fibroblast line and murine glial cells (primary astrocytes and an oligodendroglioma line) were examined. 2475435 Human
ifn-alpha uveal melanoma We investigated the expression of integrins, ICAM-1, and CD44 and the influence of interferon-alpha (IFN-alpha), interferon-gamma (IFN-gamma), and tumour necrosis factor-alpha (TNF-alpha) on expression of these molecules on four uveal melanoma cell lines. 7496158 Human
ifn alpha stage iv colorectal cancer A total of 29 patients with stage IV colorectal cancer were entered into a phase II trial of bolus interleukin-2 (IL-2) and interferon-alpha (IFN alpha) (3 x 10(6) U/m2 of each cytokine given i.v. q8h x 15 doses and repeated in 2 weeks). 8680653 Human
ifn-alpha megakaryoblastic leukemia Whereas numerous chemical and biologic agents induce granulocytic and/or monocytic differentiation of myeloid leukemia cell lines, only a few agents including phorbol myristate acetate, vitamin D3, IFN-alpha, IL-6 and thrombin have been reported to induce 8750618 Human
ifn carcinoid syndrome Chemotherapy, IFN, octreotide, and hepatic artery embolization can be useful for palliation, both of local symptoms and of the carcinoid syndrome, but they have little effect on tumor progression, MIBG therapy is still experimental but may have a future r 9346550 Human
ifn refractory cancers Forty-five patients with advanced or refractory cancers were treated with 5-FU by CI, plus IFN during the infusion only, by one of four schedules: schedule A: 24-h 5-FU infusion repeated weekly, 9 x 10(6) units IFN x 2 doses weekly; schedule B: 48-h 5-FU 9816023 Human
ifn alpha pseudolymphoma The possible association between IFN alpha treatment and chronic hepatitis B with the development of pseudolymphoma is discussed. 7514058 Human
ifn-alpha stage 0 cll In eight patients with stage 0 CLL on IFN-alpha therapy, peripheral lymphocyte counts fell to 61.7 +/- 19.5% of baseline at week 2 (P < 0.01), while serum M-CSF levels rose from 455 +/- 183 U/ml to 686 +/- 110 U/ml (P < 0.05). 8199046 Human
ifn malignant glioma Deletions of the 9p-localized type-I interferon (IFN) genes and adjacent loci often occur during the development of malignant glioma. 8205529 Human
ifn malignant gliomas In total these data indicate the frequent inactivation of a novel tumor suppressor gene residing adjacent to and centromeric of the type-I IFN genes in malignant gliomas. 8205529 Human
ifn-alpha iv non-small-cell lung cancer Data are presented on the general and hematological toxicity of a cisplatin (DDP), 5-fluorouracil (5-FU) and alpha interferon (IFN-alpha) association in patients with stage III B or IV non small cell lung cancer (NSCLC). 7516637 Human
ifn tumoral diseases The interferon (IFN) system (alpha, beta and gamma IFNs) is closely related to the first line of defenses against viral and tumoral diseases. 7912973 Human
ifn-alpha human colon tumor 5-FU, fluorouridine (FUR) or fluoro-5'-deoxyuridine (FUdR) were tested against cultured human colon tumor C-1 cells with or without IFN-alpha. 8074466 Human
ifn-alpha mouse liver tumor This study tested the effect of intratumoral injection with activated tumor-infiltrating lymphocytes (TIL), and simultaneous administration of recombinant interleukin-2 (rIL-2) and interferon alpha (IFN-alpha) (LII protocol), on mouse liver tumor. 7923100 Human
ifn-alpha malignant astrocytoma We have used natural IFN-alpha in 16 patients with malignant astrocytoma treated between 1987 and 1990; 6 for recurrent tumors. 7946443 Human
ifn-alpha recurrent tumors We have used natural IFN-alpha in 16 patients with malignant astrocytoma treated between 1987 and 1990; 6 for recurrent tumors. 7946443 Human
ifn-alpha malignant astrocytoma The study suggests that malignant astrocytoma can be successfully eradicated with surgery, irradiation, IFN-alpha and chemotherapy. 7946443 Human
ifn-alpha murine adenocarcinoma IFN-alpha 1 gene expression into a metastatic murine adenocarcinoma (TS/A) results in CD8+ T cell-mediated tumor rejection and development of antitumor immunity. 7963533 Mouse
ifn accelerated phase chronic myelogenous leukemia Three patients are described with late-stage myeloproliferative diseases, two with accelerated phase chronic myelogenous leukemia (CML) and one with refractory polycythemia vera (P vera), who achieved hematologic control after the addition of interferon ( 7890266 Human
ifn-alpha midgut carcinoid tumors The study supports the idea that induction of MHC class I antigens could contribute to the beneficial clinical effect of IFN-alpha treatment in patients with midgut carcinoid tumors. 7725732 Human
ifn undifferentiated carcinoma The presence of Epstein-Barr virus (EBV) genomes in the DNA of tumor cells of undifferentiated carcinoma of nasopharyngeal type (UCNT), associated with significant lymphocytic infiltration of tumor led to therapeutic trials with interferon (IFN) because o 8382670 Human
ifn endometrial cancer CONCLUSIONS. These preliminary data on PR expression modulation support other studies, which have shown that IFN modulate hormone receptor expression and, therefore, may play a role in the treatment of endometrial cancer. 8467457 Human
ifn-alpha myeloid metaplasia IFN-alpha is particularly indicated for patients with myeloid metaplasia evidenced by splenomegaly. 12682879 Human
ifn alpha stage iv neuroblastoma In this study we have investigated, at the population and the clonal levels, the immunophenotypes and the non-specific cytotoxic functions of peripheral blood lymphocytes from three stage IV neuroblastoma patients receiving treatment with recombinant inte 8513451 Human
ifn malignant glioma Southern blot analyses of the 9p-localized type I interferon (IFN) genes in DNAs obtained from malignant glioma cell lines and glial tumor tissue have indicated that homozygous deletions of the IFN-alpha and IFN-beta genes often occur during the developme 8339274 Human
ifn-alpha malignant glioma Southern blot analyses of the 9p-localized type I interferon (IFN) genes in DNAs obtained from malignant glioma cell lines and glial tumor tissue have indicated that homozygous deletions of the IFN-alpha and IFN-beta genes often occur during the developme 8339274 Human
ifn malignant central nervous system neoplasm Southern blot analyses of the 9p-localized type I interferon (IFN) genes in DNAs obtained from malignant glioma cell lines and glial tumor tissue have indicated that homozygous deletions of the IFN-alpha and IFN-beta genes often occur during the developme 8339274 Human
ifn-alpha malignant central nervous system neoplasm Southern blot analyses of the 9p-localized type I interferon (IFN) genes in DNAs obtained from malignant glioma cell lines and glial tumor tissue have indicated that homozygous deletions of the IFN-alpha and IFN-beta genes often occur during the developme 8339274 Human
ifn-alpha metastatic adenocarcinoma This report describes our use of 13-cis-retinoic acid plus IFN-alpha to treat a case of cisplatin- and hormone-resistant, locally advanced and distantly metastatic adenocarcinoma of the endometrium. 8358060 Human
ifn anaplastic large-cell lymphoma We describe a patient with Philadelphia-chromosome-positive (Ph' +) chronic myelogenous leukemia (CML), who developed an anaplastic large cell lymphoma (ALCL) with T-phenotype, after 43 months successful treatment with alpha-interferon (IFN). 8231259 Human
ifn mastocytosis However, Nb-induced increases in serum IgG levels and intestinal mastocytosis were only temporarily delayed by IFN. 8258713 Human
ifn aplasia In four patients with Philadelphia chromosome-positive (Ph1) chronic myelogenous leukemia (CML), bone marrow hypoplasia (three patients) and aplasia (one patient) developed during or after therapy with either alpha-interferon (IFN) or gamma-IFN. 1370212 Human
ifn endometrial carcinoma Both IFN types reduced the expression of HER-2 in the ovarian carcinoma cell lines OVCAR-3, HTB-77, 2774 and SKOV-6, and in the SKUT-2 endometrial carcinoma cells. 1370227 Human
ifn adenocarcinoma of the esophagus MATERIALS AND METHODS: In this prospective phase II trial conducted at a large tertiary referral cancer center and university hospital, 40 patients with advanced locoregional, metastatic epidermoid, or adenocarcinoma of the esophagus were given FU 750 mg/ 1732428 Human
ifn metastatic renal-cell carcinoma This report details a prospective study of the immunological effects on peripheral blood mononuclear cells of sequentially administered recombinant (r) interferon (IFN) gamma and rIFN alpha in 28 patients with metastatic renal cell carcinoma. 1737346 Human
ifn acute leukemia Correlation between interferon (IFN) alpha resistance and deletion of the IFN alpha/beta genes in acute leukemia cell lines suggests selection against the IFN system. 1386261 Human
ifn alpha acute leukemia Correlation between interferon (IFN) alpha resistance and deletion of the IFN alpha/beta genes in acute leukemia cell lines suggests selection against the IFN system. 1386261 Human
ifn acute leukemia To test if selection against the IFN system was operating in acute leukemias, the sensitivity to the antiproliferative effect of IFN alpha 2 was studied in acute leukemia cell lines with and without alterations of the IFNA/B genes. 1386261 Human
ifn alpha acute leukemia To test if selection against the IFN system was operating in acute leukemias, the sensitivity to the antiproliferative effect of IFN alpha 2 was studied in acute leukemia cell lines with and without alterations of the IFNA/B genes. 1386261 Human
ifn low-grade tumors IFN may be useful in the treatment of a number of benign, in situ, or low-grade tumors. 1379117 Human
ifn-alpha teratocarcinoma XD mRNA is also induced in NIH3T3 fibroblastic cells, but not in F9 teratocarcinoma or B16 melanoma cells after treatment with IFN-alpha A/D. 1379796 Human
ifn-alpha carcinoid syndrome 18 patients had carcinoid syndrome when IFN-alpha was added in 10 (56%) symptoms ameliorated. 1382492 Human
ifn alpha pleural carcinomatosis Intrapleural application of natural IFN alpha in breast cancer patients with pleural carcinomatosis. 1414464 Human
ifn-alpha mouse neuroblastoma Mouse neuroblastoma cells (MNA) were primed with 20 I.U. of alpha interferon (Mu IFN-alpha) prior to exposure to the Challenge Virus Standard strain of rabies virus (CVS). 1360753 Human
ifn-alpha solid carcinomas Using a sensitive immunoassay, the mitogen-induced production of interferon-gamma (IFN-gamma) and virus-stimulated IFN-alpha production was investigated in whole blood cell cultures of 115 control subjects and 225 untreated patients with various solid car 1290032 Human
ifn recurrent cutaneous carcinomas High-titered spontaneous interferon (IFN) antibodies were detected in a patient with pure red cell aplasia (PRCA), a benign mediastinal tumor, and recurrent cutaneous carcinomas. 1903312 Human
ifn mediastinal tumor High-titered spontaneous interferon (IFN) antibodies were detected in a patient with pure red cell aplasia (PRCA), a benign mediastinal tumor, and recurrent cutaneous carcinomas. 1903312 Human
ifn pure red-cell aplasia (prca) High-titered spontaneous interferon (IFN) antibodies were detected in a patient with pure red cell aplasia (PRCA), a benign mediastinal tumor, and recurrent cutaneous carcinomas. 1903312 Human
ifn-alpha neurofibromatosis type 2 A consecutive series of six meningiomas and one meningioma/neurofibroma derived from a patient with neurofibromatosis type 2 was investigated and it was found that the growth of all seven tumours in response to mitotic stimuli (fetal bovine serum or epide 1828169 Human
ifn-alpha neurofibroma A consecutive series of six meningiomas and one meningioma/neurofibroma derived from a patient with neurofibromatosis type 2 was investigated and it was found that the growth of all seven tumours in response to mitotic stimuli (fetal bovine serum or epide 1828169 Human
ifn-alpha midgut carcinoid tumors We here summarize the experience from a group of 135 patients with midgut carcinoid tumors treated with natural leukocyte IFN-alpha or recombinant IFN-alpha (rIFN-alpha). 1854511 Human
ifn metastatic carcinoid tumors Alpha-interferon (IFN) in the treatment of metastatic carcinoid tumors. 1855191 Human
ifn peyronie's disease To determine the therapeutic potential of interferon (IFN) treatment for Peyronie's disease, we investigated the effect of human recombinant (hu-r) IFNs on cultured fibroblasts derived from a Peyronie's disease penile plaque. 1651559 Human
ifn myelofibrosis The effect of imatinib mesylate (imatinib) therapy on angiogenesis and myelofibrosis was investigated and compared with interferon (IFN) and hydroxyurea (HU) in 98 patients with newly diagnosed Philadelphia chromosome-positive/BCR-ABL(+) (Ph(+)/BCR-ABL(+) 14726401 Human
ifn-alpha philadelphia chromosome positive cml Four patients with Philadelphia chromosome positive CML were treated with 18-42 x 10(6) IU of purified natural leukocyte IFN-alpha per week, after high-dose chemotherapy for blast phase and attainment of 2nd chronic phase. 1892679 Human
ifn malignant ascites Intraperitoneal treatment with interferon (IFN) for malignant ascites due to advanced ovarian carcinoma refractory to chemotherapy gave an objective response rate of 36% (7/19 patients treated). 1835858 Human
ifn peritoneal carcinomatosis IFN plus cisplatin proved to be more effective than intraperitoneal cisplatin alone in control of peritoneal carcinomatosis. 1835858 Human
ifn-alpha non-small cell lung carcinoma Cotylenin A, a differentiation-inducing agent, and IFN-alpha cooperatively induce apoptosis and have an antitumor effect on human non-small cell lung carcinoma cells in nude mice. 12839956 Human
ifn-alpha non-small cell lung carcinoma Cotylenin A, a novel inducer of the differentiation of leukemia cells, and IFN-alpha synergistically inhibited the growth of and induced apoptosis in several human non-small cell lung carcinoma cell lines. 12839956 Human
ifn vaginal intraepithelial neoplasia The present placebo-controlled, double-blind trial was designed to determine the effect of potent human leukocyte interferon cream (IFN) on genital HPV 16 (high-risk-type) infections associated with cervical intraepithelial neoplasia (CIN) and/or vaginal 2156764 Human
ifn urothelial carcinomas In previous investigations, it was demonstrated that interferons (IFN) have antiproliferative effects in human urothelial carcinomas. 2140214 Human
ifn histiocytic lymphoma In contrast, less PS:PC-IFN than free IFN was needed to inhibit histiocytic lymphoma cells. 2111353 Human
ifn-alpha hairy-cell leukemia (hcl) B-cell growth factor-induced and alpha-interferon-inhibited proliferation of hairy cells coincides with modulation of cell surface antigens. alpha-Interferon (IFN-alpha) induced unique ultrastructural alterations in peripheral blood and splenic hairy cell 2354460 Human
ifn ehrlich ascites tumor Therapy consisted of nine consecutive daily intraperitoneal (i.p.) injections of 10(6) units of Ehrlich ascites tumor cell IFN (specific activity 5 X 10(7) IU/mg). 6183380 Human
ifn ehrlich ascites carcinoma Inoculation of Ehrlich ascites carcinoma cells (EAC) into the peritoneal cavities of outbred ddY mice induced interferon (IFN) in the circulation. 6168892 Human
ifn ehrlich ascites tumor The N-terminal sequences of mouse Ehrlich ascites tumor cell IFN beta (35,000-40,000 daltons) and IFN alpha (20,000 daltons) differ in 18 out of 20 positions. 6180051 Human
ifn alpha ehrlich ascites tumor The N-terminal sequences of mouse Ehrlich ascites tumor cell IFN beta (35,000-40,000 daltons) and IFN alpha (20,000 daltons) differ in 18 out of 20 positions. 6180051 Human
ifn-alpha actinic keratosis EXPERIMENTAL DESIGN: To determine the timing of the suppression of IFN-alpha signaling proteins in squamous skin carcinogenesis, we have now compared ISGF-3 expression by immunohistochemical staining in biopsies of actinic keratosis, a form of skin premal 12114405 Human
ifn-alpha waldenström's macroglobulinemia IFN-alpha is an effective agent for the induction and maintenance treatment of Waldenström's macroglobulinemia patients. 12433280 Human
ifn-alpha tumordraining lymph nodes In tumor-draining lymph nodes, suppression of CpG-induced IFN-alpha production was less pronounced than in single-cell suspensions of primary tumor tissue. 14559840 Human
ifn-alpha retroperitoneal tumors RESULTS: Subcutaneous and retroperitoneal tumors were significantly smaller in IFN-alpha-treated mice, as compared with control mice. 15300178 Human
ifn tumourinfiltrating lymphocytes To date, the association of tumour-infiltrating lymphocytes, IL-2 and IFN alpha provided the best results in terms of survival and toxicity. 11549203 Human
ifn tumourbearing We conclude that murine IFN mediates this tumour inhibition via an effect on the tumour-bearing host that may or may not involve immune mechanisms. 2427457 Human
ifn epidermoid cervical carcinomas The authors studied the effects of recombinant interferons (IFN), doxorubicin, and cisplatin against three cell lines derived from human epidermoid cervical carcinomas. 2491828 Human
ifn corneal stromal disease Together with our previous findings that HSV-1-specific CTLs participate in the pathogenesis of corneal stromal disease, these results indicate that i.v. injection of UV HSV-1 at the time of corneal infection may prevent stromal disease by the combined ef 1649898 Human
ifn female genital cancers However, in the cases of rectum, prostate and female genital cancers, a significant elevated level of serum IFN was observed at a late stage of the disease, followed by a decrease after chemotherapy treatment. 2582327 Human
ifn ehrlich ascitestumour (eat) Treatment of Ehrlich ascites-tumour (EAT) cells with interferon (IFN) abolished their ability to secrete a 32 kDa protein that was secreted by growing EAT cells. 2775220 Human
ifn-alpha waldenström's macroglobulinemia IFN-alpha as induction and maintenance treatment of patients newly diagnosed with Waldenström's macroglobulinemia. 12433280 Human
ifn-alpha androgeninsensitive prostate cancer CONCLUSIONS: Treatment with IFN-alpha and DOX should be further explored as a therapeutic strategy for androgen-insensitive prostate cancer. 11550207 Human
ifn hematopoietic tumor This study reports the induction of interferon (IFN) in human mononuclear cells (MNC) by hematopoietic tumor cells. 6430810 Human
ifn benign tumor In the case of the benign tumor juvenile laryngeal papillomatosis, IFN has been shown to be superior to other treatment modalities. 6400035 Human
ifn immunocytoma In search for a rationale for the use of interferons (IFNs) in treatment of non-Hodgkin lymphoma (NHL), we have investigated the IFN system of 13 patients with low-grade NHL, 15 patients with high-grade NHL, and 20 patients with chronic lymphocytic leukem 2459268 Human
ifn epidemic kaposi's sarcoma Alpha IFN is the best studied and displays activity in many neoplastic diseases; it has shown the most promise in the hematological cancers although several solid tumors, including epidemic Kaposi's sarcoma, renal cell carcinoma, and melanoma, respon 2479178 Human
ifn t-cell neoplasms Here, we summarize the current understanding of the IFN system and IL-2 system in the context of host defense against viral infections and T cell neoplasms, respectively. 3269361 Human
ifn vain The present placebo-controlled, double-blind trial was designed to determine the effect of potent human leukocyte interferon cream (IFN) on genital HPV 16 (high-risk-type) infections associated with cervical intraepithelial neoplasia (CIN) and/or vaginal 2156764 Human
ifn benign mediastinal tumor High-titered spontaneous interferon (IFN) antibodies were detected in a patient with pure red cell aplasia (PRCA), a benign mediastinal tumor, and recurrent cutaneous carcinomas. 1903312 Human
ifn immunocytoma In search for a rationale for the use of interferons (IFNs) in treatment of non-Hodgkin lymphoma (NHL), we have investigated the IFN system of 13 patients with low-grade NHL, 15 patients with high-grade NHL, and 20 patients with chronic lymphocytic leukem 1379288 Human
ifn childhood all We conclude that deletion of alpha- and beta-IFN genes is a relatively common event in ALL and that RFLP analysis of the IFN genes may provide additional prognostic information in childhood ALL. 8100807 Human
ifn alcl We describe a patient with Philadelphia-chromosome-positive (Ph' +) chronic myelogenous leukemia (CML), who developed an anaplastic large cell lymphoma (ALCL) with T-phenotype, after 43 months successful treatment with alpha-interferon (IFN). 8231259 Human
ifn hbl Children given antineoplastic and immunostimulatory treatment for cancer were also given nHuIFN-alpha--HBL lozenges containing 50-200 units of IFN per lozenge. 8129565 Human
ifn aggressive non-hodgkin's lymphoma Cytosine arabinoside (Ara-C) plus alpha-interferon (alpha IFN) determine prolonged complete remissions in patients with aggressive non-Hodgkin's lymphoma partially responsive to first-line doxorubicin-containing regimens. 7803297 Human
ifn aggressive lymphomas In aggressive lymphomas, IFN has minimal activity, and in Hodgkin's disease the limited available experience suggests only modest activity. 8881370 Human
ifn mammary tumor A second aim was to test whether pretreatment of mammary tumor cell lines with IFN gamma could enhance the effect of IFN alpha/beta. 9581833 Human
ifn aids-related kaposi's sarcoma CONCLUSION: Whereas in AIDS-related Kaposi's sarcoma patients become refractory to IFN, this was not observed in our patients with classic Kaposi's sarcoma. 9693183 Human
ifn ehrlich ascites tumour Mouse interferon (IFN) was produced to high titres after induction of Ehrlich ascites tumour cells with Sendai virus by using an improved procedure. 6187892 Human
ifn indolent lymphomas However, it is clear that from the clinical standpoint, IFN has been able to increase 2-fold the length of remission in patients with advanced indolent lymphomas. 10068269 Human
ifn epidemic kaposi's sarcoma The inhibitory effect of IFN class I on HIV-Tat associated angiogenesis further supports its use as a therapy for epidemic Kaposi's sarcoma. 10669956 Human
ifn aids-related kaposi's sarcoma The major oncological indications for IFN include melanoma, renal cell carcinoma, AIDS-related Kaposi's sarcoma, follicular lymphoma, hairy cell leukemia, and chronic myelogenous leukemia. 11161227 Human
ifn recurrent tumor In the IFN alpha-1b 3 10(7)U/kg/d treated group, there was only one recurrent tumor (0.5 mm(3)), no lung metastasis, and the positivity of AFP mRNA was 0% (?(2)=11.67, P<0.01). 12113675 Mouse
ifn stage ii melanoma We modelled the cost-effectiveness of first testing with SLM and then treating with adjuvant interferon (IFN) therapy for stage II melanoma. 12459651 Human
ifn stage ii melanoma In conclusion appropriate dosing of IFN therapy based on the results of SLM is a cost-effective strategy for stage II melanoma patients. 12459651 Human
ifn midgut carcinoid tumours METHODS: In this prospective randomized study, the effect of interferon (IFN) alpha on survival and risk of tumour progression was evaluated in 68 patients with midgut carcinoid tumours metastatic to the liver. 12808615 Human
ifn jmml We report a 12-month-old child with JMML relapsed after unrelated marrow transplantation who received cytoreduction followed by donor lymphocyte infusion (DLI) with improvement, and after addition of interferon-alpha (IFN) achieved complete donor chimeris 14704663 Human
ifn jmml This is the first published report of a patient with non-monosomy-7 JMML responding to post-transplant immunomodulation and suggests a role for DLI plus IFN in these patients. 14704663 Human
ifn uveal melanoma BACKGROUND/AIM: Interferons (IFN) are currently being used to treat melanoma, including some patients with uveal melanoma. 15548813 Human
ifn bladder tumors Combination therapy strategies aimed at overcoming TRAIL resistance may be very effective in restoring IFN sensitivity in a subset of human bladder tumors. 15604261 Human
ifn mouse lymphoma To determine if a deregulated oncogene could alter the cellular response to IFN, a mouse lymphoma cell line (J3D) was stably transfected with the viral human papillomavirus-16 (HPV-16) E7 oncogene. 15695927 Human
ifn hepatitis c virus-related hepatocellular carcinoma Conclusion: Postoperative IFN therapy improves the outcome after resection of hepatitis C virus-related hepatocellular carcinoma. 15785093 Human
ifn stage iii colon cancer The purpose of this trial was to examine the efficacy of the addition of levamisole (LEV) or interferon alfa (IFN) to an adjuvant chemotherapy with 5-fluorouracil (5-FU) in patients with stage III colon cancer. 15856042 Human
ifn myeloproliferative disorders The dendritic cell/NK cell cross-talk in ABL/ABL-induced CML seems unique because JunB or IFN consensus sequence binding protein loss of functions, associated with other myeloproliferative disorders, do not promote dendritic cell-mediated NK cell activati 16024645 Human
ifn esophageal scc These findings indicated that 5-FU stimulated IFN pathways in esophageal SCC cells following up-regulation of the IFN type I receptor. 16101138 Human
ifn-alpha human osteosarcoma The sensitivity of 11 human osteosarcoma xenografts in nude mice to human interferon-alpha (IFN-alpha) was studied. 3466689 Human
ifn-alpha skin metastasis Fifty-one evaluable patients with histologically proven metastatic melanoma and at least one skin metastasis were treated intralesionally with interferon-alpha (IFN-alpha). 3342367 Human
ifn-alpha aids-related kaposi's sarcoma This dual effect of IFN-alpha and 5-FU was found to be applicable to target cells of different origins including a cervical carcinoma cell line (ME-180), a hairy cell leukemia-like cell line (Eskol), a CML cell line (K-562) and a primary culture of AIDS-r 1370257 Human
ifn-alpha aids-related kaposi's sarcoma In one patient with AIDS-related Kaposi's sarcoma, interferon-alpha (IFN-alpha) therapy increased 2, 5A synthetase activity twofold. 1356675 Human
ifn-alpha metastatic tumors These results indicate that: (a) the genetic modification of highly metastatic FLC by means of transfer of the IFN-alpha 1 gene results in potent tumor cell rejection, which is mediated by an IFN-induced host immune response; (b) injections of IFN-produci 8439955 Mouse
ifn-alpha metastatic esophageal carcinoma A Phase II trial, therefore, was undertaken to evaluate the antitumor activity of the three-drug combination of IFN-alpha, 5-FU, and cisplatin in unresectable or metastatic esophageal carcinoma. 7712428 Human
ifn-alpha indolent lymphomas As a single agent, interferon-alpha (IFN-alpha) can induce remissions, mostly partial, in a large fraction of patients with indolent lymphomas, including the low grade B-cell lymphomas and cutaneous T-cell lymphoma. 8881370 Human
ifn-alpha central nervous system metastases Except for the study using tamoxifen, combination chemotherapy (cisplatin, DTIC, BCNU), plus biological therapy (IFN-alpha and/or IL-2), which achieved a 57% response rate, virtually any combination of agents or modalities yielded response rates of only 2 8903599 Human
ifn-alpha adenocarcinoma of the pancreas Twenty-six patients with advanced, surgically incurable adenocarcinoma of the pancreas received PCI 5-FU (250 mg/m2 daily for 28 days) in combination with IFN-alpha (5 x 10(6) IU/m2 s.c. thrice weekly). 8931668 Human
ifn-alpha stage ii melanoma On the basis of the activity demonstrated in vitro against melanoma cell lines and the results obtained in many clinical trials in patients with advanced melanoma, the authors chose to study the use of recombinant interferon-alpha (IFN-alpha) as adjuvant 9191523 Human
ifn-alpha hepatic disorders Our case study focused on four points: the clinical course of an HCV-infected recipient; the pathogenesis of hepatic disorders in such a patient; interferon (IFN)-alpha therapy; and the risk of IFN-alpha therapy. 9448159 Human
ifn-alpha bladder papilloma Systemic IFN-alpha treatment of multiple bladder papilloma grade I or II patients: pilot study. 7130757 Human
ifn-alpha squamous cell carcinoma of the uterine cervix PURPOSE: Preclinical and clinical data support the study of retinoids and interferon-alpha (IFN-alpha) in advanced squamous cell carcinoma of the uterine cervix (SCC). 9887236 Human
ifn-alpha carcinoid tumours Expression of p68 protein kinase and its prognostic significance during IFN-alpha therapy in patients with carcinoid tumours. 10070309 Human
ifn-alpha pancreatic tumour The aim of this study was to evaluate the antiproliferative effects of interferon alpha (IFN-alpha) on neuroendocrine differentiated cell lines and, retrospectively, to assess the prognostic significance of p68 protein kinase (PKR) induction in neuroendoc 10070309 Human
ifn-alpha carcinoid tumours The induction of p68 could be a prognostic indicator of response in patients with carcinoid tumours during IFN-alpha treatment. 10070309 Human
ifn-alpha aids-related burkitt's lymphoma We reported previously that patients with AIDS-related Burkitt's lymphoma (BL) responded to parenteral azidothymidine (AZT) and IFN-alpha. 10554028 Human
ifn-alpha pel IFN-alpha did not up-regulate CD95 in BL or PEL but did induce expression of the death receptor ligand, CD95 ligand. 10554028 Human
ifn-alpha pel EBV-positive BL cells that expressed low BCL-2 levels were sensitive to AZT alone; PEL cells required the addition of IFN-alpha to enhance apoptosis, and EBV-negative lymphomas were insensitive to both agents. 10554028 Human
ifn-alpha desmoid tumors METHODS: Thirteen patients with extra-abdominal desmoid tumors and a median age of 32 years (range, 15-73) received IFN-alpha. 10649274 Human
ifn-alpha keratoacanthoma [Use of interferon-alpha (IFN-alpha) in the treatment of keratoacanthoma] BACKGROUND AND OBJECTIVE: Keratoacanthoma are benign epithelial tumors. 10789078 Human
ifn-alpha castleman's disease This argues for early use of IFN-alpha in Castleman's disease, in association or not with corticosteroids. 10874763 Human
ifn-alpha hcl Therefore, we investigated the pattern of IFN-alpha gene expression and protein production in HCL and their potential regulation by rhIFN-alpha. 11034083 Human
ifn-alpha hcl Results showed that, in contrast to blood samples from HDs, freshly isolated PBMCs from un treated HCL patients did not express IFN-alpha mRNA, whereas IFN-alpha transcripts were found in patients who were under rhIFN-alpha therapy Plasma of untreated pat 11034083 Human
ifn-alpha hcl In HCL, however the amounts of IFN-alpha protein remained less than in HD. 11034083 Human
ifn-alpha hcl Finally, a reduced capacity to produce IFN-alpha was found within B- cell, T-cell, and monocyte compartments in HCL patients which could be enhanced by rhIFN-alpha. 11034083 Human
ifn-alpha hcl The results demonstrate the ability, of rhIFN-alpha to up-regulate the expression of IFN-alpha gene and protein production and suggest that priming the production of endogenous IFN-alpha is a critical step in the mechanism of action of rhIFN-alpha in HCL. 11034083 Human
ifn-alpha merkel-cell carcinoma IFN-alpha or TNF-alpha may be considered for the treatment of recurrent or advanced Merkel cell carcinoma. 11544938 Human
ifn-alpha aids lymphomas Our analysis of a series of AIDS lymphomas revealed that IFN-alpha selectively induced very high levels of the Death Receptor (DR) tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in HHV-8 positive PEL lines and primary tumor cells whereas 11704827 Human
ifn-alpha ewing tumor We have recently reported that Ewing tumor cell proliferation was strongly inhibited by IFN-beta and to a lesser degree by IFN-alpha. 12400012 Human
ifn-alpha macroglobulinemia IFN-alpha as induction and maintenance treatment of patients newly diagnosed with Waldenström's macroglobulinemia. 12433280 Human
ifn-alpha macroglobulinemia IFN-alpha is an effective agent for the induction and maintenance treatment of Waldenström's macroglobulinemia patients. 12433280 Human
ifn-alpha intraepithelial neoplasm IFN-gamma and IFN-alpha production in vitro by peripheral blood cells activated by phytohemagglutinin or the Newcastle disease virus was impaired in patients with a benign process, cervical intraepithelial neoplasm and cancer in situ associated with human 12630331 Human
ifn-alpha midgut carcinoid tumours CONCLUSION: Addition of IFN-alpha to octreotide may retard tumour growth in patients with midgut carcinoid tumours. 12808615 Human
ifn-alpha nevus To determine possible changes in the level of expression of these molecules in atypical nevi, excised before and after 3 months of systemic low-dose IFN-alpha treatment, newly designed optical imaging software was used to quantitate the captured fluoresce 12926238 Human
ifn-alpha colon tumor Recombinant IL-6, but not IL-10, TNF-alpha, and IFN-alpha, stimulated the secretion of IL-10 by colon tumor cells. mAbs against IL-6 and IL-6R prevented the effect of macrophage culture supernatants and of rIL-6, respectively, on the production of IL-10 b 15034082 Human
ifn-alpha infantile hemangiomas Instead, regressing and involuting infantile hemangiomas due to treatment with IFN-alpha showed positive staining of beta(4) integrin, which might point to the angiogenic significance of beta(4) integrin in infantile hemangiomas. 15188141 Human
ifn-alpha intracranial tumor On the basis of these results, we believe that local expression of IFN-alpha by DCs within the intracranial tumor site may enhance the clinical efficacy of peripheral vaccine approaches for brain tumors. 15313927 Human
ifn-alpha brain tumors On the basis of these results, we believe that local expression of IFN-alpha by DCs within the intracranial tumor site may enhance the clinical efficacy of peripheral vaccine approaches for brain tumors. 15313927 Human
ifn-alpha calgb We compared the outcome of 29 newly diagnosed Ph+ CML patients with additional abnormalities to that of 234 sole Ph+ patients, treated on CALGB protocols with IFN-alpha alone or together with IFN-gamma or low-dose cytarabine. 15201999 Human
ifn-alpha noncaseating granulomas Sarcoidosis, a multisystem disease characterized by noncaseating granulomas, has been reported to be associated with interferon alpha (IFN-alpha) therapy for hepatitis C infection. 15367877 Human
ifn-alpha low-grade lymphoma To improve outcomes, the German Low-Grade Lymphoma Study Group (GLSG) initiated a randomized trial to compare the effect of potentially curative myeloablative radiochemotherapy followed by autologous stem cell transplantation (ASCT) with interferon-alpha 15238420 Human
ifn-alpha indolent lymphoma To assess this risk more precisely, the German Low Grade Lymphoma Study Group investigated the incidence of t-MDS/t-AML after ASCT on the basis of a randomized comparison of ASCT versus interferon alfa (IFN-alpha) maintenance in indolent lymphoma. 15611507 Human
ifn-alpha indolent lymphoma PATIENTS AND METHODS: Between 1996 and 2002, 440 patients with indolent lymphoma were randomly assigned after a cyclophosphamide, doxorubicin, vincristine, and prednisone-like induction therapy regimen to myeloablative radiochemotherapy followed by ASCT o 15611507 Human
ifn-alpha stage iv melanoma EXPERIMENTAL DESIGN: Ninety patients with stage IV melanoma were treated with biochemotherapy, including cisplatin, vinblastine, and dacarbazine combined with interleukin (IL)-2 and IFN-alpha either with or without tamoxifen. 15709194 Human
ifn-alpha hepatoblastoma METHODS: Hepatoblastoma, myelocyte-derived and T cell leukemia-derived cell lines were treated with titrated doses of IFN-alpha for different incubation times and analyzed by Western blot, RT-PCR, and microarrays. 15885359 Human
ifn-alpha indolent lymphoma In a chemoimmunotherapy trial conducted between 1997 and 2003 in patients with stage IV indolent lymphoma, 202 patients were treated and 8 have developed MDS between 1 and 5 years after therapy, including 4 who received only fludarabine, mitoxantrone, and 15741224 Human
ifn-alpha cutaneous lymphoma Biologic response modifiers such as IFN-alpha, retinoids and extracorporeal photopheresis have been widely used in the treatment of cutaneous lymphoma. 15988920 Human
ifn-alpha hepatoblastoma Recently, the role of p53 in the cellular response to IFN-alpha has been proposed in other tumor models (hepatoblastoma). 15941683 Human
ifn-alpha recurrent tumor A case study of one patient who experienced recurrent disease during IFN-alpha treatment revealed that STAT1 levels were greater in the recurrent tumor when compared to the original lesion. 15668815 Human
ifn-alpha central nervous system tumors Delivery of dendritic cells engineered to secrete IFN-alpha into central nervous system tumors enhances the efficacy of peripheral tumor cell vaccines: dependence on apoptotic pathways. 16081851 Human
ifn-alpha esophageal scc The growth of esophageal SCC cells with 5-FU was suppressed synergistically or semi-additively by IFN-alpha and -beta, but not by IFN-gamma. 16101138 Human
ifn-alpha craniopharyngioma Additional studies should be carried out to determine the optimal dose of IFN-alpha in the treatment of cystic craniopharyngioma. 16133276 Human
ifn-alpha stage iv melanoma Twenty-two HLA A*0201 patients with stage IV melanoma were enrolled in a phase 1 safety and feasibility trial using a composite dendritic cell (DC) vaccine generated by culturing CD34 hematopoietic progenitors and activated with IFN-alpha. 16113607 Human
ifn alpha molar pregnancy In molar pregnancy, reactivity for IFN alpha, beta, and gamma was observed in syncytiotrophoblast. 2115786 Human
ifn alpha wart Presently, only one antiviral/immunomodulatory drug is available for wart therapy; this agent, interferon alpha (IFN alpha), is approved only for genital warts (condylomata acuminata) and is expensive, relatively difficult to use, associated with systemic 9098642 Human
ifn alpha hereditary renal cell carcinoma Two of the 4 patients underwent partial nephrectomy, 1 with multiple bone and lung metastases had all carcinoma foci extracted at the second stage and was administered UFT and IFN alpha, and the remaining 2 patients, who both had hereditary renal cell car 15170982 Human
ifn alpha carcinoma foci Two of the 4 patients underwent partial nephrectomy, 1 with multiple bone and lung metastases had all carcinoma foci extracted at the second stage and was administered UFT and IFN alpha, and the remaining 2 patients, who both had hereditary renal cell car 15170982 Human
ifnalpha metastatic osteosarcoma CONCLUSIONS: ATRA/IFNalpha treatment may be considered as an alternative approach in the treatment of patients with metastatic osteosarcoma who have disease that is resistant to conventional chemotherapy and in the treatment of patients with minimal tumor 11135229 Human
ifnalpha bcc IFNalpha induces Fas expression and apoptosis in hedgehog pathway activated BCC cells through inhibiting Ras-Erk signaling. 14647422 Human
ifnalpha bcc In the presence of IFNalpha, we observed increased apoptosis in a BCC cell line ASZ001, in which PTC is null, and therefore with constitutive activation of the sonic hedgehog pathway. 14647422 Human
ifnalpha bcc We further show that IFNalpha induces expression of Fas in BCC cells through interfering with Mek function. 14647422 Human
ifnalpha ewing tumor Here, we investigated the sensitivity of the Ewing tumor cell line, SK-N-MC, to the apoptotic effect of type I (IFNalpha) and type II (IFNgamma) interferons and TNFalpha. 15077162 Human
ifnalpha head and neck tumours Interferon-alpha (IFNalpha) is a recombinant protein widely used in the therapy of several neoplasms such as myeloma, renal cell carcinoma, epidermoid cervical and head and neck tumours and melanoma. 15290347 Human
ifnalpha head and neck tumors Interferon-alpha (IFNalpha) is a recombinant protein widely used in the therapy of several neoplasms such as myeloma, renal cell carcinoma, epidermoid cervical and head and neck tumors, and melanoma. 15389589 Human
ifnalpha head and neck tumours Interferon-alpha (IFNalpha) is a recombinant protein widely used in the therapy of several neoplasms such as myeloma, renal cell carcinoma, epidermoid cervical and head and neck tumours and melanoma. 15581417 Human
ifnalpha cutaneous lymphoma Biologic response modifiers such as IFN-alpha, retinoids and extracorporeal photopheresis have been widely used in the treatment of cutaneous lymphoma. 15988920 Human
ifnalpha stage iv melanoma We report the results of a phase II study using a novel biochemotherapy regimen containing temozolomide, cisplatin, decrescendo IL-2, IFNalpha, and GM-CSF in the treatment of stage IV melanoma. 16100942 Human
ifn oligodendroglioma Local injection of IFN to the tumor was effective even at the dose of 1 million units every other day for 16 days for glioblastoma and 50 days for oligodendroglioma. 2590560 Human
ifn oligodendroglioma For the oligodendroglioma, NK activities were significantly increased in the 9 million units of IFN injected group when compared to those of control group. 2590560 Human
ifn endometrial carcinoma Human lymphoblastoid interferon (IFN) was administered intraperitoneally to nude mice with yolk sac tumors of the ovary (YST-1 and YST-2) and endometrial carcinoma (AD-19). 6182258 Human
ifn yolk sac tumors of the ovary Human lymphoblastoid interferon (IFN) was administered intraperitoneally to nude mice with yolk sac tumors of the ovary (YST-1 and YST-2) and endometrial carcinoma (AD-19). 6182258 Human
ifn ocular melanoma Due to the current interest in natural killer (NK) cells as a host defence mechanism against neoplasia, we have investigated the susceptibility of short-term cultures of human ocular melanoma cells to spontaneous and interferon (IFN)-augmented natural cyt 6187437 Human
ifn oligodendrogliomas Effects of IFN and VCR against oligodendrogliomas were as follows: control; IFN (IP) less than VCR less than IFN (Local) less than VCR + IFN (IP); VCR + IFN (Local). 6239639 Human
ifn secondary malignancies Whether IFN can prevent secondary malignancies is also topic of these investigations. 7505988 Human
ifn cervix adenocarcinoma Relationship with the antiproliferative effect] Alpha Interferon (IFN) membrane receptor expression was studied in four human tumor cell lines from several origins: Burkitt's lymphoma (Daudi cells), cervix adenocarcinoma (HeLa cells), larynx carcinom 8154235 Human
ifn anaplastic large cell lymphoma We describe a patient with Philadelphia-chromosome-positive (Ph' +) chronic myelogenous leukemia (CML), who developed an anaplastic large cell lymphoma (ALCL) with T-phenotype, after 43 months successful treatment with alpha-interferon (IFN). 8231259 Human
ifn plasma cell leukemia (pcl) A 69-year-old woman with IgE/kappa plasma cell leukemia (PCL) was treated with a sequential combination of VAD (vincristine, doxorubicin, dexamethasone) and MP (melphalan, prednisolone) followed by interferon-alpha (IFN alpha). 8296801 Human
ifn squamous cell carcinomas of the skin Phase II trials of the novel biologic combination of 13-cis-retinoic acid plus interferon (IFN)-alpha have achieved major activity in advanced squamous cell carcinomas of the skin and cervix, but not of the lung or head and neck. 8358060 Human
ifn stage iv neuroblastoma In this study we have investigated, at the population and the clonal levels, the immunophenotypes and the non-specific cytotoxic functions of peripheral blood lymphocytes from three stage IV neuroblastoma patients receiving treatment with recombinant inte 8513451 Human
ifn pleural carcinomatosis Intrapleural application of natural IFN alpha in breast cancer patients with pleural carcinomatosis. 1414464 Human
ifn dnt About 40% of the double negative T (DNT) cells bore TcR-alpha beta, and in vitro clones of the same phenotype, established from the i.t. challenged lungs, were shown, upon ConA stimulation, to synthesize mRNA for IL-2, IL-3, IL-4, IL-5, IL-6, IFN gamma, T 1533311 Human
ifn metastatic renal cell carcinoma This report details a prospective study of the immunological effects on peripheral blood mononuclear cells of sequentially administered recombinant (r) interferon (IFN) gamma and rIFN alpha in 28 patients with metastatic renal cell carcinoma. 1737346 Human
ifn pure red cell aplasia (prca) High-titered spontaneous interferon (IFN) antibodies were detected in a patient with pure red cell aplasia (PRCA), a benign mediastinal tumor, and recurrent cutaneous carcinomas. 1903312 Human
ifn molar pregnancy In molar pregnancy, reactivity for IFN alpha, beta, and gamma was observed in syncytiotrophoblast. 2115786 Human
ifn erythroleukemia Administration of alpha/beta-interferon (IFN) exerts a marked antitumor effect in DBA/2 mice given injections i.v. of large numbers of IFN-alpha/beta-resistant erythroleukemia cells (FLC). 2140290 Human
ifn histiocytic lymphoma The effect of retinoic acid (RA) on the level of interferon (IFN)-induced 2-5 oligoadenylate (2-5A) synthetase activity was examined in human histiocytic lymphoma U937 cells and WISH cells** in order to ascertain the role of this polymerase in interaction 2472992 Human
ifn-alpha osteosarcoma It appears that less proliferative osteosarcoma xenografts are more sensitive to growth inhibition by IFN-alpha. 3466689 Human
ifn-alpha b cell prolymphocytic leukemia In two cases of resistance to IFN-alpha administration, we diagnosed variant HCL, a form of HCL with intermediate features between typical HCL and B cell prolymphocytic leukemia. 3530350 Human
ifn-alpha cervical tumor IFN-alpha was administered subcutaneously to mice with renal tumor (ACHN), intratumorally for glioblastoma (U-373MG) or intravenously with uterine cervical tumor (HeLa S3). 3753641 Human
ifn-alpha cutaneous squamous cell carcinoma A number of clinical trials were thus carried out in cancer and viral diseases, and IFN-alpha therapy was shown to have a wide range of indications in hematology and dermatology: B-cell malignancies (hairy cell leukemia, non-Hodgkin's lymphoma, multi 7515733 Human
ifn-alpha adenocarcinoma of the breast Preclinical evidence suggests a similar potential role for IFN-alpha combined with cyclophosphamide, doxorubicin (Adriamycin, Adria Laboratories, Columbus, OH), and 5-fluorouracil (CAF) in advanced adenocarcinoma of the breast. 8339255 Human
ifn-alpha urothelial carcinoma In addition, responses have been observed in patients with adenocarcinomas of the lung, pancreas, breast, and kidney, squamous cell carcinoma of the oesophagus, and urothelial carcinoma treated with 5-FU/IFN-alpha. 8509231 Human
ifn-alpha liver cysts The highest titers of IFN-alpha was found in A2 antigen carriers with the liver cysts, the highest level of IFN-gamma had B5 antigen carriers with the lung damage. 1380632 Human
ifn-alpha hydatidiform mole Using an immunohistochemical technique and a panel of monoclonal antibodies we have localized IFN-alpha, -beta and -gamma directly on formalin-fixed paraffin-embedded normal human placentae at different stages of pregnancy and in the hydatidiform mole. 1722381 Human
ifn-alpha gastrointestinal cancer IFN-alpha therapy is suggested to be useful for the treatment of CML associated with gastrointestinal cancer because of its possible parenteral administration and mild toxicity. 1920843 Human
ifn-alpha erythroleukemia Administration of alpha/beta-interferon (IFN) exerts a marked antitumor effect in DBA/2 mice given injections i.v. of large numbers of IFN-alpha/beta-resistant erythroleukemia cells (FLC). 2140290 Human
ifna anaplastic astrocytomas Human malignant gliomas (glioblastomas and anaplastic astrocytomas) are the most frequent brain tumors and are associated with a variety of genetic alterations including retinoblastoma (RB) and p53 gene mutations, loss of interferon alpha and beta (IFNA, 1501894 Human
ifna malignant glioma Absence of IFNA and IFNB genes from human malignant glioma cell lines and lack of correlation with cellular sensitivity to interferons. 2295067 Human
ifn-alpha corneal stromal disease IFN-alpha-treated mice developed a normal CTL response to HSV-1 after corneal infection, but the corneal invasiveness of the virus was markedly reduced and none of the treated mice developed corneal stromal disease. 1649898 Human
ifn-alpha tumorinfiltrating leukocytes Analysis of tumor-infiltrating leukocytes from mice treated with the combined IL-12 and IFN-alpha gene therapy showed upregulation of CD40 molecules on antigen-presenting cells (Mac-1(hi) cells). 10986558 Human
ifn intraperitoneal tumor Only one out of 20 animals receiving TNF or TNF in combination with IFN was found to have intraperitoneal tumor at the time of laparotomy, whereas all the untreated controls had gross intraabdominal carcinomatosis. 2504653 Human
ifn acute erythroleukemia (ael) A patient in second relapse of acute erythroleukemia (AEL) was treated with 10 MU of recombinant interferon (IFN)-alpha subcutaneously for 24 days after he had failed standard chemotherapy. 2754435 Human
ifn oral cavity cancers We studied the effects of combining OK-432 with alpha-interferon (IFN-alpha) on the endogenous production of IFN and the postoperative courses of patients with oral cavity cancers. 3101655 Human
ifn abdominal tumors Increased mortality with the combination was not due to added toxicity of CY and IFN since the mice developed abdominal tumors and ascites. 3356000 Human
ifn ehrlich ascites tumor (eat) The increase in number of Ehrlich ascites tumor (EAT) cells was diminished significantly when the cell culture was treated with 1,000 IU/ml of recombinant mouse alpha or beta interferon (IFN). 3372601 Human
ifn spleen metastases We conclude that IFN alpha/beta was particularly effective in inhibiting the development of liver and spleen metastases and in increasing mouse survival time after iv inoculation of FLCs. 3422696 Human
ifn ehrlich ascites tumors The inactivated preparations of serum IFN induced by Ge-132 did not show antitumor activity when administered to mice bearing Ehrlich ascites tumors. 3935051 Human
ifn reticulum cell sarcoma Although reticulum cell sarcoma cell extracts had no detectable effect in vitro, they were capable of inducing transient IFN production in vivo. 6420599 Human
ifn recurrent respiratory papillomatosis (rrp) The observation that interferon (IFN) therapy causes regression of lesions in some patients with recurrent respiratory papillomatosis (RRP) raises the possibilities that these patients may have abnormalities in endogenous IFN production or in antitumor im 6437314 Human
ifn anaplastic germ cell tumours Lymphoblastoid IFN does not appear to be active against anaplastic germ cell tumours but both lymphoblastoid and recombinant leukocyte A IFN may be useful in the treatment of unresectable differentiated teratoma. 6498061 Human
ifn primary osteogenic sarcomas These findings establish that conjugates containing IFN linked to a monoclonal antibody reacting with osteogenic sarcoma-associated antigens have potential for targeted immunotherapy and in related investigations with antibody has been shown by gamma came 6577942 Human
ifn gastrointestinal carcinoma The blood plasma levels of 5-fluorouracil (5FU) after i.v. administration have been determined without and under the influence of 1, 5 or 9 million units (MU) preadministered interferon (IFN) in patients with gastrointestinal carcinoma. 8149941 Human
ifn digestive tract cancer Due to the unfavorable cost/benefit ratio, the study was closed and a new trial, with different doses and schedule of IFN, was started within the GISCAD (Italian Group for the Study of Digestive Tract Cancer). 1609456 Human
ifn mucoepidermoid tumor [Enhanced cytotoxicity of antineoplastics by interferon] Cytotoxicities of bleomycin (BLM), vincristine (VCR) and adriamycin (ADM), and influence of interferon (IFN) on their effects were examined on three tumor cell lines of HeLa, HSG (established from h 2109027 Human
ifn murine renal cancer Flavone acetic acid (FAA) is an investigational drug that augments natural killer activity, induces the genes for alpha- and gamma-interferon (IFN) and tumor necrosis factor alpha, and synergizes with recombinant interleukin 2 for the successful treatment 2253233 Human
ifn moloney sarcoma We previously demonstrated that although natural killer (NK) cells participated in interferon (IFN)-induced inhibition of growth of the Moloney sarcoma MSC cell tumor, the need for NK cells could be circumvented by using a small tumor cell challenge or an 2463077 Human
ifn-alpha tumor infiltrating lymphocytes The article also discusses the rationale, preclinical data, and preliminary clinical trial experience with IL-2 in combination with other cytokines such as IFN-alpha, monoclonal antitumor antibodies, and tumor infiltrating lymphocytes (TILs). 2687810 Human
ifn-alpha oral cavity cancers We studied the effects of combining OK-432 with alpha-interferon (IFN-alpha) on the endogenous production of IFN and the postoperative courses of patients with oral cavity cancers. 3101655 Human
ifn-alpha oral cavity cancers Next, 50 patients operated on for oral cavity cancers were given OK-432 or a combination of OK-432 and IFN-alpha for 4 months, and their postoperative courses were followed for 2-5 years. 3101655 Human
ifn-alpha epidermodysplasia verruciformis (ev) The susceptibility of human papillomavirus infection to polyclonal human leukocyte interferon (IFN-alpha) has been evaluated in patients with epidermodysplasia verruciformis (EV), a disease with extensive chronic papillomavirus-induced warts. 6384282 Human
ifn-alpha intraperitoneal tumor Whole body hyperthermia was found to enhance the antitumor activity of IFN-alpha by approximately 1.0 fold and 1.2 fold for the subcutaneous and intraperitoneal tumor models, respectively. 1283487 Human
ifn-alpha rectum cancer Eleven patients with rectum cancer and four patients with colon cancer were treated according to the following schedule: 9 million units IFN-alpha subcutaneous three times a week; 500 mg/m2 5-FU via an intravenous bolus 1 hour after the initiation of a 2- 1557648 Human
ifn-a pancreatic tumor A 48-year-old woman with a nonresectable pancreatic tumor received combination chemotherapy with cytokines (IFN-a plus TNF-a) and 5-FU. 7872711 Human
ifn-a philadelphia chromosome positive chronic myelogenous leukemia An asymptomatic HIV-positive patient with Philadelphia chromosome positive chronic myelogenous leukemia (CML) was treated by interferon-a (IFN-a) for four years. 9250808 Human
ifn acute megakaryoblastic leukaemia The effects of interferons (IFN)-alpha, beta 2 and -gamma in inducing megakaryocytic differentiation of blast cells from a patient with acute megakaryoblastic leukaemia (AMegL) was investigated in liquid suspension culture by the increase in CD41 and CD42 7536511 Human
ifn cml In 55 patients with Ph1+ CML under interferon (IFN) monotherapy, an immunohistochemical and morphometric study on pretreatment bone marrow biopsies was performed to evaluate the prognostic impact of clinical as well as histological disease features. 7545352 Human
ifn primary colorectal cancer In this study, the induction by interferon alpha (IFN alpha) of two tumor surface antigens was evaluated in six patients with primary colorectal cancer. 7600563 Human
ifn biliary tract cancer The role of biomodulating chemotherapy of 5-FU by IFN or IFN and LV must also be investigated in the field of head and neck cancers, esophageal cancer, biliary tract cancer, all of which are relatively sensitive to the effector of 5-FU. 7611752 Human
ifn colon cancer Interferon-alpha (IFN alpha) potentiates the antitumor activity of 5-fluorouracil (FUra) in colon cancer in vitro, in vivo, and clinically. 7642571 Human
ifn oral hairy leukoplakia In vivo induction of detectable levels of bioactive acid-stable interferon (IFN)-alpha, but not of other cytokines studied, upon activated CD8 cell reinfusion was associated consistently with improvement of oral hairy leukoplakia. 7986402 Human
ifn skin cancers At present, IFN is clinically used in therapy against virus infections such as hepatitis B and C, and for malignancies such as renal cell carcinoma, multiple myeloma, malignant melanoma, glioblastoma, skin cancers, malignant lymphoma and chronic myelogeno 7993128 Human
ifn pancreatic adenocarcinoma Based on in vitro evidence of synergy and observed clinical activity, we conducted a pilot phase II trial of 13-cis-retinoic acid (1 mg/kg/day) and IFN alpha (6 million units/day) in patients with advanced pancreatic adenocarcinoma. 8526197 Human
ifn relapsed cml Guillain Barré syndrome, a possible side effect of buffy coat transfusion and IFN alpha therapy in relapsed CML after bone marrow transplantation. 8573544 Human
ifn stage iv colorectal cancer A total of 29 patients with stage IV colorectal cancer were entered into a phase II trial of bolus interleukin-2 (IL-2) and interferon-alpha (IFN alpha) (3 x 10(6) U/m2 of each cytokine given i.v. q8h x 15 doses and repeated in 2 weeks). 8680653 Human
ifn inflammatory pseudotumor [A case of inflammatory pseudotumor of the lung with suppressed immune response in the patient with renal cell carcinoma after nephrectomy and administration of interferon] A 60-year-old man with renal cell carcinoma was treated of right nephrectomy and h 8753039 Human
ifn vulvar carcinoma All cytokines, with the exception of IFN alpha, showed inhibitory effects on DNA synthesis by vulvar carcinoma cells. 9067409 Human
ifn wart Presently, only one antiviral/immunomodulatory drug is available for wart therapy; this agent, interferon alpha (IFN alpha), is approved only for genital warts (condylomata acuminata) and is expensive, relatively difficult to use, associated with systemic 9098642 Human
ifn metastatic carcinoma BACKGROUND: Recent clinical trials with a combination of interferon (IFN alpha) and 13 cis-retinoic acid resulted in high response rates among women with locally advanced and metastatic carcinoma of the uterine cervix. 9118041 Human
ifn recurrent carcinoma of the cervix METHODS: Sequential clinical trials were initiated by the New York Gynecologic Oncology Group to test the combination of tRA and IFN alpha in women with metastatic or recurrent carcinoma of the cervix who had failed primary therapy. 9118041 Human
ifn colorectal carcinomas CONCLUSIONS: It is unlikely that ras mutations will have significant prognostic value for either response to therapy or survival in patients with colorectal carcinomas treated with 5-FU and IFN. 9327152 Human
ifn thyroid papillary carcinoma In 1 patient, a small thyroid papillary carcinoma was observed, but no evidence of relationship with the liver disease or with IFN therapy was found. 9362390 Human
ifn transitional cell carcinoma (tcc) Natural killer (NK) cell assay within bladder mucosa of patients bearing transitional cell carcinoma (TCC) after interferon (IFN) therapy: an immunohistochemical and ultrastructural study. 9403351 Human
ifn hepatic disorders Our case study focused on four points: the clinical course of an HCV-infected recipient; the pathogenesis of hepatic disorders in such a patient; interferon (IFN)-alpha therapy; and the risk of IFN-alpha therapy. 9448159 Human
ifn mcl PATIENTS AND METHODS: Patients with MCL and FCL who entered onto the prospective randomized comparison of cyclophosphamide, vincristine, and prednisone (COP) versus prednimustine and mitoxantrone (PmM) followed by a second randomization for interferon (IF 9586911 Human
ifn relapsed cml The literature review identified 108 patients treated with IFN alpha as sole therapy for relapsed CML. 10100563 Human
ifn pituitary adenomas We investigated the effect of IFN alpha on hormone production by 15 GH-secreting pituitary adenomas, 4 clinically nonfunctioning or gonadotroph pituitary adenomas, and 4 prolactinomas in vitro. 10487708 Human
ifn pituitary adenoma In the GH-secreting pituitary adenoma cultures, a short term (72-h) incubation with IFN alpha (50-100 U/mL) significantly inhibited GH secretion in 3 of 7 cases and PRL secretion in 6 of 7 cultures. 10487708 Human
ifn prolactinoma In the clinically nonfunctioning or gonadotroph cultures, incubation with IFN alpha resulted in inhibition of the secretion of gonadotropins and/or alpha-subunit in all cases (27-62%), whereas in the prolactinoma cultures PRL secretion was inhibited by IF 10487708 Human
ifn pituitary adenomas In conclusion, the potent antihormonal effect of IFN alpha on cultured pituitary adenomas suggests that this drug might be of benefit in the treatment of selected patients with secreting pituitary adenomas. 10487708 Human
ifn meningeal carcinomatosis DEVELOPMENT: We reviewed studies of the applications of the IFN in viral diseases (experimental and human rabies, herpes zoster, herpes virus, non-herpetic meningoencephalitic viruses, HTLV-I myelopathy, arbovirus in animals, subacute sclerosing panenceph 10652752 Human
ifn pure red cell aplasia (prca) We report a case of pure red cell aplasia (PRCA) that resulted from interferon (IFN)-alpha therapy for chronic myelogenous leukemia. 11272289 Human
ifn chronic phase cml This study aimed to determine whether the changes in the cellular expression of Bcl-2, Bax, and Fas correlate with caspase-3 activity and disease progression in CML, or with response to interferon (IFN)-alpha therapy and prognosis in early chronic phase C 11391574 Human
ifn cml This study aimed to determine whether the changes in the cellular expression of Bcl-2, Bax, and Fas correlate with caspase-3 activity and disease progression in CML, or with response to interferon (IFN)-alpha therapy and prognosis in early chronic phase C 11391574 Human
ifn acute undifferentiated leukaemia (aul) AIM: The aims of the present study were to examine the efficacy and toxicity of IFN therapy administered after granulocyte colony-stimulating factor (G-CSF)-stimulated blood cells given as DLI in patients with acute myeloid leukaemia (AML), chronic myeloi 11478351 Human
ifn metastasis The purpose of this study was first to determine whether an imbalance between MMP-9 and E-cadherin expression correlates with metastasis from human transitional cell carcinoma (TCC) of the bladder after therapy with neoadjuvant chemotherapy and radical cy 11555602 Human
ifn transitional cell carcinoma (tcc) The purpose of this study was first to determine whether an imbalance between MMP-9 and E-cadherin expression correlates with metastasis from human transitional cell carcinoma (TCC) of the bladder after therapy with neoadjuvant chemotherapy and radical cy 11555602 Human
ifn recurrent tumor The recurrent tumor in liver of the IFN alpha-1b 1.5 10(7)U/kg/d treated group was much smaller than that of the controlled group (25 mm(3) 2 mm(3) vs 1143 mm(3) 3 mm(3), t =9.27, P<0.01), and the level of AFP mRNA was also lower than that of the controll 12113675 Mouse
ifn gastrointestinal stromal tumors (gists) Imatinib is indicated for the treatment of patients with CML who failed interferon (IFN)-alpha therapy and for the treatment of patients with gastrointestinal stromal tumors (GISTs) expressing the tyrosine kinase receptor c-kit. 12389876 Human
ifn hepatocellular carcinoma Interferon can block telomere erosion and in rare cases result in hepatocellular carcinoma development with telomeric repeat binding factor 1 overexpression in chronic hepatitis C. PURPOSE: The purpose of this study was to evaluate whether IFN therapy for 14614008 Human
ifn hepatocellular carcinoma (hcc) Interferon can block telomere erosion and in rare cases result in hepatocellular carcinoma development with telomeric repeat binding factor 1 overexpression in chronic hepatitis C. PURPOSE: The purpose of this study was to evaluate whether IFN therapy for 14614008 Human
ifn philadelphia chromosome positive chronic myelogenous leukemia [Therapy-related changes of angiogenesis in Philadelphia chromosome positive chronic myelogenous leukemia] To elucidate the effect of first-line treatment with interferon (IFN), hydroxyurea (HU) and the tyrosine kinase inhibitor imatinib (STI571) on angio 15010998 Human
ifn mcl To improve clinical outcome, the European MCL Network initiated a randomized trial comparing consolidation with myeloablative radiochemotherapy followed by autologous stem cell transplantation (ASCT) to alpha-interferon maintenance (IFN alpha) in first re 15591112 Human
ifn mcl Patients 65 years of age or younger with advanced-stage MCL were assigned to ASCT or IFN alpha after achievement of complete or partial remission by a cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP)-like induction therapy. 15591112 Human
ifn bone metastasis Thus, the interaction between T cells and bone cells could be physiologically critical for the maintenance of normal bone metabolism, and IFN might be an attractive cytokine for use in therapy for bone disease in pathological bone resorptive conditions su 16838644 Human
ifn indolent lymphoma The anti-CD20 monoclonal antibody, rituximab, and interferon alpha (IFN) are active agents in advanced stage, indolent lymphoma. 16923555 Human
ifn-alpha accelerated phase cml It would therefore seem that late chronic and accelerated phase CML patients benefit from combined IFN-alpha/ARA-C treatment and achieve haematological and cytogenetic responses not obtained during previous treatment without being exposed to undue toxicit 7672091 Human
ifn-alpha head and neck tumors CONCLUSIONS: We emphasize further clinical investigations evaluating the combined treatment with retinoids/IFN-alpha and ionizing radiation in squamous cell carcinomas such as head and neck tumors and cervical cancer. 7863423 Human
ifn-alpha mouse liver tumor We conclude that the LII protocol appears to be more effective in the treatment of mouse liver tumor than the IL-2 + IFN-alpha schedule, and that it may be a new promise for the treatment of patients with liver malignancies. 7923100 Human
ifn-alpha idiopathic pulmonary fibrosis (ipf) BACKGROUND: Previous studies have shown that patients with idiopathic pulmonary fibrosis (IPF) were more likely to be seropositive for hepatitis C virus (HCV) than normal controls, and that patients with chronic hepatitis C treated with interferon alpha ( 9039237 Human
ifn-alpha uveal melanoma IFN-alpha, IFN-gamma, IL1-beta, IL12, and TNF-alpha had limited effects on m-RCA expression on uveal melanoma cells in vitro. 9402107 Human
ifn-alpha primary macroglobulinemia This case report showed that IFN-alpha was also available for primary macroglobulinemia. 9754016 Human
ifn-alpha chronic myelomonocytic leukemia (cml) We report on an infant with chronic myelomonocytic leukemia (CML) diagnosed at 3 months of age who was treated with increasing IFN-alpha dosage (2.5-5.5 million U/m2/day) given subcutaneously for 7.5 months. 10368457 Human
ifn-alpha chronic myelomonocytic leukemia (cmml) Patients with chronic myelogenous leukemia (CML) who have failed or cannot receive interferon alpha (IFN-alpha) based regimens or patients with advanced chronic myelomonocytic leukemia (CMML) have very limited current therapeutic options. 10721772 Human
ifn-alpha benign epithelial tumors [Use of interferon-alpha (IFN-alpha) in the treatment of keratoacanthoma] BACKGROUND AND OBJECTIVE: Keratoacanthoma are benign epithelial tumors. 10789078 Human
ifn-alpha castleman's disease Our results indicate that IFN-alpha is truly directed against Castleman's disease and has less toxicity than drugs usually prescribed. 10874763 Human
ifn-alpha juvenile myelomonocytic leukemia (jmml) We report a 5-year-old boy with juvenile myelomonocytic leukemia (JMML) which relapsed after an allogeneic bone marrow transplant who was successfully treated with interferon-alpha (IFN-alpha). 11041570 Human
ifn-alpha merkel cell carcinoma IFN-alpha or TNF-alpha may be considered for the treatment of recurrent or advanced Merkel cell carcinoma. 11544938 Human
ifn-alpha recurrent hepatocellular carcinoma [A case of recurrent hepatocellular carcinoma successfully treated with a combination therapy of interferon-alpha and intravenous continuous infusion of 5-fluorouracil] We report a case of recurrent hepatocellular carcinoma (HCC) successfully treated with 12402433 Human
ifn-alpha stage iv melanoma Ten stage IV melanoma patients were treated by infusion of these CTL clones with IL-2 and IFN-alpha. 16177129 Human
ifn-alpha recurrent tumors Intrahepatic recurrent tumors were treated with transcatheter arterial chemoembolization (TACE), and lung metastases were treated with systemic combination chemotherapy of 5-fluorouracil (5FU) and interferon-alpha (IFN-alpha). 16297659 Human
ifna adenomas In order to elucidate the significance of the adenoma-carcinoma sequence in gastric carcinogenesis from a genetic point of view, we examined microsatellite alterations (replication error and loss of heterozygosity) on chromosomes 2p (D2S123), 3p (D3S1317) 7728762 Human
ifna differentiated adenocarcinomas In order to elucidate the significance of the adenoma-carcinoma sequence in gastric carcinogenesis from a genetic point of view, we examined microsatellite alterations (replication error and loss of heterozygosity) on chromosomes 2p (D2S123), 3p (D3S1317) 7728762 Human
ifna differentiated adenocarcinomas In differentiated adenocarcinomas, replication error was detected in 4 (17%, 4/23) at single or multiple loci, and loss of heterozygosity was observed frequently at D3S1317 (25%, 3/12), D5S409 (67%, 6/9), and IFNA (26%, 5/19). 7728762 Human
ifna adenomas LOH on 9p (IFNA; alpha-interferon locus) was detected in 22% (5/23 informative cases) of differentiated adenocarcinomas, 10% (1/10) of undifferentiated carcinomas and none (0/6) of the adenomas. 7775254 Human
ifna undifferentiated carcinomas LOH on 9p (IFNA; alpha-interferon locus) was detected in 22% (5/23 informative cases) of differentiated adenocarcinomas, 10% (1/10) of undifferentiated carcinomas and none (0/6) of the adenomas. 7775254 Human
ifna esophageal squamous cell carcinoma By the microsatellite assay, two types of genetic alterations, loss of heterozygosity (LOH) and replication error (RER), were examined using 7 dinucleotide repeat markers [D3S1317 (3p26); CI3-1169 (3p25); CI3-946 (3p25); D3S1255 (3p24.2-25); CI3-771 (3p21 7850805 Human
ifna adenocarcinoma of the esophagus Since esophageal cancer shares characteristics with some of the above tumor types, we performed a detailed examination of 60 patients with squamous cell carcinoma or adenocarcinoma of the esophagus for LOH at loci D9S162, IFNA, D9S171, D9S126, D9S104, D9S 7954453 Human
ifna esophageal cancer Since esophageal cancer shares characteristics with some of the above tumor types, we performed a detailed examination of 60 patients with squamous cell carcinoma or adenocarcinoma of the esophagus for LOH at loci D9S162, IFNA, D9S171, D9S126, D9S104, D9S 7954453 Human
ifna anaplastic astrocytomas We analyzed 19 samples of various astrocytic tumors (3 astrocytomas, 5 anaplastic astrocytomas, and 11 glioblastomas) for loss of heterozygosity (LOH) on chromosome 9p at 6 microsatellite loci (D9S54, IFNA, D9S171, D9S104, D9S165, and D9S166). 8864999 Human
ifna metastatic bladder cancers DESIGN: The authors examined the pattern of allelic loss with polymorphic microsatellite markers on chromosome 9p21 (D9S161, D9S171, IFNA), regions of putative tumor suppressor gene p16, and on chromosome 17p13 (TP53), the p53 locus, in matched primary an 11520271 Human
ifna recurrent pituitary tumours In contrast, however, the metastatic lesion showed a loss-to-retention pattern at two distinct loci (IFNA and D22S156) compared to the primary and recurrent pituitary tumours. 11678840 Human
ifna ampullary carcinoma Sixty-two point five percent (5/8) of ampullary carcinoma cases showed loss of heterozygosity at one or more of the loci, frequent site of loss being D9S942 (42.9%) and the next most frequent being IFNA (37.5%) and D9S171 (37.5%). 11780432 Human
ifna benign melanocytic nevi We have analyzed 54 benign melanocytic nevi and 6 DMN for loss of heterozygosity (LOH) at microsatellite markers D9S171, IFNA, D9S270, D9S265. 12079204 Human
ifna adenomas RESULT: High LOH frequencies (> 50%) of 9p (IFNA) and 17p (TP53) were observed in adenomas and carcinomas. 12926143 Human
ifna small-cell carcinoma We examined five polymorphic microsatellite markers located on chromosome 3p25-26 (D3S3050), chromosome 9p21 (IFNA and D9S171), chromosome 9q32-33 (D9S177), and chromosome 17p13 (TP53) in 20 patients with small-cell carcinoma of the urinary bladder and co 15855652 Human
ifna urothelial carcinoma We examined five polymorphic microsatellite markers located on chromosome 3p25-26 (D3S3050), chromosome 9p21 (IFNA and D9S171), chromosome 9q32-33 (D9S177), and chromosome 17p13 (TP53) in 20 patients with small-cell carcinoma of the urinary bladder and co 15855652 Human
ifn-a malignant liver tumours The objective of regional chemoimmunotherapy, i.e. the use of cytokines, in particular interferon alpha (IFN-a) and interleukin-2 (IL-2) in the therapeutic regimens is to improve the survival of patients with malignant liver tumours. 9221580 Human
ifn primary bladder cancer Preliminary loss of heterozygosity studies with 10 primary bladder cancer specimens using 10 markers spanning chromosome 9 revealed loss of heterozygosity at the IFN locus with retention of heterozygosity with more centromeric 9p markers and all informati 7513608 Human
ifn organ metastasis 5) The number of metastatic organ: there observed an improved survival in patients with one organ metastasis compared to those with more than two. 6) The treatment modality: there observed an improved survival in patients receiving interferon (IFN) therap 7807775 Human
ifn second malignancies We found second malignancies in 8 cases (4.0%), all but one of whom had received IFN. 8724535 Human
ifn second malignancies However, when compared to age- and sex- matched population data this represents no increase in relative risk of second cancer in patients with HCL and provides no evidence of a role for IFN in the pathogenesis of these second malignancies. 8724535 Human
ifn graft versus leukemia (gvl) The efficacy of IFN appears to be due to an anti-malignancy effect, not to graft versus leukemia (GVL) effect. 8923790 Human
ifn second malignancies Second malignancies occurred in eight (4.7%) of 386 patients who never received interferon (IFN), nine (5.9%) of 495 patients treated with IFN at the time of diagnosis, and seven (6.9%) of 102 patients who received IFN as second-line therapy. 11821443 Human
ifn m1 myeloid leukaemia Treatment of a range of murine cell lines with a combination of type I and II IFN showed that the muIfnar-2a and -2c mRNA isoforms were up-regulated independently of each other in L929 fibroblasts and hepa-1c1c7 hepatoma cells, but not in M1 myeloid leuka 11939908 Human
ifn lymph node metastasis We then analyzed 359 patients without lymph node metastasis, and the presence of symptoms, pT, grade, IFN and venous involvement were considered significant. 12411566 Human
ifn skin malignancy This finding led to the hypothesis that suppressed expression of ISGF-3 proteins may lead to reduced IFN responsiveness, which in turn may contribute to skin malignancy by conferring a growth and/or survival advantage. 12748307 Human
ifn postpolycythemic myelofibrosis (ppmf) Eleven patients (median age, 63 years; range, 33-82 years) with IMF (n = 8) or postpolycythemic myelofibrosis (PPMF) (n = 3) were studied All patients had been treated with HU (n = 9) and/or IFN (n = 7) before study entry. 14635203 Human
ifn carcinoma foci Two of the 4 patients underwent partial nephrectomy, 1 with multiple bone and lung metastases had all carcinoma foci extracted at the second stage and was administered UFT and IFN alpha, and the remaining 2 patients, who both had hereditary renal cell car 15170982 Human
ifn hereditary renal cell carcinoma Two of the 4 patients underwent partial nephrectomy, 1 with multiple bone and lung metastases had all carcinoma foci extracted at the second stage and was administered UFT and IFN alpha, and the remaining 2 patients, who both had hereditary renal cell car 15170982 Human
ifn skin malignancies Interferon (IFN) is a pro-inflammatory cytokine that is widely used for the treatment of a number of disorders including viral infections, hematological proliferative disorders, and skin malignancies. 15907352 Human
ifn large b cell lymphoma The effect of interferon (IFN)-alpha, beta and gamma on the growth of DHL-4 diffuse large B cell lymphoma cells was studied. 15922860 Human
ifn cholangiocellular carcinoma (ccc) Six months after completion of IFN therapy, cholangiocellular carcinoma (CCC) was detected in the posterior inferior segment and was resected surgically. 16001668 Human
ifn-alpha squamous cell skin cancer Our findings indicate that IFN-alpha can directly induce apoptosis (programmed cell death) in sensitive squamous cell skin cancer cell lines. 7705922 Human
ifn-alpha chronic b lymphocytic leukemia We show that interferon-alpha (IFN-alpha), although able to decrease in vivo the number of leukemic cells, protects chronic B lymphocytic leukemia cells from in vitro programmed cell death or apoptosis. 7923926 Human
ifn-alpha mediated tumor cytotoxicity Neutralizing antibodies to IFN-alpha/beta reversed TNF-alpha and NOS mRNA synthesis, as well as nitric oxide (NO)-mediated tumor cytotoxicity. 8564712 Human
ifn-alpha low grade b-cell lymphomas As a single agent, interferon-alpha (IFN-alpha) can induce remissions, mostly partial, in a large fraction of patients with indolent lymphomas, including the low grade B-cell lymphomas and cutaneous T-cell lymphoma. 8881370 Human
ifn-alpha endocrine pancreatic tumours We studied the development of antibodies against double-stranded DNA (dsDNA) and clinical signs of autoimmune disease in 214 patients with malignant carcinoids or endocrine pancreatic tumours consecutively admitted for treatment with IFN-alpha. 9709457 Human
ifn-alpha epidermotropic cutaneous t-cell lymphoma (ectl) Although interferon-alfa (IFN-alpha) has proved effective in treating epidermotropic cutaneous T-cell lymphoma (ECTL), few studies have considered the follow-up of treated patients and whether complete remission was maintained. 10233261 Human
ifn-alpha pancreatic neuroendocrine tumor To test the hypothesis that IFN-alpha can directly interfere with CgA gene transcription, we performed transient transfection studies in pancreatic neuroendocrine tumor cells employing CgA-luciferase reporter gene constructs showing that IFN-alpha inhibit 10570944 Human
ifn-alpha methylcholanthrene-induced fibrosarcoma Here, we report that the combination of IFN-alpha and CD80 cancer gene therapy in poorly immunogenic murine tumor models, the colorectal adenocarcinoma cell line MC38, and the methylcholanthrene-induced fibrosarcoma cell line MCA205 reduces tumor growth m 10637450 Human
ifn-alpha primary plasma cell leukemia Long-term disease-free survival in a primary plasma cell leukemia treated by VAD, autologous PBSC transplantation, and IFN-alpha. 12221683 Human
ifn-alpha intraperitoneal tumor In contrast, STAT1-/- mice could not utilize exogenous IFN-alpha to inhibit the growth of STAT1+/+ melanoma cells in either an intraperitoneal tumor model or in the adjuvant setting. 12865406 Human
ifn-alpha ovarian clear cell adenocarcinoma EXPERIMENTAL DESIGN: (a) The effects of IFN-alphaCon1 on growth, morphology, cell cycle, and type I IFN-alpha receptor (IFNAR-2) expression were examined on two ovarian clear cell adenocarcinoma cell lines (KOC-5C and KOC-7C) in vitro. 15534119 Human
ifn desmoid tumours The observations provide the first comparative molecular characterization of desmoid tumours and nodular fasciitis and suggest that selected tyrosine kinases, transcription factors, and members of the Wnt, TGF-beta, IFN, and TNF signalling pathways may be 16440290 Human
ifn liver cancer Productive infections have been achieved recently with genotype 2a virus, but cirrhosis and liver cancer are typically associated with genotype 1 HCV, which is more prevalent and relatively resistant to IFN therapy. 16461899 Human
ifn dlbcl In fact, IFN-gamma induced BAL1 and BBAP expression in DLBCL cell lines; doxycycline-induced BAL1 also increased the expression of multiple IFN-stimulated genes, directly implicating BAL1 in an IFN signaling pathway. 16809771 Human
ifn-alpha neuroendocrine carcinomas Interferon-alpha (IFN-alpha) is well established in the treatment of neuroendocrine carcinomas (NEC). 16426143 Human
ifn-alpha neuroendocrine carcinomas Interferon-alpha (IFN-alpha) is used for biotherapy of neuroendocrine carcinomas. 16650825 Human
ifn-alpha stage iv melanoma We have carried out a pilot phase I-II trial to determine the effects of IFN-alpha, administered as an adjuvant of Melan-A/MART-1:26-35(27L) and gp100:209-217(210M) peptides, on immune responses in stage IV melanoma patients. 16651452 Human
ifn-alpha hcl-v HCL variant (HCL-V) is a distinct clinico-pathological entity which seems to be resistant to IFN-alpha and purine nucleoside analogs - DCF and 2-CdA. 16781083 Human
ifn-alpha idiopathic myelofibrosis The lack of adequate therapies for patients with MPDs and the superior pharmacokinetic and pharmacodynamic profile of PEG-IFN-alpha relative to standard IFN-alpha has prompted the investigation of the activity and safety of PEG-IFN-alpha in patients with 16810616 Human
ifn-alpha gastrointestinal neoplasms The clinical efficacy of IFN-alpha mono- or combination therapies in patients with gastrointestinal neoplasms is expected to be lower than in patients with HCC based on the expression level of IFNAR2. 16820899 Human
ifn-alpha recurrent pancreatic cancer [Interferon-alpha+cisplatin+5-FU therapy for gemcitabine-refractory unresectable and recurrent pancreatic cancer] Interferon-alpha (IFN-Alpha) + cisplatin (CDDP) + 5-FU therapy was given to 10 patients with gemcitabine (GEM)-refractory unresectable or rec 16835483 Human
ifn-alpha tumor thrombus This report describes the preliminary results of treatment of IFN-alpha/5-FU combined chemotherapy following palliative hepatic resection for advanced hepatocellular carcinoma with tumor thrombus in the main trunk of the portal vein with multiple nodules 17212125 Human
ifn-alpha tumor thrombus [Intra arterial infusion chemotherapy combined with interferon-alpha following palliative hepatic resection against advanced hepatoma with portal venous tumor thrombus in the major trunk and multiple nodules--a preliminary study] Recently, we reported the 17212125 Human
ifn-alpha postpolycythemic myelofibrosis Moreover IFN-alpha may prevent or delay the development of postpolycythemic myelofibrosis if used early in the course of the disease. 10674896 Human
ifn-alpha gastroenteropancreatic neuroendocrine tumors IFN-alpha controls hormone secretion and symptoms in human gastroenteropancreatic neuroendocrine tumors (GEP-NET) but it rarely induces a measurable tumor size reduction. 16397272 Human
ifl hodgkin's disease Objective evidence of antitumor activity was seen in non-Hodgkin's lymphoma, chronic lymphocytic leukemia, Hodgkin's disease, breast cancer, and melanoma, indicating that IFL-rA, the first genetically engineered biological response modifier avai 6752447 Human
ifn laryngeal papillomatosis IFN-dosage for each patient was determined using the induction kinetics of (2'-5')-oligo(A)synthetase (OAS) in the mononuclear cells of the circulating blood of patients with laryngeal papillomatosis. 3114545 Human
ifn cmml In two CMML-patients investigated CFU-C proliferation appeared to some extent inhibited by the addition of IFN-alpha, IFN-gamma and TNF-alpha to cell cultures. 3164085 Human
ifn ehrlich ascites tumors [Antitumor mechanisms of carboxyethyl-germanium sesquioxide (Ge-132) in mice bearing Ehrlich ascites tumors] The administration of IFN-containing sera (Ge-sera) obtained from Ge-132-treated mice (Ge-mice) or the passive transfer of macrophages (M phi) to 3800401 Human
ifn malignant transformation Decay of these constituents during some virus-induced or malignant transformation processes could result in a defect in the synthesis of one of these constituents, causing in parallel a loss of IFN sensitivity. 6184818 Human
ifn histiocytic lymphoma Effects of human fibroblast (beta) or leukocyte (alpha) interferon (IFN) on differentiations of a human histiocytic lymphoma-derived cell line (U937) or promyelocytic leukemia-derived cell line (HL-60) were studied. 6348086 Human
ifn urinary tract tumors Part II: Specificity of NK cell activity of IFN-stimulated PBL against cell lines derived from malignant urinary tract tumors] 6376902 Human
ifn midgut carcinoid tumours Nine patients with mid-gut carcinoid tumours received leucocyte interferon (IFN) i.m. daily for 90 days. 6616963 Human
ifn uveal melanoma We investigated the expression of integrins, ICAM-1, and CD44 and the influence of interferon-alpha (IFN-alpha), interferon-gamma (IFN-gamma), and tumour necrosis factor-alpha (TNF-alpha) on expression of these molecules on four uveal melanoma cell lines. 7496158 Human
ifn pseudolymphoma The possible association between IFN alpha treatment and chronic hepatitis B with the development of pseudolymphoma is discussed. 7514058 Human
ifn carcinogenesis Interferon (IFN) seems to be effective in some patients but whether it prevents carcinogenesis is unknown. 7564784 Human
ifn jcml The above results, along with the easy administration and absence of considerable side effects, suggest that alpha(Ly)-IFN may be a useful therapeutic tool in patients affected by JCML awaiting bone marrow transplantation. 7626389 Human
ifn renal carcinoma The human renal carcinoma cell metastatic line SN12PM6 was established in culture from a lung metastasis and SN12PM6-resistant cells were selected in vitro for resistance to the antiproliferative effects of IFN-alpha or IFN-beta. 7753843 Human
ifn pleural malignant mesothelioma The aim of this study was to assess the response of four mesothelioma cell lines, derived from diffuse asbestos-related pleural malignant mesothelioma, to methotrexate alone and in combination with recombinant IFN-alpha and IFN-gamma. 7756687 Human
ifn pediatric all Pediatric ALL patients with IFN-gene deletions or homozygosity for all polymorphisms in the IFN-loci had a significantly worse prognosis than heterozygotes. 8100807 Human
ifn metastatic tumors Contralateral injection (s.c.) of IFN-producing FLC into mice with established metastatic tumors produced a marked inhibition of tumor growth, with a survival rate of 10% for injected mice. 8439955 Mouse
ifn metastatic tumors These results indicate that: (a) the genetic modification of highly metastatic FLC by means of transfer of the IFN-alpha 1 gene results in potent tumor cell rejection, which is mediated by an IFN-induced host immune response; (b) injections of IFN-produci 8439955 Mouse
ifn immunoblastic lymphoma Treatment of an established Eskol tumor (histologically a malignant immunoblastic lymphoma) with AAV/IFN-con1-transduced 293 cells resulted in tumor regression, whereas treatment of Eskol tumors with IFN-con1 resulted in a small decrease in tumor size. 8785709 Human
ifn adh Since interferon (IFN) is known to affect retroviral assembly and maturation on the cell membrane, we have studied the effects of IFN on endogenous MMTV-related structures, as well as on the immunogenicity of T-25-Adh cells. 9247559 Human
ifn uveal melanoma IFN-alpha, IFN-gamma, IL1-beta, IL12, and TNF-alpha had limited effects on m-RCA expression on uveal melanoma cells in vitro. 9402107 Human
ifn solid tumors Despite the potential of type 1 interferons (IFNs) for the treatment of cancer, clinical experience with IFN protein therapy of solid tumors has been disappointing. 9826714 Human
ifn pancreatic carcinoid tumor The purpose of this study was to determine the effect of IFN-alpha and IFN-gamma on the Stat pathway using a unique human pancreatic carcinoid tumor, BON, established in our laboratory. 9831114 Human
ifn human endometrial adenocarcinoma In the present study, we have investigated the effects of interferons-alpha (IFN-alpha) and -gamma (IFN-gamma), interleukin-10 (IL-10) and -13 (IL-13), transforming growth factor-beta1 (TGF-beta1), granulocyte-macrophage colony-stimulating factor (GM-CSF) 10367939 Human
ifn solid carcinomas Using a sensitive immunoassay, the mitogen-induced production of interferon-gamma (IFN-gamma) and virus-stimulated IFN-alpha production was investigated in whole blood cell cultures of 115 control subjects and 225 untreated patients with various solid car 1290032 Human
ifn emc In vitro, it appears that MAG = 3but predisposes malignant MSV cells to a later, complete establishment of the antiproliferative and the cell-differentiating effects of IFN, and the antiviral action of the latter in the same line of cells infected with en 1318271 Human
ifn liver cysts The highest titers of IFN-alpha was found in A2 antigen carriers with the liver cysts, the highest level of IFN-gamma had B5 antigen carriers with the lung damage. 1380632 Human
ifn malignant transformation Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase. 1382315 Human
ifn malignant transformation This finding may add some support to the hypothesis that defects in the IFN system could be a step on the path to malignant transformation in ALL. 1562733 Human
ifn erythroleukemia Administration of alpha/beta-interferon (IFN) exerts a marked antitumor effect in DBA/2 mice given injections i.v. of large numbers of IFN-alpha/beta-resistant erythroleukemia cells (FLC). 2140290 Human
ifn stage i melanoma Stage I melanoma patients did not differ in their IFN-induced NK activity from healthy control subjects using Chang hepatoma and JY cell lines. 2474550 Human
ifn stage i melanoma Finally, the IFN-induced increase in NK activity directed against primarily NK-insensitive target cell lines was significant in stage I melanoma patients and in healthy controls (P less than 0.01, respectively), but not in patients with metastatic melanom 2474550 Human
ifn-alpha cmml In two CMML-patients investigated CFU-C proliferation appeared to some extent inhibited by the addition of IFN-alpha, IFN-gamma and TNF-alpha to cell cultures. 3164085 Human
ifn-alpha leukemia Our results suggest that: (1) the presence of bcr rearrangement in CML is associated with clinical features of Ph-positive disease, even in the absence of the Ph chromosome; (2) deletions occur within bcr and necessitate the use of probes covering both 5& 3171624 Human
ifn-alpha osteosarcoma It appears that less proliferative osteosarcoma xenografts are more sensitive to growth inhibition by IFN-alpha. 3466689 Human
ifn-alpha liver tumor Two modifications in this study, including the use of subcutaneous transposed spleen (STS) as a port for administration of recombinant interleukin-2 (IL-2) and interferon-alpha (IFN-alpha), and the mixture of IL-2 and IFN-alpha with degradable starch micr 7923099 Human
ifn-alpha cancer Most importantly, the possibility of hypothyroidism must be considered; however, diagnosis of hypothyroidism in cancer patients is complicated by the occurrence of the "sick euthyroid syndrome." Clinical recommendations for assessment and treatm 9482541 Human
ifn-alpha hnscc Retinoic acid (RA) and interferon alpha (IFN-alpha), drugs with known biological activity against HNSCC when used individually, are also inhibitors of angiogenesis. 9850093 Human
ifn-alpha ovarian malignancies Human lymphoblastoid interferon (IFN-alpha-N1) plus doxorubicin, cyclophosphamide, and cisplatin in the treatment of advanced epithelial ovarian malignancies. 1987744 Human
ifn-alpha erythroleukemia Administration of alpha/beta-interferon (IFN) exerts a marked antitumor effect in DBA/2 mice given injections i.v. of large numbers of IFN-alpha/beta-resistant erythroleukemia cells (FLC). 2140290 Human
ifn-alpha bladder transitional cell carcinoma The authors sought to determine the prognostic value of nuclear p53 and pRb in superficial bladder transitional cell carcinoma patients who were treated with intravesical bacille Calmette-Guerin (BCG) or BCG with interferon-alpha (IFN-alpha). 17311305 Human
ifn-alpha bladder transitional cell carcinoma METHODS: A prospective histological review was performed for 80 superficial bladder transitional cell carcinoma patients who underwent postresection intravesical regimes of BCG (81 mg, n = 33 or 27 mg, n = 20) or BCG (27 mg) with IFN-alpha (n = 27), and f 17311305 Human
ifn-alpha low-grade tumors Low-grade tumors were associated with pRb overexpression, with or without nuclear p53 underexpression (P = .019; P = .043, respectively). p53 expression alone or in combination with pRb expression had no significant relation with tumor response to BCG alo 17311305 Human
ifna urothelial carcinomas Six polymorphic microsatellite markers where genetic alterations occur frequently in early or advanced stages of urothelial carcinomas, including D3S3050, D8S261, IFNA, D9S177, D11S569 and TP53, were investigated in the current study. 17236170 Human
ifn mouse fibrosarcoma To directly measure the effect of RNase L on tumour growth in the absence of other IFN-induced proteins, human RNase L cDNA was stably expressed in P-57 cells, an aggressive mouse fibrosarcoma cell line. 17055253 Human
ifn prostate tumors An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors. 17234809 Human
ifn liver tumors A 42-year-old woman with biopsy-proven chronic hepatitis B, who had been treated with human leukocyte-derived interferon-alpha (huLe-IFN alpha) therapy for two months was found to have liver tumors on routine abdominal ultrasonography examination. 7514058 Human
ifn-alpha waldenström's macroglobulinemia IFN-alpha as induction and maintenance treatment of patients newly diagnosed with Waldenström's macroglobulinemia. 12433280 Human
ifn-alpha waldenström's macroglobulinemia IFN-alpha is an effective agent for the induction and maintenance treatment of Waldenström's macroglobulinemia patients. 12433280 Human
ifn-alpha tumor thrombi In conclusion, IFN-alpha/5-FU combined therapy may be a promising modality for advanced HCC with tumor thrombi in the major trunk with multiple nodules after following palliative surgery. 17212125 Human
ifn malignant pleural mesothelioma The combination of high dose MTX and IFN-alpha and IFN-gamma is active against malignant pleural mesothelioma and well-tolerated. 10468296 Human
ifn lymphomagenesis The IFN resistance of the dominant T-helper 2 cells might be important for lymphomagenesis. 11154232 Human
ifn human endometrial adenocarcinoma We observed that treatment of human endometrial adenocarcinoma cell, Ishikawa, with IFN-gamma or IFN-alpha markedly induced the expression of GBP1 mRNA. 11397834 Human
ifn tcc The purpose of this study was first to determine whether an imbalance between MMP-9 and E-cadherin expression correlates with metastasis from human transitional cell carcinoma (TCC) of the bladder after therapy with neoadjuvant chemotherapy and radical cy 11555602 Human
ifn prostatic adenocarcinomas Furthermore, in silico data-mining with the GeneLogic database revealed that expression of the IFN-inducible genes was down-regulated in approximately 30% of the 49 clinically characterized samples of prostatic adenocarcinomas. 11880635 Human
ifn prostatic tumor Collectively, we show that there seems to be a direct link between IFN-inducible molecules and prostatic tumor progression. 11880635 Human
ifn non-melanoma skin cancer PURPOSE: IFN-based therapy has been shown to be active in the treatmentof squamous cell carcinoma (SCC) of the skin, the most aggressive form of non-melanoma skin cancer. 12114405 Human
ifn ewing tumor We have recently reported that Ewing tumor cell proliferation was strongly inhibited by IFN-beta and to a lesser degree by IFN-alpha. 12400012 Human
ifn intraepithelial neoplasm IFN-gamma and IFN-alpha production in vitro by peripheral blood cells activated by phytohemagglutinin or the Newcastle disease virus was impaired in patients with a benign process, cervical intraepithelial neoplasm and cancer in situ associated with human 12630331 Human
ifn leukemogenesis Recently, the role of oncogenic K-ras in leukemogenesis was investigated in a novel mouse model utilizing interferon (IFN)-inducible, Cre-mediated expression of oncogenic K-ras from its endogenous promoter. 15020845 Human
ifn calgb We compared the outcome of 29 newly diagnosed Ph+ CML patients with additional abnormalities to that of 234 sole Ph+ patients, treated on CALGB protocols with IFN-alpha alone or together with IFN-gamma or low-dose cytarabine. 15201999 Human
ifn ovarian clear cell adenocarcinoma PURPOSE: We examined the antiproliferative effect of IFN-alphaCon1 and its mechanism on ovarian clear cell adenocarcinoma in vitro and in vivo. 15534119 Human
ifn ovarian clear cell adenocarcinoma EXPERIMENTAL DESIGN: (a) The effects of IFN-alphaCon1 on growth, morphology, cell cycle, and type I IFN-alpha receptor (IFNAR-2) expression were examined on two ovarian clear cell adenocarcinoma cell lines (KOC-5C and KOC-7C) in vitro. 15534119 Human
ifn bladder cancer Our data show that IFN-induced apoptosis in bladder cancer cells frequently involves autocrine TRAIL production. 15604261 Human
ifn leukoplakia We present a case of erosive OLP, cutaneous lichen planus (CLP), and leukoplakia of the vocal cord in a man with chronic hepatitis C infection treated with IFN and ribavirin. 15647837 Human
ifn sarcoma The Kaposi's sarcoma-associated herpesvirus open reading frame K9 encodes viral IFN regulatory factor 1 (vIRF1), which functions as a repressor of IFN-mediated signal transduction. vIRF1 expression in NIH 3T3 cells leads to transformation and consequ 15753369 Human
ifn esophageal scc The growth of esophageal SCC cells with 5-FU was suppressed synergistically or semi-additively by IFN-alpha and -beta, but not by IFN-gamma. 16101138 Human
ifn lung tumors To determine the role of Foxm1 during the development of mouse lung tumors, we used IFN-inducible Mx-Cre recombinase transgene to delete mouse Foxm1 fl/fl-targeted allele before inducing lung tumors with urethane. 16489016 Human
ifn skin cancer A scenario of dermal events following skin cancer treatment with imiquimod presumably comprises (i) an initial low amount of pro-inflammatory cytokine secretion by macrophages and dermal dendritic cells (DCs), thereby (ii) attracting an increasing number 16630072 Human
ifn angiosarcomas IFN-alpha1,8 inhibits tumor-induced angiogenesis in murine angiosarcomas. 16689662 Mouse
ifn mastocytosis We treated four patients (mean age 52 years) with severe osteoporosis and mastocytosis proven by bone marrow biopsy (more than 40 mast cells/mm3), according to the following protocol: interferon alpha (IFN) 3 million units (MU) three times a week, reduced 16902757 Human
ifn mastocytosis The association of IFN and Pam led to a major increase in bone marrow density in osteoporosis with concomitant mastocytosis and this gain was then maintained by monthly infusions of Pam. 16902757 Human
ifn gist Analysis of RNA expression profiles in GIST lesions with and without imatinib treatment showed changes in expression of IFN-inducible genes and cell cycle regulators. 16908864 Human
ifn mouse neuroblastoma The growth of a virulent strain of fixed rabies virus, Nishigahara, in mouse neuroblastoma NA cells treated with type I interferon (IFN) was compared with that of a derivative avirulent strain, Ni-CE. 17179666 Human
ifn-alpha extraabdominal desmoid tumors METHODS: Thirteen patients with extra-abdominal desmoid tumors and a median age of 32 years (range, 15-73) received IFN-alpha. 10649274 Human
ifn-alpha recurrent tumor This study was undertaken to investigate the effects of interferon-alfa-1b (IFN-alpha-1b) on recurrent tumor and metastasis after curative resection in nude mice bearing an HCC xenograft with high metastatic potential. 10869287 Human
ifn-alpha hepatocarcinogenesis The present study therefore highlights that early preventive administration of IFN-alpha can slow down evolution towards hepatocellular carcinoma via repression of c-myc and hepatocyte proliferation at premalignant steps in experimental c-myc-induced hepa 12743599 Human
ifn-alpha hnscc We found that HNSCC diminished the ability of PDC to produce IFN-alpha in response to CpG motif containing oligonucleotide. 14559840 Human
ifn-alpha primary tumor In tumor-draining lymph nodes, suppression of CpG-induced IFN-alpha production was less pronounced than in single-cell suspensions of primary tumor tissue. 14559840 Human
ifn-alpha malignant transformation The HPV typing revealed an association of HPV 11 with a more aggressive disease course (64% of HPV 11 patients versus 24% of HPV 6 patients), a lower incidence of long-term response to IFN-alpha therapy (14% of HPV 11 patients versus 64% of HPV 6 patients 16042104 Human
ifn-alpha malignant transformation The association of HPV 11 with a worse long-term response to IFN-alpha therapy and a higher incidence of malignant transformation and mortality is clinically important and indicates the necessity of HPV typing in RRP patients after the first biopsy. 16042104 Human
ifn-alpha head and neck cancer Synergistic antitumor activity of epidermal growth factor receptor tyrosine kinase inhibitor gefitinib and IFN-alpha in head and neck cancer cells in vitro and in vivo. 16428508 Human
ifn-alpha stage iv melanoma Immunization of stage IV melanoma patients with Melan-A/MART-1 and gp100 peptides plus IFN-alpha results in the activation of specific CD8(+) T cells and monocyte/dendritic cell precursors. 16651452 Human
ifn-alpha systemic mastocytosis (sm) In the absence of curative options, therapy for aggressive forms of systemic mastocytosis (SM) has relied in the use of cytoreductive agents, mainly interferon-alpha (IFN-alpha) and cladribine. 16948123 Human
ifna urothelial carcinomas We examined four polymorphic microsatellite markers located on chromosome 9q32-33(D9S177), chromosome 9p22 (IFNA), chromosome 3p14.2 (D3S1300) and chromosome 17p13.1 (TP53), where genetic alterations occur frequently in urothelial carcinomas. 16862073 Human
ifna mature teratoma The frequency of allelic loss in informative cases of metastatic mature teratoma was 27% (8 of 30) with D1S1646, 34% (10 of 29) with D9S171, 37% (10 of 27) with IFNA, 27% (8 of 30) with D9S303, 46% (13 of 28) with D13S317, 26% (7 of 27) with D18S543, and 16982812 Human

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