IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ELAVL2 Ensembl ENSG00000107105 Chromosome 9 Start 23680102 End 23816335
Description ELAV-like protein 2 (Hu-antigen B)(HuB)(ELAV-like neuronal protein 1)(Nervous system-specific RNA-binding protein Hel-N1) [Source:UniProtKB/Swiss-Prot;Acc:Q12926]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 3313
     Entrez Gene : 1993
     UCSC : uc003zpu.2
     GeneCards : 3313
     RefSeq : NM_001171195
     CCDS : CCDS6515.1
     Uniprot : Q12926
     Interpro : Q12926
     OMIM : 601673
     GeneTests : ELAVL2
     CGAP : ELAVL2
     PMID : 8812435

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  36410_f_at  0.16  4.99e-1  6.03e-1  0.27  4.44e-1  5.49e-1
 HG_U95  36411_s_at  0.45  1.46e-3  4.39e-3  0.53  6.78e-3  1.64e-2
 HG_U133A  208427_s_at  -0.17  2.50e-1  2.99e-1  0.77  9.60e-10  1.20e-9
 HG_U133_Plus2  208427_s_at  0.48  1.86e-2  3.53e-2  0.12  6.33e-1  6.84e-1
 HG_U133_Plus2  228260_at  0.74  2.71e-4  7.91e-4  0.30  1.71e-1  2.18e-1
 Agilent_HS_21.6K  1085  0.07  5.38e-3  2.87e-2  0.05  7.36e-2  1.65e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  208427_s_at  -0.16  7.63e-1  9.75e-1  -0.04  9.15e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 36410_f_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 36411_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208427_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208427_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 228260_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 1085    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
hel-n1 glioblastoma Surprisingly, 55% of the glioblastoma cell lines showed Hel-N1 expression. 9988134 Human
hel-n1 tumor Hel-N1 and HuD transcriptional activity are stable markers for medulloblastoma cell lines, a tumor, which is thought to be derived from a neuronal precursor cell. 9988134 Human
hel-n1 glial tumors The role of Hel-N1 in glioblastomas, the most prominent representative of the glial tumors is presently unclear. 9988134 Human
hel-n1 tumor ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells. 10049360 Human
hel-n1 human teratocarcinoma ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells. 10049360 Human
hel-n1 teratocarcinoma In human embryonic teratocarcinoma (hNT2) cells transfected with the human neuronal ELAV-like protein, Hel-N1, neurites formed, yet cells were not terminally differentiated. 10049360 Human
hel-n1 childhood acute lymphoblastic leukemia Mutational analysis of the Hel-N1 gene in childhood acute lymphoblastic leukemia with LOH at 9p21. 10214879 Human
hel-n1 cancer Reverse transcriptase-polymerase chain reaction also showed that the Hu D, Hu C, Hel-N1 and Hel-N2 mRNAs were extensively and widely expressed through the neural tissues and cancer cells, but not in the visceral tissues. 9650757 Human
hel-n1 tumors Alterations of HuD and Hel-N1 structure are associated with small cell lung tumors and medulloblastomas. 9003489 Human
hel-n1 human tumors HuD and Hel-N1 are aberrantly spliced in human tumors yielding isoforms that are incapable of inducing differentiation (Gao et al. 1994; Antic et al. 1996). 9003489 Human
hel-n1 small-cell lung carcinoma Differential expression of the neuroendocrine genes Hel-N1 and HuD in small-cell lung carcinoma: evidence for down-regulation of HuD in the variant phenotype. 9291425 Human
hel-ni small-cell lung carcinoma Hel-NI and HuD belong to the elav gene family and have gained recent attention as potential neuroendocrine markers for small-cell lung carcinoma (SCLC). 9291425 Human
hel-n1 lung cancers Genomic organization and mutation analysis of Hel-N1 in lung cancers with chromosome 9p21 deletions. 9393760 Human
hel-n1 tumors A homozygous deletion including Hel-N1 and CDKN2a was found in a SCLC cell line, and a single-base polymorphism in exon 2 of Hel-N1 was observed in eight tumors. 9393760 Human
hel-n1 tumors No somatic mutations of Hel-N1 were found in this panel of lung tumors. 9393760 Human
hel-n1 lung cancer Hel-N1 does not appear to be a primary inactivation target of 9p21 deletion in lung cancer. 9393760 Human
hel-n1 tumors Fluorescence in situ hybridization (FISH) analysis using genomic probes spanning either the p16 or Hel-N1 (located at D9S126) gene was performed in 14 tumors. 9421353 Human
hel-n1 neuroblastoma Neuron-specific hel-N1 and HuD as novel molecular markers of neuroblastoma: a correlation of HuD messenger RNA levels with favorable prognostic features. 9815574 Human
hel-n1 tumor We, therefore, sought to determine: (a) the extent to which Hel-N1 and HuD are expressed in neuroblastoma (NB); and (b) whether the individual patterns of expression are associated with clinical features of the tumor. 9815574 Human
hel-n1 primary tumor We used a sensitive and quantitative RNase protection assay that reliably distinguishes between these homologous genes, and with it we show that Hel-N1 and HuD transcripts were detected in 100% of cultured cells (11 of 11) and 97% of primary tumor samples 9815574 Human
hel-n1 tumor In summary, the ubiquitous detection of HuD and Hel-N1 in NB indicates that they are molecular neuronal markers of this tumor. 9815574 Human
hel-n1 small-cell lung carcinoma Expression of Hel-N1 and Hel-N2 in small-cell lung carcinoma. 8619556 Human
hel-ni small-cell lung carcinoma Although expression of Hu antigens is most commonly seen in small-cell lung carcinoma, their exact identity (e.g., Hel-NI, Hel-N2, HuD, and HuC cannot be distinguished by immunological methods. Analysis of messenger RNA expression is needed for this disti 8619556 Human
hel-ni small-cell lung carcinoma Here we demonstrate that Hel-NI and Hel-N2 are expressed in small-cell lung carcinoma using reverse transcription-polymerase chain reaction. 8619556 Human
hel-n1 childhood brain tumors Here we demonstrate that in medulloblastoma cells derived from childhood brain tumors, Hel-N1 and Hel-N2 are mainly expressed in the cytoplasm, but are detectable in the nucleus. 8907704 Human
hel-n1 embryonic carcinoma In addition, we demonstrate that expression of the Hel-N1 protein family is up-regulated during neuronal differentiation of embryonic carcinoma P19 cells. 8907704 Human
hel-n1 small-cell lung cancer In the current study we examined (1) the reactivity of anti-Hu sera with HuD, HuC, and Hel-N1; (2) the expression of HuD, HuC, and Hel-N1 messenger RNA in small-cell lung cancer of patients with and those without paraneoplastic encephalomyelitis/sensory n 7541976 Human
hel-n1 lung carcinoma Autoantibodies against the Hel-N1 RNA-binding protein among patients with lung carcinoma: an association with type I anti-neuronal nuclear antibodies. 8053656 Human
hel-n1 lung carcinoma The aim of the present study was to determine the prevalence of antibodies against the Hel-N1 protein among patients with lung carcinoma, including those with paraneoplastic disorders. 8053656 Human
hel-n1 lung cancer Sera from 45 patients with lung cancer (42 with small-cell carcinoma) and from 28 control patients with other neurological diseases were studied by enzyme-linked immunosorbent assay (ELISA) and by immunoblotting with recombinant Hel-N1 protein. 8053656 Human
hel-n1 small-cell carcinoma Sera from 45 patients with lung cancer (42 with small-cell carcinoma) and from 28 control patients with other neurological diseases were studied by enzyme-linked immunosorbent assay (ELISA) and by immunoblotting with recombinant Hel-N1 protein. 8053656 Human
hel-n1 undifferentiated carcinoma Sixteen of the 45 lung cancer patients (14 with small-cell and 2 with undifferentiated carcinoma) had paraneoplastic encephalomyelitis and high-titer type I anti-neuronal nuclear antibodies; sera from each of these 16 patients also showed strong reactivit 8053656 Human
hel-n1 lung cancer Sixteen of the 45 lung cancer patients (14 with small-cell and 2 with undifferentiated carcinoma) had paraneoplastic encephalomyelitis and high-titer type I anti-neuronal nuclear antibodies; sera from each of these 16 patients also showed strong reactivit 8053656 Human

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